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dimethyl octanol

Chemical Structure

General Material Information

Preferred name dimethyl octanol
Trivial Name 3,7-Dimethyl-1-octanol
Short Description 3,7-dimethyl-1-octanol
Formula C10 H22 O
CAS Number 106-21-8
Deleted CAS Number 59204-02-3
FEMA Number 2391
ECHA Number 203-374-5
FDA UNII DPY9K1927C
Nikkaji Number J37.634E
Beilstein Number 1719638
MDL MFCD00002936
COE Number 75
xLogP3-AA 3.60 (est)
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 272 3,7-dimethyl-1-octanol
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 106-21-8 ; 3,7-DIMETHYL-1-OCTANOL
Synonyms
  • citronellol, dihydro-
  • L- dihydro citronellol
  • dihydrocitronellol
  • 3,7-dimethyl octan-1-ol
  • dimethyl octanol FCC
  • dimethyl octanol PQ
  • 3,7-dimethyl-1-octanol
  • 3,7-dimethyloctan-1-ol
  • 3,7-dimethyloctanol
  • geraniol tetrahydride
  • geraniol, perhydro-
  • geraniol, tetrahydro-
  • per hydrogeraniol
  • octan-1-ol, 3,7-dimethyl-
  • 1-octanol, 3,7-dimethyl-
  • pelargol
  • tetrahydro geraniol
  • tetrahydrogeraniol
  • 3,7-dimethyloctan-1-ol
  • 1-Octanol, 3,7-dimethyl-
  • 3,7-Dimethyl-1-octanol
  • 2,6-Dimethyl-8-octanol
  • Perhydrogeraniol
  • 3,7-Dimethyloctane-1-ol
  • (±)-3,7-Dimethyloctan-1-ol
  • NSC 18917

