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cinnamomum cassia oil

General Material Information

Trivial Name cinnamomum cassia oil
Short Description volatile oil obtained from the whole plant of the chinese cinnamon, cinnamomum cassia (l.), lauraceae
CAS Number 8007-80-5
FEMA Number 2258
FDA UNII Search
MDL MFCD00130805
COE Number 131
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8007-80-5 ; CINNAMON BARK, OIL (CINNAMOMUM SPP.)
Synonyms
  • camphorina cassia oil
  • cassia bark oil
  • cassia EO
  • cassia essential oil
  • cassia oil (cinnamomum cassia)
  • cassia oil B & F
  • cassia oil cleaned and filtered
  • cassia oil crude
  • cassia oil crude, cinnamomum cassia oil
  • cassia oil natural
  • cassia oil natural redistilled
  • cassia oil organic
  • cassia oil rectified FCC
  • cassia oil redistilled
  • cassia oil redistilled FCC
  • cassia oil redistilled, cinnamomum cassia oil
  • cinnamomum aromaticum oil
  • cinnamomum longifolium oil
  • cinnamomum medium oil
  • cinnamomum nitidum oil
  • laurus cassia oil
  • persea cassia oil
  • volatile oil obtained from the whole plant of the chinese cinnamon, cinnamomum cassia (l.), lauraceae
  • cinnamomum cassia blume oil
  • Essential oils, cassia
  • Cassia oil
  • Oil of cassia
  • Oils, cassia
  • Oils, essential, cassia
  • Cinnamomum cassia, essential oil
  • Oil of Chinese cinnamon
  • Cassia oils
  • Chinese cinnamon oil
  • Oils, Chinese cinnamon
  • Cinnamomum cassia leaf oil
  • Cinnamomum cassia bark oil
  • Cinnamomum cassia twig oil

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Literature & References

cinnamomum cassia blume oil
Canada Domestic Sub. List:8007-80-5
Pubchem (sid):135352886
Publications by PubMed
The traditional herbal medicine, Ge-Gen-Tang, inhibits pacemaker potentials by nitric oxide/cGMP dependent ATP-sensitive K(+) channels in cultured interstitial cells of Cajal from mouse small intestine.
Efficacy of Cinnamomum cassia Blume. in age induced sexual dysfunction of rats.
Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus in South Africa using in vitro methods.
The extract of Cinnamomum cassia twigs inhibits adipocyte differentiation via activation of the insulin signaling pathway in 3T3-L1 preadipocytes.
Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization, and syncytium formation.
2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.
The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action.
Anti-gastric actions of eugenol and cinnamic acid isolated from Cinnamomi Ramulus.
Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats.
Inhibitory effects of cinnamic acid on melanin biosynthesis in skin.
Protective effects of Guizhi-Fuling-Capsules on rat brain ischemia/reperfusion injury.
Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3-E1 cells.
Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti (Diptera: Culicidae) under laboratory and indoor conditions.
Toxicity of spray and fumigant products containing cassia oil to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae).
Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume.
Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia.
In vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to.
Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma.
Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat.
Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria.
Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells.
Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae).
Inhibition of human tumor growth by 2'-hydroxy- and 2'-benzoyloxycinnamaldehydes.
Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells.
2'-Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia.
[Salmonella and fecal coliforms in cinnamon (Cinnamomum cassia Blume and Cinnamomum zeylanicum Nees) sold in the city of Florian polis, Santa Catarina, Brazil].
Alterations of pulse by Chinese herb medicine.
A reticuloendothelial system-activating arabinoxylan from the bark of Cinnamomum cassia.

Other Information

FDA Substances Added to Food (formerly EAFUS):View
MedlinePlusSupp:View
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
FAO:CINNAMOMUM OILS (INCLUDING CINNAMON AND CASSIA)

PhysChem Properties

Material listed in food chemical codex No
Solubility
alcohol Yes
water No

Organoleptic Properties

Odor Type: Spicy
cassia, cinnamon
General comment At 10.00 % in dipropylene glycol. cassia
Flavor Type: Spicy
cassia, cinnamon
General comment Cassia

Occurrences

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 4), H227
Acute toxicity, Dermal (Category 3), H311
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
GHS Label elements, including precautionary statements
Pictogramskull.jpg
Signal word Danger
Hazard statement(s)
H227 - Combustible liquid
H311 - Toxic in contact with skin
H315 - Causes skin irritation
H319 - Causes serious eye irritation
Precautionary statement(s)
P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264 - Wash skin thouroughly after handling.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P361 - Remove/Take off immediately all contaminated clothing.
P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.
P403 + P235 - Store in a well-ventilated place. Keep cool.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 500 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Pharmacologist. Vol. 3, Pg. 62, 1961.

oral-mouse LD50 2670 mg/kg
Tokishikoroji Foramu. Toxicology Forum. Vol. 8, Pg. 91, 1985.

oral-rat LD50 2800 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 109, 1975.

Dermal Toxicity:
skin-rabbit LD50 320 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 109, 1975.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
benzaldehyde Max. Found: 1.00 % and Reason: Sensitization
benzyl benzoate Max. Found: 0.1 % and Reason: Sensitization
cinnamyl alcohol Max. Found: 0.2 % and Reason: Sensitization
cinnamaldehyde Max. Found: 80.00 % and Reason: Sensitization
coumarin Max. Found: 2.00 % and Reason: Sensitization
eugenol Max. Found: 0.1 % and Reason: Sensitization
isoeugenol Max. Found: 0.1 % and Reason: Sensitization
ortho-methoxycinnamaldehyde Max. Found: 9.00 % and Reason: Sensitization
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -73.00000
beverages(nonalcoholic): -3.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -1900.00000
condiments / relishes: -140.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -11.00000
fruit ices: -11.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -150.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -290.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8007-80-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2810
cinnamomum cassia blume oil
Chemidplus:0008007805
RTECS:FI4050000 for cas# 8007-80-5