We have found 46587 results matching your criteria.
Please wait while we search...
  1. 1.
    General Material Information
  2. 2.
    PhysChem Properties
  3. 3.
    Occurrences
  4. 4.
    Organoleptic Properties
  5. 5.
    Suppliers
  6. 6.
    Potential Uses
  7. 7.
    Regulatory & Documentation
  8. 8.
    Safety Information
  9. 9.
    Other Information
  10. 10.
    Blenders & Components
  11. 11.
    Literature & References

methyl anthranilate

Chemical Structure

General Material Information

Preferred name methyl anthranilate
Trivial Name Methyl anthranilate
Short Description benzoic acid, 2-amino-, methyl ester
Formula C8 H9 N O2
CAS Number 134-20-3
FEMA Number 2682
Flavis Number 9.715
ECHA Number 205-132-4
FDA UNII 981I0C1E5W
Nikkaji Number J2.018D
Beilstein Number 0606965
MDL MFCD00007710
COE Number 250
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1534 methyl anthranilate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 134-20-3 ; METHYL ANTHRANILATE
Synonyms
  • o- amino methyl benzoate
  • 2-amino-benzoic acid methyl ester
  • 2-aminobenzoic acid methyl ester
  • o- aminobenzoic acid methyl ester
  • ortho- aminobenzoic acid methyl ester
  • o- aminomethyl benzoate
  • ortho- aminomethyl benzoate
  • anthranilic acid methyl ester
  • anthranilic acid methylester
  • benzoic acid, 2-amino-, methyl ester
  • 2-carbomethoxyaniline
  • o- carbomethoxyaniline
  • ortho- carbomethoxyaniline
  • 2-( methoxycarbonyl) aniline
  • 2-( methoxycarbonyl)aniline
  • methyl 2-aminobenzoate
  • methyl aminobenzoate
  • methyl anthranilate (natural)
  • methyl anthranilate extra
  • methyl anthranilate extra BHT free
  • methyl anthranilate extra FCC
  • methyl anthranilate FCC
  • methyl anthranilate natural
  • methyl anthranilate natural EEC
  • methyl anthranilate purified FCC
  • methyl anthranilate, natural
  • methyl o-aminobenzoate
  • methyl ortho-aminobenzoate
  • nevoli oil
  • Anthranilic acid, methyl ester
  • 2-Aminobenzoic acid methyl ester
  • 2-(Methoxycarbonyl)aniline
  • o-Carbomethoxyaniline
  • 2-Carbomethoxyaniline
  • o-Aminobenzoic acid methyl ester
  • ReJex-iT
  • Bird Shield
  • Rejex-iT TP 40
  • Rejex-iT AP 50
  • [2-(Methoxycarbonyl)phenyl]amine
  • o-(Methoxycarbonyl)aniline
  • NSC 3109
  • Grain 96-1
  • Sunarome UVA
  • Methyl 6-aminobenzoate
  • Fog Force
  • RejeX-it Fog Force
  • 2-Amino-1-methylbenzoate
  • PPC 17F

US / EU / FDA / JECFA / FEMA / Scholar / Patents

Google Scholar Start search
Google Books Start search
Google Patents Start search
Perfumer & Flavorists Start search
EU Patents Start search
PubMeb Start search
NCBI Start search

