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nutmeg

General Material Information

Preferred name nutmeg
Trivial Name Myristica fragrans, ext.
Short Description myristica fragrans
CAS Number 84082-68-8
FEMA Number 2792
ECHA Number 282-013-3
FDA UNII Search
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 977051-44-7 ; NUTMEG (MYRISTICA FRAGRANS HOUTT.)
Synonyms
  • myristica fragrans
  • myristica fragrans moluccas
  • myristica fragrans venezuela
  • nutmeg whole or ground, available as 100% certified organic
  • myristica fragrans houtt.
  • Myristica fragrans, ext.
  • Nutmeg ext.

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Literature & References

myristica fragrans houtt.
Pubchem (sid):135361447
Publications by PubMed
Modulation of Colon Cancer by Nutmeg.
Ultra high performance liquid chromatography tandem mass spectrometry method for the simultaneous determination of multiple bioactive constituents in fruit extracts of Myristica fragrans and its marketed multi-herbal formulations using a polarity switching technique.
Effect of some essential oils on phagocytosis and complement system activity.
Assessing intake of spices by pattern of spice use, frequency of consumption and portion size of spices consumed from routinely prepared dishes in southern India.
Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.
Antimutagenic effects of aqueous fraction of Myristica fragrans (Houtt.) leaves on Salmonella typhimurium and Mus musculus.
New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production.
Screening and study of antifungal activity of leaf litter actinomycetes isolated from Ternate Island, Indonesia.
Structure-plant phytotoxic activity relationship of 7,7'-epoxylignanes, (+)- and (-)-verrucosin: simplification on the aromatic ring substituents.
Chemical constituents and activities of the essential oil from Myristica fragrans against cigarette beetle Lasioderma serricorne.
Antifungal compounds from turmeric and nutmeg with activity against plant pathogens.
'Just a pinch of salt'. An experimental comparison of the effect of repeated exposure and flavor-flavor learning with salt or spice on vegetable acceptance in toddlers.
Chemical constituents from Myristica fragrans fruit.
[Serious powdered nutmeg intoxication].
Catalytically and biologically active silver nanoparticles synthesized using essential oil.
Myristicin and phenytoin toxicity in an infant.
Potent acetylcholinesterase inhibitory compounds from Myristica fragrans.
Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
The fetal MR appearance of 'nutmeg lung': findings in 8 cases linked to pulmonary lymphangiectasia.
Benign Hepatic Mesenchymal Hamartoma (HMH) - A Case Report.
Aflatoxins in various food from Istanbul, Turkey.
Plant extracts and plant-derived compounds: promising players in a countermeasure strategy against radiological exposure.
Allergy to illicit drugs and narcotics.
Binary Combination of Carica papaya, Areca catechu and Myristica fragrans with Piperonyl Butoxide / MGK-264 against Freshwater Snail Lymnaea acuminata.
[Acute intoxication with nutmeg used as a recreational purpose--a case report].
Protective effect of nutmeg aqueous extract against experimentally-induced hepatotoxicity and oxidative stress in rats.
In Vitro Antibacterial Activity of Several Plant Extracts and Oils against Some Gram-Negative Bacteria.
Nutmeg poisonings: a retrospective review of 10 years experience from the Illinois Poison Center, 2001-2011.
Insecticidal and oviposition deterrent properties of some spices against coleopteran beetle, Sitophilus oryzae.
A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.
Tree size and its relationship with flowering phenology and reproductive output in Wild Nutmeg trees.
Analysis of 2-alkylcyclobutanones in cashew nut, nutmeg, apricot kernel, and pine nut samples: re-evaluating the uniqueness of 2-alkylcyclobutanones for irradiated food identification.
Scientific evaluation of edible fruits and spices used for the treatment of peptic ulcer in traditional Iranian medicine.
Myristica fragrans seed extract protects against dextran sulfate sodium-induced colitis in mice.
New inhibitors of nitric oxide production from the seeds of Myristica fragrans.
Impact of cooking and digestion, in vitro, on the antioxidant capacity and anti-inflammatory activity of cinnamon, clove and nutmeg.
Pediculicidal effect of herbal shampoo against Pediculus humanus capitis in vitro.
Evaluation of analgesic activity and toxicity of alkaloids in Myristica fragrans seeds in mice.
[Characterization and nutritional value of a food artisan: the meat pie of Murcia].
Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.
