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perilla seed oil

Perilla seed oil is a fixed oil derived from Perilla frutescens seeds, noted for its fatty odor and use in flavor and fragrance applications.

General Material Description

Perilla seed oil is a fixed vegetable oil obtained from the seeds of the plant Perilla frutescens, belonging to the Lamiaceae family. This oil appears as a pale yellow to yellow liquid with a characteristic fatty and oily aroma reminiscent of cod liver oil. Known by several synonyms including shiso oil and fixed oil from Perilla ocymoides, it is a significant botanical oil in flavor and fragrance industries. The chemical profile of perilla seed oil is documented in public chemical databases such as PubChem. The oil is primarily extracted via cold pressing or solvent extraction from the seeds of cultivated perilla plants widely grown in East Asia. Its sensory properties and broad applicability make it a valuable natural ingredient sourced sustainably from the Perilla genus.

Occurrence, Applicability & Potential Uses

Perilla seed oil naturally occurs as the fixed oil contained within the seeds of Perilla frutescens, a herbaceous plant native to East Asia. It is used predominantly as a flavoring and fragrance agent due to its fatty and mild oily odor profile. In perfumery, it serves as a base that complements notes such as bergamot, jasmine, orange blossom, spearmint, and ylang-ylang. Additionally, perilla oil functions in cosmetic formulations as a skin-conditioning agent, contributing emollient properties. Regulatory frameworks like IFRA (Global) guide its safe usage levels in fragrances to ensure consumer safety. Its application extends into natural product development where botanical fixed oils are preferred.

Physico-Chemical Properties Summary

Perilla seed oil exhibits specific gravity values ranging from 0.923 to 0.938 at 15°C, indicating a density slightly less than water. Its refractive index varies between 1.497 and 1.504 at 20°C, characteristic of fixed botanical oils. The maximum acid value is limited to 1 KOH per gram, reflecting low free fatty acid content and good oil quality. In terms of solubility, the oil dissolves readily in alcohol but is insoluble in water, which influences its formulation considerations in emulsions or blends. These properties allow perilla seed oil to be incorporated effectively in fragrance oils and skin conditioning products, impacting texture and stability. The fatty odor contributes to its sensory profile, influencing its role as a carrier or blending component.

FAQ

What is perilla seed oil and where does it come from?
Perilla seed oil is a fixed oil extracted from the seeds of the Perilla frutescens plant, a member of the Lamiaceae family. It is also known by other names such as shiso oil and perilla frutescens seed oil. The plant is cultivated primarily in East Asia, and the oil is obtained through mechanical pressing or solvent extraction of the seeds. This oil is recognized for its fatty, oily odor and is used mainly in flavoring and fragrance applications.
How is perilla seed oil used and in what products can it be found?
Perilla seed oil is commonly used as a flavor and fragrance agent. Its fatty odor and compatibility with aromatic notes like bergamot, jasmine, orange blossom, spearmint, and ylang-ylang make it suitable for perfumery. Besides fragrance, it functions as a skin-conditioning agent in cosmetic products, contributing moisturizing and emollient properties. Its solubility characteristics, such as being soluble in alcohol and insoluble in water, allow it to be formulated efficiently in various products including perfumes and creams.
Are there regulations governing the use of perilla seed oil and how is its safety assessed?
The use of perilla seed oil in fragrance and flavor applications falls under standards such as the IFRA Code of Practice (Global), which provides guidelines to ensure safe exposure levels. Safety assessments, including toxicity studies, indicate no significant hazards; for example, oral and dermal LD50 values in animal studies are relatively high, implying low acute toxicity. No GHS hazard classifications currently apply to this substance. RIFM and other safety organizations have reviewed the material, supporting its safe use within regulated limits.

