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General Material Information

Trivial Name lemon oil
Short Description volatile oil obtained from the fresh peel of the lemon, citrus limon (l.), rutaceae
CAS Number 8008-56-8
FEMA Number 2625
FDA UNII Search
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8008-56-8 ; LEMON, OIL (CITRUS LIMON (L.) BURM. F.)
Synonyms
  • citrus limon peel oil
  • citrus medica limonum peel oil
  • citrus x limon peel oil
  • hydroessential citrus limon (Vevy)
  • lemon citrustt
  • lemon ess BM 01
  • lemon ess for limonade
  • lemon ess nat 01
  • lemon ess nat 02
  • lemon ess nat 05
  • lemon ess select 01
  • treattzest lemon juicy
  • citreatt lemon oil
  • essential lemon oil
  • lemon oil # 925637
  • lemon oil NF
  • lemon oil organic
  • essential lemon oil organic
  • volatile oil obtained from the fresh peel of the lemon, citrus limon (l.), rutaceae
  • citrus limon l. burm. f. peel oil
  • Oils, lemon
  • Essential oils, lemon
  • Oil of Lemon
  • Lemon tincture
  • Oils, Citrus limonis
  • Oil, lemon
  • Lemon essential oils
  • PH 6968
  • Limonene White
  • Lemon oils
  • Lemon essential oil
  • Essential lemon oils
  • Essential lemon peel oil
  • Citrus limon fruit peel oil
  • Citrus limon essential oil
  • Citrus limon oil
  • Lemon peel oil
  • TC 1901
  • FY 9930