Quantitation of tr-cinnamaldehyde, safrole and myristicin in cola-flavoured soft drinks to improve the assessment of their dietary exposure.
In vitro evaluation of five different herbal extracts as an antimicrobial endodontic irrigant using real time quantitative polymerase chain reaction.
Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma.
Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria.
Knowledge of Eastern materia medica (Indian and Chinese) in pre-modern Mediterranean medical traditions: a study in comparative historical ethnopharmacology.
Lipid bilayer membrane affinity rationalizes inhibition of lipid peroxidation by a natural lignan antioxidant.
Simultaneous multi-mycotoxin determination in nutmeg by ultrasound-assisted solid-liquid extraction and immunoaffinity column clean-up coupled with liquid chromatography and on-line post-column photochemical derivatization-fluorescence detection.
Eugenol alters the integrity of cell membrane and acts against the nosocomial pathogen Proteus mirabilis.
Simple and rapid determination of myristicin in human serum.
Multiple biological properties of macelignan and its pharmacological implications.
Large scale screening of commonly used Iranian traditional medicinal plants against urease activity.
Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine.
Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans.
[Impact of internet on poisoning with psychoactive substances in young people].
LEARNING TO CHOOSE AMONG SOCIAL FORAGING STRATEGIES IN ADULT HOUSE SPARROWS (Passer domesticus).
Aflatoxins B and g contamination and aflatoxigenic fungi in nutmeg.
In vitro antibacterial effects of five volatile oil extracts against intramacrophage Brucella abortus 544.
Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study.
In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC.
Antibacterial Activity of Myristica fragrans against Oral Pathogens.
Effects of macelignan isolated from Myristica fragrans (Nutmeg) on expression of matrix metalloproteinase-1 and type I procollagen in UVB-irradiated human skin fibroblasts.
Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation.
Malabaricone C suppresses lipopolysaccharide-induced inflammatory responses via inhibiting ROS-mediated Akt/IKK/NF-κB signaling in murine macrophages.
Extraction of betulin, trimyristin, eugenol and carnosic acid using water-organic solvent mixtures.
Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
Formulas used by Tibetan doctors at Men-Tsee-Khang in India for the treatment of neuropsychiatric disorders and their correlation with pharmacological data.
Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells.
Antibacterial activity of crude extracts of prasaprohyai formula and its components against pathogenic bacteria.
Fragrant volatile oil composition of Nutmeg Geranium (Pelargonium × fragrans Willd.) from India.
Interesting asian plants: their compounds and effects on electrophysiology and behaviour.
Estimation of trace elements in mace (Myristica fragrans Houtt) and their effect on uterine cervix cancer induced by methylcholanthrene.
Determination of myristicin in commonly spices applying SPE/GC.
Malabaricone C inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through induction of heme oxygenase-1.
Total and soluble oxalate content of some Indian spices.
How to address the physical needs of clients in a mental health setting.
Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.
Nutmeg liver and ascites resulting from a membranous web obstruction at the hepatic origin of the inferior vena cava.
Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia.
Extraction and separation of volatile and fixed oils from seeds of Myristica fragrans by supercritical COâ‚‚: chemical composition and cytotoxic activity on Caco-2 cancer cells.
Myrislignan attenuates lipopolysaccharide-induced inflammation reaction in murine macrophage cells through inhibition of NF-κB signalling pathway activation.
Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia.
The not-so-nice spice: a teenage girl with palpitations and dry mouth.
Mutagenic and antimutagenic assessment of methanol leaf extract of Myristica fragrans (Houtt.) using in vitro and in vivo genetic assays.
Antioxidants in aqueous extract of Myristica fragrans (Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L. cells.
Food components with anticaries activity.
Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid.
Inhibitory effect on NO production of phenolic compounds from Myristica fragrans.
meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
Nectandrin B activates endothelial nitric-oxide synthase phosphorylation in endothelial cells: role of the AMP-activated protein kinase/estrogen receptor α/phosphatidylinositol 3-kinase/Akt pathway.
Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV.
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Screening of selected Asian spices for anti obesity-related bioactivities.
Nutmeg liver.
Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways.
Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat.
Effects of licarin E on expression of matrix metalloproteinase-1 and type-1 procollagen in UVB-irradiated human skin fibroblasts.
Metabolism of the lignan dehydrodiisoeugenol in rats.
Macelignan inhibits melanosome transfer mediated by protease-activated receptor-2 in keratinocytes.
Mycotoxins in foods in Lower Saxony (Germany): results of official control analyses performed in 2009.
Determination of ochratoxin A in food: comparison of a stable isotope dilution assay, liquid chromatography-fluorescence detection and an enzyme-linked immunosorbent assay.
The spice of life: an analysis of nutmeg exposures in California.
Standardization of the Unani drug - Myristica fragrans Houtt. (Javetri) - with modern analytical techniques.
Molecular phylogeny of the nutmeg shells (Neogastropoda, Cancellariidae).
Insulin secretagogue, alpha-glucosidase and antioxidant activity of some selected spices in streptozotocin-induced diabetic rats.
MEG/EEG source reconstruction, statistical evaluation, and visualization with NUTMEG.
Toxicology and carcinogenesis studies of isoeugenol (CAS No. 97-54-1) in F344/N rats and B6C3F1 mice (gavage studies).
Exploring the costs and benefits of social information use: an appraisal of current experimental evidence.
Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice.
Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity.
Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata.
PPARα activation by culinary herbs and spices.
Individual differences in plasticity and sampling when playing behavioural games.
[Unusual use of nutmeg].
Acaricidal activity of eugenol based compounds against scabies mites.
Septicemic salmonellosis in a two-humped camel calf (Camelus bactrianus).
AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect.
[The elixir of doctor Garrus. Drug or liquor? Original formula or imitation?].
Contact dermatitis to Vicks VapoRub.
Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.
Antioxidant activity of spice extracts in a liposome system and in cooked pork patties and the possible mode of action.
The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model.
Histological effects of oral administration of nutmeg on the kidneys of adult Wister rats.
Histological effects of long term consumption of nutmeg on the medial geniculate body of adult Wistar rats.
[Antioxidant properties of essential oils].
Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells.
Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay.
Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells.
[Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice].
Nutmeg (Myristica fragrans Houtt.).
Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans.
The science of salsa: antimicrobial properties of salsa components to learn scientific methodology.
Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.
[Nutmeg poisoning].
Anticonvulsant activities of nutmeg oil of Myristica fragrans.
Natural existence of 2-alkylcyclobutanones.
Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue.
Images in pathology. Nutmeg liver.
Historical perspective on the usage of perfumes and scented Articles in ancient Indian literatures.
Efficacy of plant essential oils against foodborne pathogens and spoilage bacteria associated with ready-to-eat vegetables: antimicrobial and sensory screening.
Larvicidal and adulticidal activities of some medicinal plants against the malarial vector, Anopheles stephensi (Liston).
Determination of dehydrodiisoeugenol in rat tissues using HPLC method.
Patent ductus arteriosus in Murrah buffalos.
[New neolignan from seed of Myristica fragrans].
Simultaneous determination of diastereomers (+)-licarin A and isolicarin A from Myristica fragrans in rat plasma by HPLC and its application to their pharmacokinetics.
Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti-inflammatory Effects.
Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation.
Inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanin biosynthesis.
Testing candidate plant barcode regions in the Myristicaceae.
Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes.
Toxicity of plant essential oils and their components against Lycoriella ingenua (Diptera: Sciaridae).
Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae).
Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation.
[Acute nutmeg intoxication in Spain].
Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation.
[Chemical constituents of Myristica fragrans Houttuyn seed and their physiological activities].
Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.
Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage.
Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken.
[GC-MS analysis of essential oil from nutmeg processed by different traditional methods].
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
Biotransformation of myrislignan by rat liver microsomes in vitro.
In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria.
Approach for ochratoxin A fast screening in spices using clean-up tandem immunoassay columns with confirmation by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
Modulatory effect of spice extracts on iron-induced lipid peroxidation in rat liver.
Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi.
Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity.
Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage.
Toxicity of Myristica fagrans seed compounds against Blattella germanica (Dictyoptera: Blattellidae).
Rapid all-in-one three-step immunoassay for non-instrumental detection of ochratoxin A in high-coloured herbs and spices.
Effect of food seasoning spices mixture on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats.
Radioprotection of Swiss albino mice by Myristica fragrans houtt.
Safety assessment of myristic acid as a food ingredient.
[Comparing analysis of components in volatile oils of nutmeg and prepared nutmeg by GC-MS].
Antibacterial principles from Myristica fragrans seeds.
Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry.
Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice.
Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans.
Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol.
Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice.
Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.
Estimation of aroma glycosides of nutmeg and their changes during radiation processing.
Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori.
Nutmeg intoxication in Texas, 1998-2004.
In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.
Antimicrobial activity of nutmeg against Escherichia coli O157.
Drug abuse in Slovak Republic.
Comparison of effects of extract of Myristica fragrans and verapamil on the volume and acidity of carbachol induced gastric secretion in fasting rabbits.
An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg).
Effects of flavorings, storage conditions, and storage time on survival of Staphylococcus aureus in Sürk cheese.
NUTMEG: a neuromagnetic source reconstruction toolbox.
Christmas gingerbread (Lebkuchen) and Christmas cheer--review of the potential role of mood elevating amphetamine-like compounds formed in vivo and in furno.
meso-dihydroguaiaretic acid from Machilus thunbergii down-regulates TGF-beta1 gene expression in activated hepatic stellate cells via inhibition of AP-1 activity.
In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea.
Assortment of the plants in the Medieval diet in Czech countries (based on archaeobotanical finds).
[Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation].
Report from the 2004 AES Annual Meeting. Highlights from the 58th Annual Meeting of the American Epilepsy Society, December 3-7, 2004, New Orleans, LA.
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells.
Low cost, high risk: accidental nutmeg intoxication.
[GC-MS analysis of essential oils from seeds of Myristica fragrans in Chinese market].
Acute intoxication by Crotalaria retusa in sheep.
[Preliminary attempt at the speciation of 25-elements in the Chinese medicinal herbs].
Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi.
Influence of subinhibitory concentrations of plant essential oils on the production of enterotoxins A and B and alpha-toxin by Staphylococcus aureus.
Constituents of aromatic plants: elemicin.
Improvement of mouse memory by Myristica fragrans seeds.
Effects of different spices used in production of fermented sausages on growth of and curvacin A production by Lactobacillus curvatus LTH 1174.
Acute nutmeg poisoning.
[Fennel tea: risk assessment of the phytogenic monosubstance estragole in comparison to the natural multicomponent mixture].
Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure.
Myristica fragrans [nutmeg] and its activity against the enteric pathogens.
Extracts of spice and food plants from Thai traditional medicine inhibit the growth of the human carcinogen Helicobacter pylori.
Atmospheric pressure photo-ionization liquid chromatography/mass spectrometric determination of aflatoxins in food.
