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allyl isothiocyanate

General Material Information

Preferred name	allyl isothiocyanate
Trivial Name	Allyl isothiocyanate
Short Description	2-propenyl isothiocyanate
Formula	C4 H5 N S
CAS Number	57-06-7
Deleted CAS Number	107231-30-1
FEMA Number	2034
Flavis Number	12.025
ECHA Number	200-309-2
FDA UNII	BN34FX42G3
Nikkaji Number	J1.165G
Beilstein Number	0773748
MDL	MFCD00004822
COE Number	2110
xLogP3-AA	2.40 (est)
Bio Activity Summary	External link
NMR Predictor	External link
JECFA Food Flavoring	1560 allyl isothiocyanate
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	57-06-7 ; ALLYL ISOTHIOCYANATE
Synonyms	alinat allinat allinat/allyl isothiocyanate allinat/allyl isothiocyanate BHT allinat/allyl isothiocyanate toco allyl iso thiocyanate allyl isorhodanide allyl isosulfocyanate allyl isothiocianate no stab. allyl isothiocianate stab. allyl isothiocianate toco. allyl isothiocyanate natural allyl isothiocyanate (allinat) synthite 4010001265 (mus2018) allyl isothiocyanate (mustard oil) natural allyl isothiocyanate 10% in polysorbate 80 allyl isothiocyanate 10% in soybean oil allyl isothiocyanate 97% up allyl isothiocyanate FCC allyl isothiocyanate stabilized allyl isothiocyanate synthetic allyl isothiocyanate, natural allyl mustard oil allyl senevol allyl sevenolum allyl thiocarbonimide allylisothiocyanate allylsenevol allyspol carbospol artificial mustard oil mustard oil natural mustard oil natural 60% in TEC mustard oil, allyl isothiocyanate artificial oil of mustard ol eum sinapis volatile prop-2-enisothiocyanate 1-propene, 3-isothiocyanato- propenyl isothiocyanate 2-propenyl isothiocyanate 3-iso thiocyanato-1-propene iso thiocyanato-1-propene 3-iso thiocyanato-propene 3-iso thiocyanatoprop-1-ene 3-iso thiocyanatopropene iso thiocyanic acid allyl ester 3-isothiocyanatoprop-1-ene 1-Propene, 3-isothiocyanato- Isothiocyanic acid, allyl ester 3-Isothiocyanato-1-propene AITC 2-Propenyl isothiocyanate Redskin Oleum sinapis Allylsevenolum Senfoel Allyl thioisocyanate Allyspol 75EC NSC 5572 Wasaouro EXT Wasaouro

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Literature & References

	3-isothiocyanatoprop-1-ene
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	57-06-7
Pubchem (cid):	5971
Pubchem (sid):	134970695
Flavornet:	57-06-7
Pherobase:	View

