sage oil lithuania

General Material Information

Preferred name	sage oil lithuania
Trivial Name	Sage oil
Short Description	essential oil derived from the herbal plant the sage, salvia officinalis l., lamiaceae lithuania
CAS Number	8022-56-8
FEMA Number	3001
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	8022-56-8 ; SAGE, OIL (SALVIA OFFICINALIS L.)
Synonyms	essential oil derived from the herbal plant the sage, salvia officinalis l., lamiaceae lithuania salvia officinalis oil lithuania salvia officinalis l. oil Sage oil Oils, sage Oils, essential, sage, Salvia officinalis Essential oils, sage, Salvia officinalis Sage oil Dalmatian Dalmatian sage oil Spanish sage oil Sage leaf oil Oils, Dalmatian sage leaf Salvia officinalis leaf oil Salvia officinalis oils Salvia officinalis oil Oils, essential, Salvia officinalis oil Sage leaf Liq. E Sage leaf Liquid E Salviae aetheroleum

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Literature & References

	salvia officinalis l. oil
Canada Domestic Sub. List:	8022-56-8
Pubchem (sid):	135308063

Publications by PubMed
In vitro effects of Salvia officinalis L. essential oil on Candida albicans.
Formulation of sage essential oil (Salvia officinalis, L.) monoterpenes into chitosan hydrogels and permeation study with GC-MS analysis.
[Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)].
Antibacterial, allelopathic and antioxidant activities of essential oil of Salvia officinalis L. growing wild in the Atlas Mountains of Morocco.
Chemotype diversity of indigenous Dalmatian sage (Salvia officinalis L.) populations in Montenegro.
High diversity of indigenous populations of dalmatian sage (Salvia officinalis L.) in essential-oil composition.
Essential oil of common sage (Salvia officinalis L.) from Jordan: assessment of safety in mammalian cells and its antifungal and anti-inflammatory potential.
Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions.
Epileptic seizures caused by accidental ingestion of sage (Salvia officinalis L.) oil in children: a rare, exceptional case or a threat to public health?
GC-MS analysis of essential oils from Salvia officinalis L.: comparison of extraction methods of the volatile components.
A simple and efficient DNA isolation method for Salvia officinalis.
Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae).
Antioxidant activity and sensory evaluation of a rosmarinic acid-enriched extract of Salvia officinalis.
Influence of ionic interactions on essential oil and phenolic diterpene composition of Dalmatian sage (Salvia officinalis L.).
Effects of foliar fertilization and arbuscular mycorrhizal colonization on Salvia officinalis L. growth, antioxidant capacity, and essential oil composition.
Toxicity of Salvia officinalis in a newborn and a child: an alarming report.
Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis).
Chemical composition of the essential oil of Salvia officinalis L. from Romania.
Salvia officinalis L. essential oils: effect of hydrodistillation time on the chemical composition, antioxidant and antimicrobial activities.
Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L.
Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs.
Reliable identification and quantification of volatile components of sage essential oil using ultra HRGC.
Chemical and genetic relationships among sage ( Salvia officinalis L.) cultivars and Judean sage ( Salvia judaica Boiss.).
Effects of PAR and UV-B radiation on herbal yield, bioactive compounds and their antioxidant capacity of some medicinal plants under controlled environmental conditions.
Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses.
Composition of the essential oil of Salvia officinalis L. from various European countries.
Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method.
Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae.
Effects of Salvia officinalis L. extract on experimental acute inflammation.
A direct liquid, non-equilibrium solid-phase micro-extraction application for analysing chemical variation of single peltate trichomes on leaves of Salvia officinalis.
Dynamics of yield components and essential oil production in a commercial hybrid sage (Salvia officinalis x Salvia fruticosa cv. Newe Ya'ar no. 4).
Tunisian Salvia officinalis L. and Schinus molle L. essential oils: their chemical compositions and their preservative effects against Salmonella inoculated in minced beef meat.
Empirical prediction and validation of antibacterial inhibitory effects of various plant essential oils on common pathogenic bacteria.
Growth performance and antioxidant enzyme activities in rainbow trout (Oncorhynchus mykiss) juveniles fed diets supplemented with sage, mint and thyme oils.
Rapid screening of antioxidant activity of sage (Salvia officinalis L.) extracts obtained by supercritical carbon dioxide at different extraction conditions.
Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils.
Capillary gas chromatography-mass spectrometry of volatile and semi-volatile compounds of Salvia officinalis.
Evaluating the antimicrobial activity of commercially available herbal toothpastes on microorganisms associated with diabetes mellitus.
Development and Essential Oil Content of Secretory Glands of Sage (Salvia officinalis).
[Chemical diversity of the biological active ingredients of salvia officinalis and some closely related species].
Evaluation of toxic/protective effects of the essential oil of Salvia officinalis on freshly isolated rat hepatocytes.
Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?
Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo.
Organ- and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two different sites.
Analysis and evaluation of antibacterial effects of new herbal formulas, AP-001 and AP-002, against Escherichia coli O157:H7.
Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.
[Effect of mineral fertilizers on the development of sage (Salvia officinalis L.) and on its oil content].
[Diurnal variations of the active constituents of medicinal plants. III. Daily periodicity of the volatile oil content in the leaves of Salvia officinalis].
[Oxytriterpenic acids of sage oil. 9. Constituents of Salvia officinalis L..].
In vitro effects of some herbs used in Egyptian traditional medicine on viability of protoscolices of hydatid cysts.
Evaluation of cholinesterase inhibitory and antioxidant activities of wild and cultivated samples of sage (Salvia fruticosa) by activity-guided fractionation.
The inhibition the Tet(K) efflux pump of tetracycline resistant Staphylococcus epidermidis by essential oils from three Salvia species.
Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats.
Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites.
Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes.
Comprehensive two-dimensional chromatography with coupling of reversed phase high performance liquid chromatography and supercritical fluid chromatography.
[Salvia officinalis l. I. Botanic characteristics, composition, use and cultivation].
Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model.
Metabolism of monoterpenes: lactonization of (+)-camphor and conversion of the corresponding hydroxy acid to the glucoside-glucose ester in sage (Salvia officinalis).
Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid.
Antioxidant activity of sweetgrass (Hierochloë odorata Wahlnb.) extract in lard and rapeseed oil emulsions.
Metabolism of Monoterpenes : Metabolic Fate of (+)-Camphor in Sage (Salvia officinalis).
In Vitro Antibacterial and Antibiotic Resistance Modifying Effect of Bioactive Plant Extracts on Methicillin-Resistant Staphylococcus epidermidis.
Induction and Characterization of a Cytochrome P-450-Dependent Camphor Hydroxylase in Tissue Cultures of Common Sage (Salvia officinalis).
Relationship of Camphor Biosynthesis to Leaf Development in Sage (Salvia officinalis).
Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin.
Antioxidant activities of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil.
Efficacy of plant essential oils on postharvest control of rots caused by fungi on different stone fruits in vivo.
Study on the combined effects of essential oils on microbiological quality of Fior di Latte cheese.
α-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway.
Chemical composition of essential oil and leaf anatomy of Salvia bertolonii Vis. and Salvia pratensis L. (Sect. Plethiosphace, Lamiaceae).
In vitro study on the transfer of volatile oil components.
Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults.
The effect of herbicides on the qualitative properties of healing plants. Part 2: Content and composition of the essential oil from Salvia officinal is L. after application of Afalon 50 WP.
Morphological characterisation and agronomical parameters of different species of Salvia sp. (Lamiaceae).
Carnosic acid, a new class of lipid absorption inhibitor from sage.
The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis: a clinico-biochemical study.
Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers.
Assessment of the antioxidant potential of selected plant extracts--in vitro and in vivo experiments on pork.
An attempt of postharvest orange fruit rot control using essential oils from Mediterranean plants.
Chromatographic (GC-MS, HPLC) and virological evaluations of Salvia sclarea infected by BBWV-I.
Characterization of essential oils from lamiaceae species by fourier transform Raman spectroscopy.
Matrix solid-phase dispersion (MSPD) in chromatographic analysis of essential oils in herbs.
Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory.
The psychopharmacology of European herbs with cognition-enhancing properties.
Performance of phytochemical antioxidant systems in refined-bleached-deodorized palm olein during frying.
Nematicidal activity of essential oils and volatiles derived from Portuguese aromatic flora against the pinewood nematode, Bursaphelenchus xylophilus.
Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species.
[Influence of extraction methods on the composition of essential oils].
Activity of essential oils from Mediterranean Lamiaceae species against food spoilage yeasts.
[Plant anatomical and phytochemical evaluation of Salvia species].
In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp.
The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal.
Effects of borneol and thymoquinone on TNBS-induced colitis in mice.
Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models.
Studies on the genotoxic properties of essential oils with Bacillus subtilis rec-assay and Salmonella/microsome reversion assay.
Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor.
Clomazone does not inhibit the conversion of isopentenyl pyrophosphate to geranyl, farnesyl, or geranylgeranyl pyrophosphate in vitro.
Comparison of different extraction methods for the determination of essential oils and related compounds from aromatic plants and optimization of solid-phase microextraction/gas chromatography.

