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terpinolene

Chemical Structure

General Material Information

Preferred name terpinolene
Trivial Name Terpinolene
Short Description 4-isopropylidene-1-methylcyclohexene
Formula C10 H16
CAS Number 586-62-9
FEMA Number 3046
Flavis Number 1.005
ECHA Number 209-578-0
FDA UNII N9830X5KSL
Nikkaji Number J9.438B
Beilstein Number 1851203
MDL MFCD00049191
COE Number 2115
xLogP3-AA 2.80 (est)
NMR Predictor External link
JECFA Food Flavoring 1331 terpinolene
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 586-62-9 ; TERPINOLENE
Synonyms
  • cyclohexene, 1-methyl-4-(1-methylethylidene)-
  • cyclohexene, 3-methyl-6-(1-methylethylidene)-
  • p- menth-1,4,8-diene
  • para- menth-1,4,8-diene
  • p- menth-1,4(8)-diene
  • p- mentha-1,4,8-diene
  • para- mentha-1,4,8-diene
  • p- mentha-1,4(8)-diene
  • para- mentha-1,4(8)-diene
  • 1,4(8)-p- menthadiene
  • 1,4(8)-para- menthadiene
  • p- meth-1-en-8-yl-formate
  • 1-methyl-4-(1-methyl ethylidene) cyclohexene
  • 1-methyl-4-(1-methylethylidene)-1-cyclohexene
  • 1-methyl-4-(1-methylethylidene)cyclohexene
  • 1-methyl-4-(propan-2-ylidene)cyclohexene
  • 1-methyl-4-isopropylidene-1-cyclohexene
  • 1-methyl-4-propan-2-ylidenecyclohexene
  • nofmer TP
  • 4-iso propylidene-1-methyl cylohexene
  • 4-iso propylidene-1-methylcyclohexene
  • 4-iso propylidene-1-methylcylohexene
  • 1,4,8-terpadiene
  • 1,4(8)- terpadiene
  • iso terpinene
  • terpineolene
  • terpinolene 20
  • terpinolene 30
  • terpinolene 90
  • terpinolene 90 PQ
  • terpinolene 95 PF
  • terpinolene natural
  • terpinolene rect.
  • terpinolene special rein 95%
  • 1-methyl-4-propan-2-ylidenecyclohexene
  • p-Mentha-1,4(8)-diene
  • 1-Methyl-4-(1-methylethylidene)cyclohexene
  • α-Terpinolene
  • Terpinolen
  • 4-Isopropylidene-1-methylcyclohexene
  • Isoterpinene
  • δ-Terpinene
  • Terpinolene 95PF
  • 1-Methyl-4-propan-2-ylidene-cyclohexene
  • 1-Methyl-4-(propan-2-ylidene)cyclohex-1-ene
  • δ-Terpinolene