Publications by Info
miscellaneous nitrogen derivatives
Publications by PubMed
Evaluation of natural antimicrobials on typical meat spoilage bacteria in vitro and in vacuum-packed pork meat.
Active packaging of cheese with allyl isothiocyanate, an alternative to modified atmosphere packaging.
Flavor-active compounds potentially implicated in cooked cauliflower acceptance.
Corn oil and milk enhance the absorption of orally administered allyl isothiocyanate in rats.
Use of allyl isothiocyanate and carbon nanotubes in an antimicrobial film to package shredded, cooked chicken meat.
Chewing gum containing allyl isothiocyanate from mustard seed extract is effective in reducing volatile sulfur compounds responsible for oral malodor.
Brown seaweed (Saccharina japonica) as an edible natural delivery matrix for allyl isothiocyanate inhibiting food-borne bacteria.
Characterization of the covalent binding of allyl isothiocyanate to Î²-lactoglobulin by fluorescence quenching, equilibrium measurement, and mass spectrometry.
Cell cycle kinetics, apoptosis rates, DNA damage and TP53 gene expression in bladder cancer cells treated with allyl isothiocyanate (mustard essential oil).
Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(Îº) B and microRNA-155.
Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination.
Effect of allyl isothiocyanate on ultra-structure and the activities of four enzymes in adult Sitophilus zeamais.
Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate.
Allyl isothiocyanate increases MRP1 function and expression in a human bronchial epithelial cell line.
Purinoceptor-mediated, capsaicin-resistant excitatory effect of allyl isothiocyanate on neurons of the guinea-pig small intestine.
Effect of various process treatment conditions on the allyl isothiocyanate extraction rate from mustard meal.
Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway.
Assessment of DNA damage and repair in adults consuming allyl isothiocyanate or Brassica vegetables.
Antimicrobial effects of allyl isothiocyanate and modified atmosphere on Pseduomonas aeruginosa in fresh catfish fillet under abuse temperatures.
Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.
Release of allyl isothiocyanate from mustard seed meal powder.
TRPA1 is functionally expressed in melanoma cells but is not critical for impaired proliferation caused by allyl isothiocyanate or cinnamaldehyde.
Allyl isothiocyanate inhibits cell metastasis through suppression of the MAPK pathways in epidermal growth factorâstimulated HT29 human colorectal adenocarcinoma cells.
Intragastric administration of allyl isothiocyanate reduces hyperglycemia in intraperitoneal glucose tolerance test (IPGTT) by enhancing blood glucose consumption in mice.
Contact and fumigant toxicity of Armoracia rusticana essential oil, allyl isothiocyanate and related compounds to Dermatophagoides farinae.
Antimicrobial activity of allyl isothiocyanate used to coat biodegradable composite films as affected by storage and handling conditions.
ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells.
The bactericidal effects of allyl isothiocyanate in water.
Development of an antimicrobial sachet containing encapsulated allyl isothiocyanate to inactivate Escherichia coli O157:H7 on spinach leaves.
Suppression of TRIF-dependent signaling pathway of toll-like receptors by allyl isothiocyanate in RAW 264.7 macrophages.
Allyl isothiocyanate from mustard seed is effective in reducing the levels of volatile sulfur compounds responsible for intrinsic oral malodor.
Chemical reduction of the mycotoxin beauvericin using allyl isothiocyanate.
Antimicrobial activity of cyclodextrin entrapped allyl isothiocyanate in a model system and packaged fresh-cut onions.
Inactivation of Salmonella on whole cantaloupe by application of an antimicrobial coating containing chitosan and allyl isothiocyanate.
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.
Effects of microencapsulated Allyl isothiocyanate (AITC) on the extension of the shelf-life of Kimchi.
The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer.
Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation.
Allyl isothiocyanate (AITC) induces stomatal closure in Arabidopsis.
Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice.
Inactivation of Salmonella in liquid egg albumen by antimicrobial bottle coatings infused with allyl isothiocyanate, nisin and zinc oxide nanoparticles.
Effect of allyl isothiocyanate (AITC) in both nitrite- and nitrosamine-induced cell death, production of reactive oxygen species, and DNA damage by the single-cell gel electrophoresis (SCGE): does it have any protective effect on HepG2 cells?
In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates.
Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats.
Allyl isothiocyanate induced stress response in Caenorhabditis elegans.
Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats.
Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.
Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion.
Preservation of acidified cucumbers with a natural preservative combination of fumaric acid and allyl isothiocyanate that target lactic acid bacteria and yeasts.
Allyl isothiocyanate-induced changes in the distribution of white blood cells in rats.
Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway.
Allyl isothiocyanate regulates caspase-1/receptor interacting protein-2 expression.
Stability and antimicrobial activity of allyl isothiocyanate during long-term storage in an oil-in-water emulsion.
Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C.
Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor.
Inhibition of bladder cancer development by allyl isothiocyanate.
Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons.
Allyl isothiocyanate as a cancer chemopreventive phytochemical.
Active packaging of fresh chicken breast, with allyl isothiocyanate (AITC) in combination with modified atmosphere packaging (MAP) to control the growth of pathogens.
Inactivation of Escherichia coli O157:H7 on the intact and damaged portions of lettuce and spinach leaves by using allyl isothiocyanate, carvacrol, and cinnamaldehyde in vapor phase.
Increased presevation of sliced mozzarella cheese by antimibrobial sachet incorporated with allyl isothiocyanate.
Extraction of allyl isothiocyanate from horseradish (Armoracia rusticana) and its fumigant insecticidal activity on four stored-product pests of paddy.
Mechanisms of pelvic organ crosstalk: 1. Peripheral modulation of bladder inhibition by colorectal distention in rats.
Enzymatic inhibition by allyl isothiocyanate and factors affecting its antimicrobial action against Escherichia coli O157:H7.
Interactive effects of sulfur and nitrogen supply on the concentration of sinigrin and allyl isothiocyanate in Indian mustard (Brassica juncea L.).
Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo.
Covalent modification of lysine residues by allyl isothiocyanate in physiological conditions: plausible transformation of isothiocyanate from thiol to amine.
