clover herb distillate (melilotus officinalis)

General Material Information

Preferred name	clover herb distillate (melilotus officinalis)
Trivial Name	Sweet clover, Melilotus officinalis, ext.
CAS Number	84082-81-5
FEMA Number	4727
ECHA Number	282-028-5
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	977188-84-3 ; CLOVER HERB DISTILLATE
Synonyms	brachylobus officinalis distillate yellow sweet clover distillate (melilotus officinalis) melilotus arvensis distillate melilotus graveolens distillate melilotus officinalis distillate melilotus officinalis fo. suaveolens distillate melilotus pallidus distillate melilotus suaveolens distillate sertula officinalis distillate trifolium officinale distillate Sweet clover, Melilotus officinalis, ext. Melilotus officinalis ext.

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Literature & References

	melilotus officinalis distillate
Pubchem (sid):	135330290

Publications by PubMed
[Allelopathic effects of the humus soils from Betula platyphylla and Quercus liaotungensis pure plantations on 9 kinds of common shrubs and herbs].
In vitro screening of forty medicinal plant extracts from the United States Northern Great Plains for anthelmintic activity against Haemonchus contortus.
Fatty acids, α-tocopherol, β-carotene, and lutein contents in forage legumes, forbs, and a grass-clover mixture.
The diversity of Rhizobia, Sinorhizobia and novel non-Rhizobial Paenibacillus nodulating wild herbaceous legumes.
[Soil and water losses and phosphorus output at the places between ridges in sloping peanut land under different planting modes in Yimeng mountainous area of Shandong Province, East China].
Using the pollen viability and morphology for fluoride pollution biomonitoring.
Isolation and characterization of pyrene metabolizing microbial consortia from the plant rhizoplane.
Pyrene effects on rhizoplane bacterial communities.
Rhizobium tibeticum sp. nov., a symbiotic bacterium isolated from Trigonella archiducis-nicolai (Sirj.) Vassilcz.
Stable low molecular weight RNA profiling showed variations within Sinorhizobium meliloti and Sinorhizobium medicae nodulating different legumes from the alfalfa cross-inoculation group.
De-inking sludge and phosphorus effects on growth and symbiotic dinitrogen fixation in forage legumes.
Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction.
The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.
Effect of root death and decay on dissipation of polycyclic aromatic hydrocarbons in the rhizosphere of yellow sweet clover and tall fescue.
Effectiveness of phytoremediation as a secondary treatment for polycyclic aromatic hydrocarbons (PAHs) in composted soil.
Ability of cold-tolerant plants to grow in hydrocarbon-contaminated soil.
[Chronic venous insufficiency: an open trial of FLEBS Crema].
Leghaemoglobin oxygenation gradients in alfalfa and yellow sweetclover nodules.
Effects of Melilotus officinalis on acute inflammation.
[Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency].
[Lymphedema of the upper extremity in patients operated for carcinoma of the breast: clinical experience with coumarinic extract from Melilotus officinalis].
A new oleanene glucuronide obtained from the aerial parts of Melilotus officinalis.
Expression of beta-amylase from alfalfa taproots.
A new oleanene glucuronide having a branched-chain sugar from Melilotus officinalis.
Importance of Temperature in the Pathology of Meloidogyne hapla and M. chitwoodi on Legumes.
[Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2d stage of the surgical classification].
[Immunocorrecting, antianemia, and adaptogenic effects of polysaccharides from Melilotus officinalis].
Impact of Multi-year Cropping Regimes on Solanum tuberosum Tuber Yields in the Presence of Pratylenchus penetrans and Verticillium dahliae.
Ferric Leghemoglobin in Plant-Attached Leguminous Nodules.
Forage intake and digestion by cattle grazing midgrass prairie rangeland or sideoats grama/sweetclover pasture.
A PCR-based method of identifying species-specific repeated DNAs.
Ultrastructure of fusion products from soybean cell culture and sweet clover leaf protoplasts.
Multielement residues in tissues of guinea pigs fed sweet clover grown on fly ash.
[Extraction of Melilotus officinalis].
[The anti-inflammatory and anti-edematous effects of coumarins from Melilotus officinalis].
[Effect of coumarin from Melilotus officinalis on the function of the lymphatic vessel].
[Effect of coumarin from Melilotus officinalis on the blood circulation of the dog].
[Experimental lymphostatic encephalopathy as a consequence of cervical lymphangiothrombophlebitis and its therapy by coumarin from Melilotus officinalis].
[Effect of coumarin from Melilotus officinalis on the convulsion threshold of the central nervous system in rats and guinea pigs].
[Effect of pantothenic acid and pyridoxine deficiency on unconditioned reflex activity and its influencing by coumarin from Melilotus officinalis in rats].
[Unconditioned reflex activity in experimental lymphogenic encephalopathy and therapeutic effects thereon by coumarin from Melilotus officinalis].
[Influence of isoniazid (INH) on the central nervous system and the antagonism between isoniazid and pyridoxine as well as pantothenic acid and coumarin from Melilotus officinalis in rats].
[Effect of chlorpromazine on conditioned reflexes and antagonistic activity of coumarin from Melilotus officinalis].
[Effect of deficiency of pantothenic acid and pyridoxine on the function of the central nervous system and its response to coumarin from Melilotus officinalis].
[Decrease of spontaneous motility in experimental lymphogenic encephalopathy and the prophylactic activity of coumarin from Melilotus officinalis].
[Learning ability in experimental lymphogenic encephalopathy, under the influence of coumarin from Melilotus officinalis].
[Conditioned reflex function in experimental lymphogenic encephalopathy and its therapeutic modification by coumarin from Melilotus officinalis].
[LOCAL TREATMENT OF DISEASES OF VARICOSE ORIGIN. CLINICAL EXPERIENCES WITH ESBERIVEN, A MELILOTUS OFFICINALIS PREPARATION].
[Effect of aqueous extracts of Melilotus officinalis on the regenerating liver].
Biosynthesis of the coumarins. Tracer studies on coumarin formation in Hierochloe odorata and Melilotus officinalis.
[Effect of Melilotus officinalis tea and its comparison with pelentan].

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
Wikipedia:	View

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Flavor Type: Herbal
clover, green, herbal, rooty, tonka, coumarinic, tobacco
General comment	Clover

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for clover herb distillate (melilotus officinalis) usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 25
Click here to view publication 25
		average usual ppm	average maximum ppm
baked goods:		0.50000	2.00000
beverages(nonalcoholic):		0.30000	0.80000
beverages(alcoholic):		0.50000	2.00000
breakfast cereal:		0.50000	2.00000
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		0.50000	2.00000
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		0.40000	2.00000
fruit ices:		-	-
gelatins / puddings:		0.40000	2.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		0.40000	1.60000
instant coffee / tea:		0.30000	1.00000
jams / jellies:		0.40000	3.00000
meat products:		-	-
milk products:		0.40000	1.60000
nut products:		0.40000	1.60000
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		0.20000	1.00000
snack foods:		0.50000	2.00000
soft candy:		0.60000	2.00000
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		0.30000	0.80000

Safety references

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

melilotus officinalis distillate

Chemidplus:0084082815