perilla leaf oil

General Material Information

Preferred name	perilla leaf oil
Trivial Name	Oils, perilla
Short Description	essential oil obtained from the leaves of the plant, perilla frutescens, labiatae
CAS Number	68132-21-8
FEMA Number	4013
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	977186-33-6 ; PERILLA LEAF OIL
Synonyms	essential oil obtained from the leaves of the plant, perilla frutescens, labiatae ocimum frutescens leaf oil perilla frutescens leaf oil perilla frutescens var. frutescens leaf oil perilla ocymoides leaf oil salvia infuscata leaf oil shiso ess. oil (for fragrance) (Robertet) shiso essential oil asia (Robertet) shiso leaf oil Oils, perilla

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Literature & References

	perilla frutescens leaf oil
Canada Domestic Sub. List:	68132-21-8
Pubchem (sid):	199105

Publications by PubMed
Anti-inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide-stimulated RAW264.7 cells.
Synthesis of gold and silver nanoparticles using leaf extract of Perilla frutescens--a biogenic approach.
Rosmarinic acid extract for antioxidant, antiallergic, and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves.
Perilla frutescens leaf extract inhibits mite major allergen Der p 2-induced gene expression of pro-allergic and pro-inflammatory cytokines in human bronchial epithelial cell BEAS-2B.
Accumulation of PrLeg, a Perilla legumin protein in potato tuber results in enhanced level of sulphur-containing amino acids.
Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice.
Perilla frutescens (L.) Britton: honeybee forage and preliminary results on the metabolic profiling by NMR spectroscopy.
Nuclear Factor-κB: central regulator in ocular surface inflammation and diseases.
Optimization of antibacterial activity of Perilla frutescens var. acuta leaf against Staphylococcus aureus using evolutionary operation factorial design technique.
Controllable spectrum artificial sunlight source system using LEDs with 32 different peak wavelengths of 385-910 nm.
Effect of Perilla frutescens var. acuta Kudo and rosmarinic acid on allergic inflammatory reactions.
Optimization of antibacterial activity of Perilla frutescens var. acuta leaf against Pseudomonas aeruginosa using the evolutionary operation-factorial design technique.
Monoterpene engineering in a woody plant Eucalyptus camaldulensis using a limonene synthase cDNA.
Characteristic aroma-active compounds of Korean perilla (Perilla frutescens Britton) leaf.
Perilla leaf, Perilla frutescens, induces apoptosis and G1 phase arrest in human leukemia HL-60 cells through the combinations of death receptor-mediated, mitochondrial, and endoplasmic reticulum stress-induced pathways.
Antioxidant activities of polyphenols extracted from Perilla frutescens varieties.
Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System.
Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus.
Perilla frutescens var. frutescens in northern Laos.
Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells.
Protective effect of aqueous extract of Perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats.
Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis.
Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model.
Limonene production in tobacco with Perilla limonene synthase cDNA.
Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion.
Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.
[Inhibition of antigen-specific T helper type 2 responses by Perilla frutescens extract].
The effects of developmental stage and source leaf position on integration and sectorial patterns of carbohydrate movement in an annual plant, Perilla frutescens (Lamiaceae).
Genetic analysis of essential oil variants in Perilla frutescens.
Genetic Control of Peltate Glandular Trichome Formation in Perilla frutescens.
An Intestinal Propulsion Promoting Substance from Perilla frutescens and Its Mechanism of Action.
Separation and measurement of direct and indirect effects of light on stomata.

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
Wikipedia:	View
FAO:	BASIC PRINCIPLES OF STEAM DISTILLATION

Suppliers

Berjé	BOC Sciences
Penta International	Robertet
Soda Aromatic	Berje Inc.
Penta International Corporation	Robertet, Inc.
Soda Aromatic Co., Ltd.

PhysChem Properties

Material listed in food chemical codex	No
Specific gravity	@ 20 °C
Pounds per Gallon	7.573 to 7.739

Organoleptic Properties

Odor Type: Herbal
herbal, green, spicy, caraway, apple, tea
General comment	At 100.00 %. herbal green spicy caraway apple tea

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 2770 mg/kg Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988. oral-rat LDLo 5000 mg/kg Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.
Dermal Toxicity:
skin-guinea pig LDLo 5000 mg/kg Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988. skin-rabbit LDLo 5000 mg/kg Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
perillaldehyde	Max. Found: 60.00 % and Reason: Sensitization
Recommendation for perilla leaf oil usage levels up to:
	6.0000 % in the fragrance concentrate.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 20
Click here to view publication 20
		average usual ppm	average maximum ppm
baked goods:		10.00000	100.00000
beverages(nonalcoholic):		2.00000	200.00000
beverages(alcoholic):		1.00000	10.00000
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		20.00000	2000.00000
condiments / relishes:		-	-
confectionery froastings:		1.00000	20.00000
egg products:		-	-
fats / oils:		1.00000	10.00000
fish products:		-	-
frozen dairy:		2.00000	200.00000
fruit ices:		2.00000	200.00000
gelatins / puddings:		2.00000	200.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		2.00000	200.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		5.00000	100.00000
reconstituted vegetables:		-	-
seasonings / flavors:		100.00000	500.00000
snack foods:		1.00000	100.00000
soft candy:		2.00000	200.00000
soups:		1.00000	100.00000
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):68132-21-8

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

perilla frutescens leaf oil

Chemidplus:0068132218