Inactivation of Salmonella and Escherichia coli O157:H7 on sliced and whole tomatoes by allyl isothiocyanate, carvacrol, and cinnamaldehyde in vapor phase.
Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells.
Impairment by allyl isothiocyanate of gastric epithelial wound repair through inhibition of ion transporters.
[Development of allyl isothiocyanate detection kit].
TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion.
Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells.
Desflurane but not sevoflurane augments laryngeal C-fiber inputs to nucleus tractus solitarii neurons by activating transient receptor potential-A1.
Effect of free-SH containing compounds on allyl isothiocyanate antimicrobial activity against Escherichia coli O157:H7.
Preferential activation of the vagal nodose nociceptive subtype by TRPA1 agonists in the guinea pig esophagus.
Scratching inhibits serotonin-evoked responses of rat dorsal horn neurons in a site- and state-dependent manner.
Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate.
Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine.
Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum.
Allergic contact dermatitis from allyl isothiocyanate in a Danish cohort of 259 selected patients.
Influence of cooking duration of cabbage and presence of colonic microbiota on the excretion of N-acetylcysteine conjugates of allyl isothiocyanate and bioactivity of phase 2 enzymes in F344 rats.
Carcinogenesis Bioassay of Allyl Isothiocyanate (CAS No. 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study).
Allyl isothiocyanate is mutagenic in Salmonella typhimurium.
Species spectrum of flea beetles (Phyllotreta spp., Coleoptera, Chrysomelidae) attracted to allyl isothiocyanate-baited traps.
Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells.
Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29.
Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics.
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.
Mechanism of oxidative DNA damage induced by carcinogenic allyl isothiocyanate.
Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate.
[Devising a detector tube for allyl isothiocyanate].
Actinidia callosa peel (kiwi fruit) ethanol extracts protected neural cells apoptosis induced by methylglyoxal through Nrf2 activation.
Influence of local treatments with capsaicin or allyl isothiocyanate in the sensitization phase of a fluorescein-isothiocyanate-induced contact sensitivity model.
Involvement of a glucosinolate (sinigrin) in the regulation of water transport in Brassica oleracea grown under salt stress.
TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity.
Effect of post harvest radiation processing and storage on the volatile oil composition and glucosinolate profile of cabbage.
Comparison of effects of Wasabia japonica and allyl isothiocyanate on the growth of four strains of Vibrio parahaemolyticus in lean and fatty tuna meat suspensions.
Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets.
Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats.
Transcriptional responses to exposure to the brassicaceous defence metabolites camalexin and allyl-isothiocyanate in the necrotrophic fungus Alternaria brassicicola.
Active packaging of cheese with allyl isothiocyanate, an alternative to modified atmosphere packaging.
Elimination of Escherichia coli O157:H7 from fermented dry sausages at an organoleptically acceptable level of microencapsulated allyl isothiocyanate.
Pheromonal activity of compounds identified from male Phyllotreta cruciferae: field tests of racemic mixtures, pure enantiomers, and combinations with allyl isothiocyanate.
Inhibitory effects of microencapsulated allyl isothiocyanate (AIT) against Escherichia coli O157:H7 in refrigerated, nitrogen packed, finely chopped beef.
Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.
Direct and simultaneous analysis of sinigrin and allyl isothiocyanate in mustard samples by high-performance liquid chromatography.
Formation of allyl isothiocyanate from sinigrin in the digestive tract of rats monoassociated with a human colonic strain of Bacteroides thetaiotaomicron.
Efficacy of allyl isothiocyanate in killing enterohemorrhagic Escherichia coli O157:H7 on alfalfa seeds.
Efficient peptide ladder sequencing by MALDI-TOF mass spectrometry using allyl isothiocyanate.
Short-term toxicity study of allyl isothiocyanate in rats.
Age-related changes in the metabolism and excretion of allyl isothiocyanate. A model compound for glutathione conjugation.
Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells.
Sensitivity to allyl isothiocyanate, dimethyl trisulfide, sinigrin, and cooked cauliflower consumption.
Inactivation of Escherichia coli O157:H7 in packaged ground beef by allyl isothiocyanate.
Effects of ionized cyclodextrin on decomposition of allyl isothiocyanate in alkaline solutions.
Bactericidal effects of Lactobacillus reuteri and allyl isothiocyanate on Escherichia coli O157:H7 in refrigerated ground beef.
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis.
Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables.
Sensitization and desensitization to allyl isothiocyanate (mustard oil) in the nasal cavity.
Reactions of allyl isothiocyanate with alanine, glycine, and several peptides in model systems.
Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC).
Combined effects of hydrostatic pressure, temperature, and the addition of allyl isothiocyanate on inactivation of Escherichia coli.
Antibacterial mechanism of allyl isothiocyanate.
Factors affecting the dissolution and degradation of oriental mustard-derived sinigrin and allyl isothiocyanate in aqueous media.
Identification and quantification of the N-acetylcysteine conjugate of allyl isothiocyanate in human urine after ingestion of mustard.
Effects of oral administration of brassica secondary metabolites, allyl cyanide, allyl isothiocyanate and dimethyl disulphide, on the voluntary food intake and metabolism of sheep.
Effect of allyl isothiocyanate on hepatic monooxygenases and serum transferases in rats.
[Safety of animal husbandry products produced by using allyl isothiocyanate-preserved feeds].
Allyl isothiocyanate: comparative disposition in rats and mice.
Responses of the crucifer flea beetle to Brassica volatiles in an olfactometer.
Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channels.
The role of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat.
Polysulfides are possible H2S-derived signaling molecules in rat brain.
Influence of NaCl and NaNO3 on sinigrin hydrolysis by foodborne bacteria.
Opioid modulation of facial itch- and pain-related responses and grooming behavior in rats.
Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve.
Thermal Degradation of Allyl Isothiocyanate in Aqueous Solution.
Comparison of TRPA1-versus TRPV1-mediated cough in guinea pigs.
The effect of menthol vapor on nasal sensitivity to chemical irritation.
