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General Material Information

Preferred name melissa oil
Trivial Name Oils, Melissa officinalis
Short Description volatile oil obtained from the leaves and tops of the balmmintoil, melissa officinalis l., labiatae
CAS Number 8014-71-9
FEMA Number 2113
FDA UNII Search
MDL MFCD00130600
COE Number 280
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8014-71-9 ; BALM, OIL (MELISSA OFFICINALIS L.)
Synonyms
  • lemon balm essential oil
  • bee balm leaf oil
  • sweet balm leaf oil
  • balm lemon oil (melissa officinalis)
  • balm oil
  • lemon balm oil
  • sweet balm oil
  • lemon balm oil organic
  • hydroessential melissa (Vevy)
  • melissa bicornis leaf oil
  • melissa officinalis leaf oil
  • melissa oil bulgaria organic
  • melissa true oil south africa organic
  • volatile oil obtained from the leaves and tops of the balmmintoil, melissa officinalis l., labiatae
  • xiang feng hua leaf oil
  • melissa officinalis l. leaf oil
  • Oils, Melissa officinalis
  • Balm oil (Melissa officinalis)
  • Oil of Balm
  • Oil of lemon balm
  • Oil of melissa

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Literature & References

melissa officinalis l. leaf oil
Canada Domestic Sub. List:8014-71-9
Pubchem (sid):135304641
Publications by PubMed
http://www.ncbi.nlm.nih.gov/pubmed/19295032
Composition of the fresh leaves and stems of Melissa officinalis and evaluation of skin irritation in a reconstituted human epidermis model.
Lemon balm--Melissa officinalis; also known as lemon balm, bee balm, garden balm, Melissa, melissengeist.
Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania.
Monitoring of phenolic compounds for the quality control of Melissa officinalis products by capillary electrophoresis.
Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.
Effect of Time of Harvesting on Yield and Quality of Melissa Officinalis L. in Doon Valley, India.
Antinociceptive and Antihyperglycemic Effects of Melissa officinalis Essential Oil in an Experimental Model of Diabetes.
Volatile constituents of Melissa officinalis leaves determined by plant age.
Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.
Fumigant toxicity of summer savory and lemon balm oil constituents and efficacy of spray formulations containing the oils to B- and neonicotinoid-resistant Q-biotypes of Bemisia tabaci (Homoptera: Aleyrodidae).
Enzymatic profile, adhesive and invasive properties of Candida albicans under the influence of selected plant essential oils.
In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil.
Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract.
Neuroprotective properties of Melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo.
Effects of PAR and UV-B radiation on herbal yield, bioactive compounds and their antioxidant capacity of some medicinal plants under controlled environmental conditions.
Inhibition of cholinesterase by essential oil from food plant.
Melissa officinalis essential oil reduces plasma triglycerides in human apolipoprotein E2 transgenic mice by inhibiting sterol regulatory element-binding protein-1c-dependent fatty acid synthesis.
Chemical composition analysis of the essential oil of Melissa officinalis L. from Kurdistan, Iran by HS/SPME method and calculation of the biophysicochemical coefficients of the components.
"High in omega-3 fatty acids" bologna-type sausages stabilized with an aqueous-ethanol extract of Melissa officinalis.
Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.
A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease.
Effect of distillation waste water and plant hormones on spearmint growth and composition.
An attempt of postharvest orange fruit rot control using essential oils from Mediterranean plants.
Assessment of the antioxidant potential of selected plant extracts--in vitro and in vivo experiments on pork.
Anti-diabetic effects of lemon balm ( Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice.
Chemical composition and larvicidal evaluation of Mentha, Salvia, and Melissa essential oils against the West Nile virus mosquito Culex pipiens.
Effect of lyophilized water extracts of Melissa officinalis on the stability of algae and linseed oil-in-water emulsion to be used as a functional ingredient in meat products.
Solvent-free microwave extraction of essential oils from Laurus nobilis and Melissa officinalis: comparison with conventional hydro-distillation and ultrasound extraction.
Antimicrobial effect of garlic (Allium sativum).
Investigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley rat.
Antimicrobial activity of plant essential oils using food model media: efficacy, synergistic potential and interactions with food components.
Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.
Melissa officinalis oil affects infectivity of enveloped herpesviruses.
Herbal remedies for dyspepsia: peppermint seems effective.
Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania.
[Advances on the effects of the compounds of a phytotherapic agent (COLIMIL) on upper gastrointestinal transit in mice].
The antimicrobial efficacy of plant essential oil combinations and interactions with food ingredients.
Aromatic plant production on metal contaminated soils.
Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.
Effects of the herbal formulation ColiMil on upper gastrointestinal transit in mice in vivo.
Identification of Melissa officinalis Subspecies by DNA Fingerprinting.
The psychopharmacology of European herbs with cognition-enhancing properties.
Authenticity control of essential oils containing citronellal and citral by chiral and stable-isotope gas-chromatographic analysis.
The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal.
Bacterial colonization of the phyllosphere of mediterranean perennial species as influenced by leaf structural and chemical features.
Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: a morphological and biochemical study.
Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2.
Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora.
Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers.
Melissa officinalis L. essential oil: antitumoral and antioxidant activities.
Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil.
Variability in the content and composition of essential oil from lemon balm (Melissa officinalis L.) cultivated in Poland.
Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions.
Activity of essential oils from Mediterranean Lamiaceae species against food spoilage yeasts.
Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.
The influence of the harvest cut height on the quality of the herbal drugs Melissae folium and Melissae herba.
[Comparison of the quality of Melissa officinalis L. cultivar Citra with Mellissas of European origin].
[The content and quality of Melissa officinalis essential oil after application of Rastim 30 DKV].
In vitro effect of essential oils and isolated mono- and sesquiterpenes on Leishmania major and Trypanosoma brucei.
The effect of herbicides on the qualitative properties of medicinal plants. Part 3: Content and composition of the essential oil from Melissa officinalis L. after application of Basagran.
Genetic Variability of the Essential Oil Content of Melissa officinalis1.
Constituents of the Essential Oil from Melissa officinalis.
Extraction of light filth from whole leaves of alfalfa, lemon balm, papaya, and spearmint: collaborative study.
[Chemical composition of the essential oil from melissa].
[Composition of etheric oil of Melissa officinalis L. and secondary changes of oil composition].