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

Leffingwell:Chirality or Article
3,7-dimethyloctan-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:106-21-8
Pubchem (cid):7792
Pubchem (sid):134971624
Publications by PubMed
Structural parameters, molecular properties, and biological evaluation of some terpenes targeting Schistosoma mansoni parasite.
Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding.
Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts.
Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation.
Studies on volatile organic compounds of some truffles and false truffles.
Photodynamic characterization of amino acid conjugated 15(1)-hydroxypurpurin-7-lactone for cancer treatment.
Trophodynamics of current use pesticides and ecological relationships in the Bathurst region vegetation-caribou-wolf food chain of the Canadian Arctic.
Preparation of stimuli-responsive "mushroom-like" janus polymer particles as particulate surfactant by site-selective surface-initiated AGET ATRP in aqueous dispersed systems.
Characteristic odorants from bailingu oyster mushroom (Pleurotus eryngii var. tuoliensis) and summer oyster mushroom (Pleurotus cystidiosus).
Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(II) complexes for hydrophobic environments.
Characterization of the key aroma compounds in beef extract using aroma extract dilution analysis.
Development and validation of a liquid chromatography isotope dilution mass spectrometry method for the reliable quantification of alkylphenols in environmental water samples by isotope pattern deconvolution.
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.
Removal of mixed pesticides from aqueous solutions using organoclays: evaluation of equilibrium and kinetic model.
The Anti-calcification Effect of Dithiobispropionimidate, Carbodiimide and Ultraviolet Irradiation Cross-linking Compared to Glutaraldehyde in Rabbit Implantation Models.
From biomass to chemicals: synthesis of precursors of biodegradable surfactants from 5-hydroxymethylfurfural.
Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects.
Preferential solvation of thiophene and furan-2-carboxaldehyde phenylhydrazone derivatives in DMSO-water and DMSO-n-octanol mixtures.
Scent chemicals of the brushtail possum, Trichosurus vulpecula.
Artemia salina acute immobilization test: a possible tool for aquatic ecotoxicity assessment.
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity.
GC-MS based metabolomics for rapid simultaneous detection of Escherichia coli O157:H7, Salmonella Typhimurium, Salmonella Muenchen, and Salmonella Hartford in ground beef and chicken.
Monitoring of aglycons of yew glycosides (3,5-dimethoxyphenol, myrtenol and 1-octen-3-ol) as first indicator of yew presence.
Chemical vapor detection using a capacitive micromachined ultrasonic transducer.
Preparation and evaluation of 5, 9-dimethyl-2-cyclopropyl-2-decanol as a penetration enhancer for drugs through rat skin.
Development of normal phase-high performance liquid chromatography-atmospherical pressure chemical ionization-mass spectrometry method for the study of 6,6'-bis-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-benzo[1,2,4]-triazin-3-yl)-[2,2']-bipyridine hydrolytic degradation.
Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity.
Comparison of nonideal sorption formulations in modeling the transport of phthalate esters through packed soil columns.
Sorption of biocides, triazine and phenylurea herbicides, and UV-filters onto secondary sludge.
Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines.
6-(3,5-Dimethyl-1H-pyrazol-1-yl)-2,2'-bipyridine as ligand for actinide(III)/lanthanide(III) separation.
Antihypertensive and antiarrhythmic properties of a para-hydroxy[bis(ortho-morpholinylmethyl)]phenyl-1,4-DHP compound: comparison with other compounds of the same kind and relationship with logP values.
Fragrance material review on 3,7-dimethyl-7-methoxyoctan-2-ol.
Biomimetic chromatographic analysis of selenium species: application for the estimation of their pharmacokinetic properties.
A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection.
Ultrasound-assisted dispersive liquid-liquid microextraction combined with high-performance liquid chromatography-fluorescence detection for sensitive determination of biogenic amines in rice wine samples.
Seasonal distribution of phthalate esters in surface water of the urban lakes in the subtropical city, Guangzhou, China.
Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique.
Transition from vesicles to small nanometer scaled vesicles, arising from the manipulation of curvature in dialkyl chain cationic/nonionic surfactant mixed aggregates by the addition of straight chain alkanols.
1,6-Dimethyl-4-hydroxy-3-pyridinecarboxylic acid and 4-hydroxy-2-methyl-3-pyridinecarboxylic acid as new possible chelating agents for iron and aluminium.
Zr-zeolite beta: a new heterogeneous catalyst system for the highly selective cascade transformation of citral to (+/-)-menthol.
Alkylamine sensing using langmuir-blodgett films of n-alkyl-N-phenylamide-substituted zinc porphyrins.
Fragrance material review on 3,7-dimethyl-1-octanol.
Fragrance material review on tetrahydrolinalool.
Fragrance material review on rhodinol.
Fragrance material review on ocimenol.
Fragrance material review on (5E)-2,6-dimethyl-3,5-octadien-2-ol.
Transdermal delivery of praziquantel: effects of solvents on permeation across rabbit skin.
Micromachined GC columns for fast separation of organophosphonate and organosulfur compounds.
Dose formulation and analysis of diapocynin.
Nanometer sized tridecylamine capped Rhodium dispersed on high surface area support: catalytic investigations.
Physical origin for the nonlinear sorption of very hydrophobic organic chemicals in a membrane-like polymer film.
Sources and occurrence of dacthal in the Canadian atmosphere.