Inactivation of Salmonella enterica serovar Typhimurium and quality maintenance of cherry tomatoes treated with gaseous essential oils.
Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress.
Modulation of TRP channels by resveratrol and other stilbenoids.
Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice.
Allyl isothiocyanate.
The disposition of allyl isothiocyanate in the rat and mouse.
Toxicity of allyl isothiocyanate and cinnamic aldehyde assessed using cultured human KB cells and yeast, Saccharomyces cerevisiae.
Allyl isothiocyanate.
Allyl isothiocyanate selectively kills undifferentiated HT29 cells in vitro and suppresses aberrant crypt foci in the colonic mucosa of rats.
[Effect of allyl isothiocyanate on cytochrome P-450 of rat liver microsomes].
Carcinogenesis bioassay of allyl isothiocyanate.
Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.
Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice.
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Removal of off-flavors from sea tangle (Laminaria japonica) extract by fermentation with Aspergillus oryzae.
Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production.
Toxicity of allyl isothiocyanate-amended soil toLimonius californicus (Mann.) (Coleoptera: Elateridae) wireworms.
Differential effects of raising and lowering intracellular glutathione levels on the cytotoxicity of allyl isothiocyanate, tert-butylhydroperoxide and chlorodinitrobenzene.
Effect of allyl isothiocyanate on field behavior of crucifer-feeding flea beetles (Coleoptera: Chrysomelidae).
A study of the chemical binding of allyl isothiocyanate with thyroxine and of the effect of allyl isothiocyanate on lipid metabolism in the rat.
Effects of acute stressors on itch- and pain-related behaviors in rats.
Kinetic and thermodynamic analysis of the cyclodextrin-allyl isothiocyanate inclusion complex in an aqueous solution.
Effect of allyl isothiocyanate on plasma and urinary concentrations of some biochemical entities in the rat.
Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects.
Antimicrobial activities of isothiocyanates against Campylobacter jejuni isolates.
Pronociceptive response elicited by TRPA1 receptor activation in mice.
Zingerone enhances glutamatergic spontaneous excitatory transmission by activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa.
REMOVED: Allyl isothiocyanate influences in vitro invasion, adhesion and gene expression in SK-Hep1 cells.
Evaluation of urinary N-acetyl cysteinyl allyl isothiocyanate as a biomarker for intake and bioactivity of Brussels sprouts.
Allyl isothiocyanate and allyl cyanide production in cell-free cabbage leaf extracts, shredded cabbage, and cole slaw.
Effects of allyl isothiocyanate upon Spirostomum ambiguum.
A note on the combination of cysteine with allyl isothiocyanate.
Trapping cabbage maggots with plant bait and allyl isothiocyanate.
Allyl isothiocyanate: a new broad-spectrum antibiotic from nasturtium.
[REACTION OF ALLYL ISOTHIOCYANATE WITH THE REAGENTS FOR SUGARS].
[Inhibition of the growth of sections of oat coleoptiles, in the presence of allyl isothiocyanate].
[Antibiotic effect of the allyl isothiocyanate extracted from various horticultural forms of the seeds of Raphanus Sativus L., var. radicula Pers. towards various bacteria, including two strains of tubercle bacillus avian type, Cow 18 and Cow 70; Note II].
Effects of allyl isothiocyanate upon Spirostomum ambiguum.
The Effects of Allyl Isothiocyanate Compared With Ultraviolet Radiation.
Control of the potato-root eelworm, Heterodera rostochiensis Wollenweber, by allyl isothiocyanate, the mustard oil of Brassica nigra L.
Allyl Isothiocyanate: Some Aspects of its Physiological Action.
Efficacy of washing with hydrogen peroxide followed by aerosolized antimicrobials as a novel sanitizing process to inactivate Escherichia coli O157:H7 on baby spinach.
Acute toxicity of plant essential oils to scarab larvae (Coleoptera: Scarabaeidae) and their analysis by gas chromatography-mass spectrometry.
Ruminal methane inhibition potential of various pure compounds in comparison with garlic oil as determined with a rumen simulation technique (Rusitec).
Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells.
Comparative efficacy of plant-derived essential oils for managing ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) and their corresponding mass spectral characterization.
Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells.
Larvicidal activity of Myrtaceae essential oils and their components against Aedes aegypti, acute toxicity on Daphnia magna, and aqueous residue.
Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine.
The role of N-methyl-D-aspartate receptor subunits in the rat thalamic mediodorsal nucleus during central sensitization.
TRPA1 receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation.
Cross-sensitization mechanisms between colon and bladder via transient receptor potential A1 stimulation in rats.
Enhanced production of nitric oxide in A549 cells through activation of TRPA1 ion channel by cold stress.
Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat.
Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism.
Inhibition of Listeria monocytogenes and Salmonella by combinations of oriental mustard, malic acid, and EDTA.
Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice.
Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture.
Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin.
Activation of transient receptor potential ankyrin 1 by eugenol.
LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.
Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass.
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
Heat and AITC activate green anole TRPA1 in a membrane-delimited manner.
In vitro evaluation of antimicrobial activities of various commercial essential oils, oleoresin and pure compounds against food pathogens and application in ham.
Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts.
Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry.
Etodolac activates and desensitizes transient receptor potential ankyrin 1.
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs).
Immunolocalization and distribution of functional temperature-sensitive TRP channels in salivary glands.
TRP-channel-specific cutaneous eicosanoid release patterns.
TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep.
Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation.
Neural processing of itch.
Information processing in brainstem bitter taste-relaying neurons defined by genetic tracing.
Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels.
Effects of antimicrobial coatings and cryogenic freezing on survival and growth of Listeria innocua on frozen ready-to-eat shrimp during thawing.
Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line.
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
[Effects of pulpal inflammation on the activities of periodontal mechanoreceptive afferent fibers].