Nutmeg mannikins ( Lonchura punctulata) reduce their feeding rates in response to simulated competition.
Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study.
Effect of gamma-irradiation on the lipid profile of nutmeg (Myristica fragrans Houtt.).
Element analysis and biological studies on ten oriental spices using XRF and Ames test.
Lead toxicosis in cats-a review.
[Direct identification of Myristica fragrans and Myristica sp. by FTIR].
Antibacterial activity of 11 essential oils against Bacillus cereus in tyndallized carrot broth.
In vitro antagonistic activity of monoterpenes and their mixtures against 'toe nail fungus' pathogens.
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury.
Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters.
Inhibitory activity of spices and essential oils on psychrotrophic bacteria.
Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices.
Nutmeg and psychosis.
Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils.
Food allergy and IgE sensitization caused by spices: CICBAA data (based on 589 cases of food allergy).
Abundant apoptosis in nutmeg liver of cardiomyopathic hamsters. Apoptotic cell death as a possible mechanism of hepatic remodeling by congestion.
Report by the analytical methods committee. Application of gas-liquid chromatography to the analysis of essential oils. Part XVIII. Determination of safrole in oils of cinnamon leaf, Litsea cubeba, and nutmeg.
[Balneological use of bath concentrate containing xidifon and essential oils from ginger, nutmeg, and sandal].
Anxiogenic activity of Myristica fragrans seeds.
[The nutmeg story].
Determination of aflatoxins B1, B2, G1 and G2 in spices using a multifunctional column clean-up.
[Effect of different processing conditions on content of myrisiticin, volatile oil and fatty lipid in semen Myristicae].
[Quality standards of processed nutmegs].
Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum.
[Mycotoxins in spices].
Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre.
Aflatoxins in spices marketed in Portugal.
Toxicology of nutmeg abuse.
[Comparative study on nutmeg, mace and their processed products].
Stabilization of rapeseed oil with allspice, clove and nutmeg extracts.
Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage.
Effect of cinnamon, clove and some of their constituents on the Na(+)-K(+)-ATPase activity and alanine absorption in the rat jejunum.
Simple synthesis of benzofuranoid neolignans from Myristica fragrans.
An olfactory discrimination procedure for mice.
Antimicrobial agents from plants: antibacterial activity of plant volatile oils.
Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro.
The IDB and IEDB: intron sequence and evolution databases.
Antimicrobial screening of some Indian spices.
Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C.
Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation.
Biological effects of Myristica fragrans (nutmeg) extract.
Determinants of salt use in cooked meals in The Netherlands: attitudes and practices of food preparers.
[Nutmeg--more than a spice].
[Hallucinations after voluntary ingestion of nutmeg: an unrecognized drug abuse].
Microbial stability of mango (Mangifera indica L.) juice preserved by combined application of mild heat and extracts of two tropical spices.
Nutmeg intoxication.
Acute nutmeg intoxication.
Inhibition of fos-jun-DNA complex formation by dihydroguaiaretic acid and in vitro cytotoxic effects on cancer cells.
Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens.
Hot spices influence permeability of human intestinal epithelial monolayers.
A preliminary study of the effect of essential oils on skeletal and smooth muscle in vitro.
Pollination by deceit in nutmeg (Myristica insipida, Myristicaceae): floral displays and beetle activity at male and female trees.
[Determination of eugenol, methyleugenol and methylisoeugenol in volatile oil of differently processed nutmeg].
Cochlosoma infections in finches.
[Determination of myristicin and safrol in volatile oil of nutmeg and its processed products by HPLC].
Broad-range and binary-range acyl-acyl-carrier protein thioesterases suggest an alternative mechanism for medium-chain production in seeds.
[A case report. Poisoned by nutmeg].
Evaluation of the efficacy and safety of a new herbal revitalizer revivin.
Toxicological evaluation of myristicin.
Rapid opioid detoxification using opioid antagonists: history, theory and the state of the art.
Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits.
[Ecstasy, a new designer drug in the techno-scene].
The rationale for naltrexone therapy as an alternative to methadone treatment for opiate addiction.
The potential effectiveness of essential oils as a treatment for headlice, Pediculus humanus capitis.