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

1-methyl-4-propan-2-ylidenecyclohexene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:586-62-9
Pubchem (cid):11463
Pubchem (sid):134975967
Flavornet:586-62-9
Pherobase:View
Publications by PubMed
A novel synthetic pathway for tropolone ring formation via the olefin monoterpene intermediate terpinolene in cultured Cupressus lusitanica cells.
An expedient synthesis of linden ether.
Analysis of volatile components extracted from the peels of four different Chinese pomelos using TDS-GC-MS.
Terpene constituents of the leaves of five Vietnamese species of Clausena (Rutaceae).
Exocrine secretions of wheel bugs (Heteroptera: Reduviidae: Arilus spp.): clarification and chemistry.
Genotoxic and oxidative damage potentials in human lymphocytes after exposure to terpinolene in vitro.
Review of Pharmacological Effects of Myrtus communis L. and its Active Constituents.
Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites.
CYP345E2, an antenna-specific cytochrome P450 from the mountain pine beetle, Dendroctonus ponderosae Hopkins, catalyses the oxidation of pine host monoterpene volatiles.
Bacteria isolated from roots and rhizosphere of Vitis vinifera retard water losses, induce abscisic acid accumulation and synthesis of defense-related terpenes in in vitro cultured grapevine.
Anticancer and antioxidant properties of terpinolene in rat brain cells.
Vibrational spectroscopy as a rapid quality control method for Melaleuca alternifolia cheel (tea tree oil).
In vitro and in vivo anti-tobacco mosaic virus activities of essential oils and individual compounds.
Chemical composition of essential oils and in vitro antioxidant activity of fresh and dry leaves crude extracts of medicinal plant of Lactuca Sativa L. native to Sultanate of Oman.
Functional characterization of myrcene hydroxylases from two geographically distinct Ips pini populations.
The sedative effect of inhaled terpinolene in mice and its structure-activity relationships.
Comparative study of the chemical composition of essential oils of five Tagetes species collected in Venezuela.
Distillation time alters essential oil yield, composition, and antioxidant activity of male Juniperus scopulorum trees.
Chemical composition, antimicrobial, antioxidant and cytotoxic activity of essential oils of Plectranthus cylindraceus and Meriandra benghalensis from Yemen.
Determination of chemical constituents of leaf and stem essential oils of Artemisia monosperma from central Saudi Arabia.
Esterification of bio-oil from mallee (Eucalyptus loxophleba ssp. gratiae) leaves with a solid acid catalyst: Conversion of the cyclic ether and terpenoids into hydrocarbons.
Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract.
A gas chromatography-mass spectrometry assay to quantify camphor extracted from goat serum.
Exposure to Anacardiaceae volatile oils and their constituents induces lipid peroxidation within food-borne bacteria cells.
Growth-inhibiting effects of Paeonia lactiflora root steam distillate constituents and structurally related compounds on human intestinal bacteria.
Differences in the volatile compositions of ginseng species (Panax sp.).
Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells.
Contact and fumigant toxicity of Cyperus rotundus steam distillate constituents and related compounds to insecticide-susceptible and -resistant Blattella germanica.
New monocyclic monoterpenoid glycoside from Mentha haplocalyx Briq.
Alleviating monoterpene toxicity using a two-phase extractive fermentation for the bioproduction of jet fuel mixtures in Saccharomyces cerevisiae.
Isolation and identification of host cues from mango, Mangifera indica, that attract gravid female oriental fruit fly, Bactrocera dorsalis.
Degradation of terpenes and terpenoids from Mediterranean rangelands by mixed rumen bacteria in vitro.
Chemical constituents of the essential oil from aerial parts and fruit of Anisosciadium orientale.
Chemical stability of extra-virgin olive oil added with oregano essential oil.
Metabolism of terpenes in the response of grape (Vitis vinifera L.) leaf tissues to UV-B radiation.
Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass).
Larvicidal and repellent activity of Hyptis suaveolens (Lamiaceae) essential oil against the mosquito Aedes albopictus Skuse (Diptera: Culicidae).
Chemical composition, antimicrobial, and cytotoxicity studies on S. erianthum and S. macranthum essential oils.
Modulation of volatile organic compound formation in the Mycodiesel-producing endophyte Hypoxylon sp. CI-4.
Fire injury reduces inducible defenses of lodgepole pine against Mountain pine beetle.
Helichrysum gymnocephalum essential oil: chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations.
Composition and antimicrobial activity of the essential oil of Heracleum thomsonii (Clarke) from the cold desert of the western Himalayas.
Volatile constituents and antioxidant activity of flowers, stems and leaves of Nasturtium officinale R. Br.
Comparative study of volatile oil compositions of two Plectranthus species from northern India.
Reciprocal interactions between the bark beetle-associated yeast Ogataea pini and host plant phytochemistry.
Antimicrobial activity and chemical constituents of the essential oils from flower, leaf and stem of Gypsophila bicolor from Iran.
α-Pinene- and β-myrcene-rich volatile fruit oil of Cupressus arizonica Greene from northwest Iran.
Survey of ex situ fruit and leaf volatiles from several Pistacia cultivars grown in California.
Comparison of volatile constituents, and antioxidant and antibacterial activities of the essential oils of Thymus caucasicus, T. kotschyanus and T. vulgaris.
Chemoprevention by essential oil of turmeric leaves (Curcuma longa L.) on the growth of Aspergillus flavus and aflatoxin production.
Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds.
Effectiveness of different solid-phase microextraction fibres for differentiation of selected Madeira island fruits based on their volatile metabolite profile--identification of novel compounds.
Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: study on the mechanism of action.
Comparative analysis of essential oil components of two Pinus species from Taibai Mountain in China.
Composition of volatile organic compounds in flowers of Astragalus sahendi.
Solid-phase microextraction of volatile organic compounds released from leaves and flowers of Artemisia fragrans, followed by GC and GC/MS analysis.
