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beta-naphthyl ethyl ether

Chemical Structure

General Material Information

Preferred name beta-naphthyl ethyl ether
Trivial Name 2-Ethoxynaphthalene
Short Description nerolin bromelia
Formula C12 H12 O
CAS Number 93-18-5
FEMA Number 2768
ECHA Number 202-226-7
FDA UNII ZF3IS6G3R7
Nikkaji Number J4.670A
Beilstein Number 2042397
MDL MFCD00016808
COE Number 2058
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1258 beta-naphthyl ethyl ether
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 93-18-5 ; BETA-NAPHTHYL ETHYL ETHER
Synonyms
  • bromelia
  • 2-ethoxy-naphthalene
  • 2-ethoxynaphthalene
  • ethyl 2-naphthyl ether
  • ethyl b-naphtholate
  • ethyl b-naphthyl ether
  • ethyl beta-naphtholate
  • ethyl beta-naphthyl ether
  • naphthalene, 2-ethoxy-
  • 2-naphthol ethyl ether
  • beta- naphthol ethyl ether
  • b- naphthyl ethyl ether
  • beta- naphthyl ethyl ether
  • naphthyl ethyl ether 10% dpg
  • nerolin
  • nerolin bromelia
  • nerolin bromelia crystals
  • nerolin crystals
  • nerolin II
  • neroline
  • neroline bromelia
  • 2-Ethoxynaphthalene
  • Ethyl β-naphtholate
  • Ethyl β-naphthyl ether
  • β-Naphthol ethyl ether
  • β-Naphthyl ethyl ether
  • Nerolin (new)
  • Bromelia (compound)
  • NSC 1319

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB29688
FooDB:FDB000874
Export Tariff Code:2909.30.2000
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 172.2268371582
Melting Point 37 to 38°C @ 760 mm Hg
Vapor Pressure 0.005 mmHg @ 25 °C
Flash Point TCC Value 93.33 °C TCC
logP (o/w) 3.864 est
Shelf life 36 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
dipropylene glycol Yes
isopropyl myristate Yes
water, 38.32 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Naphthyl
naphthyl, floral, orangeflower, powdery, grape, citrus
Odor strength high , recommend smelling in a 10.00 % solution or less
Substantivity 400 hour(s) at 20.00 % in dipropylene glycol
Luebke, William tgsc, (1984) At 10.00 % in dipropylene glycol. naphtha floral orange blossom powdery grape
Mosciano, Gerard P&F 22, No. 4, 75, (1997) Powdery, floral, naphthyl and citrus
Flavor Type: Powdery
powdery, floral, soapy, berry, grape
Mosciano, Gerard P&F 22, No. 4, 75, (1997) At 4.00 ppm. Powdery, floral, soapy and heavy with a berry and grape nuance

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn N - Harmful, Dangerous for the environment.
R 20/22 - Harmful by inhalation and if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
GHS Label elements, including precautionary statements
Pictogramexclamation-mark.jpg
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
Precautionary statement(s)
P264 - Wash skin thouroughly after handling.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P321 - Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
Human Experience:
2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 3110 mg/kg
(Wong & Weir, 1971c)

oral-mouse LD50 [sex: M,F] 1213 mg/kg
(Schafer & Bowles, 1985)

intravenous-mouse LD50 100 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00191

intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD691-490

oral-rat LD50 3110 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 883, 1975.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 883, 1975.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for beta-naphthyl ethyl ether usage levels up to:
5.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 43.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 4.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -3.60000
beverages(nonalcoholic): -0.65000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.74000
fruit ices: -0.74000
gelatins / puddings: -0.12000
granulated sugar: --
gravies: --
hard candy: -2.80000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):93-18-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7129
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-ethoxynaphthalene
Chemidplus:0000093185
RTECS:QJ6900000 for cas# 93-18-5