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Literature & References

citrus limon l. burm. f. peel oil
Canada Domestic Sub. List:8008-56-8
Pubchem (sid):135328486
Publications by PubMed
In vitro biological evaluation of eight different essential oils against Trypanosoma cruzi, with emphasis on Cinnamomum verum essential oil.
Does antioxidant properties of the main component of essential oil reflect its antioxidant properties? The comparison of antioxidant properties of essential oils and their main components.
Insecticidal activity of plant essential oils against the vine mealybug, Planococcus ficus.
Fatty acids profile and alteration of lemon seeds extract (Citrus limon) added to soybean oil under thermoxidation.
Effect of Melia azedarach (Sapindales: Meliaceae) fruit extracts on Citrus Leafminer Phyllocnistis citrella (Lepidoptera: Gracillariidae).
In vitro and in vivo antifungal activity of some essential oils against feline isolates of Microsporum canis.
Evaluation of Clausena pentaphylla (Roxb.) DC oil as a fungitoxicant against storage mycoflora of pigeon pea seeds.
Evaluation of bioefficacy of three Citrus essential oils against the dengue vector Aedes albopictus (Diptera: Culicidae) in correlation to their components enantiomeric distribution.
Changes of peel essential oil composition of four Tunisian citrus during fruit maturation.
Lemon (Citrus limon, Burm.f.) essential oil enhances the trans-epidermal release of lipid-(A, E) and water-(B6, C) soluble vitamins from topical emulsions in reconstructed human epidermis.
Volatile constituents of wild citrus Mangshanyegan (Citrus nobilis Lauriro) peel oil.
Increasing antibiotic activity against a multidrug-resistant Acinetobacter spp by essential oils of Citrus limon and Cinnamomum zeylanicum.
Sedative, anxiolytic and antidepressant activities of Citrus limon (Burn) essential oil in mice.
Antioxidant and antiacetylcholinesterase activities of some commercial essential oils and their major compounds.
Chemical composition and fumigant toxicity of some essential oils against Ephestia kuehniella.
Antioxidant and antinociceptive effects of Citrus limon essential oil in mice.
Antioxidant activity of Citrus limon essential oil in mouse hippocampus.
[Autooxidation of a mixture of lemon essential oils, methyl linolenoate, and methyl oleinate].
Sicilian lemon oil: Composition of volatile and oxygen heterocyclic fractions and enantiomeric distribution of volatile components.
Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells.
Comparative study of the chemical composition and antioxidant activity of six essential oils and their components.
Isolation and characterization of total volatile components from leaves of citrus limon linn.
Oxidative stability and alpha-tocopherol retention in soybean oil with lemon seed extract (Citrus limon) under thermoxidation.
[Antioxidant properties of essential oils from lemon, grapefruit, coriander, clove, and their mixtures].
Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit.
Volatiles emission patterns of different plant organs and pollen of Citrus limon.
Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash.
The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems.
Authenticity control of essential oils containing citronellal and citral by chiral and stable-isotope gas-chromatographic analysis.
Essential oil composition of Citrus meyerii Y. Tan. and Citrus medica L. cv. Diamante and their lemon hybrids.
Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells.
In vitro effect of essential oils from Cinnamomum aromaticum, Citrus limon and Allium sativum on two intestinal flagellates of poultry, Tetratrichomonas gallinarum and Histomonas meleagridis.
Natural enemies of three mealybug species (Hemiptera: Pseudococcidae) found on citrus and effects of some insecticides on the mealybug parasitoid Coccidoxenoides peregrinus (Hymenoptera: Encyrtidae) in South Africa.
Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases.
Composition and seasonal variation of the essential oil from leaves and peel of a Cretan lemon variety.
Local anaesthetic activity of the essential oil of Lavandula angustifolia.
Citrus peel oil extracts as mosquito larvae insecticides.
Fungitoxic properties of the essential oil of Citrus limon (L.) Burm. against a few dermatophytes.
[Effects of low doses of essential oil on the antioxidant state of the erythrocytes, liver, and the brains of mice].
Pre-treatment of Stegomyia aegypti mosquitoes with a sublethal dose of imidacloprid impairs behavioural avoidance induced by lemon oil and DEET.
Does antioxidant properties of the main component of essential oil reflect its antioxidant properties? The comparison of antioxidant properties of essential oils and their main components.
Insecticidal activity of plant essential oils against the vine mealybug, Planococcus ficus.
Interventions for nausea and vomiting in early pregnancy.
Essential oil from lemon peels inhibit key enzymes linked to neurodegenerative conditions and pro-oxidant induced lipid peroxidation.
Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice.
Nanoemulsion-based delivery systems for polyunsaturated (ω-3) oils: formation using a spontaneous emulsification method.
Fatty acids profile and alteration of lemon seeds extract (Citrus limon) added to soybean oil under thermoxidation.
Comprehensive profiling and marker identification in non-volatile citrus oil residues by mass spectrometry and nuclear magnetic resonance.
Box jellyfish envenomation: case report of effective lemon and oil emulsion treatment.
Identification of oil residues in Roman amphorae (Monte Testaccio, Rome): a comparative FTIR spectroscopic study of archeological and artificially aged samples.
Effect of Melia azedarach (Sapindales: Meliaceae) fruit extracts on Citrus Leafminer Phyllocnistis citrella (Lepidoptera: Gracillariidae).
In vitro and in vivo antifungal activity of some essential oils against feline isolates of Microsporum canis.
Efficacy of grapefruit, tangerine, lime, and lemon oils as solvents for softening gutta-percha in root canal retreatment procedures.
