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General Material Information

Trivial Name orange extract
FDA UNII Search
FDA Mainterm 977130-92-9 ; ORANGE, EXTRACT
Synonyms
  • extrapone orange (Symrise)
  • fruitapone orange (Symrise)
  • fruitapone orange B (Symrise)
  • organic orange extract
  • pure orange extract
  • sweet orange extract 60%
  • orange extract natural
  • organic orange extract natural
  • orange extract organic

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Literature & References

Pubchem (cas):977130-92-9
Publications by PubMed
[Comparative analysis of ergogenic efficacy of energy drinks components (caffeine and bitter orange extract) in combination with alcohol].
Absence of furanocoumarins in Advantra Z® (Citrus aurantium, bitter orange) extracts.
Protective effect of red orange extract supplementation against UV-induced skin damages: photoaging and solar lentigines.
Recognizing and overcoming analytical error in the use of ICP-MS for the determination of cadmium in breakfast cereal and dietary supplements.
A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract.
A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine.
Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones.
Physiological effects following administration of Citrus aurantium for 28 days in rats.
Developmental toxicity of Citrus aurantium in rats.
Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.
The safety of Citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine.
Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans.
Involvement of inducible nitric oxide synthase and cyclooxygenase-2 in the anti-inflammatory effects of a red orange extract in human chondrocytes.
A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts.
Antiinflammatory effects of a red orange extract in human keratinocytes treated with interferon-gamma and histamine.
Control of downy mildew on grapes in organic viticulture.
Protective effects of a standardised red orange extract on air pollution-induced oxidative damage in traffic police officers.
Influence of glucose on cyanidin 3-glucoside absorption in rats.
In vitro antioxidant activity and in vivo photoprotective effect of a red orange extract.
Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium).
Molecular and immunological characterization of the glycosylated orange allergen Cit s 1.
Germin-like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits.
Absence of QTc-interval-prolonging or hemodynamic effects of a single dose of bitter-orange extract in healthy subjects.
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.
Potential for toxicity with use of bitter orange extract and guarana for weight loss.
Evaluation of oxidative stress in diabetic patients after supplementation with a standardised red orange extract.
Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults.
An opioid receptor antagonist, naltrexone, does not alter taste and smell responses in humans.
Iron-induced Lipid Peroxidation in Human Skin-derived Cell Lines: Protection by a Red Orange Extract.
[Conditioned aversion to an intraperitoneally injected odor CS in rats].
Olfactory-guided orientation in neonatal rats is enhanced by a conditioned change in behavioral state.

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No

Organoleptic Properties

Odor Type: Citrus
orange
General comment At 100.00 %. orange
Flavor Type: Citrus
orange
General comment Orange

Potential Uses

Applications
Flavoring purposes Beverage

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Safety references

EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0977130929