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leather cyclohexanol
Leather cyclohexanol, or 4-Isopropylcyclohexanol, is a medium-strength leathery-scented fragrance ingredient with floral nuances and good odor stability.
General Material Description
Leather cyclohexanol, chemically known as 4-Isopropylcyclohexanol, is a synthetic fragrance compound categorized under cyclohexanol derivatives. It appears as a liquid with the molecular formula C9H18O and a molecular weight of approximately 142.24 g/mol. This ingredient is renowned for its medium-strength leathery odor complemented by floral notes reminiscent of lilac, rose, and geranium, contributing to complex scent profiles. Commonly referred to by trade names such as apo patchone and folrosia, it is widely employed in the fragrance industry. The compound is sourced through chemical synthesis methods that produce both cis and trans isomers, offering perfumers a reliable and stable material for crafting leather accords and floral blends. A controlled-vocabulary reference for this compound is accessible via PubChem for further chemical and safety data.
Occurrence, Applicability & Potential Uses
Leather cyclohexanol does not occur naturally but is synthetically produced to impart characteristic leathery and floral notes in fragrance formulations. It is a valued component in perfuming agents targeting leathery, rose, geranium, lilac, and green aroma profiles. Its application in diffusion contributes to sustained scent release without discoloration. Regulatory frameworks such as IFRA (Global) address its usage guidelines to ensure safe incorporation in consumer products. Leather cyclohexanol's medium substantivity, maintaining scent presence for up to 12 hours at full concentration, supports its role in durable fragrance compositions. It is specifically favored for stability and compatibility in diverse product types including fabric softeners, soaps, and shampoos, providing nuanced scent facets aligned with contemporary perfumery demands.
Physico-Chemical Properties Summary
This compound exhibits a specific gravity ranging roughly between 0.912 and 0.92 at 25 °C, aligning with typical cyclohexanol derivatives. Its refractive index at 20 °C varies from 1.463 to 1.469, indicative of its optical properties affecting formulation clarity. Boiling points span from 202 to 203 °C at atmospheric pressure (760 mm Hg), supporting its thermal stability in processing conditions. Leather cyclohexanol has a relatively low vapor pressure of 0.068 mmHg at 25 °C, contributing to its persistent scent release. The octanol-water partition coefficient estimate (logP) around 2.68 suggests moderate lipophilicity, influencing its solubility and skin absorption parameters. It is soluble in alcohol and exhibits moderate water solubility at 1525 mg/L at 20 °C. The flash point is approximately 194 °F (90 °C), which further informs its handling and storage considerations. Notably, this compound demonstrates non-discoloring behavior and stability when exposed to various formulations including detergents, shampoos, and alcohol-based products.
FAQ
What is leather cyclohexanol and what are its main characteristics?
Leather cyclohexanol, also known as 4-Isopropylcyclohexanol or apo patchone, is a synthetic fragrance ingredient characterized by a medium-strength leathery odor with floral undertones reminiscent of lilac, rose, and geranium. It typically appears as a liquid with the molecular formula C9H18O. This compound is valued for its pleasant and diffusive scent as well as its stability and non-discoloring properties within various fragrance applications.
How and where is leather cyclohexanol used in fragrance formulations?
Leather cyclohexanol is mainly used as an odorant in perfuming agents to create leathery and floral scent profiles. It is incorporated into formulations such as soaps, shampoos, detergents, fabric softeners, and other personal care products due to its excellent stability and moderate substantivity, preserving fragrance presence for up to 12 hours. It is soluble in alcohol, which facilitates its use in alcohol-based formulations. Its non-discoloring nature and compatibility with multiple product types make it a versatile ingredient for diffusive scent effects.
What safety considerations and regulations apply to leather cyclohexanol?
Leather cyclohexanol is classified as an irritant under European regulations, indicated by the hazard code Xi and risk phrases R36/38, which denote irritation to skin and eyes. Safety data recommend avoiding direct contact and employing appropriate protective measures during handling. The IFRA (International Fragrance Association) Code of Practice globally regulates its use, suggesting usage levels up to 10% in fragrance concentrates. This compound is not approved for flavoring uses. Toxicity profiles show relatively low acute toxicity with oral rat LD50 of 2750 mg/kg and dermal rabbit LD50 exceeding 5000 mg/kg.
US / EU / FDA / JECFA / FEMA / Scholar / Patents
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| NCBI | Start search |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2906.19.0000 |
| ChemSpider: | View |
General Material Information
| Preferred name | leather cyclohexanol |
| Trivial Name | 4-Isopropylcyclohexanol |
| Short Description | apo patchone (IFF) |
| Formula | C9 H18 O |
| CAS Number | 4621-04-9 |
| ECHA Number | 225-035-0 |
| FDA UNII | Q5HS2TR1NE |
| Nikkaji Number | J34.007C |
| Beilstein Number | 2322224 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| Synonyms |
|
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 142.24165344238 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 7.589 to 7.655 |
| Specific gravity | @ 20 °C |
| Pounds per Gallon | 7.606 to 7.673 |
| Refractive Index | 1.463 to 1.469 @ 20 °C |
| Boiling Point | 202 to 203°C @ 760 mm Hg |
| Vapor Pressure | 0.068 mmHg @ 25 °C |
| Flash Point TCC Value | 90 °C TCC |
| logP (o/w) | 2.681 est |
| Solubility | |
| alcohol | Yes |
| water, 1525 mg/L @ 20 °C (exp) | Yes |
| water | No |
| Stability | |
| acid cleaner | Unspecified |
| alcoholic lotion | Unspecified |
| antiperspirant | Unspecified |
| bleach | Unspecified |
| deo stick | Unspecified |
| detergent | Unspecified |
| fabric softener | Unspecified |
| hard surface cleaner | Unspecified |
| non-discoloring | Unspecified |
| shampoo | Unspecified |
| soap | Unspecified |
Organoleptic Properties
| Odor Type: Leathery | |
| leathery, rose red rose, green, dusty, weedy, metallic | |
| Odor strength | medium , recommend smelling in a 10.00 % solution or less |
| Substantivity | 12 hour(s) at 100.00 % |
| Luebke, William tgsc, (1984) | At 10.00 % in dipropylene glycol. leather red rose green dusty weedy metallic |
| Diffusive leathery, floral effect reminiscent of lilac, rose and geranium. Excellent stability. Non-discoloring. | A diffusive floral effect reminiscent of a combination of lilac, rose and geranium |
| General comment | Discreet leather scent with a hint of rose |
Potential Uses
| Applications | |
| Odor purposes | Geranium , Green , Leather , Lilac , Lily of the valley , Moss , Neroli , Orris , Rose , Rose red rose |
| Other purposes | Diffusion |
| Cosmetic purposes | Perfuming agents |
Safety Information
Safety information
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 2750 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 803, 1978. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 803, 1978. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for leather cyclohexanol usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| Recommendation for leather cyclohexanol flavor usage levels up to: | |||
| not for flavor use. | |||
Safety references
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):4621-04-9 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :20739 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 4-propan-2-ylcyclohexan-1-ol |
| Chemidplus:0004621049 |