stevia rebaudiana extract, rebaudioside A 60%

General Material Information

Trivial Name	stevia rebaudiana extract, rebaudioside A 60%
Short Description	stevia extract, rebaudioside A 60%
CAS Number	91722-21-3
FEMA Number	4771
ECHA Number	294-422-4
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
Synonyms	stevia rebaudiana extract stevia extract, rebaudioside A 60% steviol glycoside extract, rebaudioside A 60% steviol glycoside extract, stevia rebaudiana, rebaudioside A 60% Stevia rebaudiana, ext.

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Literature & References

	stevia rebaudiana extract
Pubchem (sid):	135328141

Publications by Google Patents
Composition and process for modifying or enhancing flavors
Publications by PubMed
New seminal variety of Stevia rebaudiana: Obtaining fractions with high antioxidant potential of leaves.
Development of a high-performance liquid chromatography procedure to identify known and detect novel C-13 oligosaccharide moieties in diterpene glycosides from Stevia rebaudiana (Bertoni) Bertoni (Asteraceae): Structure elucidation of rebaudiosides V and W.
Antihyperglycemic and Antihyperlipidemic Activity of Hydroponic Stevia rebaudiana Aqueous Extract in Hyperglycemia Induced by Immobilization Stress in Rabbits.
Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation.
Antioxidant activities of aqueous extract from Stevia rebaudiana stem waste to inhibit fish oil oxidation and identification of its phenolic compounds.
Size dependent effects of antifungal phytogenic silver nanoparticles on germination, growth and biochemical parameters of rice (Oryza sativa L), maize (Zea mays L) and peanut (Arachis hypogaea L).
Optimization of microwave-assisted extraction of total extract, stevioside and rebaudioside-A from Stevia rebaudiana (Bertoni) leaves, using response surface methodology (RSM) and artificial neural network (ANN) modelling.
Toxicological evaluation of ethanolic extract from Stevia rebaudiana Bertoni leaves: Genotoxicity and subchronic oral toxicity.
Development of an efficient high-performance thin layer chromatography method for determination of jasmonic acid in leaf tissue of Stevia rebaudiana (Bertoni) Bertoni.
A Novel Diterpene Glycoside with Nine Glucose Units from Stevia rebaudiana Bertoni.
Rebaudiosides T and U, minor C-19 xylopyranosyl and arabinopyranosyl steviol glycoside derivatives from Stevia rebaudiana (Bertoni) Bertoni.
Stevia preferences in Wistar rats.
Comparison of reduced sugar high quality chocolates sweetened with stevioside and crude stevia 'green' extract.
Docking and Molecular Dynamics of Steviol Glycoside-Human Bitter Receptor Interactions.
Antidiabetic potential of bioactive molecules coated chitosan nanoparticles in experimental rats.
Hypoglycemic Effect of Aquatic Extract of Stevia in Pancreas of Diabetic Rats: PPARγ-dependent Regulation or Antioxidant Potential.
Rebaudiosides R and S, Minor Diterpene Glycosides from the Leaves of Stevia rebaudiana.
Stevia rebaudiana ethanolic extract exerts better antioxidant properties and antiproliferative effects in tumour cells than its diterpene glycoside stevioside.
Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro.
Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review.
Antidiabetic and antioxidant activity of Stevia rebaudiana extracts (Var. Morita) and their incorporation into a potential functional bread.
A New Diterpene Glycoside: 15α-Hydroxy-Rebaudioside M Isolated from Stevia rebaudiana.
Extraction of rebaudioside-A by sonication from Stevia rebaudiana Bertoni leaf and decolorization of the extract by polymers.
Nutritional, amylolytic enzymes inhibition and antioxidant properties of bread incorporated with Stevia rebaudiana.
Study of Stevia rebaudiana Bertoni antioxidant activities and cellular properties.
Isolation and characterization of inulin with a high degree of polymerization from roots of Stevia rebaudiana (Bert.) Bertoni.
Green synthesis of gold nanoparticles using Stevia rebaudiana leaf extracts: Characterization and their stability.
Stevia rebaudiana Bert. leaf extracts as a multifunctional source of natural antioxidants.
Intensified Separation of Steviol Glycosides from a Crude Aqueous Extract of Stevia rebaudiana Leaves Using Centrifugal Partition Chromatography.
Influence of Extraction Methods on the Yield of Steviol Glycosides and Antioxidants in Stevia rebaudiana Extracts.
Isolation and structural characterization of a new minor diterpene glycoside from Stevia rebaudiana.
Effect of aqueous and alcoholic Stevia (Stevia rebaudiana) extracts against Streptococcus mutans and Lactobacillus acidophilus in comparison to chlorhexidine: An in vitro study.
Identification, quantification, and sensory characterization of steviol glycosides from differently processed Stevia rebaudiana commercial extracts.
Separation of Rebaudiana A from Steviol glycoside using a polymeric adsorbent with multi-hydrogen bonding in a non-aqueous system.
[Safety assessment of stevia rebaudiana bertoni grown in southeastern Mexico as food sweetener].
Effect of partial replacement of sugar with stevia on the quality of kulfi.
Minor diterpene glycosides from the leaves of Stevia rebaudiana.
