valeriana officinalis rhizome/root extract

General Material Information

Preferred name	valeriana officinalis rhizome/root extract
Trivial Name	Valeriana
Short Description	extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae
CAS Number	8057-49-6
FEMA Number	3099
ECHA Number	232-501-7
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	8057-49-6 ; VALERIAN ROOT, EXTRACT (VALERIANA OFFICINALIS L.)
Synonyms	extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae valerian rhizome/root extract Valeriana Valerian Valerian (Valeriana) Valerianae extractum MeSH ID: D014632

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Literature & References

	valeriana officinalis l. rhizome/root extract
Pubchem (sid):	135331255

Publications by PubMed
Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region.
Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish).
Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites.
The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.
Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats.
Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia.
Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.
Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.
Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization.
Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors.
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus.
Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.
[Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies].
Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study.
Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.
Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.
Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine.
In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents.
Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.
A feasibility study of valerian extract for sleep disturbance in person with arthritis.
Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.).
Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study.
Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease.
A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.
Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties.
Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors.
Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors.
NF-kappaB modulators from Valeriana officinalis.
Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice.
New acylated clionasterol glycosides from Valeriana officinalis.
A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects.
Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers.
Neuroprotective properties of Valeriana officinalis extracts.
Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.
Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers.
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.
(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.
Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia.
Synergy and other interactions in phytomedicines.
Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system.
Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.
Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.
[Effects of Valeriana officinalis L extract on cardiovascular system].
Quantifying the effects of mild sedatives.
[Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
MedlinePlusSupp:	View
Wikipedia:	View

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Odor Type: Fruity
valerian root, root beer
General comment	At 100.00 %. valerian root
Flavor Type: Fruity
valerian root, root beer
General comment	Valerian root

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mammal (species unspecified) LD50 975 mg/kg Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988. oral-mammal (species unspecified) LD50 2250 mg/kg Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988. intraperitoneal-mouse LD50 3300 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Journal of Pharmaceutical Sciences. Vol. 50, Pg. 240, 1961.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
	average usual ppm	average maximum ppm
baked goods:	-	69.00000
beverages(nonalcoholic):	-	25.00000
beverages(alcoholic):	-	-
breakfast cereal:	-	-
cheese:	-	-
chewing gum:	-	-
condiments / relishes:	-	24.00000
confectionery froastings:	-	-
egg products:	-	-
fats / oils:	-	-
fish products:	-	-
frozen dairy:	-	35.00000
fruit ices:	-	35.00000
gelatins / puddings:	-	-
granulated sugar:	-	-
gravies:	-	-
hard candy:	-	65.00000
imitation dairy:	-	-
instant coffee / tea:	-	-
jams / jellies:	-	-
meat products:	-	-
milk products:	-	-
nut products:	-	-
other grains:	-	-
poultry:	-	-
processed fruits:	-	-
processed vegetables:	-	-
reconstituted vegetables:	-	-
seasonings / flavors:	-	-
snack foods:	-	-
soft candy:	-	-
soups:	-	-
sugar substitutes:	-	-
sweet sauces:	-	-

Safety references

ClinicalTrials.gov:search

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

valeriana officinalis l. rhizome/root extract

Chemidplus:0008057496