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glycyrrhiza glabra root extract

General Material Information

Preferred name glycyrrhiza glabra root extract
Trivial Name Licorice, Glycyrrhiza glabra, ext.
Short Description extract of the roots of the licorice, glycyrrhiza glabra l., leguminosae
CAS Number 84775-66-6
FEMA Number 2628
ECHA Number 283-895-2
FDA UNII 2788Z9758H
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 68916-91-6 ; LICORICE EXTRACT (GLYCYRRHIZA SPP.)
Synonyms
  • aqua licorice extract P-T
  • extract of the roots of the licorice, glycyrrhiza glabra l., leguminosae
  • glycyrrhiza glabra (mulethi) extract
  • licorice root extract
  • actiphyte of licorice root extract
  • licorice root extract natural
  • licorice root extract, 20% glycyrrhizic acid
  • liquorice kiinote (Omega)
  • liquorice root kiinote organic (Omega)
  • polyol soluble licorice extract HG
  • polyol soluble licorice extract P-T(40)
  • vedaplex 146
  • Licorice, Glycyrrhiza glabra, ext.
  • Glycyrrhiza glabra ext.

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Literature & References

glycyrrhiza glabra root extract
Pubchem (sid):135314337
Publications by PubMed
Evaluation of sodium benzoate and licorice (Glycyrrhiza glabra) root extract as heat-sensitizing additives against Escherichia coli O157:H7 in mildly heated young coconut liquid endosperm.
Enhancement of Hippocampal CA3 Neuronal Dendritic Arborization by Glycyrrhiza glabra root extract Treatment in Wistar Albino Rats.
Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study.
Improving the thrombin inhibitory activity of glycyrrhizin, a triterpenic saponin, through a molecular simplification of the carbohydrate moiety.
Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study.
Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats.
Chromolithic method development, validation and system suitability analysis of ultra-sound assisted extraction of glycyrrhizic acid and glycyrrhetinic acid from Glycyrrhiza glabra.
18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice.
Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation.
Immunological studies of Revitonil, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract.
Inhibition of human complement by beta-glycyrrhetinic acid.
Transdermal microemulsions of Glycyrrhiza glabra L.: characterization, stability and evaluation of antioxidant potential.
Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™).
Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6.
Memory enhancing activity of Glycyrrhiza glabra in mice.
Screening of traditionally used South African plants for antifungal activity against Candida albicans.
[Differences between the root and rhizome of Ural licorice (Glycyrrhiza uralensis Fisch.) and those of smooth licorice (Glycyrrhiza glabra L.)].

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:1302.12.0000
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 8.249 to 8.831
Refractive Index 1.34 to 1.39 @ 20 °C
Shelf life 6 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.

Organoleptic Properties

Odor Type: Licorice
sweet, licorice
General comment At 100.00 %. sweet licorice root
Flavor Type: Licorice
licorice
General comment Licorice

Occurrences

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 14200 mg/kg

intraperitoneal-rat LD50 1420 mg/kg

oral-mouse LD50 > 7500 mg/kg

intraperitoneal-mouse LD50 1500 mg/kg

Dermal Toxicity:
subcutaneous-rat LD50 4200 mg/kg

subcutaneous-mouse LD50 4000 mg/kg

Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -84.00000
beverages(nonalcoholic): -33.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -29000.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -39.00000
fruit ices: -39.00000
gelatins / puddings: -4.00000
granulated sugar: --
gravies: --
hard candy: -130.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
glycyrrhiza glabra root extract
Chemidplus:0084775666