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licorice oil

Licorice oil is a flavor and fragrance material derived from licorice, characterized by a distinctive licorice odor and flavor.

General Material Description

Licorice oil is a natural flavor and fragrance compound extracted primarily from the roots of the Glycyrrhiza plant genus. It appears as an essential oil component classified under oils, licorice and is known for its unmistakable licorice sensory profile, exhibiting both characteristic odor and flavor reminiscent of the licorice herb. The compound is also identified by related names such as secondary acid liquor, tertiary acid liquor, and tertiary licorice extract. Structurally, licorice oil comprises a complex mixture of aromatic molecules contributing to its sensory qualities. For detailed chemical information, the PubChem database provides comprehensive data under this oil’s identifiers. Licorice oil is generally obtained via steam distillation or solvent extraction of licorice root material, methods of extraction commonly described by the Food and Agriculture Organization (FAO).

Occurrence, Applicability & Potential Uses

Licorice oil naturally occurs in the roots of Glycyrrhiza species, where it contributes to the characteristic aromatic and flavor profile of licorice. It is predominantly applied as a flavor and fragrance agent in formulations requiring sweet, herbaceous licorice notes. The material is valued for its ability to impart distinctive aroma and taste in various consumer products including confectionery, beverages, perfumes, and cosmetic fragrances. Its usage is guided by standards such as the Flavor and Extract Manufacturers Association (FEMA) in the United States, which provides regulatory frameworks ensuring safety and quality in flavor and fragrance applications. These standards help define acceptable concentration levels and quality criteria for licorice oil in consumer goods.

Physico-Chemical Properties Summary

Licorice oil demonstrates limited solubility in water, with an estimated value of approximately 73.14 milligrams per liter at 25 °C, indicating moderate hydrophobic character. This property influences its formulation behavior, favoring incorporation into oil-based or nonpolar matrices for optimal stability and performance. The oil possesses a characteristic licorice odor and flavor at pure concentrations, important for sensory impact in end products. Such physico-chemical attributes dictate its compatibility and dispersion in flavors, fragrances, and aromatic blends, enabling tailored use depending on the intended sensory profile and product medium.

FAQ

What is licorice oil and what are its main characteristics?
Licorice oil is an aromatic essential oil derived from the roots of licorice plants, primarily from the Glycyrrhiza genus. It is recognized for its distinctive licorice-like odor and flavor, which are key to its use in flavorings and fragrances. The oil comprises various aromatic compounds that provide its characteristic sensory profile. It appears in the literature also under synonyms such as secondary acid liquor or tertiary licorice extract. The aroma and taste it imparts are sweet and herbaceous, closely resembling that of the licorice plant itself.
How is licorice oil used and where does it commonly occur?
Licorice oil occurs naturally in the roots of licorice plants and is extracted using methods like steam distillation or solvent extraction. It finds application mainly as a flavor and fragrance agent to deliver licorice notes in consumer products such as confectionery items, beverages, and perfumes. In formulations, it can add complex herbal sweetness and aroma, enhancing both scent and taste profiles. Its natural origin and sensory qualities make it a valuable ingredient in the flavor and fragrance industry, adaptable for various product types.
What safety standards regulate the use of licorice oil in flavor and fragrance products?
The use of licorice oil in flavor and fragrance products is regulated under guidelines such as those established by FEMA (US) and the International Fragrance Association (IFRA) globally. According to these frameworks, licorice oil is assessed for safety to determine acceptable concentration limits in consumer products, ensuring responsible usage. No specific hazard classifications have been identified under OSHA HCS standards in the United States for this compound. Comprehensive safety assessments include toxicological data and industry reviews accessible through resources like RIFM and EPA databases. Such regulatory oversight supports safe incorporation of licorice oil into consumer goods.