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

Canada Domestic Sub. List:68132-21-8
Pubchem (sid):135358943
Publications by PubMed
Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour.
[Evaluation of a new medium, eggplant (Solanum melongena) agar as a screening medium for Cryptococcus neoformans in environmental samples].
Identification and Quantitation of Phenolic Compounds from the Seed and Pomace of Perilla frutescens Using HPLC/PDA and HPLC-ESI/QTOF/MS/MS.
Antidepressant-like effects of Perilla frutescens seed oil during a forced swimming test.
Transfer and targeted overexpression of γ-tocopherol methyltransferase (γ-TMT) gene using seed-specific promoter improves tocopherol composition in Indian soybean cultivars.
Accumulation of PrLeg, a Perilla legumin protein in potato tuber results in enhanced level of sulphur-containing amino acids.
Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice.
Development of botanical and fish oil standard reference materials for fatty acids.
[Effect of exogenous nitric oxide donor SNP on seed germination and antioxidase activities of Perilla frutescens seedlings under NaCl stress].
Health effects of omega-3,6,9 fatty acids: Perilla frutescens is a good example of plant oils.
Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice.
Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens var. japonica).
[Effect of exogenous Ca2+, ALA, SA and Spd on seed germination and physiological characteristics of Perilla frutescens seedlings under NaCl stress].
[Effect of exogenous Ca2+ and NO donor SNP on seed germination and antioxidase activities of Perilla frutescens seedlings under NaCl stress].
Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus.
Perilla frutescens seed agar, a new medium for identification of the Cryptococcus species complex: evaluation for all major molecular types.
[Effect of zinc sulphate and PEG priming on ageing seed germination and antioxidase activities of Perilla frutescens seedlings].
Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons.
Germination rates of perilla (Perilla frutescens (L.) Britton) mericarps stored at 4 degrees C for 1-20 years.
Plant derived omega-3-fatty acids protect mitochondrial function in the brain.
Characteristics of high alpha-linolenic acid accumulation in seed oils.
Herbal medicines for the treatment of allergic rhinitis: a systematic review.
Authentic seed-specific activity of the Perilla oleosin 19 gene promoter in transgenic Arabidopsis.
The influence of meteorological factors on growth and vegetation process of Perilla frutescens (L.) Britton in Lithuania.
Increased alpha-tocopherol content in soybean seed overexpressing the Perilla frutescens gamma-tocopherol methyltransferase gene.
Two cases of anaphylaxis caused by perilla seed.
Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor.
Antimicrobial activity of perilla seed polyphenols against oral pathogenic bacteria.
Transcriptional expression characteristics and subcellular localization of ADP-glucose pyrophosphorylase in the oil plant Perilla frutescens.
Molecular cloning and functional expression of Perilla frutescens 3-ketoacyl-(acyl carrier protein) synthase III.
Cloning and characterization of a seed-specific omega-3 fatty acid desaturase cDNA from Perilla frutescens.
The effects of developmental stage and source leaf position on integration and sectorial patterns of carbohydrate movement in an annual plant, Perilla frutescens (Lamiaceae).
Intoxication of cattle by Perilla frutescens (purple mint).

Other Information

FDA Indirect Additives used in Food Contact Substances:View
Export Tariff Code:3301.29.6000
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

General Material Information

Preferred name perilla seed oil
Trivial Name Oils, perilla
Short Description fixed oil obtained from the seeds of the perilla, perilla ocymoides l., lamiaceae
CAS Number 68132-21-8
FDA UNII 322MS57V7Z
Synonyms
  • fixed oil obtained from the seeds of the perilla, perilla ocymoides l., lamiaceae
  • ocimum frutescens seed oil
  • perilla frutescens seed oil
  • perilla frutescens var. frutescens seed oil
  • perilla ocymoides seed oil
  • salvia infuscata seed oil
  • shiso oil
  • Oils, perilla

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 15 °C
Pounds per Gallon 7.696 to 7.821
Refractive Index 1.497 to 1.504 @ 20 °C
Acid Value 1 max KOH/g
Solubility
alcohol Yes
water No

Organoleptic Properties

Odor Type: Fatty
fatty, oily, fishy
General comment At 100.00 %. fatty oily cod liver oil

Occurrences

Potential Uses

Applications
Odor purposes Bergamot , Floral , Jasmin , Orange blossom , Spearmint , Ylang ylang
Cosmetic purposes Skin conditioning

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 2770 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

oral-rat LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

Dermal Toxicity:
skin-guinea pig LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

skin-rabbit LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Safety references

Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):68132-21-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0068132218