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    General Material Information
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sandalwood oil

General Material Information

Trivial Name sandalwood oil
Short Description santalum album wood oil
CAS Number 8006-87-9
FEMA Number 3005
FDA UNII X7X01WMQ5F
MDL MFCD00148248
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8006-87-9 ; SANDALWOOD, YELLOW, OIL (SANTALUM ALBUM L.)
Synonyms
  • arheol oil (santalum album)
  • oil sandalwood indian FCC
  • oil sandalwood indonesian FCC
  • extrapone sandalwood (Symrise)
  • sandalwood EO
  • sandalwood ess. oil (for fragrance) (Robertet)
  • sandalwood essential oil
  • sandalwood india EO
  • sandalwood india type EO 01
  • sandalwood oil - agmark
  • sandalwood oil east indian FCC
  • sandalwood oil india
  • sandalwood oil india rectified
  • sandalwood oil indian
  • sandalwood oil indonesia CO2
  • sandalwood oil indonesian
  • sandalwood oil yellow (santalum album)
  • sandalwood oil, E.I.
  • sandalwood type inde EO 01
  • sandalwood type inde EO 02
  • santalum album wood oil
  • saunders white oil (santalum album)
  • santalum album l. wood oil
  • Essential oils, sandalwood
  • Oils, sandalwood
  • Oils, essential, sandalwood
  • Santalum album, essential oil
  • Oil of santal
  • Santal oil
  • Arheol
  • East Indian sandalwood oil
  • Oils, East Indian sandalwood
  • Sandalwood essential oils
  • YH 98002

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

santalum album l. wood oil
Canada Domestic Sub. List:8006-87-9
Pubchem (sid):135309309
Publications by PubMed
Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study.
Anti-diarrhoeal activity of methanol extract of Santalum album L. in mice and gastrointestinal effect on the contraction of isolated jejunum in rats.
Biosynthesis of Sandalwood Oil: Santalum album CYP76F cytochromes P450 produce santalols and bergamotol.
Molecular regulation of santalol biosynthesis in Santalum album L.
Comparative phytochemical analysis and antibacterial efficacy of in vitro and in vivo extracts from East Indian sandalwood tree (Santalum album L.).
Revisiting sesquiterpene biosynthetic pathways leading to santalene and its analogues: a comprehensive mechanistic study.
Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods.
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases.
Bioreactor production of secondary metabolites from cell cultures of periwinkle and sandalwood.
Isolation of cDNAs and functional characterisation of two multi-product terpene synthase enzymes from sandalwood, Santalum album L.
Safety assessment of sandalwood oil (Santalum album L.).
Quantitative co-occurrence of sesquiterpenes; a tool for elucidating their biosynthesis in Indian sandalwood, Santalum album.
Evaluating the effectiveness of aromatherapy in reducing levels of anxiety in palliative care patients: results of a pilot study.
Lipids as renewable resources: current state of chemical and biotechnological conversion and diversification.
Fragrance contact dermatitis in Korea: a joint study.
Evaluation of the quality of sandalwood essential oils by gas chromatography-mass spectrometry.
Synthesis of novel tri- and tetrasubstituted C18 furan fatty esters.
Evaluation of the effects of East Indian sandalwood oil and alpha-santalol on humans after transdermal absorption.
Temporal association of Ca(2+)-dependent protein kinase with oil bodies during seed development in Santalum album L.: its biochemical characterization and significance.
[The influence of external stimulation on content and quality of volatile oil in Lignun Santali albi].
Antiviral activity of sandalwood oil against herpes simplex viruses-1 and -2.
Chemopreventive effects of sandalwood oil on skin papillomas in mice.
Ultrasound-assisted synthesis of santalbic acid and a study of triacylglycerol species in Santalum album (Linn.) seed oil.
Modulatory influence of sandalwood oil on mouse hepatic glutathione S-transferase activity and acid soluble sulphydryl level.
[Studies on the structure of alpha-trans-bergamotenol from Chinese santalwood oil].

