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costus root oil

General Material Information

Preferred name costus root oil
Trivial Name Oils, costus
Short Description saussurea lappa root oil
CAS Number 8023-88-9
FEMA Number 2336
FDA UNII 2WF6750061
MDL MFCD01771687
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8023-88-9 ; COSTUS ROOT, OIL (SAUSSUREA LAPPA CLARKE)
Synonyms
  • aplotaxis lappa root oil
  • aucklandia costus root oil
  • auklandra costus root oil
  • costus oil
  • costus oil 100
  • costus root oil (saussurea lappa clarke)
  • saussurea costus root oil
  • saussurea lappa root oil
  • spiral flag root oil (saussurea lappa clarke)
  • Oils, costus
  • Changala
  • Chob-i-qut
  • Goshtam
  • Kashmirja
  • Kastam
  • Koost
  • Koot
  • Kost
  • Kur
  • Kushtha
  • Kusta
  • Kuth
  • Ouplate
  • Pachak
  • Patchuk
  • Putchuk
  • Seppudy
  • Sepuddy
  • Upalet
  • Oils, Saussurealappa
  • Saussurea lappa oil
  • Oils, costus root

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Literature & References

saussurea lappa root oil
Canada Domestic Sub. List:8023-88-9
Pubchem (sid):135352797
Publications by PubMed
UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa.
Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India.
Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens.
Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats.
Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells.
Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.).
Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke.
Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.
A new sesquiterpene and other constituents from Saussurea lappa root.
Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice.
Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa.
Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing.
Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma).
Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm.
Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells.
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
Germacrenes from fresh costus roots.
Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release.
Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line.
Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice.
Effect of polyols on heat inactivation of Aspergillus niger van Teighem inulinase.
Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells.
Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix.
Sesquiterpenoids from costum root oil (Saussurea lappa Clarke)

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.6000
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex No
Solubility
alcohol Yes
water, 9.376 mg/L @ 25 °C (est) Yes
water No
Stability
non-discoloring in most media Unspecified

Organoleptic Properties

Odor Type: Animal
orris, green, hairy, woody, melon unripe melon
Odor strength medium
Substantivity 316 hour(s) at 100.00 %
Luebke, William tgsc, (1983) At 100.00 %. orris green hairy woody unripe melons
Flavor Type: Orris
costus
General comment Costus
For creation in spirits tonalities and brown notes Fatty metallic like herbal

Occurrences

Potential Uses

Applications
Odor purposes Aldehydic, Animal, Chypre, Fern, Floral, Narcissus, Oriental, Orris, Patchouli oil replacer, Tuberose, Vetiver, Woody
Flavoring purposes Violet
Other purposes Bellodgia, Cachet, Diffusion, Fur, Hair, My sin, Presence, Scandal, Tabu, Topnotes, Vol de nuit
Cosmetic purposes Not used anymore

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3400 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
IFRA Critical Effect:
Dermal sensitization
View the IFRA Standard
Recommendation for costus root oil usage levels up to:
PROHIBITED: Should not be used as a fragrance ingredient.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -1.20000
beverages(nonalcoholic): -0.08000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.90000
fruit ices: -0.90000
gelatins / puddings: -0.10000
granulated sugar: --
gravies: --
hard candy: -1.90000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8023-88-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
saussurea lappa root oil
Chemidplus:0008023889
RTECS:GN1775000 for cas# 8023-88-9