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    General Material Information
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manzanate (Givaudan)

Chemical Structure

General Material Information

Preferred name manzanate (Givaudan)
Trivial Name Ethyl 2-methylpentanoate
Short Description ethyl 2-methylpentanoate
Formula C8 H16 O2
CAS Number 39255-32-8
FEMA Number 3488
Flavis Number 9.526
ECHA Number 254-384-1
FDA UNII 405SN8638D
Nikkaji Number J101.336J
MDL MFCD00036564
COE Number 10616
xLogP3-AA 2.40 (est)
NMR Predictor External link
JECFA Food Flavoring 214 ethyl 2-methyl pentanoate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 39255-32-8 ; ETHYL 2-METHYLPENTANOATE
Synonyms
  • applinate
  • ethyl 2 methyl pentanoate (manzanate)
  • ethyl 2-methyl pentanoate
  • ethyl 2-methyl valerate
  • ethyl 2-methyl-4-pentanoate
  • ethyl 2-methylpentanoate
  • ethyl 2-methylpentanoate (manzanate)
  • ethyl 2-methylpentanoate FCC
  • ethyl 2-methylvalerate
  • ethyl a-methylvalerate
  • ethyl alpha-methyl valerate
  • ethyl-2-methyl pentanoate
  • ethyl-2-methyl pentanoate (manzanate type)
  • ethyl-2-methyl valerate
  • ethyl-2-methylpentanoate
  • ethyl-2-methylvalerate
  • mazanate (Tadimety)
  • melon valerate
  • 2-methyl pentanoic acid ethyl ester
  • 2-methylpentanoic acid ethyl ester
  • 2-methylvaleric acid ethyl ester
  • pentanoic acid, 2-methyl-, ethyl ester
  • Ethyl α-methylvalerate
  • Manzanate

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

Leffingwell:Chirality or Article
ethyl 2-methylpentanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:39255-32-8
Pubchem (cid):62902
Pubchem (sid):135020072
Publications by PubMed
Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.) seeds.
Enantioselective carbonyl reduction of eperisone in human liver microsomes.
Management of experimental benign prostatic hyperplasia in rats using a food-based therapy containing Telfairia occidentalis seeds.
Isovaleric acid accumulation in odontocete melon during development.
High concentrations of isovaleric acid in the fats of odontocetes: variation and patterns of accumulation in blubber vs. stability in the melon.
2-Methylacetoacetyl-coenzyme A reductase from Ascaris muscle: purification and properties.
Role of isovaleroyl lipids in channeling of sound in the porpoise melon.
Rapid determination of valproate sodium in serum by gas-liquid chromatography.
Positional analysis of isovaleroyl triglycerides using proton magnetic resonance with Eu(fod)3 and Pr(fod)3 shift reagents: II. Cetacean triglycerides.
Heterogeneity of lipid composition within the cephalic melon tissue of the pilot whale (Globicephala melaena).
Isovaleroyl triglycerides from the blubber and melon oils of the beluga whale (Delphinapterus leucas).
Unique lipids of the porpoise (Tursiops gilli): differences in triacyl glycerols and wax esters of acoustic (mandibular canal and melon) and blubber tissues.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB31579
FooDB:FDB008204
Export Tariff Code:2915.60.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 144.21391296387
Boiling Point 152 to 153°C @ 760 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 2.906 mmHg @ 25 °C
Flash Point TCC Value 40.56 °C TCC
logP (o/w) 2.667 est
Solubility
alcohol Yes
water, 356.7 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Green
fresh, fruity, green, melon, apple skin, pineapple, natural, waxy, fatty
Odor strength medium , recommend smelling in a 10.00 % solution or less
Substantivity > 4 hour(s) at 100.00 %
Luebke, William tgsc, (1988) At 10.00 % in dipropylene glycol. fresh fruity green melon apple skin pineapple natural waxy
Mosciano, Gerard P&F 19, No. 3, 51, (1994) Fruity, green, melon and waxy with a fatty nuance
Flavor Type: Cooling
cooling, green, cucumber, tropical, oily
Mosciano, Gerard P&F 19, No. 3, 51, (1994) At 30.00 ppm. Cooling, green, cucumber, tropical and oily
A variety of fruit flavors, especially ripe strawberry and sweet pineapple. Fruity, ripe strawberry, sweet pineapple with acidic cheesy background
General comment Cooling green cucumber tropical oily

Occurrences

Potential Uses

Applications
Odor purposes Apple, Cucumber, Fresh and clean, Green, Herbal, Honeydew, Lily, Melon, Musk, Neroli, Pineapple, Valerian
Flavoring purposes Tropical, Valerian
Other purposes Topnotes
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for manzanate (Givaudan) usage levels up to:
2.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 6.50 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 10
Click here to view publication 10
average usual ppmaverage maximum ppm
baked goods: -400.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -1500.00000
condiments / relishes: -30.00000
confectionery froastings: -500.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -100.00000
fruit ices: -100.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 1, Revision 1 (FGE.01Rev 1): Branched-chain aliphatic saturated aldehydes, carboxylic acids and related esters of primary alcohols and branched-chain carboxylic acids from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
View page or View pdf

Flavouring Group Evaluation 01 Rev2 (FGE.01 Rev2): Branched-chain aliphatic saturated aldehydes, carboxylic acids and related esters of primary alcohols and branched-chain carboxylic acids from chemical groups 1 and 2
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):39255-32-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62902
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3272
WGK Germany:2
ethyl 2-methylpentanoate
Chemidplus:0039255328