Comparison of some antioxidant properties of plant extracts from Origanum vulgare, Salvia officinalis, Eleutherococcus senticosus and Stevia rebaudiana.
Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract.
The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats.
Impact of sensory feed additives on feed intake, feed preferences, and growth of female piglets during the early postweaning period.
Isolation, characterization and sensory evaluation of a Hexa beta-D-glucopyranosyl diterpene from Stevia rebaudiana.
Use of the modified Gompertz equation to assess the Stevia rebaudiana Bertoni antilisterial kinetics.
Stevia rebaudiana Bertoni as a natural antioxidant/antimicrobial for high pressure processed fruit extract: processing parameter optimization.
Additional minor diterpene glycosides from Stevia rebaudiana Bertoni.
HPTLC method for simultaneous analysis of stevioside and rebaudioside-A in Stevia rebaudiana.
Isolation, NMR Spectral Analysis and Hydrolysis Studies of a Hepta Pyranosyl Diterpene Glycoside from Stevia rebaudiana Bertoni.
Antimicrobial potential of extracts from Stevia rebaudiana leaves against bacteria of importance in dental caries.
Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana.
Absolute quantitation of stevioside and rebaudioside A in commercial standards by quantitative NMR.
Comprehensive characterization of Stevia rebaudiana using two-dimensional reversed-phase liquid chromatography/hydrophilic interaction liquid chromatography.
Effect of Equisetum arvense and Stevia rebaudiana extracts on growth and mycotoxin production by Aspergillus flavus and Fusarium verticillioides in maize seeds as affected by water activity.
Additional minor diterpene glycosides from Stevia rebaudiana.
Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats.
Structures of the novel α-glucosyl linked diterpene glycosides from Stevia rebaudiana.
In vitro larvicidal potential against Anopheles stephensi and antioxidative enzyme activities of Ginkgo biloba, Stevia rebaudiana and Parthenium hysterophorous.
Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats.
Effects of Stevia rebaudiana (Bertoni) extract and N-nitro-L-arginine on renal function and ultrastructure of kidney cells in experimental type 2 Diabetes.
Diterpene glycosides from Stevia rebaudiana.
Structures of the novel diterpene glycosides from Stevia rebaudiana.
A new diterpene glycoside from Stevia rebaudiana.
Antioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana Bert.
Stevia and saccharin preferences in rats and mice.
Stevia rebaudiana Bertoni extract supplementation improves lipid and carnitine profiles in C57BL/6J mice fed a high-fat diet.
Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry.
Nutrient composition of cultivated stevia leaves and the influence of polyphenols and plant pigments on sensory and antioxidant properties of leaf extracts.
In vitro antioxidant activity and total phenolic content of ethanolic leaf extract of Stevia rebaudiana Bert.
Formulation development and in vitro antioxidant studies of Churnas containing natural sweetener and nutraceutical.
Validation of green-solvent extraction combined with chromatographic chemical fingerprint to evaluate quality of Stevia rebaudiana Bertoni.
Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni) Bertoni, a natural sweetener.
Enzymatic modification of stevioside by cell-free extract of Gibberella fujikuroi.
Comparison of two different solvents employed for pressurised fluid extraction of stevioside from Stevia rebaudiana: methanol versus water.
Safety evaluation of aqueous extracts from Aegle marmelos and Stevia rebaudiana on reproduction of female rats.
Characterisation of Stevia rebaudiana by comprehensive two-dimensional liquid chromatography time-of-flight mass spectrometry.
Inhibitory effects of hot water extract of the Stevia stem on the contractile response of the smooth muscle of the guinea pig ileum.
FREE RADICAL SCAVENGING ACTIVITY OF FLAVONOID CONTAINING LEAF EXTRACTS OF Stevia rebaudiana Bert.
Analysis of sweet diterpene glycosides from Stevia rebaudiana: improved HPLC method.
Dominant lethal test in rats treated with some plant extracts.
Analysis of anti-rotavirus activity of extract from Stevia rebaudiana.
Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations.
Effects of chronic administration of Stevia rebaudiana on fertility in rats.
Effect of crude extract of Stevia rebaudiana on renal water and electrolytes excretion.
Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni towards enterohemorrhagic Escherichia coli O157:H7 and other food-borne pathogenic bacteria.
Hydroxylation of ent-kaurenoic acid to steviol in Stevia rebaudiana Bertoni--purification and partial characterization of the enzyme.
A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats.
Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects.
Oral use of a topical preparation containing an extract of Stevia rebaudiana and the chrysanthemum flower in the management of hyperglycemia.
Chronic administration of aqueous extract of Stevia rebaudiana (Bert.) Bertoni in rats: endocrine effects.
Effect of Stevia rebaudiana on glucose tolerance in normal adult humans.