The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies.
Chemical composition and antibacterial activity of essential oil of Heracleum rechingeri Manden from Iran.
Inhibition of predator attraction to kairomones by non-host plant volatiles for herbivores: a bypass-trophic signal.
Complex interactions among host pines and fungi vectored by an invasive bark beetle.
A biochemical interpretation of terpene chemotypes in Melaleuca alternifolia.
Chemical characterization of orange juice from trees infected with citrus greening (Huanglongbing).
MSU-S mesoporous materials: an efficient catalyst for isomerization of alpha-pinene.
Chemical composition and antibacterial, antifungal and antioxidant activities of the flower oil of Retama raetam (Forssk.) Webb from Tunisia.
Acetylcholinesterase and butyrylcholinesterase inhibitory activity of Pinus species essential oils and their constituents.
Essential oil yield and composition of Pistacia vera 'Kerman' fruits, peduncles and leaves grown in California.
[Simultaneous determination of alpha-pinene, beta-pinene, eucalyptol and alpha-terpineolin in essential oil from Alpinia officinarum Hance by GC].
The role of secreting structures position on the leaf volatile organic compounds of Hypericum androsaemum.
Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor.
Larvicidal activity of compounds isolated from Asarum heterotropoides against Culex pipiens pallens, Aedes aegypti, and Ochlerotatus togoi (Diptera: Culicidae).
Seasonal variation in the essential oil composition of Origanum majorana L. cultivated in Egypt.
Headspace volatile composition of the flowers of Caralluma europaea N.E.Br. (Apocynaceae).
Repellency of essential oils of Cryptomeria japonica (Pinaceae) against adults of the mosquitoes Aedes aegypti and Aedes albopictus (Diptera:Culicidae).
In vitro antiviral activity of Melaleuca alternifolia essential oil.
Supercritical fluid extraction of the volatile oil from Santolina chamaecyparissus.
Evaluation of monoterpenes for the control of Tribolium castaneum (Herbst) and Sitophilus zeamaise Motschulsky.
Chemical composition and antimicrobial activity of Clausena indica (Dalz) Oliv. (Rutaceae) essential oil from Vietnam.
Antibacterial activity and composition of essential oils from flower, leaf and stem of Chaerophyllum macropodum Boiss. from Iran.
Control and reduction of peak temperature in self-curing resins.
Formation of organic acids from the gas-phase ozonolysis of terpinolene.
HIV-1-inhibiting activity of the essential oil of Ridolfia segetum and Oenanthe crocata.
Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry.
Insecticidal activities of leaf and twig essential oils from Clausena excavata against Aedes aegypti and Aedes albopictus larvae.
Volatile and non-volatile monoterpenes produced by elicitor-stimulated Cupressus lusitanica cultured cells.
Analysis of volatiles in dehydrated carrot samples by solid-phase microextraction followed by GC-MS.
Effect of adhesive matrix composition and terpinolene on indomethacin bioavailability in rats from transdermal therapeutic system.
Synergistic blends of monoterpenes for aggregation pheromones of the mountain pine beetle (Coleoptera: Curculionidae).
Organosulfate formation in biogenic secondary organic aerosol.
Responses of the Mediterranean pine shoot beetle Tomicus destruens (Wollaston) to pine shoot and bark volatiles.
Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia.
A comparison of volatile components from the peel of Ohshima no. 1 with its parent cultivars.
Chemical composition and fungitoxic activity of essential oil of Thuja orientalis L. grown in the north-western Himalaya.
Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport.
Characterization of steam volatiles in the essential oil of black currant buds and the antioxidant properties of different bud extracts.
The essential oil qualitative and quantitative composition in the needles of Pinus sylvestris L. growing along industrial transects.
Variations in insecticidal activity and chemical compositions of leaf essential oils from Cryptomeria japonica at different ages.
Antimicrobial activity and the major components of the essential oil of Plectranthus cylindraceus.
Composition and enantiomeric analysis of the essential oil of the fruits and the leaves of Pistacia vera from Greece.
Analysis of volatile compounds emitted from fresh Syringa oblata flowers in different florescence by headspace solid-phase microextraction-gas chromatography-mass spectrometry.
Cloning and functional characterization of three terpene synthases from lavender (Lavandula angustifolia).
Comparison of pistachio hull essential oils from different Tunisian localities.
The effect of the volatile oil from ginger rhizomes (Zingiber officinale), its fractions and isolated compounds on the 5-HT3 receptor complex and the serotoninergic system of the rat ileum.
Comparative analysis of the oil and supercritical CO2 extract of Ridolfia segetum (L.) Moris.
Role of host volatiles in mate location by the Japanese pine sawyer, Monochamus alternatus hope (Coleoptera: Cerambycidae).
Growth-inhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria.
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products.
From terpenoids to aliphatic acids: further evidence for late-instar switch in osmeterial defense as a characteristic trait of swallowtail butterflies in the tribe papilionini.
[Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry].
Changes in terpene content in milk from pasture-fed cows.
Cleaning products and air fresheners: emissions and resulting concentrations of glycol ethers and terpenoids.
Evaluation of extracts and oils of mosquito (Diptera: Culicidae) repellent plants from Sweden and Guinea-Bissau.
Essential oil composition and antimicrobial activity of Diplotaenia damavandica.
Identification of characteristic aroma-active compounds from water dropwort (Oenanthe javanica DC.).
Effects of gamma-terpinene, terpinolene, alpha-copaene, and alpha-terpinene on consumption of alfalfa pellets by sheep.
The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL.
Influence of environmental factors on composition of volatile constituents and biological activity of Helichrysum italicum (Roth) Don (Asteraceae).
Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii.