Comparison of three lychee cultivar odor profiles using gas chromatography-olfactometry and gas chromatography-sulfur detection.
The scent of urine spots of male mice, Mus musculus: Changes in chemical composition over time.
Solution chemistry of 1,15-bis(N,N-dimethyl)-5,11-dioxo-8-(N-benzyl)-1,4,8,12,15-pentaazapentadecane with metal ions of biological interest-Insights toward active metal ion containing therapeutics and diagnostic agents.
Maintenance of vascular endothelial growth factor and potentially other therapeutic proteins bioactivity during a photo-initiated free radical cross-linking reaction forming biodegradable elastomers.
Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins.
High throughput solubility measurement with automated polarized light microscopy analysis.
Ideal mixing behavior of the debye process in supercooled monohydroxy alcohols.
Considerations on ultra-trace analysis of phthalates in drinking water.
Sorption of phthalate esters and PCBs in a marine ecosystem.
Synthesis of a library of fucopyranosyl-galactopyranosides consisting of a complete set of anomeric configurations and linkage positions.
Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification.
[Chemical components in essential oils from tender branches and leaves of Rhododendron].
Copper- and magnesium protoporphyrin complexes inhibit oxidative modification of LDL induced by hemin, transition metal ions and tyrosyl radicals.
Quantification of lipid alkyl radicals trapped with nitroxyl radical via HPLC with postcolumn thermal decomposition.
Odorant binding initially occurring at the central pocket in bovine odorant-binding protein.
Solid phase dosing and sampling technique to determine partition coefficients of hydrophobic chemicals in complex matrixes.
Dynamics of glass-forming liquids. IX. Structural versus dielectric relaxation in monohydroxy alcohols.
Study of the lipophilicity of selenium species.
Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane.
Metabolic O-demethylation does not alter the influence of isoflavones on the biophysical properties of membranes and MRP1-like protein transport activity.
Vapour pressures, aqueous solubilities, Henry's Law constants, and octanol/water partition coefficients of a series of mixed halogenated dimethyl bipyrroles.
[Attraction effect of main volatile components from tea shoots and flowers on Sphaerophoria menthastri (Diptera: Syrphidae) and Chrysopa septempunctata (Neuroptera: Chrysopidae)].
Aroma extract dilution analysis of cv. Meeker (Rubus idaeus L.) red raspberries from Oregon and Washington.
Distribution of phthalate esters in a marine aquatic food web: comparison to polychlorinated biphenyls.
A quantitative structure-antifungal activity relationship study of oxygenated aromatic essential oil compounds using data structuring and PLS regression analysis.
Identification of male-specific chiral compound from the sugarcane weevil Sphenophorus levis.
Site-activity relationship of nitroxide radical's antioxidative effect.
Population growth kinetics and bulk membrane lipid alterations in Tetrahymena pyriformis: exposure to pentachlorophenol.
Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity.
Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media.
Switching of a macromolecular helicity for visual distinction of molecular recognition events.
An assessment of the toxicity of phthalate esters to freshwater benthos. 1. Aqueous exposures.
Radical generation, radical-scavenging activity, and cytotoxicity of eugenol-related compounds.
Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.
Effect of the photocatalytic activity of TiO(2) on plasmid DNA.
Relative hydrophobicity of organic compounds measured by partitioning in aqueous two-phase systems.
Ligand-binding properties and structural characterization of a novel rat odorant-binding protein variant.
Conformational stability and binding properties of porcine odorant binding protein.
Diffusion of dialkylnitrosamines into the rat esophagus as a factor in esophageal carcinogenesis.
Porcine odorant-binding protein: structural stability and ligand affinities measured by fourier-transform infrared spectroscopy and fluorescence spectroscopy.
Response-surface analyses for toxicity to Tetrahymena pyriformis: reactive carbonyl-containing aliphatic chemicals.
Biotransformation of citronellol by the basidiomycete Cystoderma carcharias in an aerated-membrane bioreactor.
Penetration enhancing effect of tetrahydrogeraniol on the percutaneous absorption of 5-fluorouracil from gels in excised rat skin.
Synthesis and effect of two new penetration enhancers on the transdermal delivery of 5-fluorouracil through excised rat skin.
Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
Factors affecting virus photoinactivation by a series of phenothiazine dyes.
Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke.
Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke.
Inhibition of thyroid hormone uptake by calcium antagonists of the dihydropyridine class.
Syntheses, calcium channel antagonist and anticonvulsant activities of substituted 1,4-dihydro-3,5-pyridinedicarboxylates containing various 3-alkyl ester substituents.
An analysis of dimethylsulfoxide-induced action potential block: a comparative study of DMSO and other aliphatic water soluble solutes.
The adsorption of heterocyclic aromatic amines by model dietary fibres with contrasting compositions.
Octanol/water partition coefficients for environmentally important organic compounds : Test of three RP-HPLC-methods and new experimental results.
Percutaneous penetration of fluorescein isothiocyanate-dextrans and the mechanism for enhancement effect of enhancers on the intercellular penetration.
Microbial degradation of monoterpenes in the absence of molecular oxygen.
An empirical and theoretical study on mechanisms of mutagenic activity of hydrazine compounds.
