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ethyl acetate
General Material Information
| Preferred name | ethyl acetate |
| Trivial Name | Ethyl acetate |
| Short Description | acetic acid, ethyl ester |
| Formula | C4 H8 O2 |
| CAS Number | 141-78-6 |
| FEMA Number | 2414 |
| Flavis Number | 9.001 |
| ECHA Number | 205-500-4 |
| FDA UNII | 76845O8NMZ |
| Nikkaji Number | J2.952A |
| Beilstein Number | 0506104 |
| MDL | MFCD00009171 |
| COE Number | 191 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 27 ethyl acetate |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 141-78-6 ; ETHYL ACETATE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
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| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| ethyl acetate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 141-78-6 |
| Pubchem (cid): | 8857 |
| Pubchem (sid): | 134975573 |
| Flavornet: | 141-78-6 |
| Pherobase: | View |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00849 |
| HMDB (The Human Metabolome Database): | HMDB31217 |
| FooDB: | FDB003240 |
| YMDB (Yeast Metabolome Database): | YMDB00569 |
| Export Tariff Code: | 2915.31.0000 |
| FDA Listing of Food Additive Status: | View |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Formulations/Preparations: •grades: commercial, 85-88%; 95-98%; 99%; nf national formulary grade of chemical (99%); fcc food chemical codex. •nail polish remover typically 40 wt% ethyl acetate. | |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 88.106163024902 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 7.439 to 7.472 |
| Refractive Index | 1.37 to 1.375 @ 20 °C |
| Melting Point | -84 to -83°C @ 760 mm Hg |
| Boiling Point | 76.5 to 77.5°C @ 760 mm Hg |
| Boiling Point | 26 to 27°C @ 100 mm Hg |
| Acid Value | 5 max KOH/g |
| Vapor Pressure | 111.716003 mmHg @ 25 °C |
| Vapor Density | 1.04 |
| Flash Point TCC Value | -4.44 °C TCC |
| logP (o/w) | 0.73 |
| Solubility | |
| alcohol | Yes |
| glycerin | Yes |
| propylene glycol | Yes |
| water, 8.00E+04 mg/L @ 25 °C (exp) | Yes |
Organoleptic Properties
| Odor Type: Ethereal | |
| ethereal, fruity, sweet, weedy, green, grape, rummy | |
| Odor strength | high , recommend smelling in a 10.00 % solution or less |
| Substantivity | 4 hour(s) at 100.00 % |
| Luebke, William tgsc, (1983) | At 10.00 % in propylene glycol. ethereal fruity sweet weedy green |
| Mosciano, Gerard P&F 19, No. 5, 79, (1994) | Etherial, fruity, sweet, grape and rum-like |
| Flavor Type: Ethereal | |
| ethereal, fruity, sweet, grape, cherry | |
| Mosciano, Gerard P&F 19, No. 5, 79, (1994) | At 100.00 ppm. Etherial, fruity, sweet, with a grape and cherry nuance |
| Useful in: dairy, fruity citrus, fruity red, fruity yellow, fruity tropical, fruity others, sweet others, alcoholics. | Sweet, estery, fruity, rum-like |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Apple, Apricot, Banana, Blackberry, Bubble gum, Butterscotch, Cherry, Coffee, Cologne, Cranberry, Currant, Date, Ginger, Gooseberry, Grape, Honey, Hop, Huckleberry, Lemon, Lime, Magnolia, Malt, Melon, Mulberry, Orange, Orris, Peach, Pear, Pineapple, Plum, Plum mirabelle plum, Quince, Raspberry, Saffron, Strawberry, Tangerine, Woodruff, Ylang ylang |
| Flavoring purposes | Almond, Almond, Beer, Brandy, Brandy cherry brandy, Cheese cheddar cheese, Chocolate cacao, Chocolate cocoa, Grenadine, Pistachio, Tea, Tomato |
| Other purposes | Solvents |
| Cosmetic purposes | Perfuming agents, Solvents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 11 - Highly flammable. R 36 - Irritating to eyes. R 66 - Repeated exposure may cause skin dryness or cracking. R 67 - Vapours may cause frowsiness and dizziness. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 33 - Take precautionary measures against static discharge. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Eye irritation (Category 2A), H319 | |
| GHS Label elements, including precautionary statements | |
| Pictogram |   |
| Signal word | Danger |
| Hazard statement(s) | |
| H225 - Highly Flammable liquid and vapour H319 - Causes serious eye irritation H336 - May cause drowsiness or dizziness | |
| Precautionary statement(s) | |