Monascin and AITC attenuate methylglyoxal-induced PPARÎ³ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation.
Resolving the mechanism of bacterial inhibition by plant secondary metabolites employing a combination of whole-cell biosensors.
Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder.
Development of antimicrobial coatings for improving the microbiological safety and quality of shell eggs.
Nematicidal activity of allylisothiocyanate from horseradish (Armoracia rusticana) roots against Meloidogyne incognita.
Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade.
Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo.
The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.
Study of the chemical reduction of the fumonisins toxicity using allyl, benzyl and phenyl isothiocyanate in model solution and in food products.
Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema.
Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells.
Recruitment of dynamic endothelial Ca2+ signals by the TRPA1 channel activator AITC in rat cerebral arteries.
Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels.
Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels.
Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts.
TRPV1 channels are functionally coupled with BK(mSlo1) channels in rat dorsal root ganglion (DRG) neurons.
Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity.
Glucosinolate degradation products, isothiocyanates, nitriles, and thiocyanates, induce stomatal closure accompanied by peroxidase-mediated reactive oxygen species production in Arabidopsis thaliana.
Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1.
[Field sampling methods for earthworm: a review].
TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord.
An inexpensive system for evaluating the tussive and anti-tussive properties of chemicals in conscious, unrestrained guinea pigs.
Cellular and molecular responses of Salmonella Typhimurium to antimicrobial-induced stresses during the planktonic-to-biofilm transition.
Male Phyllotreta striolata (F.) produce an aggregation pheromone: identification of male-specific compounds and interaction with host plant volatiles.
Transient receptor potential A1 channel contributes to activation of the muscle reflex.
New biomarkers for monitoring the levels of isothiocyanates in humans.
Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin.
Inactivation of salmonella on tomato stem scars by edible chitosan and organic Acid coatings.
TRPA1-like channels enhance glycinergic transmission in medullary dorsal horn neurons.
Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells.
Evaluation of natural antimicrobials on typical meat spoilage bacteria in vitro and in vacuum-packed pork meat.
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice.
Catalytic and structural diversity of the fluazifop-inducible glutathione transferases from Phaseolus vulgaris.
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Multiple cation channels mediate increases in intracellular calcium induced by the volatile irritant, trans-2-pentenal in rat trigeminal neurons.
Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle.
Effect of resiniferatoxin on glutamatergic spontaneous excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Role of transient receptor potential ankyrin 1 in gastric accommodation in conscious guinea pigs.
Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon.
Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons.
[Antimicrobial efficacy of benzyl isothiocyanate].
Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats.
Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate.
In vitro inhibitory activity of essential oil vapors against Ascosphaera apis.
Characteristics of spoilage-associated secondary cucumber fermentation.
Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.
TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons.
TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse.
Use of natural antimicrobials to increase antibiotic susceptibility of drug resistant bacteria.
Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder.
Transient receptor potential A1 channels: insights into cough and airway inflammatory disease.
Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons.
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.
Resiniferatoxin mediated ablation of TRPV1+ neurons removes TRPA1 as well.
Transient receptor potential A1 increase glutamate release on brain stem neurons.
Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.
Peripheral and central levels in nasal trigeminal sensitization and desensitization.
Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model.
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Propofol restores transient receptor potential vanilloid receptor subtype-1 sensitivity via activation of transient receptor potential ankyrin receptor subtype-1 in sensory neurons.
Optimization of ultrasonic-stimulated solvent extraction of sinigrin from Indian mustard seed (Brassica Juncea L.) using response surface methodology.
The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2.2 channels.
Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels.
Lateral hypothalamic-induced alpha-adrenoceptor modulation occurs in a model of inflammatory pain in rats.
Transient receptor potential (TRP) A1 activated currents in TRPV1 and cholecystokinin-sensitive cranial visceral afferent neurons.
The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings.
Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats.
Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions.
[Determination of isothiocyanates and related compounds in mustard extract and horseradish extract used as natural food additives].
Transient receptor potential A1 (TRPA1) activity in the human urethra--evidence for a functional role for TRPA1 in the outflow region.
TRPA1 in bradykinin-induced mechanical hypersensitivity of vagal C fibers in guinea pig esophagus.
[Antibacterial activity of essential oil vapor for histamine-producing bacteria].
A cell-based impedance assay for monitoring transient receptor potential (TRP) ion channel activity.
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.
Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.
Determination of amoxapine and nortriptyline in blood plasma and serum by salt-assisted liquid-liquid microextraction and high-performance liquid chromatography.
Differential itch- and pain-related behavioral responses and Âµ-opoid modulation in mice.
Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice.
Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-{alpha} in rat pulmonary sensory neurons.
Mortality and behavior in Heterodera glycines juveniles following exposure to isothiocyanate compounds.
Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model.
Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states.
Menthol response and adaptation in nociceptive-like and nonnociceptive-like neurons: role of protein kinases.