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
Export Tariff Code:	3301.29.5050
Typical G.C.
Wikipedia:	View
FAO:	BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex	No
Solubility
alcohol	Yes
water, 683.7 mg/L @ 25 °C (est)	Yes
water	No

Organoleptic Properties

Odor Type: Thujonic
thujonic, eucalyptus, rosemary, sage
General comment	At 10.00 % in dipropylene glycol. thujone eucalyptus rosemary sage
Flavor Type: Thujonic
sage
General comment	Sage

Occurrences

Potential Uses

Applications	flavor and fragrance agents
Odor purposes	Armoise, Cedar, Cedar, Cedar forest, Eucalyptus oil replacer, Evergreen, Fern, Herbal, Incense, Juniper, Pennyroyal, Pine, Rosemary, Sage
Flavoring purposes	Pennyroyal
Cosmetic purposes	Fragrance, Tonic

Safety Information

Safety information

European information :
Most important hazard(s):
Xn N - Harmful, Dangerous for the environment.
R 10 - Flammable. R 22 - Harmful if swallowed. R 43 - May cause sensitisation by skin contact. R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R 65 - Harmful: may cause lung damage if swallowed. R 68 - Possible risk of irreversible effects. S 02 - Keep out of the reach of children. S 24 - Avoid contact with skin. S 36/37 - Wear suitable protective clothing and gloves. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet. S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2600 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 987, 1974.
Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 987, 1974.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for sage oil lithuania usage levels up to:
	1.0000 % in the fragrance concentrate.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	14.00000
beverages(nonalcoholic):		-	3.70000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	30.00000
condiments / relishes:		-	14.00000
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	16.00000
fruit ices:		-	16.00000
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	11.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	110.00000
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

EPI System: View

EPA Substance Registry Services (TSCA):8022-56-8

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

salvia officinalis l. oil

Chemidplus:008022568