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isopropyl alcohol
General Material Information
| Preferred name | isopropyl alcohol |
| Trivial Name | Isopropanol |
| Short Description | isopropanol |
| Formula | C3 H8 O |
| CAS Number | 67-63-0 |
| FEMA Number | 2929 |
| Flavis Number | 2.079 |
| ECHA Number | 200-661-7 |
| FDA UNII | ND2M416302 |
| Nikkaji Number | J1.411G |
| Beilstein Number | 0635639 |
| MDL | MFCD00011674 |
| xLogP3-AA | 0.30 (est) |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 277 isopropyl alcohol |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 67-63-0 ; ISOPROPYL ALCOHOL |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| propan-2-ol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 67-63-0 |
| Pubchem (cid): | 3776 |
| Pubchem (sid): | 134970723 |
| Pherobase: | View |
| Publications by Info | |
| Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.) | |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C01845 |
| HMDB (The Human Metabolome Database): | HMDB00863 |
| FooDB: | FDB008282 |
| YMDB (Yeast Metabolome Database): | YMDB01718 |
| Export Tariff Code: | 2905.12.0050 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 60.095958709717 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 6.474 to 6.565 |
| Refractive Index | 1.367 to 1.378 @ 20 °C |
| Melting Point | -83 to -81°C @ 760 mm Hg |
| Boiling Point | 82 to 83°C @ 760 mm Hg |
| Boiling Point | 38 to 39°C @ 100 mm Hg |
| Vapor Pressure | 81.332001 mmHg @ 25 °C |
| Vapor Density | 2.1 |
| Flash Point TCC Value | 11.67 °C TCC |
| logP (o/w) | 0.05 |
| Solubility | |
| alcohol | Yes |
| ether | Yes |
| water, 4.024e+005 mg/L @ 25 °C (est) | Yes |
| water, 1.00E+06 mg/L @ 25 °C (exp) | Yes |
Organoleptic Properties
| Odor Type: Alcoholic | |
| alcoholic, musty, woody | |
| Odor strength | medium , recommend smelling in a 10.00 % solution or less |
| Substantivity | 4 hour(s) at 100.00 % |
| Luebke, William tgsc, (1986) | At 10.00 % in dipropylene glycol. alcohol musty woody |
| Flavor Type: Alcoholic | |
| dry, alcoholic, woody, musty | |
| Luebke, William tgsc, (1986) | Dry alcoholic woody musty |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Aldehydic, Apple, Apricot, Banana, Bluebell, Cognac, Currant, Gooseberry, Green |
| Cosmetic purposes | Antifoaming agents, Perfuming agents, Solvents, Viscosity controlling agents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 11 - Highly flammable. R 36 - Irritating to eyes. R 67 - Vapours may cause frowsiness and dizziness. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 5840 mg/kg (Smyth & Carpenter, 1948) oral-rat LD50 5280 mg/kg (Lehman & Chase, 1944) oral-rat LD50 5300 mg/kg (Kimura et al., 1971a) oral-rat LD50 5330 mg/kg (FDA, 1975a) oral-mouse LD50 5070 mg/kg (FDA, 1975a) oral-rabbit LD50 5040 mg/kg (Lehman & Chase, 1944) oral-rabbit LD50 7990 mg/kg (Munch, 1972) intraperitoneal-guinea pig LD50 2560 mg/kg (Munch, 1972) intravenous-cat LDLo 1963 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 172, 1955. oral-cat LDLo 6 mL/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 26, Pg. 285, 1921. intravenous-dog LDLo 1024 mg/kg Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 561, 1944. oral-dog LDLo 1537 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 561, 1944. parenteral-frog LDLo 20000 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935. intraperitoneal-guinea pig LD50 2560 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. intraperitoneal-hamster LD50 3444 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. oral-human LDLo 3570 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: COMA "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 339, 1969. unreported-human LDLo 2 mL/kg Japanese Journal of Toxicology. Vol. 12, Pg. 341, 1999. oral-human TDLo 223 mg/kg VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: PULSE RATE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Journal of Laboratory and Clinical Medicine. Vol. 12, Pg. 326, 1927. oral-man LDLo 5272 mg/kg LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION American Journal of Clinical Pathology. Vol. 38, Pg. 144, 1962. unreported-man LDLo 2770 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man TDLo 14432 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION New England Journal of Medicine. Vol. 277, Pg. 699, 1967. intraperitoneal-mouse LD50 4477 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. intravenous-mouse LD50 1509 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. oral-mouse LD50 3600 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978. intraperitoneal-rabbit LD50 667 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. intravenous-rabbit LD50 1184 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. oral-rabbit LD50 6410 mg/kg FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 114, 1970. intraperitoneal-rat LD50 2735 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. intravenous-rat LD50 1088 mg/kg EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. oral-rat LD50 5045 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 12800 mg/kg Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974. subcutaneous-mouse LDLo 6000 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 172, 1955. subcutaneous-mammal (species unspecified) LDLo 6000 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: GENERAL ANESTHETIC PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Archiv fuer Toxikologie. Vol. 16, Pg. 84, 1956. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 16000 ppm/8H Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974. inhalation-mouse LCLo 12800 ppm/3H Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974 | |
Safety in use information
| Category: | |||
| extraction solvents, carrier solvents, flavoring agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for isopropyl alcohol usage levels up to: | |||
| 1.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 84000.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 75.00000 | |
| beverages(nonalcoholic): | - | 25.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 10.00000 | 75.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 View page or View pdf |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Propan-2-ol as a carrier solvent for Flavourings View page or View pdf |
| Flavouring Group Evaluation 5, Revision 1 (FGE.05Rev1):Esters of branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched- and straight-chain unsaturated carboxylic acids from chemical groups 1, 2, and 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 63 (FGE.63): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission View page or View pdf |
| Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 View page or View pdf |
| Flavouring Group Evaluation 5, Revision 2 (FGE.05Rev2): Branched- and straight-chain unsaturated carboxylic acids and esters of these with aliphatic saturated alcohols from chemical groups 1, 2, 3 and 5 View page or View pdf |
| Safety and efficacy of saturated and unsaturated aliphatic secondary alcohols, ketones and esters with esters containing secondary alcohols belonging to chemical group 5 when used as flavourings for all animal species View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):67-63-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :3776 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 1219 |
| WGK Germany:1 |
| propan-2-ol |
| Chemidplus:0000067630 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:67-63-0 |