Preferred name | butyric acid |
Trivial Name | Butyric acid |
Formula | C4 H8 O2 |
CAS Number | 107-92-6 |
FEMA Number | 2221 |
Flavis Number | 8.005 |
ECHA Number | 203-532-3 |
FDA UNII | 40UIR9Q29H |
Nikkaji Number | J4.068A |
Beilstein Number | 0906770 |
MDL | MFCD00002814 |
COE Number | 5 |
Bio Activity Summary | External link |
NMR Predictor | External link |
JECFA Food Flavoring | 87 butyric acid |
FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
FDA Mainterm | 107-92-6 ; BUTYRIC ACID |
Synonyms |
|
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Perfumer & Flavorists | Start search |
EU Patents | Start search |
PubMeb | Start search |
NCBI | Start search |
butanoic acid | |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 107-92-6 |
Pubchem (cid): | 264 |
Pubchem (sid): | 134972740 |
Flavornet: | 107-92-6 |
Pherobase: | View |
(IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
Videos: | The Periodic Table of Videos |
tgsc: | Atomic Weights use for this web site |
(IUPAC): | Periodic Table of the Elements |
FDA Substances Added to Food (formerly EAFUS): | View |
FDA Indirect Additives used in Food Contact Substances: | View |
CHEBI: | View |
CHEMBL: | View |
Golm Metabolome Database: | Search |
Metabolomics Database: | Search |
UM BBD: | Search |
KEGG (GenomeNet): | C00246 |
HMDB (The Human Metabolome Database): | HMDB00039 |
FooDB: | FDB012062 |
YMDB (Yeast Metabolome Database): | YMDB01392 |
Export Tariff Code: | 2915.60.0000 |
Typical G.C. | |
VCF-Online: | VCF Volatile Compounds in Food |
ChemSpider: | View |
Wikipedia: | View |
Formulations/Preparations: •grades: 90%; 95%; 99%; edible; synthetic; reagent; technical; fcc. •grades or purity: commercial, 99.5+% |
Material listed in food chemical codex | Yes |
Molecular weight | 88.106163024902 |
Specific gravity | @ 25 °C |
Pounds per Gallon | 7.089 to 7.955 |
Refractive Index | 1.397 to 1.399 @ 20 °C |
Melting Point | -7 to -5°C @ 760 mm Hg |
Boiling Point | 162 to 164°C @ 760 mm Hg |
Boiling Point | 90 to 91°C @ 50 mm Hg |
Vapor Pressure | 1.65 mmHg @ 25 °C |
Vapor Density | 3.04 |
Flash Point TCC Value | 75 °C TCC |
logP (o/w) | 0.79 |
Shelf life | 36 months (or longer if stored properly.) |
Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
Solubility | |
alcohol | Yes |
fixed oils | Yes |
propylene glycol | Yes |
water, 6.00E+04 mg/L @ 25 °C (exp) | Yes |
paraffin oil | No |
Odor Type: Cheesy | |
sharp, acetic, cheesy, buttery, fruity, dairy | |
Odor strength | high , recommend smelling in a 1.00 % solution or less |
Substantivity | 24 hour(s) at 100.00 % |
Luebke, William tgsc, (1995) | At 1.00 % in dipropylene glycol. sharp acetic cheese butter fruit |
Mosciano, Gerard P&F 19, No. 2, 55, (1994) | Sharp, dairy-like, cheesy, buttery with a fruity nuance |
Flavor Type: Sour | |
acidic, sour, cheesy, dairy, creamy, fruity | |
Mosciano, Gerard P&F 19, No. 2, 55, (1994) | At 250.00 ppm. Acidic sour, cheesy, dairy, creamy with a fruity nuance |
Used in cheddar cheese, butter and dairy flavors. | Acidic sour |
General comment | Sour, acidic, fruity, cheesy and buttery note |
(data available) |
Applications | |
Odor purposes | Bramble arctic bramble blackberry, Castoreum, Citronella, Currant, Eucalyptus oil replacer, Hop, Melon, Nutmeg, Passion fruit, Valerian |
Flavoring purposes | Apple, Banana, Barley, Beef roasted beef, Beer, Bread white bread, Butter, Butterscotch, Cheese blue cheese, Cheese cheddar cheese, Cheese swiss cheese, Cherry, Chocolate cocoa, Cloudberry bakeapple, Coffee, Fish, Grape, Green, Honey, Mace, Mushroom, Nut, Onion, Papaya, Peach, Peanut, Pear, Pineapple, Pistachio, Brandy plum brandy, Sauerkraut, Tomato, Valerian, Walnut, Wine sherry wine, Yogurt |
Other purposes | Natural, Soybean, Trassi |
Cosmetic purposes | Fragrance |
