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General Material Information

Preferred name verbena absolute france
Trivial Name lippia citriodora absolute
Short Description aloysia triphylla absolute france
CAS Number 8024-12-2
CAS Number 85116-63-8
ECHA Number 285-515-0
FDA UNII Search
FDA Mainterm 8024-12-2 ; LEMON VERBENA, OIL (LIPPIA CITRIODORA)
Synonyms
  • aloysia triphylla absolute france
  • lippia citriodora absolute france

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Literature & References

lippia citriodora absolute
Canada Domestic Sub. List:8024-12-2
Pubchem (sid):3730676
aloysia citriodora extract
Canada Domestic Sub. List:85116-63-8
Pubchem (sid):3777682
Publications by PubMed
Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments.
Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats.
Comparative study on in vitro activities of citral, limonene and essential oils from Lippia citriodora and L. alba on yellow fever virus.
Chromatographic and mass spectrometric characterization of essential oils and extracts from Lippia (Verbenaceae) aromatic plants.
Evaluation of different extraction approaches for the determination of phenolic compounds and their metabolites in plasma by nanoLC-ESI-TOF-MS.
Antimicrobial activity of food-compatible plant extracts and chitosan against naturally occurring micro-organisms in tomato juice.
A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management.
Antihyperalgesic activity of verbascoside in two models of neuropathic pain.
Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers.
Antioxidant effect of lemon verbena extracts in lymphocytes of university students performing aerobic training program.
Characterization of phenolic and other polar compounds in a lemon verbena extract by capillary electrophoresis-electrospray ionization-mass spectrometry.
Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena).
Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro.
Antimicrobial, antioxidant and cytotoxic activities and phytochemical screening of some yemeni medicinal plants.
Authenticity control of essential oils containing citronellal and citral by chiral and stable-isotope gas-chromatographic analysis.
Antimicrobial activity of essential oils against Helicobacter pylori.
Studies on the antioxidant activity of Lippia citriodora infusion: scavenging effect on superoxide radical, hydroxyl radical and hypochlorous acid.
Flavonoids from Lippia citriodora.

Other Information

Export Tariff Code:3301.90.5000
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Solubility
alcohol Yes
water, 84.71 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Citrus
green, tea, hay, herbal, sweet, citrus
General comment At 100.00 %. green tea hay herbal sweet citrus
Mosciano, Gerard P&F 17, No. 6, 41, (1992) Green, tea-like, hay, herbal with a sweet citrus nuance
Flavor Type: Citrus
sweet, lemon, citrus, spicy, waxy, hay
Mosciano, Gerard P&F 17, No. 6, 41, (1992) At 30.00 ppm. Sweet, lemon, citrus, spice, waxy, with a hay-like nuance

Occurrences

Potential Uses

Applications
Odor purposes Hay new mown hay, Tobacco
Flavoring purposes Citrus, Lemon, Tea

Safety Information

Safety information

European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 137S, 1992.

Dermal Toxicity:
skin-rabbit LD50 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 137S, 1992.

skin-guinea pig LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 137S, 1992.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Dermal sensitization, Phototoxicity
IFRA fragrance material specification:
Verbena absolute obtained from Lippia citriodora Kunth, should not be used as a fragrance ingredient at a level over 1% in fragrance compounds. This recommendation is based on test results of RIFM showing sensitization reaction at 12% and no sensitization reaction at 2%. There is no evidence of photoxicity at 100% on hairless mice (private communication to IFRA).
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
citral Max. Found: 25.6 % and Reason: Sensitization
citronellol Max. Found: 0.45 % and Reason: Sensitization
eugenol Max. Found: 0.55 % and Reason: Sensitization
geraniol Max. Found: 4.1 % and Reason: Sensitization
methyl eugenol Max. Found: 0.1 % and Reason: Sensitization
trans-asarone Max. Found: 0.1 % and Reason: Carcinogenicity
cis-asarone Max. Found: 0.01 % and Reason: Carcinogenicity
alpha-cedrene Max. Found: 0.5 % and Reason: Sensitization
beta-cedrene Max. Found: 0.1 % and Reason: Sensitization
View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.12 %
Category 2: Products applied to the axillae
0.037 %
Category 3: Products applied to the face/body using fingertips
0.74 %
Category 4: Products related to fine fragrance
0.69 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.17 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.17 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.17 %
Category 5D: Baby Creams, baby Oils and baby talc
0.17 %
Category 6: Products with oral and lip exposure
0.40 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
1.40 %
Category 7B: Leave-on products applied to the hair with some hand contact
1.40 %
Category 8: Products with significant anogenital exposure
0.072 %
Category 9: Products with body and hand exposure, primarily rinse off
1.30 %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
4.80 %
Category 10B: Household aerosol/spray products
4.80 %
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
2.70 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
2.70 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
No Restriction
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Recommendation for verbena absolute france flavor usage levels up to:
30.0000 ppm in the finished product.

Safety references

EPI System: View
EPA Substance Registry Services (TSCA):8024-12-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
lippia citriodora absolute
Chemidplus:008024122
aloysia citriodora extract
Chemidplus:085116638