Occupational asthma due to different spices.
Gossypol toxicity in preruminant calves.
Prevention of hypercholesterolemia and atherosclerosis in rabbits after supplementation of Myristica fragrans seed extract.
Are socially acquired behaviours irreversible?
Chronic nutmeg psychosis.
Transmammary modulation of xenobiotic metabolizing enzymes in liver of mouse pups by mace (Myristica fragrans Houtt.).
Ethnobotany of nutmeg in the Spice Islands.
Maternal beliefs and practices regarding the diet and use of herbal medicines during measles and diarrhea in rural areas.
Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver.
Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro.
Spice allergy evaluated by results of patch tests.
Chronic nutmeg psychosis.
Modulatory effect of Areca nut on the action of mace (Myristica fragrans, Houtt) on the hepatic detoxification system in mice.
Flavor constituents in cola drinks induce hepatic DNA adducts in adult and fetal mice.
Chronic nutmeg psychosis.
Aflatoxin contamination in foods and foodstuffs in Tokyo: 1986-1990.
Nutmeg or mabi bark?
[Decontamination of some spices by ethylene oxide. Development of 2-chloroethanol and ethylene glycol during the preservation].
Acute nutmeg intoxication.
Symptoms in spice workers.
[Propagation methods for nutmeg seeds].
[Treatment of different variants of the mixed form of portal hypertension].
Spice allergy in celery-sensitive patients.
Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans).
The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans.
Chemopreventive action of mace (Myristica fragrans, Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice.
Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papillomagenesis in the skin of mice.
Sugar and spice: similarities and sensory attributes.
[Effects of processing on volatile oil constituents in nutmeg and on the contents of myristicin].
[Effects of processing methods on the amounts of volatile oil of nutmeg and on isolation and characterization of the volatile oil constituents].
Allelochemicals in foliage of unfavored tree hosts of the gypsy moth,Lymantria dispar L. : 1. Alkaloids and other components ofLiriodendron tulipifera L. (Magnoliaceae),Acer rubrum L. (Aceraceae), andCornus florida L. (Cornaceae).
Contact allergy to spices.
Nutmeg oil: identification and quantitation of its most active constituents as inhibitors of platelet aggregation.
[Fibrosing reaction of nutmeg liver].
Contact and systemic contact-type dermatitis to spices.
[Identification of nutmeg by thin-layer chromatography and its introduction to Japanese standards for non-pharmacopoeial crude drugs].
Studies on several naturally occurring lignans.
Effects of mace (Myristica fragrans, Houtt.) on cytosolic glutathione S-transferase activity and acid soluble sulfhydryl level in mouse liver.
Antiinflammatory effect of mace, aril of Myristica fragrans Houtt., and its active principles.
Acute and chronic effects of a nutmeg extract on the toad heart.
Studies on crude drugs effective on visceral larva migrans. V. The larvicidal principle in mace (aril of Myristica fragrans).
Determination of safrole and myristicin in nutmeg and mace by high-performance liquid chromatography.
[The chronic form of the Budd-Chiari syndrome].
Indonesia's great frontier and migration policy.
Nutmeg intoxication in pregnancy. A case report.
Nutmeg--an unusual overdose.
[Nutmeg in the treatment of diarrhea associated with medullary carcinoma of the thyroid].
Grenada.
Pharmacological influence of nutmeg and nutmeg constituents on rabbit platelet function.
Antienterotoxic effect of Myristica fragrans (nutmeg) on enterotoxigenic Escherichia coli.
Effect of nutmeg on ethanol and d-amphetamine-produced alteration of locomotor activity in the mouse.
Dyskeratosis congenita: two examples of this multisystem disorder.
Sensory effect of the sorption of some flavouring agents on blood plasma protein preparations.
The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans).
Toxic encounters of the dangerous kind. The nutmeg connection.
[On the processing of nutmeg].
High pressure liquid chromatographic determination of aflatoxins in spices.
Effect of oil of nutmeg on the fertility and induction of meiotic chromosome rearrangements in mice and their first generation.
Nutmeg dispersal by tropical birds.
Treatment of diarrhoea in calves with nutmeg.
High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers.
Simple field test for marijuana.
Nutmeg and epená snuff: differing hallucinogens.
Extraction of light filth from ground nutmeg: collaborative study.
The effect of the terpene fraction of the oil of nutmeg on the behavior of young chicks.