The effect of terpenoid extracts from 15 pine species on the feeding behavioural sequence of the late instars of the pine processionary caterpillar Thaumetopoea pityocampa.
Chemical characterization and antifungal activity of essential oil of capitula from wild Indian Tagetes patula L.
Volatile components from mango (Mangifera indica L.) cultivars.
Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways.
Particle phase acidity and oligomer formation in secondary organic aerosol.
Comparative analysis of the oil and supercritical CO2 extract of Elettaria cardamomum (L.) Maton.
Secondary organic aerosol formation from the ozonolysis of cycloalkenes and related compounds.
Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil.
Mono and diterpene production in Escherichia coli.
Essential oil composition of the leaves and stems of Meum athamanticum Jacq., from Spain.
Evaluation of antioxidant activity of Australian tea tree (Melaleuca alternifolia) oil and its components.
Biotransformation of (R)-(+)- and (S)-(-)-citronellol by Aspergillus sp. and Penicillium sp., and the use of solid-phase microextraction for screening.
Antioxidative properties of the essential oil from Pinus mugo.
Monoterpenes produced by Cupressus lusitanica cultured cells including a novel monoterpene (1R, 2S, 6S)-(+)-1,6-epoxy-4(8)-p-menthen-2-ol [corrected].
Changes in volatile compounds of carrots (Daucus carota L.) during refrigerated and frozen storage.
Chemical composition and in vitro evaluation of antioxidant effect of free volatile compounds from Satureja montana L.
Preferred age for assessment of qualitative and quantitative characteristics of the essential oil of tea tree (Melaleuca alternifolia) seedlings prior to plantation establishment.
Effects of hydration, lipids, and temperature on the binding of the volatile aroma terpenes by beta-lactoglobulin powders.
Monoterpenoid accumulation in 1,8-cineole, terpinolene and terpinen-4-ol chemotypes of Melaleuca alternifolia seedlings.
Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase.
Genetic control of monoterpene composition in the essential oil of Melaleuca alternifolia (Cheel).
Volatile emissions of eastern hemlock, Tsuga canadensis, and the influence of hemlock woolly adelgid.
Detoxification of terpinolene by plant pathogenic fungus Botrytis cinerea.
Determination of monoterpene hydrocarbons and alcohols in Majorana hortensis Moench by micellar electrokinetic capillary chromatographic.
Effects of storage conditions on the composition of Citrus tamurana Hort. ex Tanaka (hyuganatsu) essential oil.
Monoterpenoid accumulation in Melaleuca alternifolia seedlings.
Comparing the variation of needle and wood terpenoids in Scots pine provenances.
Volatile oil comparison of cotyledon leaves of chemotypes of Melaleuca alternifolia.
Isotope ratio by HRGC-MS of citrus Junos tanaka (yuzu) essential oils: m/z 137/136 of terpene hydrocarbons.
Five phloroglucinol-monoterpene adducts from Eucalyptus grandis.
In vitro studies on penetration of terpenes from matrix-type transdermal systems through human skin.
Hydroquinone derivatives and monoterpenoids from the Neotropical liverwort Plagiochila rutilans.
Strategies of a bark beetle, Pityogenes bidentatus, in an olfactory landscape.
Radical-scavenging activities of citrus essential oils and their components: detection using 1,1-diphenyl-2-picrylhydrazyl.
Volatile components of green walnut husks.
Effects of branched cyclodextrins on the solubility and stability of terpenes.
Natural variation in the essential oil content of Melaleuca alternifolia Cheel (Myrtaceae).
Chemoenzymatic synthesis of homochiral (R)- and (S)-karahanaenol from (R)-limonene.
Encapsulation of lemon oil by paste method using beta-cyclodextrin: encapsulation efficiency and profile of oil volatiles.
Inhibitory effects of citrus essential oils and their components on the formation of N-nitrosodimethylamine.
Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L.
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).
Evaluation of anti-inflammatory-related activity of essential oils from the leaves and resin of species of Protium.
The essential oil of Senecio graveolens (Compositae): chemical composition and antimicrobial activity tests.
Degradation products of monoterpenes are the sensitizing agents in tea tree oil.
Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase.
Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint (Mentha x piperita, L.) that produces the aphid alarm pheromone (E)-beta-farnesene.
Aerobic biodegradation of selected monoterpenes.
Decomposition of Terpenes by Ozone during Sampling on Tenax.
Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia.
Photooxidant-forming monoterpenes in air plumes from kraft pulp industries.
Attraction of bark beetles,Tomicus piniperda,Hylurgops palliatus, andTrypodendron domesticum and other insects to short-chain alcohols and monoterpenes.
[Studies on chemical constituents of the essential oil of Cyclorhiza waltonii].
Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage.
Effect of limonene and related compounds on the percutaneous absorption of indomethacin.
Gallery initiation byTomicus piniperda (Coleoptera: Scolytidae) on scots pine trees baited with host volatiles.
Demonstration that limonene is the first cyclic intermediate in the biosynthesis of oxygenated p-menthane monoterpenes in Mentha piperita and other Mentha species.
Soldier-specific chemicals of the termiteCurvitermes strictinasus Mathews (Isoptera, Nasutitermitinae).
Contact dermatitis to terpene derivatives in a machine cleaner.
Effect of various essential oils isolated from Douglas fir needles upon sheep and deer rumen microbial activity.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C06075
HMDB (The Human Metabolome Database):HMDB36994
FooDB:FDB015966
Export Tariff Code:2902.19.0050
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 136.23751831055
Specific gravity @ 25 °C
Pounds per Gallon 7.322 to 7.406
Refractive Index 1.46 to 1.464 @ 20 °C
Boiling Point 183 to 185°C @ 760 mm Hg
Vapor Pressure 1.126 mmHg @ 25 °C
Vapor Density 4.7
Flash Point TCC Value 64.44 °C TCC
logP (o/w) 4.47
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
water, 9.5 mg/L @ 23C (exp) Yes
Stability
antiperspirant Good
fabric softener Good
liquid detergent Good
soap Good
deo stick Unspecified
hard surface cleaner Unspecified
shampoo Unspecified
alcoholic fine fragrance Fair
perborate powder detergent Poor

