humulus lupulus extract

General Material Information

Preferred name	humulus lupulus extract
Trivial Name	humulus lupulus l. extract
Short Description	extract of the hops, humulus lupulus l., cannabidaceae
CAS Number	8060-28-4
FEMA Number	2578
ECHA Number	232-504-3
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	8060-28-4 ; HOPS, EXTRACT (HUMULUS LUPULUS L.)
Synonyms	extract of the hops, humulus lupulus l., cannabidaceae extrapone hop GW (Symrise) hop CL (Symrise) hop extract Hop, Humulus lupulus, ext. hops extract hops extract HS 2367 G hops extract LS 3473 G hops extract natural hops P.E Humuli lupuli extract Humuli lupuli extractum Humulus lupulus ext. Humulus lupulus flower, extract humulus lupulus l. extract phytovital hops hops pellets extract

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Literature & References

	humulus lupulus l. extract
Pubchem (sid):	135325910

Publications by PubMed
Effects of Xanthohumol-Rich Hop Extract on the Differentiation of Preadipocytes.
Comprehensive separation and structural analyses of polyphenols and related compounds from bracts of hops (Humulus lupulus L.).
Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet.
A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.
Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.
In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.).
Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties.
Comparative study of antioxidant properties and total phenolic content of the extracts of Humulus lupulus L. and quantification of bioactive components by LC-MS/MS and GC-MS.
A semi-automatic microextraction in packed sorbent, using a digitally controlled syringe, combined with ultra-high pressure liquid chromatography as a new and ultra-fast approach for the determination of prenylflavonoids in beers.
Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.
Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro.
Evaluation of the effect of Humulus lupulus alcoholic extract on rifampin-sensitive and resistant isolates of Mycobacterium tuberculosis.
Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.
Optimized mixture of hops rho iso-alpha acids-rich extract and acacia proanthocyanidins-rich extract reduces insulin resistance in 3T3-L1 adipocytes and improves glucose and insulin control in db/db mice.
META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse.
The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm.
Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro.
Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term.
Dose-response relationships for the antifeedant effects of Humulus lupulus extracts against larvae and adults of the Colorado potato beetle.
Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro.
Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).
[Effects of ethanol extracts of herbal medicines on dermatitis in an atopic dermatitis mouse model].
The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets.
Increased sexual motivation in female rats treated with Humulus lupulus L. extract.
A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial.
Effects of hops (Humulus lupulus L.) extract on volatile fatty acid production by rumen bacteria.
Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes.
Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naïve male rats.
The antimicrobial effects of hops (Humulus lupulus L.) on ruminal hyper ammonia-producing bacteria.
Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria.
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS.
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol.
Effects of aqueous hop (Humulus Lupulus L.) extract on vascular reactivity in rats: mechanisms and influence of gender and hormonal status.
Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids.
NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones.
Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice.
Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE.
Flavonoid glycosides extracted from hop (Humulus lupulus L.) as inhibitors of chemical mediator release from human basophilic KU812 cells.
Behavioural response of Colorado potato beetle (Leptinotarsa decemlineata) larvae to selected plant extracts.
Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy.
Effects of hop extracts on nasal rubbing and sneezing in BALB/c mice.
Effects of beer and hop on ionotropic gamma-aminobutyric acid receptors.
Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis.
A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts.
Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus).
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
New insight in the neuropharmacological activity of Humulus lupulus L.
Estrogens and congeners from spent hops (Humulus lupulus).
The antimycobacterial components of hops (Humulus lupulus) and their dereplication.
Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
Occupational airborne and hand dermatitis to hop (Humulus lupulus) with non-occupational relapses.
Comparison of the most odor-active compounds in fresh and dried hop cones (Humulus lupulus L. variety spalter select) based on GC-olfactometry and odor dilution techniques.
Molecular characterization and genome organization of 7SL RNA genes from hop (Humulus lupulus L.).
Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones.
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
Export Tariff Code:	1302.13.0000
Wikipedia:	View

Suppliers

AuNutra® Industries	Bristol Botanicals
Carrubba	Dongguan Meiherb Biotech
ECSA Chemicals	Excellentia International
Grau Aromatics	H. Erhard Wagner
Hopsteiner	Naturex
Shaanxi Y-Herb Biotechnology	SRS Aromatics
Symrise	Vege Tech
SRS Aromatics Ltd	Symrise AG
Sifar Naturals

PhysChem Properties

Material listed in food chemical codex	No
Specific gravity	@ 25 °C
Pounds per Gallon	8.086 to 8.669
Refractive Index	1.3554 to 1.3714 @ 20 °C
Shelf life	6 months (or longer if stored properly.)
Storage notes	Store in cool, dry place in tightly sealed containers, protected from heat and light.

Organoleptic Properties

Odor Type: Woody
woody, green, citrus, malty, tagette
General comment	Woody green citrus malt tagette
Flavor Type: Woody
hops
General comment	Hops

Occurrences

Potential Uses

Applications	cosmetic flavor and fragrance agents
Odor purposes	Apple, Herbal, Malt, Orange, Pear
Flavoring purposes	Beverage, Chocolate cocoa, Tomato, Tonic, Tropical
Other purposes	Antimicrobial agents, Astringents, Emollients, Skin conditioning, Soothing agents
Cosmetic purposes	Antimicrobial agents, Astringents, Perfuming agents, Skin conditioning, Skin conditioning - emollient, Soothing agents, Tonic

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
	average usual ppm	average maximum ppm
baked goods:	-	-
beverages(nonalcoholic):	-	160.00000
beverages(alcoholic):	-	-
breakfast cereal:	-	-
cheese:	-	-
chewing gum:	-	-
condiments / relishes:	-	-
confectionery froastings:	-	-
egg products:	-	-
fats / oils:	-	-
fish products:	-	-
frozen dairy:	-	-
fruit ices:	-	-
gelatins / puddings:	-	-
granulated sugar:	-	-
gravies:	-	-
hard candy:	-	-
imitation dairy:	-	-
instant coffee / tea:	-	-
jams / jellies:	-	-
meat products:	-	-
milk products:	-	-
nut products:	-	-
other grains:	-	-
poultry:	-	-
processed fruits:	-	-
processed vegetables:	-	-
reconstituted vegetables:	-	-
seasonings / flavors:	-	-
snack foods:	-	-
soft candy:	-	-
soups:	-	-
sugar substitutes:	-	-
sweet sauces:	-	-

Safety references

ClinicalTrials.gov:search

Daily Med:search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:1

humulus lupulus l. extract

Chemidplus:0008060284