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cassia bark oil china

General Material Information

Preferred name cassia bark oil china
Trivial Name Essential oils, cassia
Short Description cinnamomum cassia bark oil china
CAS Number 8007-80-5
FEMA Number 2258
FDA UNII A4WO0626T5
MDL MFCD00130805
COE Number 131
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8007-80-5 ; CINNAMON BARK, OIL (CINNAMOMUM SPP.)
Synonyms
  • camphorina cassia bark oil china
  • cassia bark oil chinese
  • cassia oil rectified china
  • cinnamomum aromaticum bark oil china
  • cinnamomum cassia bark oil china
  • cinnamomum longifolium bark oil china
  • cinnamomum medium bark oil china
  • cinnamomum nitidum bark oil china
  • cinnamon bark china ess. oil (for fragrance) (Robertet)
  • cinnamon bark oil (cinnamomum cassia) china
  • cinnamon china low coumarin EO
  • laurus cassia bark oil china
  • persea cassia bark oil china
  • cinnamomum cassia blume bark oil
  • Essential oils, cassia
  • Cassia oil
  • Oil of cassia
  • Oils, cassia
  • Oils, essential, cassia
  • Cinnamomum cassia, essential oil
  • Oil of Chinese cinnamon
  • Cassia oils
  • Cinnamomum cassia oil
  • Chinese cinnamon oil
  • Oils, Chinese cinnamon
  • Cinnamomum cassia leaf oil
  • Cinnamomum cassia bark oil
  • Cinnamomum cassia twig oil
  • Cassia bark oil

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Literature & References

cinnamomum cassia blume bark oil
Canada Domestic Sub. List:8007-80-5
Pubchem (sid):135352886
Publications by PubMed
Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells.
Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway.
In vitro antiviral activity of Cinnamomum cassia and its nanopartilces against H7N3 influenza A virus.
Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression.
Cinnamon and its Components Suppress Vascular Smooth Muscle Cell Proliferation by Up-Regulating Cyclin-Dependent Kinase Inhibitors.
Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates.
Anti-diabetic nephropathy compounds from Cinnamomum cassia.
Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala.
Cinnamomum cassia bark produced by solid-state fermentation with Phellinus baumii has the potential to alleviate atopic dermatitis-related symptoms.
A new phenolic glycoside from the barks of Cinnamomum cassia.
Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia.
Traditional formula, modern application: chinese medicine formula sini tang improves early ventricular remodeling and cardiac function after myocardial infarction in rats.
Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats.
Evaluation of the in vitro anti-hyperglycemic effect of Cinnamomum cassia derived phenolic phytochemicals, via carbohydrate hydrolyzing enzyme inhibition.
Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice.
Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer.
Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells.
A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang').
Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling.
Fumigant toxicity of plant essential oils against Camptomyia corticalis (Diptera: Cecidomyiidae).
Antioxidant activity of various parts of Cinnamomum cassia extracted with different extraction methods.
Bioactive A-type proanthocyanidins from Cinnamomum cassia.
Differential antiproliferation effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants.
2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation.
Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks.
Platelet anti-aggregation activities of compounds from Cinnamomum cassia.
Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.
The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1.
Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential.
Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells.
Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.
Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner.
[Analysis on the chemical compositions of the volatile oil from ultramicro-powder and common grinding powder of Cinnamomum cassia].
Quality assessment of cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis.
Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.
Nematicidal Activity of Cassia and Cinnamon Oil Compounds and Related Compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae).
Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3-E1 cells.
Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti (Diptera: Culicidae) under laboratory and indoor conditions.
In vitro efficacy of 75 essential oils against Aspergillus niger.
Antimicrobial effects of selected plant essential oils on the growth of a Pseudomonas putida strain isolated from meat.
Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume.
Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes.
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro.
Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography.
Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells.
Inhibition of Trypanosoma cruzi by plant extracts used in Chinese medicine.
Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia.
[Isolation of genomic DNA from Cinnamomum cassia Presl].
Repellency of aromatic medicinal plant extracts and a steam distillate to Aedes aegypti.
Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma.
Antioxidant activity of Cinnamomum cassia.
Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells.
Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat.
[Comparison studies on chemical constituents of essential oil from Ramulus Cinnamomi and Cortex Cinnamomi by GC-MS].
Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase.
Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase.
Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties.
Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria.
A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity.
Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells.
Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae).
Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells.
Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
2'-Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia.
Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas.
A reticuloendothelial system-activating arabinoxylan from the bark of Cinnamomum cassia.
Antiulcerogenic compounds isolated from Chinese cinnamon.
Effects of a Chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats.
[Pharmacological studies of Cinnamomum cassia bark. Part I. Effects on the blood and cardiovascular system (author's transl)].