Transient receptor potential A1 is involved in cold-induced contraction in the isolated rat colon smooth muscle.
Efficacy and side effects of five sampling methods for soil earthworms (Annelida, Lumbricidae).
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.
Rb+ efflux assay for assessment of non-selective cation channel activities.
Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats.
Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: relation to nerves and interstitial cells.
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells.
Glucosinolate breakdown products as insect fumigants and their effect on carbon dioxide emission of insects.
Degradation of sinigrin by Lactobacillus agilis strain R16.
Acute and long-term effects of nine chemicals on the Japanese medaka (Oryzias latipes).
A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation.
Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats.
Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception.
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway.
Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1.
Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative.
Immunochemical detection of food-derived isothiocyanate as a lysine conjugate.
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.
QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells.
TRPA1 agonists delay gastric emptying in rats through serotonergic pathways.
Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers.
Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs.
Mustard oil enhances spinal neuronal responses to noxious heat but not cooling.
Transient receptor potential A1 mediates an osmotically activated ion channel.
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.
Volatile constituents throughout Brassica oleracea L. Var. acephala germination.
Miogadial and miogatrial with alpha,beta-unsaturated 1,4-dialdehyde moieties--novel and potent TRPA1 agonists.
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones.
Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine.
Biofumigant compounds released by field pennycress (Thlaspi arvense) seedmeal.
Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice.
Diallyl sulfides in garlic activate both TRPA1 and TRPV1.
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.
Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative.
TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase.
Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L.
Mustard oil induces a transient receptor potential vanilloid 1 receptor-independent neurogenic inflammation and a non-neurogenic cellular inflammatory component in mice.
Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin.
Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa.
Plant-natural enemy association in tritrophic system,Cotesia rubecula-Pieris rapae-brassicaceae (Cruciferae). III: Collection and identification of plant and frass volatiles.
Predicting survival of Escherichia coli O157:H7 in dry fermented sausage using artificial neural networks.
Non-conventional methods for the control of post-harvest pear diseases.
Toxicity of Glucosinolates and Their Enzymatic Decomposition Products to Caenorhabditis elegans.
Antiasthmatic effects of onion extracts--detection of benzyl- and other isothiocyanates (mustard oils) as antiasthmatic compounds of plant origin.
Acaricidal constituents isolated from Sinapis alba L. seeds and structure-activity relationships.
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.
Drosophila painless is a Ca2+-requiring channel activated by noxious heat.
In vivo birthdating by BAPTISM reveals that trigeminal sensory neuron diversity depends on early neurogenesis.
Regiospecifically alpha-13C-labeled porphyrins for studies of ground-state hole transfer in multiporphyrin arrays.
Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis.
Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Management of root knot nematodes in turfgrass using mustard formulations and biostimulants.
Combined effect of volatile antimicrobial agents on the growth of Penicillium notatum.
Radioprotective activity of naturally occurring organosulfur compounds.
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Use of mustard flour to inactivate Escherichia coli O157:H7 in ground beef under nitrogen flushed packaging.
Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori.
Lateralization in human nasal chemoreception: differences in bilateral electrodermal responses related to olfactory and trigeminal stimuli.
Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.
Inhibition of fungal growth on bread by volatile components from spices and herbs, and the possible application in active packaging, with special emphasis on mustard essential oil.
Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay.
Cytomorphological changes in liver cells exposed to allyl and benzyl isothiocyanate and their cysteine and glutathione conjugates.
TRP channels as target sites for insecticides: physiology, pharmacology and toxicology.
TRP channel activation by reversible covalent modification.
Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
[Studies on chemical components of essential oil of crude semen sinapis and roasted semen sinapis].
Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
Ambient odors influence the amplitude and time course of visual distraction.
Influence of nasal trigeminal stimuli on olfactory sensitivity.
In vitro digestion of sinigrin and glucotropaeolin by single strains of Bifidobacterium and identification of the digestive products.
Effect of naturally occurring allyl and phenyl isothiocyanates in the inhibition of experimental pulmonary metastasis induced by B16F-10 melanoma cells.
Protective effects of Brussels sprouts towards B[a]P-induced DNA damage: a model study with the single-cell gel electrophoresis (SCGE)/Hep G2 assay.
Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages.
Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats.
Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.
On the cytotoxicity and genotoxicity of allyl and phenethyl isothiocyanates and their parent glucosinolates sinigrin and gluconasturtiin.
Taste responses of bullfrog to pungent stimuli.
Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate.
Metabolism of some naturally occurring isothiocyanates in the rat.
Fumigant antifungal activity of essential oil components from Acorus gramineus against three phytopathogenic fungi.
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate.
Molecular determinants of species-specific activation or blockade of TRPA1 channels.
Thymol and related alkyl phenols activate the hTRPA1 channel.
Activation of TRPA1 by farnesyl thiosalicylic acid.
Activation of transient receptor potential ankyrin 1 by hydrogen peroxide.
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress.
Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1).
Pungent products from garlic activate the sensory ion channel TRPA1.