Preferred SDS: View | |
European information : | |
Most important hazard(s): | |
C - Corrosive. | |
R 34 - Causes burns. S 01/02 - Keep locked up and out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. S 45 - In case of accident or if you feel unwell seek medical advice immediately. | |
Hazards identification | |
Classification of the substance or mixture | |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
None found. | |
GHS Label elements, including precautionary statements | |
Pictogram | |
Hazard statement(s) | |
None found. | |
Precautionary statement(s) | |
None found. | |
Oral/Parenteral Toxicity: | |
oral-rat LD50 2000 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 30, 1982. intravenous-mouse LD50 800 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica. Vol. 18, Pg. 141, 1961. intraperitoneal-mouse LD50 3180 mg/kg Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969. oral-mouse LDLo 500 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: NECROTIC GHANGES BLOOD: CHANGES IN SPLEEN Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 19, 1962. | |
Dermal Toxicity: | |
skin-rabbit LD50 530 ul/kg Union Carbide Data Sheet. Vol. 4/10/1968 subcutaneous-mouse LD50 3180 mg/kg Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969. | |
Inhalation Toxicity: | |
inhalation-mouse LC > 500 mg/m3 LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 23(5), Pg. 31, 1958. inhalation-rat LC > 500 mg/m3 LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 19, 1962. |
Category: | |||
flavor and fragrance agents | |||
RIFM Fragrance Material Safety Assessment: Search | |||
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
Recommendation for butyric acid usage levels up to: | |||
0.0500 % in the fragrance concentrate. | |||
Structure Class: | I | ||
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
publication number: 3. Update in publication number(s): 29 | |||
Click here to view publication 3 | |||
average usual ppm | average maximum ppm | ||
baked goods: | 44.00000 | 106.00000 | |
beverages(nonalcoholic): | 9.00000 | 16.00000 | |
beverages(alcoholic): | 3.50000 | 30.00000 | |
breakfast cereal: | - | - | |
cheese: | - | - | |
chewing gum: | 60.00000 | 270.00000 | |
condiments / relishes: | 125.00000 | 200.00000 | |
confectionery froastings: | - | - | |
egg products: | - | - | |
fats / oils: | 9.00000 | 26.00000 | |
fish products: | - | - | |
frozen dairy: | 9.00000 | 14.00000 | |
fruit ices: | - | - | |
gelatins / puddings: | 13.00000 | 45.00000 | |
granulated sugar: | - | - | |
gravies: | - | - | |
hard candy: | 39.00000 | 103.00000 | |
imitation dairy: | 101.00000 | 183.00000 | |
instant coffee / tea: | - | - | |
jams / jellies: | - | - | |
meat products: | 7.00000 | 7.00000 | |
milk products: | 15.00000 | 15.00000 | |
nut products: | - | - | |
other grains: | - | - | |
poultry: | - | - | |
processed fruits: | - | - | |
processed vegetables: | - | - | |
reconstituted vegetables: | - | - | |
seasonings / flavors: | - | - | |
snack foods: | 24.00000 | 48.00000 | |
soft candy: | 32.00000 | 42.00000 | |
soups: | - | - | |
sugar substitutes: | - | - | |
sweet sauces: | 9.00000 | 9.00000 |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species View page or View pdf |
EPI System: View |
ClinicalTrials.gov:search |
Daily Med:search |
NIOSH International Chemical Safety Cards:search |
Chemical Carcinogenesis Research Information System:Search |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA Substance Registry Services (TSCA):107-92-6 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :264 |
National Institute of Allergy and Infectious Diseases:Data |
WISER:UN 2820 |
WGK Germany:1 |
butanoic acid |
Chemidplus:0000107926 |
EPA/NOAA CAMEO:hazardous materials |
RTECS:107-92-6 |