Other Information

FDA Listing of Food Additive Status:	View
MedlinePlusSupp:	View
Wikipedia:	View

Suppliers

PureCircle

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Flavor Type: Sweet
sweet, sugar

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
sweeteners, flavor enhancers
Recommendation for stevia rebaudiana extract, rebaudioside A 60% usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 26
Click here to view publication 26
		average usual ppm	average maximum ppm
baked goods:		30.00000	30.00000
beverages(nonalcoholic):		30.00000	30.00000
beverages(alcoholic):		30.00000	30.00000
breakfast cereal:		30.00000	30.00000
cheese:		-	-
chewing gum:		200.00000	200.00000
condiments / relishes:		30.00000	30.00000
confectionery froastings:		30.00000	30.00000
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		30.00000	30.00000
fruit ices:		30.00000	30.00000
gelatins / puddings:		30.00000	30.00000
granulated sugar:		30.00000	30.00000
gravies:		30.00000	30.00000
hard candy:		30.00000	30.00000
imitation dairy:		30.00000	30.00000
instant coffee / tea:		30.00000	30.00000
jams / jellies:		30.00000	30.00000
meat products:		-	-
milk products:		30.00000	30.00000
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		30.00000	30.00000
processed vegetables:		30.00000	30.00000
reconstituted vegetables:		30.00000	30.00000
seasonings / flavors:		30.00000	30.00000
snack foods:		30.00000	30.00000
soft candy:		30.00000	30.00000
soups:		30.00000	30.00000
sugar substitutes:		30.00000	30.00000
sweet sauces:		30.00000	30.00000

Safety references

European Food Safety Authority (EFSA) reference(s):

Safety in use of glucosylated steviol glycosides as a food additive in different food categories
View page or View pdf

Safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract
View page or View pdf

Safety evaluation of steviol glycoside preparations, including rebaudioside AM, obtained by enzymatic bioconversion of highly purified stevioside and/or rebaudioside A stevia leaf extracts
View page or View pdf

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Daily Med:search

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EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

stevia rebaudiana extract

Chemidplus:0091722213