Effect of citrus lemon oil on growth and adherence of Streptococcus mutans.
Evaluation of Clausena pentaphylla (Roxb.) DC oil as a fungitoxicant against storage mycoflora of pigeon pea seeds.
Encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems: vitamin E, vitamin D, and lemon oil.
Volatile constituents of wild citrus Mangshanyegan (Citrus nobilis Lauriro) peel oil.
Increasing antibiotic activity against a multidrug-resistant Acinetobacter spp by essential oils of Citrus limon and Cinnamomum zeylanicum.
Chemical composition and fumigant toxicity of some essential oils against Ephestia kuehniella.
Antioxidant activity of Citrus limon essential oil in mouse hippocampus.
Formation of flavor oil microemulsions, nanoemulsions and emulsions: influence of composition and preparation method.
Evaluation of commercial essential oil samples on the growth of postharvest pathogen Monilinia fructicola (G. Winter) Honey.
Functional asymmetries in cockroach ON and OFF olfactory receptor neurons.
[Autooxidation of a mixture of lemon essential oils, methyl linolenoate, and methyl oleinate].
Sicilian lemon oil: Composition of volatile and oxygen heterocyclic fractions and enantiomeric distribution of volatile components.
Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells.
Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms.
Comparative study of the chemical composition and antioxidant activity of six essential oils and their components.
Isolation and characterization of total volatile components from leaves of citrus limon linn.
Oxidative stability and alpha-tocopherol retention in soybean oil with lemon seed extract (Citrus limon) under thermoxidation.
Improved separation of furocoumarins of essential oils by supercritical fluid chromatography.
Antimicrobial activity of lavender, tea tree and lemon oils in cosmetic preservative systems.
Components of lemon essential oil attenuate dementia induced by scopolamine.
Quantitative identification of pesticides as target compounds and unknowns by spectral deconvolution of gas chromatographic/mass spectrometric data.
[Antioxidant properties of essential oils from lemon, grapefruit, coriander, clove, and their mixtures].
Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit.
Olfactory influences on mood and autonomic, endocrine, and immune function.
Comprehensive two-dimensional liquid chromatography applying two parallel columns in the second dimension.
Influence of cinnamon and clove essential oils on the D- and z-values of Escherichia coli O157:H7 in apple cider.
An investigation and comparison of the bioactivity of selected essential oils on human lice and house dust mites.
The survival of three strains of Arcobacter butzleri in the presence of lemon, orange and bergamot essential oils and their components in vitro and on food.
Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash.
Authenticity control of essential oils containing citronellal and citral by chiral and stable-isotope gas-chromatographic analysis.
Skin diseases in workers at a perfume factory.
Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice.
Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride.
Considerations on the possibilities and limitations of comprehensive normal phase-reversed phase liquid chromatography (NPLC x RPLC).
Olfactory receptors on the cockroach antenna signal odour ON and odour OFF by excitation.
Transdermal delivery of flurbiprofen: permeation enhancement, design, pharmacokinetic, and pharmacodynamic studies in albino rats.
Essential oil composition of Citrus meyerii Y. Tan. and Citrus medica L. cv. Diamante and their lemon hybrids.
Microencapsulation of oils using whey protein/gum Arabic coacervates.
Antibacterial activities of plant essential oils and their components against Escherichia coli O157:H7 and Salmonella enterica in apple juice.
Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells.
Effect of olfactory stimulation with flavor of grapefruit oil and lemon oil on the activity of sympathetic branch in the white adipose tissue of the epididymis.
Natural enemies of three mealybug species (Hemiptera: Pseudococcidae) found on citrus and effects of some insecticides on the mealybug parasitoid Coccidoxenoides peregrinus (Hymenoptera: Encyrtidae) in South Africa.
Simultaneous determination of Cd(II), Cu(II), Pb(II), and Zn(II) in citrus essential oils by derivative potentiometric stripping analysis.
The quantification of citral in lemongrass and lemon oils by near-infrared spectroscopy.
Composition and seasonal variation of the essential oil from leaves and peel of a Cretan lemon variety.
Antioxidative effects of lemon oil and its components on copper induced oxidation of low density lipoprotein.
High-speed GC and GC/time-of-flight MS of lemon and lime oil samples.
Contamination of Italian citrus essential oils: presence of chloroparaffin.
Integration of temperature and olfactory information in cockroach antennal lobe glomeruli.
Oxidative stress and antioxidants at skin biosurface: a novel antioxidant from lemon oil capable of inhibiting oxidative damage to the skin.
Local anaesthetic activity of the essential oil of Lavandula angustifolia.
Encapsulation of lemon oil by paste method using beta-cyclodextrin: encapsulation efficiency and profile of oil volatiles.
Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology.
Insecticidal properties of citrus oils against Culex pipiens and Musca domestica.
Citrus peel oil extracts as mosquito larvae insecticides.
Effects of olfactory stimulation on the sleep time induced by pentobarbital administration in mice.
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils.
[Geraniol contact allergy].
Fungitoxic properties of the essential oil of Citrus limon (L.) Burm. against a few dermatophytes.
A study of the phototoxicity of lemon oil.
Inhibition of growth and aflatoxin production of Aspergillus parasiticus by citrus oils.
Publications by J-Stage
Characterization of Coumarin-Specific Prenyltransferase Activities in Citrus limon Peel

