leather propionate

Leather propionate, known chemically as Ethyl β-hydroxybenzenepropanoate, is a synthetic ester compound with molecular formula C₁₁H₁₄O₃. It typically appears as a clear liquid and is recognized for its medium-strength fruity and leather-like odor qualities, accompanied by strawberry and dry straw nuances. The compound is also identified under various synonyms including ethyl 3-hydroxy-3-phenylpropionate and the trade name Labdanax (IFF). Leather propionate is primarily synthesized for use in fragrance compositions, where its characteristic aroma contributes to oriental, amber, and balsamic scent profiles. Detailed chemical information and structure are available via the PubChem database. This material is derived through chemical esterification processes involving β-hydroxybenzenepropanoic acid derivatives.

Leather propionate does not naturally occur in biological systems but is manufactured for its distinctive olfactory properties that blend fruity, leather, and balsamic notes with a strawberry nuance. The ingredient is widely utilized in the fragrance industry as a perfuming agent, enhancing complexity in compositions categorized as amber, oriental, or leather accords. It has potential applications in high-end perfumes, scented products, and formulations requiring a durable leather-like aroma. Regulatory bodies such as IFRA (Global) provide guidelines ensuring its safe concentration in fragrance concentrates, recommending usage levels up to 5% to maintain consumer safety. Leather propionate is not intended for flavoring purposes under current standards.

Leather propionate exhibits a specific gravity ranging from approximately 1.092 to 1.101 at 20–25 °C, indicating a density slightly higher than water. It has a refractive index between 1.507 and 1.513 at 20 °C, which influences its optical properties in formulations. The compound's estimated logP value near 1.46 indicates moderate lipophilicity, facilitating compatibility with diverse fragrance bases. Its vapor pressure is very low at about 0.000186 mmHg at 25 °C, contributing to its substantivity and slow evaporation rate noted as 284 hours at 100% concentration. The flash point is estimated at 212 °F (100 °C), defining its handling and storage conditions. Leather propionate dissolves readily in alcohols and has limited solubility in water by weight (approximately 7553 mg/L at 25 °C), influencing its behavior in different solvents used by perfumers.

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Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for leather propionate usage levels up to:
	5.0000 % in the fragrance concentrate.
Recommendation for leather propionate flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

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Toxicology Citations:Search

EPA Substance Registry Services (TSCA):5764-85-2

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :99818

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

ethyl 3-cyclohexyl-3-hydroxypropanoate

Chemidplus:0005764852