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frankincense gum (boswellia serrata)

General Material Information

Preferred name frankincense gum (boswellia serrata)
Trivial Name Salai, ext.
Short Description olibanum gum (boswellia serrata)
CAS Number 97952-72-2
ECHA Number 308-366-6
FDA UNII Search
FDA Mainterm 8050-07-5 ; OLIBANUM, GUM, RESIN (BOSWELLIA SPP.)
Synonyms
  • boswellia serrata gum
  • olibanum gum (boswellia serrata)
  • soothex (Givaudan)
  • Salai, ext.

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Literature & References

boswellia serrata gum
Pubchem (sid):135302317
Publications by PubMed
An α-Acetoxy-Tirucallic Acid Isomer Inhibits Akt/mTOR Signaling and Induces Oxidative Stress in Prostate Cancer Cells.
Extract from gum resin of Boswellia serrata decreases IA(2)-antibody in a patient with "Late onset Autoimmune Diabetes of the Adult" (LADA).
Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.
Effect of Boswellia serrata gum resin on the morphology of hippocampal CA1 pyramidal cells in aged rat.
Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients.
Systematic review: the efficacy of herbal therapy in inflammatory bowel disease.
Biotransformation of 11-keto-β-boswellic acid by Cunninghamella blakesleana.
A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA).
Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway.
Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice.
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein.
Boswellia serrata, a potential antiinflammatory agent: an overview.
Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee.
Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens.
Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry.
Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE).
Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation.
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.
Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity.
Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study.
Safety and toxicological evaluation of Aflapin: a novel Boswellia-derived anti-inflammatory product.
Modulation of the immune system by Boswellia serrata extracts and boswellic acids.
Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid.
The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study).
Topical Boswellic acids for treatment of photoaged skin.
Effects of topical boswellic acid on photo and age-damaged skin: clinical, biophysical, and echographic evaluations in a double-blind, randomized, split-face study.
In vivo genotoxicity evaluation of a plant based antiarthritic and anticancer therapeutic agent Boswelic acids in rodents.
Bosellia serrata-induced apoptosis is related with ER stress and calcium release.
A simple high-performance liquid chromatographic method for the estimation of boswellic acids from the market formulations containing Boswellia serrata extract.
Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines.
Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders.
Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain.
Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo.
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Natural products and anti-inflammatory activity.
Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation.
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.
Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).
Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.
Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.
Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.
Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2.
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.
Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.
[Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases].
Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway.
Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells.
High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb.
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization.
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis.
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.
Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis.
Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.
Effects of Boswellia serrata gum resin in patients with ulcerative colitis.
Special extract of BOSWELLIA serrata (H 15) in the treatment of rheumatoid arthritis.
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata.
Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents.
CHEMICAL STANDARDIZATION OF 'KUNDUR' (Oleo-Gum-Resin of Boswellia serrata Roxb).
Analgesic and psychopharmacological effects of the gum resin of Boswellia serrata.

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Wikipedia:View
FAO:OLIBANUM (FRANKINCENSE), MYRRH AND OPOPANAX RESINS AND OILS

PhysChem Properties

Material listed in food chemical codex No

Organoleptic Properties

Odor Type: Woody
frankincense, woody
General comment At 100.00 %. frankincense
Flavor Type: Woody
frankincense, woody
General comment Frankincense

Occurrences

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice

Safety references

EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
boswellia serrata gum
Chemidplus:097952722