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
FAO:Melissa officinalis

PhysChem Properties

Material listed in food chemical codex No
Solubility
alcohol Yes
water, 38.94 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Citrus
sweet, citrus, citronella, herbal, grassy
Odor strength medium
Substantivity 120 hour(s) at 100.00 %
Luebke, William tgsc, (1984) At 100.00 %. sweet citrus citronella java herbal grassy

Occurrences

Potential Uses

Applications
Odor purposes Citronella
Flavoring purposes Citrus, Lemon
Cosmetic purposes Fragrance, Perfuming agents, Tonic

Safety Information

Safety information

European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37 - Wear suitable protective clothing and gloves.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
IFRA Critical Effect:
Dermal sensitization
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
geraniol Max. Found: 1.3 % and Reason: Sensitization
citral Max. Found: 58.00 % and Reason: Sensitization
citronellol Max. Found: 0.15 % and Reason: Sensitization
(E)-isocitral Max. Found: 1.00 % and Reason: Sensitization
(Z)-isocitral Max. Found: 0.3 % and Reason: Sensitization
citronellal Max. Found: 1.3 % and Reason: Sensitization
View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.11 %
Category 2: Products applied to the axillae
0.032 %
Category 3: Products applied to the face/body using fingertips
0.65 %
Category 4: Products related to fine fragrance
0.60 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.15 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.15 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.15 %
Category 5D: Baby Creams, baby Oils and baby talc
0.15 %
Category 6: Products with oral and lip exposure
0.35 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
1.20 %
Category 7B: Leave-on products applied to the hair with some hand contact
1.20 %
Category 8: Products with significant anogenital exposure
0.063 %
Category 9: Products with body and hand exposure, primarily rinse off
1.20 %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
4.20 %
Category 10B: Household aerosol/spray products
4.20 %
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
2.30 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
2.30 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
No Restriction
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: 10.0000060.00000
beverages(nonalcoholic): -8.50000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 1.7000015.00000
fruit ices: 1.7000015.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -20.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8014-71-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
melissa officinalis l. leaf oil
Chemidplus:0008014719