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General Material Information

Preferred name piper betle leaf oil
Trivial Name Pepper (Piper), P. betle, ext.
Short Description volatile oil obtained by the steam distillation of the leaves of the pepper, piper betle l., piperaceae
CAS Number 84775-81-5
ECHA Number 283-910-2
FDA UNII Search
Synonyms
  • betel leaf oil
  • volatile oil obtained by the steam distillation of the leaves of the pepper, piper betle l., piperaceae
  • Pepper (Piper), P. betle, ext.
  • Piper betle ext.
  • Piper betel oil

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Literature & References

piper betle leaf oil
Pubchem (sid):135279913
Publications by PubMed
The phytochemistry, traditional uses and pharmacology of Piper Betel. linn (Betel Leaf): A pan-asiatic medicinal plant.
Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis.
Effect of Sameera Pannaga Rasa (arsenomercurial formulation) in the management of Tamaka Shwasa (bronchial asthma) - Randomized double blind clinical study.
Salivary ascorbic acid levels in betel quid chewers: A biochemical study.
Piper betel leaf: a reservoir of potential xenohormetic nutraceuticals with cancer-fighting properties.
Inhibitory effect of Piper betel leaf extracts on copper-mediated LDL oxidation and oxLDL-induced lipid accumulation via inducing reverse cholesterol transport in macrophages.
Piper betel leaf extract: anticancer benefits and bio-guided fractionation to identify active principles for prostate cancer management.
Effects of ionic surfactants on the morphology of silver nanoparticles using Paan (Piper betel) leaf petiole extract.
Anti-microbial principles of selected remedial plants from Southern India.
Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes.
Antimicrobial Activity of Terminalia catappa, Manilkara zapota and Piper betel Leaf Extract.
Cheilitis granulomatosa associated with allergic contact dermatitis to betel quid.
Antioxidant activity of piper betel leaf extract and its constituents.
Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats.
Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract.
Radioprotective property of the ethanolic extract of Piper betel Leaf.
Epidemiology of betel quid usage.
Paan without tobacco: an independent risk factor for oral cancer.
Hydroxychavicol: a new anti-nitrosating phenolic compound from betel leaf.
Nonmutagenicity of betel leaf and its antimutagenic action against environmental mutagens.
The aetiology of oral submucous fibrosis: the stimulation of collagen synthesis by extracts of areca nut.
Susceptibility characterisation of Candida spp. to four essential oils.
Oral submucous fibrosis: a review article on etiopathogenesis.

Other Information

Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex No
Solubility
alcohol Yes
water No

Organoleptic Properties

Odor Type: Phenolic
phenolic, resinous, smoky, peppery, ginger
General comment At 0.10 % in dipropylene glycol. phenolic tar smoky mate leaves peppery ginger

Occurrences

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Sensitization
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
eugenol Max. Found:
isoeugenol Max. Found:
geraniol Max. Found:
Recommendation for piper betle leaf oil usage levels up to:
0.0100 % in the fragrance concentrate.
Recommendation for piper betle leaf oil flavor usage levels up to:
not for flavor use.

Safety references

AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
piper betle leaf oil
Chemidplus:0084775815