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
Effects of mustard sprouts and allylisothiocyanate on benzo(a)pyrene-induced DNA damage in human-derived cells: a model study with the single cell gel electrophoresis/Hep G2 assay.
Olfactory responses of Plutella xylostella natural enemies to host pheromone, larval frass, and green leaf cabbage volatiles.
Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Influence of foliar glucosinolates in oilseed rape and mustard on feeding and growth of the bertha armyworm,Mamestra configurata Walker.
New tests for the detection of azide.
Editorial comment on: distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
Effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar spinal wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats.
Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes.
Responses of the ciliates tetrahymena and paramecium to vertebrate odorants and tastants.
TRPA1 channel activation induces cholecystokinin release via extracellular calcium.
Evaluation of antifouling activity of eight commercially available organic chemicals against the early foulers marine bacteria and Ulva spores.
Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer.
A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation.
Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn.
Influence of cabbage processing methods and prebiotic manipulation of colonic microflora on glucosinolate breakdown in man.
Cold sensitivity of recombinant TRPA1 channels.
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.
Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.
Sensitivity of Meloidogyne javanica and Tylenchulus semipenetrans to Isothiocyanates in Laboratory Assays.
Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine.
The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.
Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro.
Mustard oil has differential effects on the response of trigeminal caudalis neurons to heat and acidity.
Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.
Comparison of human exposures to selected chemicals with thresholds from NTP carcinogenicity studies in rodents.
Determination of aromatic primary amines at microg l(-1) level in environmental waters by gas chromatography-mass spectrometry involving N-allyl-n'-arylthiourea formation and their on-line pyrolysis to aryl isothiocyanates.
A role for isothiocyanates in plant resistance against the specialist herbivore Pieris rapae.
Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates.
Analysis of isothiocyanate mercapturic acids in urine: a biomarker for cruciferous vegetable intake.
Antifungal activity of essential oils evaluated by two different application techniques against rye bread spoilage fungi.
Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine.
Lack of UDS activity in the livers of rats exposed to allylisothiocyanate.
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables.
Antimicrobial activity of sulfur compounds derived from cabbage.
Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study.
Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates.
Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29.
Responses of lipid membranes of taste sensor to astringent and pungent substances.
Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons.
Chemotaxis away from thiocyanic and isothiocyanic esters in Pseudomonas aeruginosa.
The clastogenic effects of isothiocyanates.
c-FOS-like immunoreactivity in rat brainstem neurons following noxious chemical stimulation of the nasal mucosa.
Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3',5'-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates.
Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals.
Neoplastic transformation of Chinese hamster cells in vitro after treatment with flavoring agents.
Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver.
Acute poisoning in cattle after eating old non-viable seed of chou moellier (Brassica oleracea convar. acephala).
A pungent ingredient of mustard, allylisothiocyanate, inhibits (H+ + K+)-ATPase.
Effect of meal composition and cooking duration on the fate of sulforaphane following consumption of broccoli by healthy human subjects.
Changes in glucosinolate concentrations, myrosinase activity, and production of metabolites of glucosinolates in cabbage (Brassica oleracea Var. capitata) cooked for different durations.
Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2.
Fumigant activity of plant essential oils and components from horseradish (Armoracia rusticana), anise (Pimpinella anisum) and garlic (Allium sativum) oils against Lycoriella ingenua (Diptera: Sciaridae).
Responses of flea beetle Phyllotreta cruciferae to synthetic aggregation pheromone components and host plant volatiles in field trials.
Characterization of antimutagenic mechanism of 3-allyl-5-substituted 2-thiohydantoins against 2-amino-3-methylimidazo[4,5-f]quinoline.
Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.
Influence of plant and bacterial myrosinase activity on the metabolic fate of glucosinolates in gnotobiotic rats.
Effect of naturally occurring isothiocyanates on the immune system.
Flavor-active compounds potentially implicated in cooked cauliflower acceptance.
4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish).
Quality of odor and olfactory lateralization processes in humans.
Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide.
Evaluation of volatile chemical treatments for lethality to Salmonella on alfalfa seeds and sprouts.
Involvement of H(+)-ATPase and carbonic anhydrase in inorganic carbon uptake for endosymbiont photosynthesis.
Limitation of sensitization to injured parts of receptive fields in human skin C-nociceptors.
The effect of food chemicals on cell aging of human diploid cells in in vitro culture.
Neurogenic inflammation in the chicken (Gallus gallus var domesticus).
Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase.
Stability of allylthiocyanate and allylisothiocyanate in bovine ruminal fluid.
Development of an orofacial model of acute inflammation in the rat.
Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents.
Natural pesticides and bioactive components in foods.
Occurrence and relevance of chemically induced benign neoplasms in long-term carcinogenicity studies.
Fanweed toxicosis in cattle: case history, analytical method, suggested treatment, and fanweed detoxification.
Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues.
Induction of unscheduled DNA synthesis in HeLa cells by allylic compounds.
Mutagenic effects of allylisothiocyanate in Escherichia coli WP 67.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C19317
HMDB (The Human Metabolome Database):	HMDB05843
FooDB:	FDB012440
Export Tariff Code:	2930.90.5050
FDA Listing of Food Additive Status:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: grades: technical. fcc; 93% purity minimum; in 1972 a food grade was available, 93% purity minimum

