We have found
46587
results matching your criteria.
Please wait while we search...
meta-cresol
General Material Information
| Preferred name | meta-cresol |
| Trivial Name | m-Cresol |
| Short Description | m-cresol |
| Formula | C7 H8 O |
| CAS Number | 108-39-4 |
| FEMA Number | 3530 |
| Flavis Number | 4.026 |
| ECHA Number | 203-577-9 |
| FDA UNII | GGO4Y809LO |
| Nikkaji Number | J1.186J |
| Beilstein Number | 0506719 |
| MDL | MFCD00002302 |
| COE Number | 617 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 692 m-cresol |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 108-39-4 ; M-CRESOL |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C01467 |
| HMDB (The Human Metabolome Database): | HMDB02048 |
| FooDB: | FDB008788 |
| YMDB (Yeast Metabolome Database): | YMDB01730 |
| Export Tariff Code: | 2907.12.0000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| Wikipedia: | View |
| Wikipedia2: | View2 |
| Formulations/Preparations: •grade: technical (95-98%) •pure cresol is a mixture of ortho-, meta- & para-isomers. crude cresol (commercial cresol) is a mixture of aromatic cmpd containing about 20% of o-cresol, 40% of m-cresol, & 30% of p-cresol with small amt of phenol & xylenols. •franklin cresolis, 50% m-cresol, 31% soap cancelled •saponated cresol solution n.f., 50% m-cresol, 35% soap cancelled •bacticin, 0.4660% m-cresol, 0.4630% 2,4-xylenol cancelled •celcure dry mix (chemicals for wood preserving), 5% m-cresol, 50% copper sulfate pentahydrate, 45% potassium dichromate cancelled •rover's dog shampoo, 0.4% m-cresol, 1.0% paradichlorobenzene, 0.1% pine oil, 19.3% soap cancelled •gallex, 0.4660% m-cresol, 0.4630% 2,4-xylenol active •generally m- and p- isomers are used industrially as a mixture containing 40% to 65% m-cresol. | |
Suppliers
| EMD Millipore | Pell Wall Perfumes |
| Penta International | Santa Cruz Biotechnology |
| Sigma-Aldrich | TCI AMERICA |
| The Good Scents Company | Penta International Corporation |
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 108.13996124268 |
| Specific gravity | @ 20 °C |
| Pounds per Gallon | 8.614 to 8.639 |
| Refractive Index | 1.538 to 1.542 @ 20 °C |
| Melting Point | 11 to 12°C @ 760 mm Hg |
| Boiling Point | 202 to 203°C @ 760 mm Hg |
| Boiling Point | 120 to 121°C @ 50 mm Hg |
| Vapor Pressure | 0.11 mmHg @ 25 °C |
| Vapor Density | 7.07 |
| Flash Point TCC Value | 86.11 °C TCC |
| logP (o/w) | 1.96 |
| Solubility | |
| alcohol | Yes |
| water, 8890 mg/L @ 25 °C (est) | Yes |
| water, 2.27E+04 mg/L @ 25 °C (exp) | Yes |
| water | No |
Organoleptic Properties
| Odor Type: Phenolic | |
| medicinal, woody, leathery, phenolic | |
| Odor strength | high , recommend smelling in a 0.01 % solution or less |
| Substantivity | 43 hour(s) at 100.00 % |
| Luebke, William tgsc, (1995) | At 0.01 % in dipropylene glycol. medicinal woody leather phenolic |
| General comment | Medicinal; woody; ethereal |
| Arctander has this to say about it: “Dry-tarry, medicinal-leathery odor, conventionally described as “phenolic. Useful as a floralizing companion to Indole in sharp-exotic flower fragrances, Lily (Bermuda-lily, etc.), Narcisse, etc. Concentration in the perfume composition will usually be about 0.1%, sometimes slightly higher, mostly lower than 0.1%.” | Medicinal, woody, leather, phenolic |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Castoreum, Myrrh |
| Other purposes | Antimicrobial agents |
| Cosmetic purposes | Antimicrobial agents, Perfuming agents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| T - Toxic. | |
| R 24/25 - Toxic in contact with skin and if swallowed. R 34 - Causes burns. S 02 - Keep out of the reach of children. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 [sex: M] 242 mg/kg (E.I. du Pont de Nemours & Company, 1969a) oral-mouse LD50 828 mg/kg (E.I. du Pont de Nemours & Company, 1969a) intraperitoneal-mouse LD50 168 mg/kg (E.I. du Pont de Nemours & Company, 1969a) gavage-rat LD50 [sex: M] 520 mg/kg (Carpenter, 1949b) oral-rat LD50 242 mg/kg GASTROINTESTINAL: PERITONITIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 3-5/1969 oral-rabbit LDLo 1400 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. intravenous-rabbit LDLo 280 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. oral-mouse LD50 828 mg/kg Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974. intraperitoneal-mouse LD50 168 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959. intraperitoneal-guinea pig LDLo 100 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. | |
| Dermal Toxicity: | |
| subcutaneous-rat LDLo 900 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959. skin-rat LD50 1100 mg/kg Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974. subcutaneous-rabbit LDLo 500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. subcutaneous-mouse LDLo 450 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. subcutaneous-guinea pig LDLo 300 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959. subcutaneous-cat LDLo 180 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 > 710 mg/m3/1H Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
Safety in use information
| Category: | |||
| food contact resinous and polymeric coatings | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for meta-cresol usage levels up to: | |||
| 0.0100 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.10 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 11. Update in publication number(s): 29 | |||
| Click here to view publication 11 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 0.50000 | 1.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | 0.30000 | 1.00000 | |
| breakfast cereal: | 0.50000 | 5.00000 | |
| cheese: | 0.10000 | 0.50000 | |
| chewing gum: | 0.10000 | 0.50000 | |
| condiments / relishes: | 0.10000 | 0.50000 | |
| confectionery froastings: | 0.10000 | 0.50000 | |
| egg products: | 0.10000 | 0.50000 | |
| fats / oils: | 0.10000 | 0.50000 | |
| fish products: | 0.50000 | 5.00000 | |
| frozen dairy: | 0.10000 | 0.50000 | |
| fruit ices: | 0.10000 | 0.50000 | |
| gelatins / puddings: | 0.10000 | 0.50000 | |
| granulated sugar: | 0.10000 | 0.50000 | |
| gravies: | 0.30000 | 0.50000 | |
| hard candy: | 0.10000 | 0.50000 | |
| imitation dairy: | 0.10000 | 0.50000 | |
| instant coffee / tea: | 0.30000 | 0.50000 | |
| jams / jellies: | 0.10000 | 0.50000 | |
| meat products: | 0.30000 | 1.00000 | |
| milk products: | 0.10000 | 0.50000 | |
| nut products: | 0.30000 | 0.50000 | |
| other grains: | 0.50000 | 5.00000 | |
| poultry: | 0.50000 | 5.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | 1.00000 | 10.00000 | |
| snack foods: | 0.30000 | 0.50000 | |
| soft candy: | - | - | |
| soups: | 0.30000 | 0.50000 | |
| sugar substitutes: | 0.10000 | 0.50000 | |
| sweet sauces: | 0.10000 | 0.50000 | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf |
| Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species View page or View pdf |
| EPI System: View |
| EPA-Iris:IRIS |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):108-39-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :342 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 2076 |
| WGK Germany:1 |
| 3-methylphenol |
| Chemidplus:0000108394 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:108-39-4 |