licorice extract

General Material Information

Preferred name	licorice extract
Trivial Name	Pharmaceutical natural products, licorice
Short Description	extract from the dried rhizomes and roots of the licorice, glycyrrhiza glabra l., leguminosae
CAS Number	68916-91-6
Deleted CAS Number	8008-94-4
ECHA Number	272-837-1
FDA UNII	Search
FDA Mainterm	68916-91-6 ; LICORICE EXTRACT (GLYCYRRHIZA SPP.)
Synonyms	extract from the dried rhizomes and roots of the licorice, glycyrrhiza glabra l., leguminosae glycyrrhiza glabra extract powder licorice extract powder (glycyrrhiza glabra l.) licorice P.E. liquiritina (Vevy) polyol soluble licorice extract BG100 yang gan cao extract glycyrrhiza glabra l. extract powder Pharmaceutical natural products, licorice Licorice, ext. Glycyrrhiza extract Licorice root extract Licorice Licorice (pharmaceutical) Natural products, pharmaceutical, licorice FM 100 FM 100 (extract) LX 103 Kanzoh Lacrinat Natural products, pharmaceutical, Glycyrrhizae radix Kanzou Glycyrrhizae radix Radix Glycyrrhizae Licorice root Liquorice root ext. Licorice root ext. Gan cao Gancao GanZao ZhiGanCao Liquiritiae radix Liquorice root extract ShengGanCao Sheng Gan Cao Zhi Gan Cao Gan Zao Radix Glycyrrhizae preparata