Suppliers

Advanced Biotech	Anhui Haibei
Berjé	DeLong Chemicals America
Ernesto Ventós	Fleurchem
George Uhe Company	Indukern F&F
Inoue Perfumery	Lluch Essence
M&U International	Moellhausen
Nippon Terpene Chemicals	O'Laughlin Industries
Pearlchem Corporation	Penta International
Pfaltz & Bauer	Reincke & Fichtner
Santa Cruz Biotechnology	Shijiazhuang Donglian Nankai Aroma Chemicals
Sigma-Aldrich	Silverline Chemicals
Symrise	Synerzine
Synthite Industries	Tengzhou Jitian Aroma Chemiclal
United International	Vigon International
Indukern, S.A. F&F Ingredients Division	M&U International LLC
Penta International Corporation	Qingdao Free Trade Zone United International Co Ltd
Ernesto Ventós S.A.

PhysChem Properties

Material listed in food chemical codex	Yes
Molecular weight	99.155853271484
Specific gravity	@ 25 °C
Pounds per Gallon	8.363 to 8.612
Specific gravity	@ 25 °C
Pounds per Gallon	8.429 to 8.487
Refractive Index	1.515 to 1.54 @ 20 °C
Melting Point	-102.5 to -101°C @ 760 mm Hg
Boiling Point	150 to 152°C @ 760 mm Hg
Boiling Point	73 to 74°C @ 50 mm Hg
Acid Value	1 max KOH/g
Vapor Pressure	3.7 mmHg @ 30 °C
Flash Point TCC Value	46.11 °C TCC
logP (o/w)	2.15
Shelf life	18 months (or longer if stored properly.)
Storage notes	Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol	Yes
water, 2000 mg/L @ 20 °C (exp)	Yes
water	No

Organoleptic Properties

Odor Type: Sulfurous
pungent, mustard
General comment	At 0.01 % in propylene glycol. strong pungent mustard
Flavor Type: Mustard
mustard, horseradish, wasabi
General comment	Mustard horseradish wasabi
Useful in: savory vegetable, savory spices, savory allium, savory others.	Pungent, sharp, horseradish

Occurrences

Potential Uses

Applications	flavoring agents
Flavoring purposes	Brussel sprouts , Cabbage , Cauliflower , Horseradish , Mustard , Wasabi
Cosmetic purposes	Not used anymore

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 10 - Flammable. R 24/25 - Toxic in contact with skin and if swallowed. R 34 - Causes burns. R 42/43 - May cause sensitization by inhalation and skin contact. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 23 - Do not breath vapour. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 339 mg/kg (Jenner et al., 1964) oral-rat LD50 [sex: M] 490 mg/kg (Vernot et al., 1977) oral-mouse LD50 [sex: M] 310 mg/kg (Vernot et al., 1977) oral-mouse LD50 308 mg/kg Aerospace Medical Research Laboratory Report. Vol. TR-73-83, Pg. 1973 intraperitoneal-mouse LDLo 4 mg/kg Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972. intravenous-rabbit LDLo 12 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Biochemical Journal. Vol. 4, Pg. 107, 1909. oral-rat LD50 112 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 219, Pg. 119, 1953. intraperitoneal-rat LDLo 80 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 870, 1966.
Dermal Toxicity:
skin-rabbit LD50 88 mg/kg Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977. subcutaneous-rat LD50 92 mg/kg SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 18, Pg. 159, 1980. subcutaneous-mouse LD50 80 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 505, 1955.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
IFRA Critical Effect:
Insufficient data
IFRA Purity Specification:
	View the IFRA Standard
Recommendation for allyl isothiocyanate usage levels up to:
	PROHIBITED: Should not be used as a fragrance ingredient.

Maximised Survey-derived Daily Intakes (MSDI-EU):		1282.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA):		133.00 (μg/capita/day)
Threshold of Concern:		540 (μg/person/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	5.20000
beverages(nonalcoholic):		0.02000	0.50000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	52.00000
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	0.50000
fruit ices:		-	0.50000
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	0.50000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	87.00000
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 85: Consideration of miscellaneous nitrogen-containing substances evaluated by JECFA (65th meeting)[1] - Scientific Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
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Flavouring Group Evaluation 38 (FGE.38)[1] 3-Butenyl isothiocyanate - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
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Opinion on the safety of allyl isothiocyanate for the proposed uses as a food additive
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Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
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Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
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EPI System: View

ClinicalTrials.gov:search

NIOSH International Chemical Safety Cards:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

Carcinogenic Potency Database:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):57-06-7

EPA ACToR:Toxicology Data