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nutmeg oil

General Material Information

Trivial Name nutmeg oil
Short Description essential oil steam-distilled from the dried kernels of the ripe seeds of the nutmeg, myristica fragrans, myristicaceae
CAS Number 8008-45-5
FEMA Number 2793
FDA UNII Z1CLM48948
MDL MFCD00147761
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8008-45-5 ; NUTMEG, OIL (MYRISTICA FRAGRANS HOUTT.)
Synonyms
  • augasorb nutmeg
  • essential oil steam-distilled from the dried kernels of the ripe seeds of the nutmeg, myristica fragrans, myristicaceae
  • myristica fragrans fruit oil
  • nutmeg EO
  • nutmeg ess select 01
  • nutmeg ess. oil (for fragrance) (Robertet)
  • nutmeg essential oil
  • nutmeg fraction EO low safrol and ME
  • nutmeg indonesie EO
  • nutmeg oil E.I.
  • nutmeg oil east indian
  • nutmeg oil El
  • nutmeg oil indonesia
  • nutmeg oil indonesian
  • nutmeg oil low safrole
  • nutmeg oil natural
  • nutmeg oil organic
  • nutmeg oil sri lanka organic
  • nutmeg oil, E.I.
  • oil nutmeg east indian extra FCC
  • oil nutmeg east indian select FCC
  • myristica fragrans houtt. fruit oil
  • Oils, nutmeg
  • Myristica oil
  • Oil of myristica
  • Oil of nutmeg
  • Oils, Myristicafragrans

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

myristica fragrans houtt. fruit oil
Canada Domestic Sub. List:8008-45-5
Pubchem (sid):135337544
Publications by PubMed
Chemical constituents and activities of the essential oil from Myristica fragrans against cigarette beetle Lasioderma serricorne.
Catalytically and biologically active silver nanoparticles synthesized using essential oil.
Nutmeg poisonings: a retrospective review of 10 years experience from the Illinois Poison Center, 2001-2011.
Simple and rapid determination of myristicin in human serum.
In vitro antibacterial effects of five volatile oil extracts against intramacrophage Brucella abortus 544.
Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study.
In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
Antibacterial activity of crude extracts of prasaprohyai formula and its components against pathogenic bacteria.
Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia.
Extraction and separation of volatile and fixed oils from seeds of Myristica fragrans by supercritical CO₂: chemical composition and cytotoxic activity on Caco-2 cancer cells.
Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia.
meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice.
Acaricidal activity of eugenol based compounds against scabies mites.
Contact dermatitis to Vicks VapoRub.
[Antioxidant properties of essential oils].
[Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice].
Anticonvulsant activities of nutmeg oil of Myristica fragrans.
Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae).
[GC-MS analysis of essential oil from nutmeg processed by different traditional methods].
[Comparing analysis of components in volatile oils of nutmeg and prepared nutmeg by GC-MS].
Assortment of the plants in the Medieval diet in Czech countries (based on archaeobotanical finds).
[Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation].
[GC-MS analysis of essential oils from seeds of Myristica fragrans in Chinese market].
Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils.
[Balneological use of bath concentrate containing xidifon and essential oils from ginger, nutmeg, and sandal].
[Effect of different processing conditions on content of myrisiticin, volatile oil and fatty lipid in semen Myristicae].
[Quality standards of processed nutmegs].
Broad-range and binary-range acyl-acyl-carrier protein thioesterases suggest an alternative mechanism for medium-chain production in seeds.
Toxicological evaluation of myristicin.
Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver.
Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papillomagenesis in the skin of mice.
Nutmeg oil: identification and quantitation of its most active constituents as inhibitors of platelet aggregation.
Nutmeg oil and camphene as inhaled expectorants.
Nutmeg oil and camphene as inhaled expectorants.

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.5045
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

