Preferred name | butyric acid |
Trivial Name | Butyric acid |
Formula | C4 H8 O2 |
CAS Number | 107-92-6 |
FEMA Number | 2221 |
Flavis Number | 8.005 |
ECHA Number | 203-532-3 |
FDA UNII | 40UIR9Q29H |
Nikkaji Number | J4.068A |
Beilstein Number | 0906770 |
MDL | MFCD00002814 |
COE Number | 5 |
Bio Activity Summary | External link |
NMR Predictor | External link |
JECFA Food Flavoring | 87 butyric acid |
FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
FDA Mainterm | 107-92-6 ; BUTYRIC ACID |
Synonyms |
|
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Google Books | Start search |
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Perfumer & Flavorists | Start search |
EU Patents | Start search |
PubMeb | Start search |
NCBI | Start search |
butanoic acid | |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 107-92-6 |
Pubchem (cid): | 264 |
Pubchem (sid): | 134972740 |
Flavornet: | 107-92-6 |
Pherobase: | View |
(IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
Videos: | The Periodic Table of Videos |
tgsc: | Atomic Weights use for this web site |
(IUPAC): | Periodic Table of the Elements |
FDA Substances Added to Food (formerly EAFUS): | View |
FDA Indirect Additives used in Food Contact Substances: | View |
CHEBI: | View |
CHEMBL: | View |
Golm Metabolome Database: | Search |
Metabolomics Database: | Search |
UM BBD: | Search |
KEGG (GenomeNet): | C00246 |
HMDB (The Human Metabolome Database): | HMDB00039 |
FooDB: | FDB012062 |
YMDB (Yeast Metabolome Database): | YMDB01392 |
Export Tariff Code: | 2915.60.0000 |
Typical G.C. | |
VCF-Online: | VCF Volatile Compounds in Food |
ChemSpider: | View |
Wikipedia: | View |
Formulations/Preparations: •grades: 90%; 95%; 99%; edible; synthetic; reagent; technical; fcc. •grades or purity: commercial, 99.5+% |
Material listed in food chemical codex | Yes |
Molecular weight | 88.106163024902 |
Specific gravity | @ 25 °C |
Pounds per Gallon | 7.089 to 7.955 |
Refractive Index | 1.397 to 1.399 @ 20 °C |
Melting Point | -7 to -5°C @ 760 mm Hg |
Boiling Point | 162 to 164°C @ 760 mm Hg |
Boiling Point | 90 to 91°C @ 50 mm Hg |
Vapor Pressure | 1.65 mmHg @ 25 °C |
Vapor Density | 3.04 |
Flash Point TCC Value | 75 °C TCC |
logP (o/w) | 0.79 |
Shelf life | 36 months (or longer if stored properly.) |
Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
Solubility | |
alcohol | Yes |
fixed oils | Yes |
propylene glycol | Yes |
water, 6.00E+04 mg/L @ 25 °C (exp) | Yes |
paraffin oil | No |
Odor Type: Cheesy | |
sharp, acetic, cheesy, buttery, fruity, dairy | |
Odor strength | high , recommend smelling in a 1.00 % solution or less |
Substantivity | 24 hour(s) at 100.00 % |
Luebke, William tgsc, (1995) | At 1.00 % in dipropylene glycol. sharp acetic cheese butter fruit |
Mosciano, Gerard P&F 19, No. 2, 55, (1994) | Sharp, dairy-like, cheesy, buttery with a fruity nuance |
Flavor Type: Sour | |
acidic, sour, cheesy, dairy, creamy, fruity | |
Mosciano, Gerard P&F 19, No. 2, 55, (1994) | At 250.00 ppm. Acidic sour, cheesy, dairy, creamy with a fruity nuance |
Used in cheddar cheese, butter and dairy flavors. | Acidic sour |
General comment | Sour, acidic, fruity, cheesy and buttery note |
(data available) |
Applications | |
Odor purposes | Bramble arctic bramble blackberry , Castoreum , Citronella , Currant , Eucalyptus oil replacer , Hop , Melon , Nutmeg , Passion fruit , Valerian |
Flavoring purposes | Apple , Banana , Barley , Beef roasted beef , Beer , Bread white bread , Butter , Butterscotch , Cheese blue cheese , Cheese cheddar cheese , Cheese swiss cheese , Cherry , Chocolate cocoa , Cloudberry bakeapple , Coffee , Fish , Grape , Green , Honey , Mace , Mushroom , Nut , Onion , Papaya , Peach , Peanut , Pear , Pineapple , Pistachio , Brandy plum brandy , Sauerkraut , Tomato , Valerian , Walnut , Wine sherry wine , Yogurt |
