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    General Material Information
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litsea cubeba fruit oil

General Material Information

Preferred name litsea cubeba fruit oil
Trivial Name Oils, Litsea cubeba
Short Description volatile oil obtained from the berries of the litsea cubeba, lauraceae
CAS Number 68855-99-2
FEMA Number 3846
FDA UNII Search
MDL MFCD00678555
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 68855-99-2 ; LITSEA CUBEBA BERRY OIL
Synonyms
  • litsea cubeba berry oil
  • litsea cubeba EO
  • litsea cubeba ess. oil (for fragrance) (Robertet)
  • litsea cubeba oil
  • litsea cubeba oil china
  • litsea cubeba oil min. 75 pct
  • litsea cubeba oil natural
  • litsea cubeba oil vietnam organic
  • oil litsea cubeba chinese 85%
  • volatile oil obtained from the berries of the litsea cubeba, lauraceae
  • Oils, Litsea cubeba

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

litsea cubeba fruit oil
Canada Domestic Sub. List:68855-99-2
Pubchem (sid):135355110
Publications by PubMed
Synergistic repellent and irritant effect of combined essential oils on Aedes aegypti (L.) mosquitoes.
Antibacterial Activity and Kinetics of Litsea cubeba Oil on Escherichia coli.
Hydrothermal liquefaction of Litsea cubeba seed to produce bio-oils.
Mosquito (Diptera: Culicidae) repellency field tests of essential oils from plants traditionally used in Laos.
Vapor of volatile oils from Litsea cubeba seed induces apoptosis and causes cell cycle arrest in lung cancer cells.
Chemical composition of essential oils of Litsea cubeba harvested from its distribution areas in China.
Antimicrobial impact of the components of essential oil of Litsea cubeba from Taiwan and antimicrobial activity of the oil in food systems.
[Analysis of volatile oil from different parts of Litsea cubeba].
The fungicidal terpenoids and essential oil from Litsea cubeba in Tibet.
Phototoxicity of essential oils intended for cosmetic use.
Compositions and in vitro anticancer activities of the leaf and fruit oils of Litsea cubeba from Taiwan.
Chemical composition and antibacterial activity of essential oils from different parts of Litsea cubeba.
Comparative toxicity of essential oils of Litsea pungens and Litsea cubeba and blends of their major constituents against the cabbage looper, Trichoplusia ni.
Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand.
Authenticity control of essential oils containing citronellal and citral by chiral and stable-isotope gas-chromatographic analysis.
Repellency effect of forty-one essential oils against Aedes, Anopheles, and Culex mosquitoes.
Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay.
Acute and genetic toxicity of essential oil extracted from Litsea cubeba (Lour.) Pers.
Effects of citral on Aspergillus flavus spores by quasi-elastic light scattering and multiplex microanalysis techniques.
[Chemical composition of essential oil from leaves of litsea cubeba and its antifungal activities].
Evaluation of massage with essential oils on childhood atopic eczema.
[Preliminary study of the antifungal effect of volatile oil of Litsea cubeba and its extracts].
[Pharmacological studies on anti-asthmatic and anti-anaphylactic activities of the essential oil of Litsea cubeba (Lour.) Pers. (author's transl)].

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.5050
FDA Listing of Food Additive Status:View
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
FAO:LITSEA CUBEBA OIL