Other Information

FDA Substances Added to Food (formerly EAFUS):View
FooDB:FDB010227
Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
FAO:SANDALWOOD OIL

Suppliers

Absolute Cosmetic Essentials Aditi Essentials
Ambles Nature et Chimie Anhui Haibei
Argeville Artiste
Astral Extracts Augustus Oils
Berjé Biolandes Parfumerie
BOC Sciences Bontoux
Bristol Botanicals Charkit Chemical
Citrus and Allied Essences De Monchy Aromatics
Diffusions Aromatiques Elixens America
Ernesto Ventós Excellentia International
F. P. Aromatics Singapore Fleurchem
Floral concept Fuzhou Farwell
George Uhe Company Global Essence
Haldin International HDDES Group
Hermitage Oils IFF
Indenta Group Indo World Trading
Indukern F&F Isobionics
Jiangyin Healthway John Kellys (London)
Kanta Enterprises Lluch Essence
M&U International Moellhausen
Noble Molecular Research OQEMA
Payand Betrand Penta International
PerfumersWorld Phoenix Aromas & Essential Oils
PT Mitra Ayu Adi Pratama PT. Nabateans Aromatic
Quimdis Quintis
R C Treatt & Co Ltd Reincke & Fichtner
Robertet Sigma-Aldrich
SRS Aromatics Symrise
Taytonn ASCC The John D. Walsh Company
The Lebermuth Company The Lermond Company
The Perfumers Apprentice The Perfumery
Ultra International Ungerer & Company
Vigon International Zanos
Argeville SAS Augustus Oils Ltd
Berje Inc. Bontoux SAS
Charkit Chemical Corporation Elixens America, Inc.
Fleurchem, Inc. Global Essence Inc.
Hermitage Oils / Neroli S.R.L. Indukern, S.A. F&F Ingredients Division
Jiangyin Healthway International Trade Co., Ltd Lluch Essence S.L.
M&U International LLC Moellhausen S.P.A.
Penta International Corporation PerfumersWorld Ltd.
Robertet, Inc. SRS Aromatics Ltd
Symrise AG Taytonn ASCC Pte Ltd
The John D. Walsh Company, Inc R C Treatt and Co Ltd
Ultra International Limited Ernesto Ventós S.A.
Zanos Ltd. Sifar Naturals

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 8.071 to 8.138
Refractive Index 1.498 to 1.512 @ 20 °C
Optical Rotation -20 to -15
Flash Point TCC Value 93.33 °C TCC
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
fixed oils Yes
paraffin oil Yes
propylene glycol Yes
water, 4.188 mg/L @ 25 °C (est) Yes
water No
glycerin No
Stability
cream Unspecified
hair spray Unspecified
lotion Unspecified
non-discoloring in most media Unspecified
powder Unspecified
shampoo Unspecified

Organoleptic Properties

Odor Type: Woody
sweet, woody, balsamic, cashew, terpenic, herbal, spicy, sandalwood
Odor strength medium
Substantivity 400 hour(s) at 100.00 %
Luebke, William tgsc, (1983) At 100.00 %. sweet woody balsamic cashew terpene herbal spicy
Mosciano, Gerard P&F 22, No. 5, 67, (1997) Woody, sandalwood, terpy, balsamic, herbal and slightly spicy
Flavor Type: Woody
woody, sandalwood, balsamic, floral, terpenic
Mosciano, Gerard P&F 22, No. 5, 67, (1997) At 5.00 ppm. Woody, sandalwood, balsamic and floral with a terpy nuance

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Skin sensitisation (Category 1), H317
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
GHS Label elements, including precautionary statements
Pictogramexclamation-mark.jpg
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H317 - May cause an allergic skin reaction
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P272 - Contaminated work clothing should not be allowed out of the workplace.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P333 + P313 - IF SKIN irritation or rash occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50 5580 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 989, 1974.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 989, 1974.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
farnesol Max. Found: 0.7 % and Reason: Sensitization
alpha-bisabolol Max. Found: 0.5 % and Reason: Sensitization
Recommendation for sandalwood oil usage levels up to:
10.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -6.60000
beverages(nonalcoholic): -2.40000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -47.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.50000
fruit ices: -7.50000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -7.70000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8006-87-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
santalum album l. wood oil
Chemidplus:0008006879
RTECS:RJ3697000 for cas# 8006-87-9