Absorption of sunscreens and other compounds through human skin in vivo: derivation of a method to predict maximum fluxes.
Synthesis and evaluation of DMPO-type spin traps.
Adsorption properties of polar/apolar inducers at a charged interface and their relevance to leukemia cell differentiation.
The effects of a soluble-fibre polysaccharide on the adsorption of carcinogens to insoluble dietary fibres.
Effects of Ca2+ channel antagonist subtypes on mitochondrial Ca2+ transport.
Ketone EC50 values in the Microtox test.
Structure-distribution relationships for metal-labeled myocardial imaging agents: comparison of a series of cationic gallium (III) complexes with hexadentate bis(salicylaldimine) ligands.
Vehicle effects on in vitro percutaneous absorption through rat and human skin.
Synthesis and evaluation of a new class of technetium-99m monocationic radiotracers from dithienyldiazalkanes.
Structure-activity relationships for contact allergenic potential of gamma,gamma-dimethyl-gamma-butyrolactone derivatives. 2. Quantitative structure-skin sensitization relationships for alpha-substituted-alpha-methyl-gamma,gamma-dimethyl-gamma-butyrolactone s.
Volatile organic chemicals of a shore-dwelling cyanobacterial mat community.
Enhancement of the mutagenicity of amino acid pyrolysates by phthalate esters.
[Carbohydrate building blocks for the construction of tumor-associated antigens. Synthesis of Lewis Y determinants].
Selection of a new generation of orally active alpha-ketohydroxypyridine iron chelators intended for use in the treatment of iron overload.
Interaction of the pyridoindole stobadine with peroxyl, superoxide and chromanoxyl radicals.
Non-oral etiologies of oral malodor and altered chemosensation.
Physiological properties of a Pseudomonas strain which grows with p-xylene in a two-phase (organic-aqueous) medium.
Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A).
Temperature-dependent perturbation of phospholipid bilayers by dimethylsulfoxide.
Reversible inhibition of intercellular communication among cardiac myocytes by halogenated hydrocarbons.
A possible Na/Ca exchange in the follicle cells of Xenopus oocyte.
Syncytial organization of cultured rat mesangial cells.
[Activity of alcohol dehydrogenase from cell cytoplasm of several types of yeast].
Odorant-binding protein. Characterization of ligand binding.
Development of an HPLC method for measuring orally administered 1-substituted 2-alkyl-3-hydroxypyrid-4-one iron chelators in biological fluids.
Synthesis and tissue distribution of four Se-labeled tertiary amines, potential brain pH imaging agents.
Mutagenicity of dimethyl heteroaromatic triazenes in the Ames test: the role of hydrophobicity and electronic effects.
Correlation between hydrophobicity of N-alkylxanthine derivatives and their biological activities on guinea-pig isolated tracheal smooth muscle.
Chemistry of mandibular and Dufour's gland secretions of ants in genusMyrmecocystus.
Partitioning and location of Bay K 8644, 1,4-dihydropyridine calcium channel agonist, in model and biological membranes.
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Automated high performance liquid chromatography and liquid scintillation counting determination of pesticide mixture octanol/water partition rates.
Function of the anthracycline amino group in cellular transport and cytotoxicity.
Spin trapping of superoxide and hydroxyl radicals with substituted pyrroline 1-oxides.
Physicochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: kinetic and thermodynamic determinants of dimethyl sulfoxide mediated mass transfer of alkanols.
Comparison of the Microtox test with the 96-hr LC50 test for the harpacticoid Nitocra spinipes.
Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate.
Mechanistic implications of the induction of thermotolerance in Chinese hamster cells by organic solvents.
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
Poly-L-methionine sulfoxide: a biologically inert analogue of dimethyl sulfoxide with solubilizing potency.
Hydroxyl free-radical spin-adduct in rat brain synaptosomes. Observations on the reduction of the nitroxide.
Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.
Alkylarylnitrosoureas--stability in aqueous solution, partition coefficient, alkylating activity and its relationship to SCE induction in Chinese hamster V 79-E cells.
Opiate and digitalis receptor assays distinguish between neuroexcitant and inactive organochlorines and between anesthetics and convulsants.
Differential perturbation of erythrocyte membrane function by structurally related polycyclic aromatic hydrocarbons.
[Quantitative aspects of the relationship of the antitumor activity and toxicity of diaziridinyl-sym. triazines to their physicochemical properties].
Functional group contribution of bile salt molecules to partitioning of a quaternary ammonium N,N-dimethyl derivative of propranolol.
Partition coefficients of selected pyridine carbamates and comparisons with their acetylcholinesterase and butyrylcholinesterase inhibitory potencies.
[Optimating the availability of homologous quaternary ammonium compounds/3rd communication: The influence of salts on in vitro distribution of benzilic acid esters of homologous dimethyl-(2-hydroxyethyl)-alkyl-ammoniumbromides (author's transl)].
Infrared spectroscopic studies of solvent-induced conformational changes in globular proteins.
[The optimization of the availability of homologous quaternary ammonium compounds. 2. In vitro studies on the partition of homologous benzilic acid esters of dimethyl-(2-hydroxyethyl)-alkylammonium bromides].
[The optimization of availability of homologous quaternary ammonium compounds. 1. Physico-chemical properties and ion-pair dissociation of homologous benzilic acid esters of dimethyl (2-hydroxyethyl)alkylammonium bromides].