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

Canada Domestic Sub. List:97676-23-8
Pubchem (sid):135272755
Publications by PubMed
Lipidomics investigation of reversal effect of glycyrrhizin (GL) towards lithocholic acid (LCA)-induced alteration of phospholipid profiles.
Cosmetic benefits of natural ingredients.
Synergy of licorice extract and pea protein hydrolysate for oxidative stability of soybean oil-in-water emulsions.
Short communication: an in vitro assessment of the antibacterial activity of plant-derived oils.
Effects of oils and emulsifiers on the skin penetration of stearyl glycyrrhetinate in oil-in-water emulsions.
Effect of licorice flavonoid oil on cholesterol metabolism in high fat diet rats.
Phytoestrogens and the metabolic syndrome.
Herbal products that may contribute to hypertension.
Volatiles profiling in medicinal licorice roots using steam distillation and solid-phase microextraction (SPME) coupled to chemometrics.
Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis.
[The study of corrective role of plant--based drugs with antioxidant action in experimental intoxication with potassium dichromate].
Formulation and evaluation of herbal anti-acne moisturizer.
Preparing glabridin-in-water nanoemulsions by high pressure homogenization with response surface methodology.
[Study on the effects of different compatibility of guizhi decoction on component of volatile oil from Cinnamomum cassia by GC-MS].
Dietary supplements and hypertension: potential benefits and precautions.
Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.
Tooth brushing, oil pulling and tissue regeneration: A review of holistic approaches to oral health.
Utility of nano-sized, water-in-oil emulsion as a sustained release formulation of glycyrrhizin.
A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity.
Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome.
The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.
Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex.
Botanicals in dermatology: an evidence-based review.
The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats.
Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay.
Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: A randomized, double-blind, placebo-controlled study.
Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats.
"Natural" ingredients in cosmetic dermatology.
Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats.
Genotoxicity studies on licorice flavonoid oil (LFO).
Artocarpus lakoocha heartwood extract as a novel cosmetic ingredient: evaluation of the in vitro anti-tyrosinase and in vivo skin whitening activities.
90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats.
Fungal contamination of raw materials of some herbal drugs and recommendation of Cinnamomum camphora oil as herbal fungitoxicant.
Less-known botanical cosmeceuticals.
Botanical ingredients in cosmeceuticals.
Absorption of dietary licorice isoflavan glabridin to blood circulation in rats.
Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update.
Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans.
Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice.
Treatment of rosacea with herbal ingredients.
Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola.
Identification of chemicals, possibly originating from misuse of refillable PET bottles, responsible for consumer complaints about off-odours in water and soft drinks.
Volatile components and key odorants of fennel (Foeniculum vulgare Mill.) and thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extraction.
The antioxidative activity of traditional Japanese herbs.
Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice.
Complementary and alternative interventions in asthma, allergy, and immunology.
Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society.
Herbal bioactivation: the good, the bad and the ugly.
Ability of cold-tolerant plants to grow in hydrocarbon-contaminated soil.
The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations.
Potential interactions between alternative therapies and warfarin.
Contact allergy due to oil-soluble licorice extracts in cosmetic products.
Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions.
Increased sodium appetite and thirst in rat induced by the ingredients of liquorice, glycyrrhizic acid and glycyrrhetinic acid.
Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants.
[Von Siebold's prescriptions (2)].
Processing of nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos nux-vomica in mice.
[Anti-promoting and anti-mutagenic actions of G9315].
Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts.
Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo(a)pyrene.
[Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo (a) pyrene].

General Material Information

Preferred name licorice oil
Trivial Name Oils, licorice
Short Description oils, licorice
CAS Number 97676-23-8
FDA UNII Search
Synonyms
  • secondary acid liquor
  • tertiary acid liquor
  • tertiary licorice extract
  • oils, licorice

PhysChem Properties

Material listed in food chemical codex No
Solubility
water, 73.14 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Licorice
licorice
General comment At 100.00 %. licorice
Flavor Type: Licorice
licorice
General comment Licorice

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Safety references

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):97676-23-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0097676238