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acetone
General Material Information
| Preferred name | acetone |
| Trivial Name | Acetone |
| Short Description | dimethyl ketone |
| Formula | C3 H6 O |
| CAS Number | 67-64-1 |
| FEMA Number | 3326 |
| Flavis Number | 7.05 |
| ECHA Number | 200-662-2 |
| FDA UNII | 1364PS73AF |
| Nikkaji Number | J2.365E |
| Beilstein Number | 0635680 |
| MDL | MFCD00008765 |
| COE Number | 737 |
| xLogP3-AA | -0.10 (est) |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 139 acetone |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 67-64-1 ; ACETONE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| propan-2-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 67-64-1 |
| Pubchem (cid): | 180 |
| Pubchem (sid): | 134970724 |
| Pherobase: | View |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00207 |
| HMDB (The Human Metabolome Database): | HMDB01659 |
| FooDB: | FDB008301 |
| Export Tariff Code: | 2914.11.5000 |
| FDA Listing of Food Additive Status: | View |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 58.080020904541 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 6.557 to 6.59 |
| Refractive Index | 1.347 to 1.359 @ 20 °C |
| Melting Point | -95 to -94°C @ 760 mm Hg |
| Boiling Point | 56 to 57°C @ 760 mm Hg |
| Boiling Point | 22 to 23°C @ 200 mm Hg |
| Vapor Pressure | 232 mmHg @ 25 °C |
| Vapor Density | 2 |
| Flash Point TCC Value | -17.22 °C TCC |
| logP (o/w) | -0.16 |
| Shelf life | 24 months (or longer if stored properly.) |
| Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Solubility | |
| alcohol | Yes |
| water, 2.199e+005 mg/L @ 25 °C (est) | Yes |
| water, 1.00E+06 mg/L @ 25 °C (exp) | Yes |
Organoleptic Properties
| Odor Type: Solvent | |
| solvent, ethereal, apple, pear | |
| Odor strength | high , recommend smelling in a 1.00 % solution or less |
| Substantivity | < 1 hour(s) at 100.00 % |
| General comment | At 1.00 % in propylene glycol. solvent ethereal apple pear |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Other purposes | Denaturants, Solvents |
| Cosmetic purposes | Denaturants, Solvents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 11 - Highly flammable. R 36 - Irritating to eyes. R 66 - Repeated exposure may cause skin dryness or cracking. R 67 - Vapours may cause frowsiness and dizziness. S 02 - Keep out of the reach of children. S 09 - Keep container in a well-ventilated place. S 16 - Keep away from sources of ignition - No Smoking. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 [sex: M] 8452 mg/kg (Smyth et al., 1970) oral-rat LD50 8930 mg/kg (Smyth et al., 1969b) oral-rat LD50 9750 mg/kg (FDA, 1975a) oral-rat LD50 6800 mg/kg (Kimura et al., 1971a) oral-rat LD50 3465 mg/kg (Kohli et al., 1967) oral-mouse LD50 [sex: M] 5250 mg/kg (Tanii et al., 1986) oral-rabbit LD50 5300 mg/kg (Krasavage et al., 1982) intraperitoneal-dog LDLo 8000 mg/kg BEHAVIORAL: COMA GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884. oral-dog LDLo 8000 mg/kg MUSCULOSKELETAL: JOINTS BEHAVIORAL: COMA BEHAVIORAL: ATAXIA Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884. oral-man TDLo 2857 mg/kg BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 64, 1969. oral-man TDLo 2857 mg/kg BEHAVIORAL: COMA Diabetes. Vol. 15, Pg. 810, 1966. intraperitoneal-mouse LD50 1297 mg/kg Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961. oral-mouse LD50 3000 mg/kg Pharmaceutical Chemistry Journal Vol. 14, Pg. 162, 1980. intravenous-mouse LDLo 4000 mg/kg FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 86, 1970. oral-rabbit LD50 5340 mg/kg FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 86, 1970. intravenous-rabbit LDLo 1576 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928. intravenous-rat LD50 5500 mg/kg Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 1, 1974. oral-rat LD50 5800 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR Journal of Toxicology and Environmental Health. Vol. 15, Pg. 609, 1985. intraperitoneal-rat LDLo 500 mg/kg KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959. | |
| Dermal Toxicity: | |
| skin-rabbit LDLo 20 ml/kg Union Carbide Data Sheet. Vol. 5/7/1970 skin-guinea pig LD50 > 9.40 ml/kg Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965. subcutaneous-dog LDLo 5000 mg/kg Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884. skin-guinea pig LD50 > 9400 uL/kg Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965. subcutaneous-guinea pig LDLo 5000 mg/kg Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 50100 mg/m3/8H American Industrial Hygiene Association Journal. Vol. 20, Pg. 364, 1959. inhalation-mouse LC50 44 gm/m3/4H Current Toxicology. Vol. 1, Pg. 47, 1993. inhalation-human TCLo 500 ppm SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943. inhalation-man TCLo 440 ug/m3/6M BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(8), Pg. 42, 1977. inhalation-man TCLo 10 mg/m3/6H Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(8), Pg. 42, 1977. inhalation-man TCLo 12000 ppm/4H BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING Annals of Occupational Hygiene. Vol. 16, Pg. 73, 1973. inhalation-mouse LC50 44000 mg/m3/4H Current Toxicology. Vol. 1, Pg. 47, 1993. | |
Safety in use information
| Category: | |||
| extraction solvents, flavoring agents | |||
| Recommendation for acetone usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 6100.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 6 | |||
| Click here to view publication 6 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 8.00000 | |
| beverages(nonalcoholic): | - | 5.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 5.00000 | |
| fruit ices: | - | 5.00000 | |
| gelatins / puddings: | - | 5.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 8.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | 5.00000 | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 View page or View pdf |
| Flavouring Group Evaluation 63 (FGE.63): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission View page or View pdf |
| Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 View page or View pdf |
| EPI System: View |
| EPA-Iris:IRIS |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):67-64-1 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :180 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 1090 |
| WGK Germany:1 |
| propan-2-one |
| Chemidplus:0000067641 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:67-64-1 |