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.13.0000
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 7.065 to 7.114
Refractive Index 1.472 to 1.474 @ 20 °C
Vapor Pressure 0.95 mmHg @ 25 °C
Flash Point TCC Value 46.11 °C TCC
Shelf life 12 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light. store under nitrogen.
Solubility
alcohol Yes
water, 4.581 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Citrus
citrus, lemon, lemon peel
Odor strength medium
Substantivity 4 hour(s) at 100.00 %
General comment At 100.00 %. citrus lemon
Flavor Type: Citrus
citrus, lemon, lemon peel
General comment Citrus lemon

Occurrences

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2840 mg/kg
PHARAT
14,435,1959

oral-rat LD50 2840 mg/kg
Pharmazie. Vol. 14, Pg. 435, 1959.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
FCTXAV
12,725,1974

skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 725, 1974.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Phototoxicity
IFRA Other Specification:
IFRA fragrance material specification:
Where the bergapten (5-methoxypsoralen) content of all relevant oils present in a compound has been determined, it is recommended that for applications on areas of skin exposed to sunshine, excluding bath preparations, soaps and other products which are washed off the skin, the total level of bergapten in the consumer products should not exceed 0.0015% (15 ppm). This is equivalent to 0.0075% (75 ppm) in a fragrance compound used at 20% in the consumer product. Where the level of bergapten has not been determined by appropriate methods, the limits specified in the guidelines on individual oils should apply. In those cases, where such oils are used in combination with other phototoxic ingredients, the additive effect has to be taken into consideration and the use levels have to be reduced accordingly. The sum of the concentrations of all phototoxic fragrance ingredients, expressed in % of their recommended maximum level in the consumer product, shall not exceed 100.
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
geraniol Max. Found: 0.1 % and Reason: Sensitization
citral Max. Found: 3.5 % and Reason: Sensitization
7-methoxycoumarin Max. Found: 0.05 % and Reason: Sensitization, photosensitization
citronellal Max. Found: 0.1 % and Reason: Sensitization
View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
2.0 %
Category 2: Products applied to the axillae
2.0 %
Category 3: Products applied to the face/body using fingertips
2.0 %
Category 4: Products related to fine fragrance
2.0 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
2.0 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
2.0 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
2.0 %
Category 5D: Baby Creams, baby Oils and baby talc
2.0 %
Category 6: Products with oral and lip exposure
2.0 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
No Restriction %
Category 7B: Leave-on products applied to the hair with some hand contact
2.0 %
Category 8: Products with significant anogenital exposure
2.0 %
Category 9: Products with body and hand exposure, primarily rinse off
No Restriction %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
No Restriction %
Category 10B: Household aerosol/spray products
2.0 %
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
No Restriction %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
2.0 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
No Restriction
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -580.00000
beverages(nonalcoholic): -230.00000
beverages(alcoholic): --
breakfast cereal: -140.00000
cheese: --
chewing gum: -1900.00000
condiments / relishes: 10.0000080.00000
confectionery froastings: 65.00000600.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -380.00000
fruit ices: -380.00000
gelatins / puddings: -340.00000
granulated sugar: --
gravies: --
hard candy: -1100.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 25.0000040.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl)
View page or View pdf

Outcome of the consultation with Member States and EFSA on the basic substance application for approval of lemon essential oil to be used in plant protection as an acaricide, insecticide and fungicide in fruit trees (citrus)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):8008-56-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2319
WGK Germany:2
citrus limon l. burm. f. peel oil
Chemidplus:0008008568