cubeb fruit

General Material Information

Preferred name	cubeb fruit
Trivial Name	piper cubeba l.
Short Description	piper cubeba fruit
FEMA Number	2338
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	977000-82-0 ; CUBEB (PIPER CUBEBA L. F.)
Synonyms	cubeb pepper piper cubeba fruit

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Literature & References

	piper cubeba l.
Pubchem (sid):	135304962

Publications by PubMed
Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.
Evaluation of lignan (-)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29).
Cytotoxic activity of Piper cubeba extract in breast cancer cell lines.
Evaluation of the effectiveness of Piper cubeba extract in the amelioration of CCl4-induced liver injuries and oxidative damage in the rodent model.
Biological activities of Zingiber officinale (Zingiberaceae) and Piper cubeba (Piperaceae) essential oils against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae).
In vitro antiparasitic activity and chemical composition of the essential oil obtained from the fruits of Piper cubeba.
Variation in manuka oil lure efficacy for capturing Xyleborus glabratus (Coleoptera: Curculionidae: Scolytinae), and cubeb oil as an alternative attractant.
A comparative study of the modulatory effects of (-)-cubebin on the mutagenicity/recombinogenicity induced by different chemical agents.
The lignan (-)-cubebin inhibits vascular contraction and induces relaxation via nitric oxide activation in isolated rat aorta.
Mutagenicity and antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays.
Nephroprotective effect of Kabab chini (Piper cubeba) in gentamycin-induced nephrotoxicity.
Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants.
Identification of ambiguous cubeb fruit by DART-MS-based fingerprinting combined with principal component analysis.
Essential and toxic elements in three Pakistan's medicinal fruits (Punica granatum, Ziziphus jujuba and Piper cubeba) analysed by INAA.
In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni.
Radical scavenging ability of some compounds isolated from Piper cubeba towards free radicals.
Was the famous astronomer Copernicus also a nephrologist.
The effect of the dibenzylbutyrolactolic lignan (-)-cubebin on doxorubicin mutagenicity and recombinogenicity in wing somatic cells of Drosophila melanogaster.
Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts.
Molluscicidal activity of Piper cubeba Linn., Piper longum Linn. and Tribulus terrestris Linn. and their combinations against snail Indoplanorbis exustus Desh.
Piper cubeba demonstrates anti-estrogenic and anti-inflammatory properties.
Piper cubeba targets multiple aspects of the androgen-signalling pathway. A potential phytotherapy against prostate cancer growth?
Evaluation of piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens.
(-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats.
Effect of some medicinal plants on plasma antioxidant system and lipid levels in rats.
Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: mechanism-based inhibition.
Potent CYP3A4 inhibitory constituents of Piper cubeba.
Enzymatic and non-enzymatic antioxidants in selected Piper species.
Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida.
Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease.
[Constituents of Aristolochia triangularis].
Comparison of vegetative anatomy of piperales. I. Juvenile xylem of twigs.
The occurrence of mature fruits of Piper cubeba in recently imported cubeb.
The problem of foreign botanicals.

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
FDA Listing of Food Additive Status:	View
Wikipedia:	View

Suppliers

Bristol Botanicals	Noble Molecular Research
Parchem

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Odor Type: Spicy
cubeb
General comment	At 100.00 %. cubeb
Flavor Type: Spicy
cubeb
General comment	Cubeb

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
spices, other natural seasonings and flavorings
Recommendation for cubeb fruit usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	-
beverages(nonalcoholic):		-	800.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

piper cubeba l.

Chemidplus:0977000820