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB014093
Export Tariff Code:2905.19.9090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 158.28454589844
Specific gravity @ 25 °C
Pounds per Gallon 6.881 to 6.906
Specific gravity @ 20 °C
Pounds per Gallon 6.873 to 6.939
Refractive Index 1.434 to 1.436 @ 20 °C
Boiling Point 95 to 96°C @ 9 mm Hg
Boiling Point 213 to 218°C @ 760 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 0.039 mmHg @ 25 °C
Vapor Density 5.4
Flash Point TCC Value 87.78 °C TCC
logP (o/w) 3.85
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
fixed oils Yes
propylene glycol Yes
water, 175.4 mg/L @ 25 °C (est) Yes
water No
glycerin No
Stability
alcoholic fine fragrance Good
antiperspirant Good
detergent perborate Good
fabric softener Good
liquid detergent Good
soap Good
toiletry application Good
acid cleaner Unspecified
alcoholic lotion Unspecified
deo stick Unspecified
hard surface cleaner Unspecified
shampoo Unspecified

Organoleptic Properties

Odor Type: Floral
waxy, soapy, aldehydic, leathery, musty, citrus, green, fresh, fatty, lemon, lime, orange, rose, woody
Odor strength medium
Substantivity 24 hour(s) at 100.00 %
Luebke, William tgsc, (1982) At 100.00 %. waxy soapy aldehydic leathery musty citrus green
Mosciano, Gerard P&F 25, No. 6, 26, (2000) At 1.00 %. Fresh fatty, waxy, soapy, aldehydic citrus with lemon, lime and orange nuances. It has rosy and green woody notes
Flavor Type: Fatty
fatty, waxy, soapy, floral, rose, fresh, citrus, woody
Mosciano, Gerard P&F 25, No. 6, 26, (2000) At 1.00 - 10.00 ppm. Fatty, waxy, soapy with floral rosy and fresh citrus woody nuances

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 36/38 - Irritating to skin and eyes.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
GHS Label elements, including precautionary statements
Pictogramexclamation-mark.jpg
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
8 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 535, 1974.

Dermal Toxicity:
skin-rabbit LD50 2400 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 535, 1974.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
maximum skin levels for fine fragrances:
0.0200 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey).
Recommendation for dimethyl octanol usage levels up to:
20.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics:
0.0200 %
Dermal Systemic Exposure in Cosmetic Products:
0.0005 mg/kg/day
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -19.00000
beverages(nonalcoholic): -4.30000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 2.0000044.00000
fruit ices: 2.0000044.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -15.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):106-21-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7792
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
3,7-dimethyloctan-1-ol
Chemidplus:0000106218
RTECS:RH0900000 for cas# 106-21-8