Suppliers

Albert Vieille SAS Ambles Nature et Chimie
Anhui Haibei Aromatic and Allied Chemicals
Artiste Asean Aromatics
Astral Extracts Augustus Oils
Azelis UK Berjé
Blue Pacific Flavors Bontoux
Charabot Citrus and Allied Essences
De Monchy Aromatics Diffusions Aromatiques
ECSA Chemicals Elixens America
Ernesto Ventós Excellentia International
F. P. Aromatics Singapore Firmenich
Fleurchem Frey + Lau
George Uhe Company Global Essence
H. Interdonati, Inc. Haldin International
HDDES Group Hermitage Oils
Indenta Group India Essential Oils
Indo World Trading Indukern F&F
Jiangyin Healthway John Kellys (London)
K.L. Koh Enterprise Kalsec
Kanta Enterprises Lionel Hitchen
Lluch Essence Mane
Moellhausen Natura Aromatik
Naturex Noble Molecular Research
OQEMA Payand Betrand
Penta International PerfumersWorld
Phoenix Aromas & Essential Oils Plant Lipids
PT Mitra Ayu Adi Pratama PT. Nabateans Aromatic
Quimdis R C Treatt & Co Ltd
Reincke & Fichtner Robertet
Sigma-Aldrich Som Extracts
Synthite Industries Taytonn ASCC
The John D. Walsh Company The Lebermuth Company
The Lermond Company The Perfumers Apprentice
The Perfumery Ultra International
Ungerer & Company Van Aroma
Vigon International Zanos
Augustus Oils Ltd Azelis UK Ltd.
Berje Inc. Bontoux SAS
Elixens America, Inc. Firmenich Inc.
Fleurchem, Inc. Global Essence Inc.
Hermitage Oils / Neroli S.R.L. Indukern, S.A. F&F Ingredients Division
Jiangyin Healthway International Trade Co., Ltd Lluch Essence S.L.
Moellhausen S.P.A. Penta International Corporation
PerfumersWorld Ltd. Robertet, Inc.
Taytonn ASCC Pte Ltd The John D. Walsh Company, Inc
R C Treatt and Co Ltd Ultra International Limited
Ernesto Ventós S.A. Zanos Ltd.
Sifar Naturals

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 7.322 to 7.572
Refractive Index 1.475 to 1.488 @ 20 °C
Flash Point TCC Value 42.78 °C TCC
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
paraffin oil Yes
water No
Stability
bath foam Unspecified
detergent Unspecified
hair spray Unspecified
lipstick Unspecified
non-discoloring in most media Unspecified
soap Unspecified

Organoleptic Properties

Odor Type: Spicy
spicy, woody, nutmeg, powdery, terpenic, aromatic, pine, woody old wood, resinous
Odor strength medium
Substantivity 52 hour(s) at 100.00 %
Luebke, William tgsc, (1993) At 100.00 %. spicy woody nutmeg powdery terpene
Mosciano, Gerard P&F 15, No. 3, 51, (1990) Spice, nutmeg, woody, terpy, slightly piney
Flavor Type: Spicy
spicy, woody, terpenic, aromatic, peppery, nut skin, resinous, anisic, sweet, nutmeg
Luebke, William tgsc, (1993) Spicy woody terpenic aromatic peppery nut skin resinous anisic
Mosciano, Gerard P&F 15, No. 3, 51, (1990) At 30.00 ppm. Sweet, woody, nutmeg, spicy with a slight terpy nuance
At a low dosage, it enhances the perception of sweetness and mouthfeel Spicy warm powdery woody terpenic

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
R 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R 65 - Harmful: may cause lung damage if swallowed.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 24 - Avoid contact with skin.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 3), H226
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
GHS Label elements, including precautionary statements
Pictogramflame.jpgexclamation-mark.jpg
Signal word Warning
Hazard statement(s)
H226 - Flammable liquid and vapour
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statement(s)
P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 - Keep container tightly closed.
P240 - Ground/bond container and receiving equipment.
P241 - Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 - Use only non-sparking tools.
P243 - Take precautionary measures against static discharge.
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 - Store in a well-ventilated place. Keep cool.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50 2620 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Food and Cosmetics Toxicology. Vol. 14, Pg. 631, 1976.

Dermal Toxicity:
skin-rabbit LD50 > 10000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 631, 1976.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Sensitization
IFRA fragrance material specification:
1.2
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
methyl eugenol Max. Found: 1.2 % and Reason: Potential carcinogenic activity in animals
geraniol Max. Found:
citronellol Max. Found:
eugenol Max. Found: 0.2 % and Reason: Sensitization
isoeugenol Max. Found: 0.5 % and Reason: Sensitization
safrole Max. Found: 1.5 % and Reason: Carcinogenicity
Recommendation for nutmeg oil usage levels up to:
2.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -75.00000
beverages(nonalcoholic): -14.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 1.20000640.00000
condiments / relishes: -21.00000
confectionery froastings: 2.0000030.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -13.00000
fruit ices: -13.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -19.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -150.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPA Substance Registry Services (TSCA):8008-45-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2319
WGK Germany:2
myristica fragrans houtt. fruit oil
Chemidplus:0008008455
RTECS:RJ3694800 for cas# 8008-45-5