valeriana officinalis root extract

General Material Information

Preferred name	valeriana officinalis root extract
Trivial Name	Valeriana
Short Description	extract of the roots from the valerian, valeriana officinalis l., valerianaceae
CAS Number	8057-49-6
FEMA Number	3099
ECHA Number	232-501-7
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	8057-49-6 ; VALERIAN ROOT, EXTRACT (VALERIANA OFFICINALIS L.)
Synonyms	extract of the roots from the valerian, valeriana officinalis l., valerianaceae valerian extract valerian extract HS 2396 G (Grau) valerian extract LS 3086 G (Grau) valerian extract natural valerian root 0.8% valerenic acid; 4:1 extract valerian root extract actiphyte of valerian root extract valerian root extract deodorized valerian root fluid extract valerian root P.E. valerian root solid extract valeriana officinalis l. root extract Valeriana Valerian Valerian (Valeriana) Valerianae extractum MeSH ID: D014632

	valeriana officinalis l. root extract
Pubchem (sid):	135331255

Publications by PubMed
Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites.
Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.
Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine.
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.
Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.

FDA Substances Added to Food (formerly EAFUS):	View
Export Tariff Code:	1302.19.0000
FDA Listing of Food Additive Status:	View
Wikipedia:	View

Astral Extracts	AuNutra® Industries
Bell Flavors & Fragrances	Bio-Botanica®
BOC Sciences	Carrubba
ECSA Chemicals	Ernesto Ventós
Frutarom	Grau Aromatics
IFF	Indis NV
Jiangyin Healthway	Lipotec USA
Naturex	Penta International
Shaanxi Y-Herb Biotechnology	SRS Aromatics
Vege Tech	Xian Yuensun Biological Technology
FRUTAROM USA INC,	Jiangyin Healthway International Trade Co., Ltd
Penta International Corporation	SRS Aromatics Ltd
Ernesto Ventós S.A.

Material listed in food chemical codex

Odor Type: Fruity
sweet, woody, dry, powdery, musk, amber
Substantivity	12 Hour(s)
General comment	At 100.00 %. sweet woody dry powdery musky amber
Flavor Type: Fruity
valerian root
General comment	Valerian root

Applications	cosmetic flavor and fragrance agents dietary supplements
Odor purposes	Amber, Balsam, Chypre, Leather, Leather russian leather, Moss, Musk, Tobacco, Woody
Cosmetic purposes	Skin conditioning


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 3300 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Journal of Pharmaceutical Sciences. Vol. 50, Pg. 240, 1961. intraperitoneal-mammal (species unspecified) LD50 975 mg/kg Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988. oral-mammal (species unspecified) LD50 2250 mg/kg Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Category:
cosmetic, flavor and fragrance agents, dietary supplements
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
	average usual ppm	average maximum ppm
baked goods:	-	69.00000
beverages(nonalcoholic):	-	25.00000
beverages(alcoholic):	-	-
breakfast cereal:	-	-
cheese:	-	-
chewing gum:	-	-
condiments / relishes:	-	24.00000
confectionery froastings:	-	-
egg products:	-	-
fats / oils:	-	-
fish products:	-	-
frozen dairy:	-	35.00000
fruit ices:	-	35.00000
gelatins / puddings:	-	-
granulated sugar:	-	-
gravies:	-	-
hard candy:	-	65.00000
imitation dairy:	-	-
instant coffee / tea:	-	-
jams / jellies:	-	-
meat products:	-	-
milk products:	-	-
nut products:	-	-
other grains:	-	-
poultry:	-	-
processed fruits:	-	-
processed vegetables:	-	-
reconstituted vegetables:	-	-
seasonings / flavors:	-	-
snack foods:	-	-
soft candy:	-	-
soups:	-	-
sugar substitutes:	-	-
sweet sauces:	-	-

ClinicalTrials.gov:search

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

valeriana officinalis l. root extract

Chemidplus:0008057496