Organoleptic Properties

Odor Type: Herbal
fresh, woody, sweet, pine, citrus, lemon peel
Odor strength medium , recommend smelling in a 10.00 % solution or less
Substantivity 4 hour(s) at 100.00 %
Luebke, William tgsc, (1985) At 10.00 % in dipropylene glycol. fresh woody sweet pine citrus
Mosciano, Gerard P&F 25, No. 6, 26, (2000) At 1.00 %. Sweet, fresh, piney citrus with a woody old lemon peel nuance
Flavor Type: Woody
woody, terpenic, lemon, lime, herbal, floral
Mosciano, Gerard P&F 25, No. 6, 26, (2000) At 2.00 - 25.00 ppm. Woody, terpy, lemon and lime-like with a slight herbal and floral nuance

Occurrences

Potential Uses

Applications
Odor purposes Ajowan, Bergamot, Citrus, Coriander, Eucalyptus oil replacer, Lemon, Lime, Mango, Pine, Pine forest, Spice
Flavoring purposes Ajowan, Coriander
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 65 - Harmful: may cause lung damage if swallowed.
S 02 - Keep out of the reach of children.
S 23 - Do not breath spray.
S 24/25 - Avoid contact with skin and eyes.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
10 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 4.39 ml/kg
Observation period not given.
(Levenstein, 1975o)

oral-rat LD50 4390 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 877, 1976.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 877, 1976.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for terpinolene usage levels up to:
50.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 660.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 70.00 (μg/capita/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -49.00000
beverages(nonalcoholic): -16.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -64.00000
fruit ices: -64.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 0.1200048.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 25, (FGE.25)[1] - Aliphatic and aromatic hydrocarbons from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 78 (FGE.78)[1] - Consideration of Aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25 - Scientific Opinion of the Panel on Food Additives,Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 25Rev1: Aliphatic and aromatic hydrocarbons from chemical group 31
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 78, Revision 1 (FGE.78Rev1): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25Rev2
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31
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Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species
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Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3
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EPA Substance Registry Services (TSCA):586-62-9
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1-methyl-4-propan-2-ylidenecyclohexene
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