| P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233 - Keep container tightly closed. P240 - Ground/bond container and receiving equipment. P241 - Use explosion-proof electrical/ventilating/lighting/…/equipment. P242 - Use only non-sparking tools. P243 - Take precautionary measures against static discharge. P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 - Call a POISON CENTER or doctor/physician if you feel unwell. P337 + P313 - IF eye irritation persists: Get medical advice/attention. P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. P403 + P233 - Store in a well-ventilated place. Keep container tightly closed. P403 + P235 - Store in a well-ventilated place. Keep cool. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Human Experience: | |
| 10 % solution: no irritation or sensitization. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 5620 mg/kg Yakkyoku. Pharmacy. Vol. 32, Pg. 1241, 1981. oral-rabbit LD50 4935 mg/kg Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972. oral-mouse LD50 4100 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(4), Pg. 66, 1983. intraperitoneal-mouse LD50 709 mg/kg Shell Chemical Company. Unpublished Report. Vol. -, Pg. 5, 1961. oral-guinea pig LD50 5500 mg/kg BEHAVIORAL: COMA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(4), Pg. 66, 1983. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 > 20 ml/kg Yakkyoku. Pharmacy. Vol. 32, Pg. 1241, 1981. subcutaneous-guinea pig LD50 3000 mg/kg Yakkyoku. Pharmacy. Vol. 32, Pg. 1241, 1981. subcutaneous-cat LD50 3000 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. subcutaneous-guinea pig LD50 3000 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. skin-rabbit LD50 > 20 mL/kg Union Carbide Data Sheet. Vol. 10/4/1968 subcutaneous-rat LDLo 5000 mg/kg Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 18, Pg. 45, 1943. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 200000 mg/m3 Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 18, Pg. 45, 1943. inhalation-mouse LC50 45000 mg/m3 Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 18, Pg. 45, 1943. inhalation-cat LCLo 61000 mg/m3 "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 336, 1955. inhalation-human TCLo 400 ppm LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943. inhalation-mouse LC50 45000 mg/m3/2H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 65, 1982. inhalation-rat LC50 200000 mg/m3 GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989. | |
Safety in use information
| Category: | |||
| flavor and fragrance agents, carrier solvents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for ethyl acetate usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3. Update in publication number(s): 29 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 154.00000 | 211.00000 | |
| beverages(nonalcoholic): | 42.00000 | 67.00000 | |
| beverages(alcoholic): | 100.00000 | 200.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 1190.00000 | 10000.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 66.00000 | 110.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | 73.00000 | 200.00000 | |
| granulated sugar: | - | - | |
| gravies: | 20.00000 | 40.00000 | |
| hard candy: | 149.00000 | 7500.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 0.10000 | 0.10000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | 8.00000 | 15.00000 | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 113.00000 | 5000.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 5: Esters of 23 branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and 24 branched- and straight-chain unsaturated carboxylic acids from chemical groups 1, 2, and 5 View page or View pdf |
| Flavouring Group Evaluation 5, Revision 1 (FGE.05Rev1):Esters of branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched- and straight-chain unsaturated carboxylic acids from chemical groups 1, 2, and 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 5, Revision 2 (FGE.05Rev2): Branched- and straight-chain unsaturated carboxylic acids and esters of these with aliphatic saturated alcohols from chemical groups 1, 2, 3 and 5 View page or View pdf |
| Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils Part I of III View page or View pdf |
| Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species View page or View pdf |
| Risk Assessment of Food Contact Materials View page or View pdf |
| EPI System: View |
| EPA-Iris:IRIS |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):141-78-6 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :8857 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 1173 |
| WGK Germany:1 |
| ethyl acetate |
| Chemidplus:0000141786 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:141-78-6 |