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Literature & References

	glycyrrhiza glabra l. extract powder
Pubchem (sid):	135314590

Publications by PubMed
Effect of GutsyGum(tm), A Novel Gum, on Subjective Ratings of Gastro Esophageal Reflux Following A Refluxogenic Meal.
Synergy of Licorice Extract and Pea Protein Hydrolysate for Oxidative Stability of Soybean Oil-in-Water Emulsions.
Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells.
Quality enhancement in the Japanese sea bass (Lateolabrax japonicas) fillets stored at 4°C by chitosan coating incorporated with citric acid or licorice extract.
Topically applied glycyrrhizic acid causes hair removal in rats.
18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity.
Special licorice extracts containing lowered glycyrrhizin and enhanced licochalcone a prevented Helicobacter pylori-initiated, salt diet-promoted gastric tumorigenesis.
[Adverse reaction induced by licorice preparations: clinical analysis of 93 cases].
Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.
18β-glycyrrhetinic acid induces UDP-glucuronosyltransferase in rats.
Identification of key licorice constituents which interact with cytochrome P450: evaluation by LC/MS/MS cocktail assay and metabolic profiling.
Inhibition of lipid oxidation and rancidity in precooked pork patties by radical-scavenging licorice (Glycyrrhiza glabra) extract.
Natural ingredients for darker skin types: growing options for hyperpigmentation.
Synergistic inhibition of lipid oxidation by pea protein hydrolysate coupled with licorice extract in a liposomal model system.
CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth.
Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation.
The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction.
Licorice abuse: time to send a warning message.
Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice.
Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry.
Licorice extract a sweet way to control decay.
Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract.
Licorice extract a sweet way to control decay.
Effects of Space Flight on the Chemical Constituents and Anti-Inflammatory Activity of Licorice (Glycyrrhiza uralensis Fisch).
Reduction of bacterial volatile sulfur compound production by licoricidin and licorisoflavan A from licorice.
Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract.
Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.
Liquiritigenin decreases selective molecular and behavioral effects of cocaine in rodents.
Licorice extract increases cyclophosphamide teratogenicity by upregulating the expression of cytochrome P-450 2B mRNA.
Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models.
Effect of licorice extract on the complications of diabetes nephropathy in rats.
Factors influencing glabridin stability.
Solid-phase extraction of liquiritin and glycyrrhizin from licorice using porous alkyl-pyridinium polymer sorbent.
Top 10 botanical ingredients in 2010 anti-aging creams.
Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway.
[Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds].
Rapid identification and preparative isolation of antioxidant components in licorice.
Control of downy mildew (Pseudoperonospora cubensis) of greenhouse grown cucumbers with alternative biological agents.
Analysis of phenolic and triterpenoid compounds in licorice and rat plasma by high-performance liquid chromatography diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry.
Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars.
Purification of flavonoids and triterpene saponins from the licorice extract using preparative HPLC under RP and HILIC mode.
Inhibitory effects of isoliquiritigenin and licorice extract on voltage-dependent K(+) currents in H9c2 cells.
Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors.
The efficacy of the bioadhesive patches containing licorice extract in the management of recurrent aphthous stomatitis.
A licorice extract reduces lipopolysaccharide-induced proinflammatory cytokine secretion by macrophages and whole blood.
Artocarpus lakoocha heartwood extract as a novel cosmetic ingredient: evaluation of the in vitro anti-tyrosinase and in vivo skin whitening activities.
HILIC for separation of co-eluted flavonoids under RP-HPLC mode.
A time course analysis of systemic administration of aqueous licorice extract on spatial memory retention in rats.
Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract.
Licorice extract does not impair the male reproductive function of rats.
Skin lightening preparations and the hydroquinone controversy.
Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer.
[Properties of commercial licorice extracts used as a food additive].
Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine.
High levels of ochratoxin A in licorice and derived products.
The effect of liquorice extract-containing starch gel on the amount and microbial composition of plaque.
Licorice: a possible anti-inflammatory and anti-ulcer drug.
The application of macroporous resins in the separation of licorice flavonoids and glycyrrhizic acid.
Toxicologic evaluation of licorice extract as a cigarette ingredient.
Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock.
Topical agents used in the management of hyperpigmentation.
Comparison of antioxidant activity of extract from roots of licorice (Glycyrrhiza glabra L.) to commercial antioxidants in 2% hydroquinone cream.
The treatment of atopic dermatitis with licorice gel.
Source of arsenic in licorice confectionery products.
Determination of low levels of methanol and ethanol in licorice extract by large volume injection head-space GC.
Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots.
Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells.
Anti-Helicobacter pylori flavonoids from licorice extract.
Effects of raw materials, ingredients, and production lines on arsenic and copper concentrations in confectionery products.
Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure.
Estrogen-like activity of glabrene and other constituents isolated from licorice root.
Isolation and identification of main constituents in an enzymatically hydrolysed licorice extract sweetener.
Constituents and their sweetness of food additive enzymatically modified licorice extract.
[State of pulmonary metabolism during radiotherapy of thoracic neoformations and possibilities of its correction].
The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation.
Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice.
[Properties of glycyrrhizin in Kampo extracts including licorice root and changes in the blood concentration of glycyrrhetic acid after oral administration of Kampo extracts].
[The choleretic effects of licorice: identification and determination of the pharmacologically active components of Glycyrrhiza glabra].
Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.
My engagement with steroids: a review.
HPLC determination of glycyrrhizin and glycyrrhetic acid in biological fluids, after licorice extract administration to humans and rats.
Bioavailability of glycyrrhizin and licorice extract in rat and human plasma as detected by a HPLC method.
Giant negative U waves in a patient with uncontrolled hypertension and severe hypokalemia.
Effect of dietary soybean and licorice on the male F344 rat: an integrated study of some parameters relevant to cancer chemoprevention.
[Studies on concentration of glycyrrhizin in plasma and its absorption after oral administration of licorice extract and glycyrrhizin].
Effect of licorice extract (Fm100) on release of secretin and exocrine pancreatic secretion in humans.
Release of secretin by licorice extract in dogs.
[Postoperative stress hemorrhage: ineffective prevention with pepsin inhibitor and deglycyrrhizinized licorice extract. Prospective study].
[Quadriplegia, severe hypokalemic alkalosis, tetany, arterial hypertension in relation to excessive licorice extract consumption in a chronic alcoholic].
[Quadriplegia with hypokalemia and metabolic alkalosis secondary to ingestion of licorice extract].
[Paralysis with hypokalemia following prolonged ingestion of licorice extract].
[A new case of severe potassium depletion caused by licorice extract].
[New case of paralysis with hypokalemia and metabolic alkalosis secondary to excessive and prolonged ingestion of licorice extract after treatment of alcoholic intoxication].
[Quadriplegia with hypokalemia and metabolic alkalosis secondary to massive and prolonged ingestion of licorice extract in an alcoholic and potomanic psychopath].
[Gastroduodenal ulcer; results obtained in treatment of 85 patients with a licorice extract].
[Critique on the use of licorice extract in the treatment of gastroduodenal ulcer].
[Treatment of gastroduodenal ulcer with a licorice extract preparation].
[Glycyrrhizin-free licorice extract].
[Licorice Extract].
[Licorice extract and glycyrrhizinic acid in therapy of Addison's disease].
[Excretion of water and electrolytes during a 24-hour period and under influence of licorice extract].

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
FDA Listing of Food Additive Status:	View
MedlinePlusSupp:	View
Wikipedia:	View

Suppliers

AuNutra® Industries	BOC Sciences
Chemical-navi - Nikkol	ECSA Chemicals
Excellentia International	Frutarom
Global Essence	H. Interdonati, Inc.
Horner International	IFF
Naturex	OQEMA
Penta International	Synthite Industries
Vege Tech	Vevy Europe
Global Essence Inc.	FRUTAROM USA INC,
Penta International Corporation

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Odor Type: Licorice
licorice
General comment	At 100.00 %. licorice
Flavor Type: Licorice
licorice
General comment	Licorice

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-man TDLo 209000 mg/kg/2Y-I BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Italian Journal of Neurological Sciences. Vol. 4, Pg. 493, 1983. intraperitoneal-mouse LD50 1500 mg/kg BLOOD: CHANGES IN SPLEEN BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. oral-mouse LD50 > 7500 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. intraperitoneal-rat LD50 1420 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. oral-rat LD50 14200 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
Dermal Toxicity:
subcutaneous-mouse LD50 4000 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. subcutaneous-rat LD50 4200 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic, flavor and fragrance agents, dietary supplements
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Safety references

ClinicalTrials.gov:search

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

glycyrrhiza glabra l. extract powder

Chemidplus:0068916916