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ascorbic acid
General Material Information
| Preferred name | ascorbic acid |
| Trivial Name | L-Ascorbic acid |
| Short Description | (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one |
| Formula | C6 H8 O6 |
| CAS Number | 50-81-7 |
| Deleted CAS Number | 129940-97-2 |
| FEMA Number | 2109 |
| ECHA Number | 200-066-2 |
| FDA UNII | PQ6CK8PD0R |
| Nikkaji Number | J2.301I |
| Beilstein Number | 0084272 |
| MDL | MFCD00064328 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 50-81-7 ; ASCORBIC ACID |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
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| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanone | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 50-81-7 |
| Pubchem (cid): | 54670067 |
| Pubchem (sid): | 134971787 |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00072 |
| HMDB (The Human Metabolome Database): | HMDB00044 |
| FooDB: | FDB001224 |
| Export Tariff Code: | 2936.27.0000 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 176.12495422363 |
| Melting Point | 191 to 193°C @ 760 mm Hg |
| Flash Point TCC Value | 100 °C TCC |
| logP (o/w) | -1.85 |
| Solubility | |
| water, 400000 mg/L @ 40C (exp) | Yes |
| paraffin oil | No |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Other purposes | Antioxidants, Buffering agents, Skin conditioning |
| Cosmetic purposes | Antioxidants, Buffering agents, Fragrance, Skin conditioning |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| None - None found. | |
| S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 11900 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976. intravenous-rat LD50 > 4000 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976. oral-mouse LD50 3367 mg/kg National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986 intravenous-mouse LD50 518 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 269, 1970. intraperitoneal-mouse LD50 643 mg/kg Progress in Mutation Research. Vol. 1, Pg. 682, 1981. intravenous-man TDLo 2300 mg/kg/2D BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA Annals of Internal Medicine. Vol. 82, Pg. 810, 1975. | |
| Dermal Toxicity: | |
| subcutaneous-rat LD50 > 10000 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| cosmetic and flavor agents | |||
| Recommendation for ascorbic acid usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 1.00000 | 500.00000 | |
| beverages(nonalcoholic): | - | 130.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 0.80000 | 250.00000 | |
| fruit ices: | 0.80000 | 250.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 4.00000 | 6000.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 0.49000 | 470.00000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | 280.00000 | 380.00000 | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Authority (EFSA) reference(s): |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd View page or View pdf |
| Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid and sodium calcium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG View page or View pdf |
| Conclusion on the peer review of the pesticide risk assessment of the active substance L-ascorbic acid View page or View pdf |
| Scientific Opinion on Dietary Reference Values for vitamin C View page or View pdf |
| Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin C View page or View pdf |
| Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006 View page or View pdf |
| Scientific Opinion on the re-evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives View page or View pdf |
| Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 View page or View pdf |
| Pesticide active substances that do not require a review of the existing maximum residue levels under Article 12 of Regulation (EC) No 396/2005 View page or View pdf |
| Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 View page or View pdf |
| Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for L-ascorbic acid in light of confirmatory data View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):50-81-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :54670067 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanone |
| Chemidplus:0000050817 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:50-81-7 |