butyl amine

General Material Information

Preferred name	butyl amine
Trivial Name	Butylamine
Short Description	butylamine
Formula	C4 H11 N
CAS Number	109-73-9
Deleted CAS Number	42939-72-0
FEMA Number	3130
Flavis Number	11.003
ECHA Number	203-699-2
FDA UNII	N2QV60B4WR
Nikkaji Number	J2.436H
Beilstein Number	0605269
MDL	MFCD00011690
COE Number	524
Bio Activity Summary	External link
NMR Predictor	External link
JECFA Food Flavoring	1582 butylamine
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	109-73-9 ; BUTYLAMINE
Synonyms	1-aminobutane butan-1-amine butanamine 1-butanamine mono- butyl amine N- butyl amine butyl-amine butylamine 1-butylamine nor valamine 1-Butanamine 1-Aminobutane Mono-n-butylamine Norvalamine n-Butylamine Monobutylamine 1-Butylamine NSC 8029

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	butan-1-amine
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	109-73-9
Pubchem (cid):	8007
Pubchem (sid):	134973851

Publications by Info
aliphatic and aromatic amines and amides
Publications by PubMed
Quantification of isocyanates and amines in polyurethane foams and coated products by liquid chromatography-tandem mass spectrometry.
Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization.
Determination of volatile nitrosamines in various meat products using comprehensive gas chromatography-nitrogen chemiluminescence detection.
Development and application of a method for analysis of phthalates in ham sausages by solid-phase extraction and gas chromatography-mass spectrometry.
A new ultra-pressure liquid chromatography method for the determination of biogenic amines in cheese.
Determination of aliphatic amines by cation-exchange chromatography with suppressed conductivity detection after solid phase extraction.
Synthesis of N-4-butylamine acridone and its use as fluorescent probe for ctDNA.
Olfactory responses in a gustatory organ of the malaria vector mosquito Anopheles gambiae.
Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters.
Protection of originality of Tokaji Aszú: amines and organic acids in botrytized wines by high-performance liquid chromatography.
Synthesis of haptens and development of an immunoassay for the olive fruit fly pheromone.
Developmental toxicity of oral n-butylamine hydrochloride and inhaled n-butylamine in rats.
Maillard reaction of D-glucose: identification of a colored product with conjugated pyrrole and furanone rings.
Structure of green pigment formed by the reaction of caffeic acid esters (or chlorogenic acid) with a primary amino compound.
Reduction of tetrazolium salt XTT by aminoreductone formed during the Maillard reaction of lactose.
Effect of common food preservatives on mycelial growth and spore germination of Fusarium oxysporum.
Rapid semi-quantitative estimation of N-nitrosodibutylamine and N-nitrosodibenzylamine in smoked hams by solid-phase microextraction followed by gas chromatography-thermal energy analysis.
Quantitative determination of amines in wine by liquid chromatography.
Investigations on organ-specific metabolism and genotoxic effects of the urinary bladder carcinogen N-nitrosobutyl-3-carboxypropylamine (BCPN) and its analogs N-nitrosodibutylamine (NDBA) and N-nitrosobutyl-4-hydroxybutylamine (4-OH-NDBA).
Trapping of reactive intermediates from the nitrosation of primary amines by a new type of scavenger reagent.
Evaluation of organosolv processes for the fractionation and modification of corn stover for bioconversion.
Effect of butylated hydroxyanisole on in vitro and in vivo nitrosation of dibutylamine.
Possible underestimation of nitrosatable amine levels in artificial saliva extracts of children's rubber pacifiers and baby-bottle teats.
Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEBI:	View
CHEMBL:	View
HMDB (The Human Metabolome Database):	HMDB31321
FooDB:	FDB003380
Export Tariff Code:	2921.19.1000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Suppliers

Augustus Oils	BASF
Eastman Chemical	EMD Millipore
Penta International	Santa Cruz Biotechnology
Sigma-Aldrich	Synerzine
Taminco (Eastman)	TCI AMERICA
Augustus Oils Ltd	Penta International Corporation
Synerzine, Inc.

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	73.138671875
Specific gravity	@ 25 °C
Pounds per Gallon	6.091 to 6.158
Refractive Index	1.398 to 1.404 @ 20 °C
Boiling Point	77 to 78°C @ 760 mm Hg
Vapor Pressure	92.9 mmHg @ 25 °C
Vapor Density	2.5
Flash Point TCC Value	-1.11 °C TCC
logP (o/w)	0.93
Solubility
alcohol	Yes
ether	Yes
water, 1.00E+06 mg/L @ 20 °C (exp)	Yes

Organoleptic Properties

Odor Type: Ammoniacal
ammoniacal, fishy
General comment	At 0.10 % in propylene glycol. ammonia-like fishy

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 11 - Highly flammable. R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R 35 - Causes severe burns. S 02 - Keep out of the reach of children. S 03 - Keep in cool place. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 23 - Do not breath vapour. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 29 - Do not empty into drains. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 366 mg/kg BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toxicology and Applied Pharmacology. Vol. 63, Pg. 150, 1982. oral-mouse LD50 430 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 40(11), Pg. 21, 1975. intravenous-mouse LD50 198 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946. intraperitoneal-mouse LD50 629 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946. oral-guinea pig LD50 430 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 40(11), Pg. 21, 1975.
Dermal Toxicity:
skin-rabbit LD50 850 ul/kg Union Carbide Data Sheet. Vol. 7/19/1965 skin-guinea pig LD50 500 ul/kg Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
Inhalation Toxicity:
inhalation-mouse LC50 800 mg/m3/2H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 28, 1982. inhalation-rat TCLo 4000 ppm/4H Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 343, 1949.

Safety in use information

Category:
flavoring agents
Recommendation for butyl amine usage levels up to:
	not for fragrance use.

Maximised Survey-derived Daily Intakes (MSDI-EU):		89.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA):		0.01 (μg/capita/day)
Threshold of Concern:		1800 (μg/person/day)
Structure Class:		I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
		average usual ppm	average maximum ppm
baked goods:		-	0.10000
beverages(nonalcoholic):		-	-
beverages(alcoholic):		-	0.10000
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	0.10000
fruit ices:		-	0.10000
gelatins / puddings:		-	0.10000
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	0.10000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

EPI System: View

NIOSH International Chemical Safety Cards:search

NIOSH Pocket Guide:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):109-73-9

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :8007

National Institute of Allergy and Infectious Diseases:Data