Other purposes | Natural , Soybean , Trassi |
Cosmetic purposes | Fragrance |
Preferred SDS: View | |
European information : | |
Most important hazard(s): | |
C - Corrosive. | |
R 34 - Causes burns. S 01/02 - Keep locked up and out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. S 45 - In case of accident or if you feel unwell seek medical advice immediately. | |
Hazards identification | |
Classification of the substance or mixture | |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
None found. | |
GHS Label elements, including precautionary statements | |
Pictogram | |
Hazard statement(s) | |
None found. | |
Precautionary statement(s) | |
None found. | |
Oral/Parenteral Toxicity: | |
oral-rat LD50 2000 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 30, 1982. intravenous-mouse LD50 800 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica. Vol. 18, Pg. 141, 1961. intraperitoneal-mouse LD50 3180 mg/kg Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969. oral-mouse LDLo 500 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: NECROTIC GHANGES BLOOD: CHANGES IN SPLEEN Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 19, 1962. | |
Dermal Toxicity: | |
skin-rabbit LD50 530 ul/kg Union Carbide Data Sheet. Vol. 4/10/1968 subcutaneous-mouse LD50 3180 mg/kg Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969. | |
Inhalation Toxicity: | |
inhalation-mouse LC > 500 mg/m3 LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 23(5), Pg. 31, 1958. inhalation-rat LC > 500 mg/m3 LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 19, 1962. |
Category: | |||
flavor and fragrance agents | |||
RIFM Fragrance Material Safety Assessment: Search | |||
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
Recommendation for butyric acid usage levels up to: | |||
0.0500 % in the fragrance concentrate. | |||
Structure Class: | I | ||
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
publication number: 3. Update in publication number(s): 29 | |||
Click here to view publication 3 | |||
average usual ppm | average maximum ppm | ||
baked goods: | 44.00000 | 106.00000 | |
beverages(nonalcoholic): | 9.00000 | 16.00000 | |
beverages(alcoholic): | 3.50000 | 30.00000 | |
breakfast cereal: | - | - | |
cheese: | - | - | |
chewing gum: | 60.00000 | 270.00000 | |
condiments / relishes: | 125.00000 | 200.00000 | |
confectionery froastings: | - | - | |
egg products: | - | - | |
fats / oils: | 9.00000 | 26.00000 | |
fish products: | - | - | |
frozen dairy: | 9.00000 | 14.00000 | |
fruit ices: | - | - | |
gelatins / puddings: | 13.00000 | 45.00000 | |
granulated sugar: | - | - | |
gravies: | - | - | |
hard candy: | 39.00000 | 103.00000 | |
imitation dairy: | 101.00000 | 183.00000 | |
instant coffee / tea: | - | - | |
jams / jellies: | - | - | |
meat products: | 7.00000 | 7.00000 | |
milk products: | 15.00000 | 15.00000 | |
nut products: | - | - | |
other grains: | - | - | |
poultry: | - | - | |
processed fruits: | - | - | |
processed vegetables: | - | - | |
reconstituted vegetables: | - | - | |
seasonings / flavors: | - | - | |
snack foods: | 24.00000 | 48.00000 | |
soft candy: | 32.00000 | 42.00000 | |
soups: | - | - | |
sugar substitutes: | - | - | |
sweet sauces: | 9.00000 | 9.00000 |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species View page or View pdf |
EPI System: View |
ClinicalTrials.gov:search |
Daily Med:search |
NIOSH International Chemical Safety Cards:search |
Chemical Carcinogenesis Research Information System:Search |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA Substance Registry Services (TSCA):107-92-6 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :264 |
National Institute of Allergy and Infectious Diseases:Data |
WISER:UN 2820 |
WGK Germany:1 |
butanoic acid |
Chemidplus:0000107926 |
EPA/NOAA CAMEO:hazardous materials |
RTECS:107-92-6 |