Suppliers

Absolute Cosmetic Essentials Albert Vieille SAS
Ambles Nature et Chimie Anhui Haibei
Artiste ASIA IMPORT AND EXPORT
Augustus Oils Azelis UK
Berjé BOC Sciences
Bontoux Camden-Grey Essential Oils
Charabot Citrus and Allied Essences
Creatingperfume.com De Monchy Aromatics
ECSA Chemicals Elixens America
Ernesto Ventós Fleurchem
Frey + Lau Fuzhou Farwell
George Uhe Company Global Essence
Hermitage Oils Indenta Group
Indukern F&F Jiangyin Healthway
John Kellys (London) K.L. Koh Enterprise
Kanta Enterprises Lluch Essence
M&U International Moellhausen
Noble Molecular Research OQEMA
Payand Betrand Pearlchem Corporation
Penta International PerfumersWorld
Phoenix Aromas & Essential Oils Primechem
Quimdis R C Treatt & Co Ltd
Reincke & Fichtner Robertet
Sunaux International The John D. Walsh Company
The Lebermuth Company The Lermond Company
The Perfumers Apprentice The Perfumery
Ungerer & Company United International
Vigon International Xiamen Doingcom Chemical
Zanos Augustus Oils Ltd
Azelis UK Ltd. Berje Inc.
Bontoux SAS Elixens America, Inc.
Fleurchem, Inc. Global Essence Inc.
Hermitage Oils / Neroli S.R.L. Indukern, S.A. F&F Ingredients Division
Jiangyin Healthway International Trade Co., Ltd Lluch Essence S.L.
M&U International LLC Moellhausen S.P.A.
Penta International Corporation PerfumersWorld Ltd.
Anhui Primechem Co., Ltd. Robertet, Inc.
The John D. Walsh Company, Inc R C Treatt and Co Ltd
Qingdao Free Trade Zone United International Co Ltd Ernesto Ventós S.A.
Zanos Ltd.

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 7.356 to 7.522
Refractive Index 1.483 to 1.489 @ 20 °C
Flash Point TCC Value 71.11 °C TCC
Shelf life 12 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
paraffin oil Yes
propylene glycol Yes
water, 84.71 mg/L @ 25 °C (est) Yes
water No
glycerin No

Organoleptic Properties

Odor Type: Citrus
sweet, fresh, lemon, green, grassy, lemongrass, aldehydic
Odor strength medium
Substantivity 44 hour(s) at 100.00 %
Luebke, William tgsc, (1997) At 100.00 %. sweet fresh lemon citral green grassy
Flavor Type: Citrus
citrus, lemon, lemongrass, aldehydic, waxy, fruity, grassy
Luebke, William tgsc, (1997) Citrus lemon lemongrass aldehydic waxy fruity grassy

Occurrences

Safety Information

Safety information

European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R 65 - Harmful: may cause lung damage if swallowed.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37 - Wear suitable gloves.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 3), H226
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
GHS Label elements, including precautionary statements
Pictogramflame.jpgexclamation-mark.jpg
Signal word Warning
Hazard statement(s)
H226 - Flammable liquid and vapour
H315 - Causes skin irritation
H319 - Causes serious eye irritation
Precautionary statement(s)
P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 - Keep container tightly closed.
P240 - Ground/bond container and receiving equipment.
P241 - Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 - Use only non-sparking tools.
P243 - Take precautionary measures against static discharge.
P264 - Wash skin thouroughly after handling.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.
P403 + P235 - Store in a well-ventilated place. Keep cool.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 20, Pg. 731, 1982.

Dermal Toxicity:
skin-rabbit LD50 4800 mg/kg
Food and Chemical Toxicology. Vol. 20, Pg. 731, 1982.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Sensitization
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
citral Max. Found: 69.00 % and Reason: Sensitization
citronellol Max. Found: 0.15 % and Reason: Sensitization
geraniol Max. Found: 1.1 % and Reason: Sensitization
safrole Max. Found: 0.05 % and Reason: Carcinogenicity
longifolene Max. Found: 0.2 % and Reason: Sensitization
(E)-isocitral Max. Found: 1.00 % and Reason: Sensitization
(Z)-isocitral Max. Found: 0.4 % and Reason: Sensitization
citronellal Max. Found: 1.1 % and Reason: Sensitization
Recommendation for litsea cubeba fruit oil usage levels up to:
9.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
Click here to view publication 18
average usual ppmaverage maximum ppm
baked goods: 178.00000356.00000
beverages(nonalcoholic): 28.0000056.00000
beverages(alcoholic): 5.9000011.80000
breakfast cereal: --
cheese: 0.200000.40000
chewing gum: --
condiments / relishes: 10.0000020.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 33.6000067.20000
fruit ices: --
gelatins / puddings: 210.00000520.00000
granulated sugar: --
gravies: 0.750001.50000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 2.250004.50000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 181.00000362.00000
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of a feed additive consisting of an essential oil from the fruits of Litsea cubeba (Lour.) Pers. (litsea berry oil) for use in all animal species (FEFANA asbl)
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):68855-99-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:1
litsea cubeba fruit oil
Chemidplus:0068855992
RTECS:RI7280000 for cas# 68855-99-2