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laurus nobilis leaf oil

General Material Information

Preferred name laurus nobilis leaf oil
Trivial Name laurus nobilis l. leaf oil
Short Description volatile oil obtained from the leaves of the laurel, laurus nobilis l., lauraceae
CAS Number 8007-48-5
CAS Number 8002-41-3
Deleted CAS Number 8023-97-0
FEMA Number 2125
FDA UNII Search
MDL MFCD00677251
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8007-48-5 ; BAY LEAVES, SWEET, OIL (LAURUS NOBILIS L.)
Synonyms
  • bay laurel leaf oil
  • sweet bay leaf oil
  • bay oil, sweet (laurus nobilis l.), natural
  • hydroessential laurus (Vevy)
  • laurel leaf essential oil
  • laurel leaf oil
  • laurel leaf oil maroc 100
  • laurel leaf oil morocco
  • laurel leaves ess. oil (for fragrance) (Robertet)
  • laurel noble balkans EO
  • laurel noble EO
  • laurel oil turkey
  • laurel select 01
  • laurel select 01 (Charabot)
  • sugandh kokila oil
  • volatile oil obtained from the leaves of the laurel, laurus nobilis l., lauraceae

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

laurus nobilis l. leaf oil
Canada Domestic Sub. List:8007-48-5
Pubchem (sid):135304193
laurus nobilis l. oil
Canada Domestic Sub. List:8002-41-3
Pubchem (sid):135322906
Publications by PubMed
Effects of herbal essential oil mixture as a dietary supplement on egg production in quail.
Neuroprotective potential of Laurus nobilis antioxidant polyphenol-enriched leaf extracts.
Coping with drought-induced xylem cavitation: coordination of embolism repair and ionic effects in three Mediterranean evergreens.
Does short-term potassium fertilization improve recovery from drought stress in laurel?
Laurel leaf extracts for honeybee pest and disease management: antimicrobial, microsporicidal, and acaricidal activity.
Comparative investigation of Umbellularia californica and Laurus nobilis leaf essential oils and identification of constituents active against Aedes aegypti.
Apolar Laurus nobilis leaf extracts induce cytotoxicity and apoptosis towards three nervous system cell lines.
Molecular size fractions of bay leaf (Laurus nobilis) exhibit differentiated regulation of colorectal cancer cell growth in vitro.
Aluminium phosphide-induced genetic and oxidative damages in vitro: attenuation by Laurus nobilis L. leaf extract.
Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts.
Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line.
Acylated kaempferol glycosides from Laurus nobilis leaves and their inhibitory effects on Na+/K+-adenosine triphosphatase.
Activity, polypeptide and gene identification of thylakoid Ndh complex in trees: potential physiological relevance of fluorescence assays.
Aluminum phosphide-induced genetic and oxidative damages in rats: attenuation by Laurus nobilis leaf extract.
Chemical polymorphism of essential oils from populations of Laurus nobilis grown on Tunisia, Algeria and France.
Antidiarrheal activity of Laurus nobilis L. leaf extract in rats.
Antioxidant and antiproliferative activity of Laurus nobilis L. (Lauraceae) leaves and seeds essential oils against K562 human chronic myelogenous leukaemia cells.
Antimicrobial sesquiterpenoids from Laurus nobilis L.
Uniformity trials in plant freezing assays involving microtitre plates.
Short-term effects of potassium fertilization on the hydraulic conductance of Laurus nobilis L.
Gastroprotective effect and antioxidant properties of different Laurus nobilis L. leaf extracts.
Spirafolide from bay leaf (Laurus nobilis) prevents dopamine-induced apoptosis by decreasing reactive oxygen species production in human neuroblastoma SH-SY5Y cells.
In vitro and in vivo effects of Laurus nobilis L. leaf extracts.
Phytochemical composition and antioxidant activity of Laurus nobilis L. leaf infusion.
A biosensor based on Bay leaf (Laurus nobilis L.) tissue homogenate: improvement of the stability characteristics by a simple bio-imprinted technique.
Short- and long-term modulation of the lutein epoxide and violaxanthin cycles in two species of the Lauraceae: sweet bay laurel (Laurus nobilis L.) and avocado (Persea americana Mill.).
Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates.
Evaluation of wound healing activity of Allamanda cathartica. L. and Laurus nobilis. L. extracts on rats.
A simple method to obtain essential oils from Salvia triloba L. and Laurus nobilis L. by using microwave-assisted hydrodistillation.
Analgesic and anti-inflammatory activity of the leaf essential oil of Laurus nobilis Linn.
Effect of drying method on the volatiles in bay leaf (Laurus nobilis L.).
Preliminary evaluation of cytotoxic properties of Laurus nobilis leaf extracts.
Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures.
Alcohol absorption inhibitors from bay leaf (Laurus nobilis): structure-requirements of sesquiterpenes for the activity.
Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction.
Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: structure requirement and suppression of gastric emptying.
Air pollution effects on the guard cells of the injury resistant leaf of Laurus nobilis L.
Allergic contact dermatitis from Dittrichia viscosa (L.) Greuter.
Air pollution effects on the leaf structure of Laurus nobilis, an injury resistant species.
Effects of Laurus nobilis (Lauraceae) on Biomphalaria glabrata (Say, 1818).

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 7.531 to 7.73
Refractive Index 1.465 to 1.47 @ 20 °C
Flash Point TCC Value 53.33 °C TCC
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
water No
Stability
non-discoloring in most media Unspecified

Organoleptic Properties

Odor Type: Herbal
herbal, eucalyptus, spicy, terpenic, camphoreous, medicinal, aromatic, woody
Odor strength medium , recommend smelling in a 10.00 % solution or less
Substantivity 117 hour(s) at 100.00 %
Luebke, William tgsc, (2021) At 10.00 % in dipropylene glycol. herbal eucalyptus spicy terpenic camphoreous medicinal aromatic woody
Flavor Type: Herbal
herbal, spicy, minty, aromatic, eucalyptus, camphoreous, woody, pimenta, pennyroyal
Luebke, William tgsc, (2021) Herbal spicy minty aromatic eucalyptus camphoreous woody pimenta pennyroyal

Occurrences

Potential Uses

Applications
Odor purposes Aldehydic, Herbal, Spice
Cosmetic purposes Fragrance, Perfuming agents

Safety Information

Safety information

European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 330 ul/kg
Journal of Ethnopharmacology. Vol. 58, Pg. 9, 1997.

oral-mouse LD50 3310 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
Journal of Agricultural and Food Chemistry. Vol. 22, Pg. 777, 1974.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
eugenol Max. Found: 1.1 % and Reason: Sensitization
methyl eugenol Max. Found: 3.00 % and Reason: Potential carcinogenic activity in animals
(E)-2-hexen-1-al Max. Found: trace to
geraniol Max. Found: 0.05 % and Reason: Sensitization
Recommendation for laurus nobilis leaf oil usage levels up to:
2.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -21.00000
beverages(nonalcoholic): -2.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -2.90000
condiments / relishes: -30.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.80000
fruit ices: -1.80000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -2.60000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8007-48-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1169
laurus nobilis l. leaf oil
Chemidplus:0008007485
laurus nobilis l. oil
Chemidplus:0008002413