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cynara scolymus leaf extract

General Material Information

Preferred name cynara scolymus leaf extract
Trivial Name Artichoke, ext.
Short Description extract of the leaves of the artichoke, cynara scolymus l., compositae
CAS Number 84012-14-6
ECHA Number 281-659-3
FDA UNII Search
Synonyms
  • artichoke leaf extract
  • artichoke leaf extract, 5% cynarin
  • artichoke leaf P.E.
  • biobenefity
  • extract of the leaves of the artichoke, cynara scolymus l., compositae
  • menofit
  • Artichoke, ext.
  • Cynara scolymus ext.

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Literature & References

cynara scolymus leaf extract
Pubchem (sid):135312255
Publications by PubMed
Use of artichoke (Cynara scolymus) flower extract as a substitute for bovine rennet in the manufacture of Gouda-type cheese: characterization of aspartic proteases.
Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells.
Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat.
Lanthanide-IMAC enrichment of carbohydrates and polyols.
Cynara Scolymus Leaf Extract Stimulates Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Hepatic Glucose Output in H4IIE Hepatocytes.
Extensive characterisation of bioactive phenolic constituents from globe artichoke (Cynara scolymus L.) by HPLC-DAD-ESI-QTOF-MS.
Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells.
Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat.
Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads.
Artichoke leaf extract for treating hypercholesterolaemia.
Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial.
[Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].
[Development and validation of method for the determination of cynarin, luteolin in plasma].
In vivo genotoxicity evaluation of an artichoke (Cynara scolymus L.) aqueous extract.
Artichoke induces genetic toxicity in the cytokinesis-block micronucleus (CBMN) cytome assay.
Separation and identification of phenolic compounds in canned artichoke by LC/DAD/ESI-MS using core-shell C18 column: a comparative study.
Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B.
Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.
Development of an automated method for Folin-Ciocalteu total phenolic assay in artichoke extracts.
Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on operant self-administration of a chocolate-flavoured beverage in rats.
Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats.
Extracts of edible and medicinal plants in inhibition of growth, adherence, and cytotoxin production of Campylobacter jejuni and Campylobacter coli.
Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters.
Appetite Control and Glycaemia Reduction in Overweight Subjects treated with a Combination of Two Highly Standardized Extracts from Phaseolus vulgaris and Cynara scolymus.
Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats.
Antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulation.
Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells.
[Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms].
Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
Effects of artichoke leaf extract on acute gastric mucosal injury in rats.
The effect of artichoke (Cynara scolymus L.) extract on respiratory chain system activity in rat liver mitochondria.
Artichoke leaf extract for treating hypercholesterolaemia.
Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet.
Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet.
Artichoke leave extract for chronic hepatitis C - a pilot study.
The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells.
Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress.
The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers.
Effect of two artichoke extracts (36_U and 36_EB) on rat ileum (with respect to bowel syndrome) and the peristaltic threshold.
Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial.
Effect of artichoke extract (Cynara scolymus L.) on palmitic-1-14C acid oxidation in rats.
Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application.
Effects of artichoke extract supplementation on gonads of cadmium-treated rats.
Clinical uses of artichoke leaf extract.
Research on biomodulatory effect of natural compounds.
Tabletted microspheres containing Cynara scolymus (var. Spinoso sardo) extract for the preparation of controlled release nutraceutical matrices.
Time-resolved spectral studies of blue-green fluorescence of artichoke (Cynara cardunculus L. Var. Scolymus) leaves: identification of chlorogenic acid as one of the major fluorophores and age-mediated changes.
Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver.
Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans.
Antifungal activity of Cynara scolymus L. extracts.
Purification of cynarases from artichoke (Cynara scolymus L.): enzymatic properties of cynarase A.
Purification and characterization of a milk-clotting aspartic proteinase from globe artichoke (Cynara scolymus L.).
Experimental mycotoxicosis in chickens induced by ochratoxin A and penicillic acid and intervention with natural plant extracts.
Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.
Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis.
Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells.
Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial.
Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial.
Validated method for the determination of six metabolites derived from artichoke leaf extract in human plasma by high-performance liquid chromatography-coulometric-array detection.
Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.
Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus).
Efficacy of different Cynara scolymus preparations on liver complaints.
Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats.
Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action.
Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes.
Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics.
Electrospray characterization of selected medicinal plant extracts.
Artichoke leaf extract - Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts.
[Action of an extract of artichoke (Cynara scolymus) on cholesterolesterase in vitro].

Other Information

FDA Listing of Food Additive Status:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No

Organoleptic Properties

Flavor Type: Green
green, artichoke, vegetable, leafy, earthy
General comment Green artichoke

Occurrences

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1000 mg/kg
Indian Journal of Experimental Biology. Vol. 9, Pg. 91, 1971.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic agents, dietary supplements
Recommendation for cynara scolymus leaf extract usage levels up to:
not for fragrance use.

Safety references

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-a-tocopheryl hydrogen succinate, riboflavin and inositol hexanicotinate in Limicol® and reduction of blood LDL-cholesterol concentrations pursuant to Article 14 of Regulation (EC) No 1924/2006
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cynara scolymus leaf extract
Chemidplus:0084012146