The pathology and pathogenesis of fatal hepatic amoebiasis--A study based on 79 autopsy cases.
Nutmeg abuse.
Treatment of diarrhoea in cattle and pigs with nutmeg.
Enhancement of ethanol-induced sleep by whole oil of nutmeg.
Role of nutmeg in inhibiting prostaglandin biosynthesis.
Acute psychosis associated with nutmeg toxicity.
The analysis of essential oils and extracts (oleoresins) from seasonings--a critical review.
[Use of cytoplasmic male sterility in selection of nutmeg sage (Salvia sclarea L.) and true lavandula (Lavandula officinalis ch)].
Letter: Nutmeg as an hallucinogen.
Letter: Nutmeg toxicology.
Letter: Nutmeg and prostaglandins.
Letter: Nutmeg poisoning.
Extractive components from the nutmeg of Myristica simarum A.DC.: the structure of lignan-ketone: otobanone.
Letter: Nutmeg and medullary carcinoma of thyroid.
Nutmeg mydriasis.
Diarrhoeae in thyroid medullary carcinoma: role of prostaglandins and therapeutic effect of nutmeg.
Examination of the diphenylpropanoids of nutmeg as their trimethylsilyl, triethylsilyl and tri-n-propylsilyl derivatives using combined gas chromatography and mass spectrometry.
[Experimental study of the morphogenesis of nutmeg fibrosis of the liver].
Quantitative fluorodensitometric determination and survey of aflatoxins in nutmeg.
Letter: Nutmeg for diarrhea.
A chromatographic comparison of the constituents of nutmeg and mace (Myristica fragrans Houtt.) with those of marihuana and hashish (Cannabis sativa L.).
Letter: Prostaglandins, nutmeg and diarrhea.
Diarylpropanoids from nutmeg and mace (Myristica fragrans Houtt.).
Nutmeg pharmacognosy.
Behavioral observations on compounds found in nutmeg.
Nutmeg for diarrhea of medullary carcinoma of thyroid.
Evidence for the biogenic formation of amphetamine derivatives from components of nutmeg.
Nutmeg and mace, the psychotropic spices from Myristica fragrans.
[Demonstration of the formation of psychotropic amphetamine derivatives from nutmeg components].
[Hallucinogen effects of nutmeg].
Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans).
Collaborative study of a new method for extraction of light filth from reconditioned (coarsely ground) nutmeg.
Nutmeg poisoning--a case report.
Nutmeg oil and camphene as inhaled expectorants.
Nutmeg oil and camphene as inhaled expectorants.
Hallucinogenic effect of nutmeg.
Hallucinogenic effects of nutmeg in adolescent.
Nutmeg as a psychoactive agent.
The use of nutmeg as a psychotrpic drug. Report of two cases.
The pharmacology of myristicin and nutmeg.
The chemistry and psychopharmacology of nutmeg and of several related phenylisopropylamines.
Myristica fragrans (nutmeg). Introduction.
Nutmeg poisoning.
POISONINGS DUE TO MACE (NUTMEG), FURNITURE POLISH, AND LEAD.
[SYMPTOMATOLOGY OF NUTMEG POISONING].
NUTMEG POISONING.
GAS CHROMATOGRAPHIC ANALYSIS OF OIL OF NUTMEG.
Nutmeg intoxication.
Evidence of monoamine oxidase inhibition by myristicin and nutmeg.
The pharmacology of myristicin. A contribution to the psychopharmacology of nutmeg.
Hallucinogenic and narcotic-like effects of powdered Myristica (nutmeg).
Nutmeg poisoning.
THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : I. THE SUSCEPTIBILITY OF ADRENALECTOMIZED RATS TO MORPHINE.
Note on Nutmeg-Poisoning.
Nutmeg Poisoning.
On the Histology of the so-called Nutmeg Liver.

Other Information

FDA Substances Added to Food (formerly EAFUS):View
FDA Listing of Food Additive Status:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No

Organoleptic Properties

Odor Type: Spicy
nutmeg
Odor strength low
General comment At 100.00 %. nutmeg
Flavor Type: Spicy
nutmeg
General comment Nutmeg

Occurrences

Potential Uses

Applications
Odor purposes Spice

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 500 mg/kg
Journal of Neuropsychiatry. Vol. 2, Pg. 205, 1961.

oral-human TDLo 214 mg/kg
BEHAVIORAL: EUPHORIA CARDIAC: CHANGE IN RATE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Neuropsychiatry. Vol. 2, Pg. 205, 1961.

oral-man TDLo 143 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CHANGE IN REM SLEEP (HUMAN)
Japanese Journal of Toxicology. Vol. 2, Pg. 169, 1989.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
spices, other natural seasonings and flavorings
Recommendation for nutmeg usage levels up to:
not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -2000.00000
beverages(nonalcoholic): -700.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -100.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -550.00000
fruit ices: -550.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -670.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

ClinicalTrials.gov:search
Daily Med:search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
myristica fragrans houtt.
Chemidplus:0084082688