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
FAO:CINNAMOMUM OILS (INCLUDING CINNAMON AND CASSIA)

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 8.695 to 8.845
Refractive Index 1.602 to 1.614 @ 20 °C
Flash Point TCC Value 93.33 °C TCC
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
fixed oils Yes
water, 2150 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Spicy
spicy, aldehydic, aromatic, cinnamyl, woody, resinous, honey, gourmand, powdery
Odor strength medium , recommend smelling in a 1.00 % solution or less
Substantivity 160 hour(s) at 100.00 %
Luebke, William tgsc, (1991) At 1.00 % in dipropylene glycol. sweet spicy aldehydic aromatic cinnamyl woody resinous honey gourmand powdery
Flavor Type: Spicy
spicy, sweet, aromatic, aldehydic, honey, cinnamyl, woody, resinous
Luebke, William tgsc, (1991) Spicy sweet aromatic aldehydic honey cinnamyl woody resinous

Occurrences

Safety Information

Safety information

European information :
Most important hazard(s):
T - Toxic.
R 21 - Harmful in contact with skin.
R 24 - Toxic in contact with skin.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 4), H227
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
GHS Label elements, including precautionary statements
Pictogramskull.jpg
Signal word Danger
Hazard statement(s)
H227 - Combustible liquid
H311 - Toxic in contact with skin
H315 - Causes skin irritation
H319 - Causes serious eye irritation
Precautionary statement(s)
P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264 - Wash skin thouroughly after handling.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P361 - Remove/Take off immediately all contaminated clothing.
P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.
P403 + P235 - Store in a well-ventilated place. Keep cool.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50 2800 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 109, 1975.

intraperitoneal-mouse LD50 500 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Pharmacologist. Vol. 3, Pg. 62, 1961.

oral-mouse LD50 2670 mg/kg
Tokishikoroji Foramu. Toxicology Forum. Vol. 8, Pg. 91, 1985.

Dermal Toxicity:
skin-rabbit LD50 320 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 109, 1975.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA fragrance material specification:
prime allergen is Cinnamic aldehyde. The concentration of Cinnamic aldehyde in the finished cosmetic product should not exceed 0.1%.The
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
cinnamyl alcohol Max. Found: 0.2 % and Reason: Sensitization
benzyl benzoate Max. Found: 0.1 % and Reason: Sensitization
methyl eugenol Max. Found:
benzaldehyde Max. Found:
eugenol Max. Found: 0.1 % and Reason: Sensitization
cinnamaldehyde Max. Found: 80.00 % and Reason: Sensitization
coumarin Max. Found: 2.00 % and Reason: Sensitization
isoeugenol Max. Found: 0.1 % and Reason: Sensitization
ortho-methoxycinnamaldehyde Max. Found: 9.00 % and Reason: Sensitization
Recommendation for cassia bark oil china usage levels up to:
1.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -73.00000
beverages(nonalcoholic): -3.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -1900.00000
condiments / relishes: -140.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -11.00000
fruit ices: -11.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -150.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -290.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8007-80-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2810
WGK Germany:3
cinnamomum cassia blume bark oil
Chemidplus:0008007805
RTECS:FI4050000 for cas# 8007-80-5