Literature & References

methyl 2-aminobenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:134-20-3
Pubchem (cid):8635
Pubchem (sid):134974914
Flavornet:134-20-3
Pherobase:View
Publications by Info
anthranilate derivatives
Publications by PubMed
Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison.
Methyl anthranilate and γ-decalactone inhibit strawberry pathogen growth and Achene Germination.
Comparative analysis of flower volatiles from nine citrus at three blooming stages.
Electrochemical preparation of polyaniline-polypyrrole solid-phase microextraction coating and its application in the GC determination of several esters.
Electrodeposition of poly(3,4-ethylenedioxythiophene) on a stainless steel wire for solid phase microextraction and GC determination of some esters with high boiling points.
Piracetam, an AMPAkine drug, facilitates memory consolidation in the day-old chick.
Methyl 2-(thio-phene-2-carboxamido)-benzoate.
Assessing the effects of three potential chemical repellents to prevent bird damage to corn seeds and seedlings.
Induced release of a plant-defense volatile 'deceptively' attracts insect vectors to plants infected with a bacterial pathogen.
Liquid CO2 extraction of Jasminum grandiflorum and comparison with conventional processes.
Memantine facilitates memory consolidation and reconsolidation in the day-old chick.
Assessment of the validity of maturity metrics for predicting the volatile composition of Concord grape juice.
[Study on constituents of essential oil from Lonicera fulvotomentosa in different collected periods].
Evaluation of volatiles from two subtropical strawberry cultivars using GC-olfactometry, GC-MS odor activity values, and sensory analysis.
A novel attractant for Anastrepha ludens (Diptera: Tephritidae) from a Concord grape product.
Comparison of odor-active compounds in grapes and wines from vitis vinifera and non-foxy American grape species.
Comparison of silica gel modified with three different functional groups with C-18 and styrene-divinylbenzene adsorbents for the analysis of selected volatile flavor compounds.
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.
Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation.
Reconciling sensory cues and varied consequences of avian repellents.
A solid-phase microextraction gas chromatography/ion trap tandem mass spectrometry method for simultaneous determination of 'foxy smelling compounds' and 3-alkyl-2-methoxypyrazines in grape juice.
Herbivore-induced SABATH methyltransferases of maize that methylate anthranilic acid using s-adenosyl-L-methionine.
Chemical composition and antibacterial, antifungal and antioxidant activities of the flower oil of Retama raetam (Forssk.) Webb from Tunisia.
Different isolation methods for determination of composition of volatiles from Nigella damascena L. seeds.
Enzymatic, expression and structural divergences among carboxyl O-methyltransferases after gene duplication and speciation in Nicotiana.
An investigation of the inclusion complex of cyclomaltoheptaose (beta-cyclodextrin) with N-methylanthranilic acid in the solid state.
Localized auxin biosynthesis and postembryonic root development in Arabidopsis.
A comparison of citrus blossom volatiles.
Effects of prenatal exposure to a 50-Hz magnetic field on one-trial passive avoidance learning in 1-day-old chicks.
Reducing honey bee defensive responses and social wasp colonization with methyl anthranilate.
Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.
Room-temperature palladium-catalyzed C-H activation: ortho-carbonylation of aniline derivatives.
2-(Methoxy-carbon-yl)anilinium dihydrogen phosphate.
The type 4 phosphodiesterase inhibitors rolipram and YM976 facilitate recall of the weak version of the passive avoidance task in the day-old chick.
Learning ability of 1-d-old partridges (Alectoris rufa) from eggs laid by hens fed with different n-3 fatty acid concentrations.
A comparison of protocols for passive and discriminative avoidance learning tasks in the domestic chick.
Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines.
A phosphine-mediated through-space exchange coupling pathway for unpaired electrons in a heterobimetallic lanthanide-transition metal complex.
Synthesis and antihypertensive activity of novel 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones.
Quantification of flavor-related compounds in the unburned contents of bidi and clove cigarettes.
Astrocytic energy metabolism consolidates memory in young chicks.
Passive avoidance training decreases synapse density in the hippocampus of the domestic chick.
Production of natural methyl anthranilate by microbial N-demethylation of N-methyl methyl anthranilate by the topsoil-isolated bacterium Bacillus megaterium.
The biosynthesis and regulation of biosynthesis of Concord grape fruit esters, including 'foxy' methylanthranilate.
Antifungal activity of tuberose absolute and some of its constituents.
Further field evaluation of synthetic herbivore-induced plant volatiles as attractants for beneficial insects.
The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
Field capture of northern and western corn rootworm beetles relative to attractant structure and volatility.
Effects of purinenucleotide analogues on microtubule assembly.
Facilitation of a weak training experience in the 1-day-old chick using diphenylhydantoin: a pharmacological and biochemical study.
Calcium responses of chicken trigeminal ganglion neurons to methyl anthranilate and capsaicin.
Facilitation and disruption of memory for the passive avoidance task in the day-old chick using dopamine D1 receptor compounds.
Conjugate additions of o-iodoanilines and methyl anthranilates to acetylenic sulfones. A new route to quinolones including first syntheses of two alkaloids from the medicinal herb Ruta chalepensis.
Passive avoidance training enhances cell proliferation in 1-day-old chicks.
Identification of potent odorants in Chinese jasmine green tea scented with flowers of Jasminum sambac.
Assessment of strawberry aroma through SPME/GC and ANN methods. Classification and discrimination of varieties.
Thiourea derivatives and their nickel(II) and platinum(II) complexes: antifungal activity.
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa.
Palatability of bird repellents to Rattus norvegicus.
Aversion of the feral pigeon and the house sparrow to pellets and sprouts treated with commercial formulations of methyl anthranilate.
High-performance liquid chromatographic determination of methyl anthranilate, hydroxymethylfurfural and related compounds in honey.
Dielectric properties of some components of fruit aroma in carbon tetrachloride solution at 298.15 K.
Influence of packaging on the aroma stability of strawberry syrup during shelf life.
Liquid chromatographic determination of methyl anthranilate in artificially flavored nonalcoholic beverages.
Substrate-induced fit of the ATP binding site of cytidine monophosphate kinase from Escherichia coli: time-resolved fluorescence of 3'-anthraniloyl-2'-deoxy-ADP and molecular modeling.
Determination of methyl anthranilate in food samples by coupling stopped-flow mixing technique and time-resolved luminescence detection.
Comparison of methyl anthranilate and denatonium benzoate as aversants for learning in chicks.
Passive avoidance training results in increased responsiveness of voltage- and ligand-gated calcium channels in chick brain synaptoneurosomes.
Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors.
Passive avoidance learning involves alpha2-noradrenergic receptors in a day old chick.
Relative importance of odour and taste in the one-trial passive avoidance learning bead task.
Response of domestic chicks to methyl anthranilate odour
D-cycloserine causes transient enhancement of memory for a weak aversive stimulus in day-old chicks (Gallus domesticus).
Passive avoidance learning in the day-old chick is modulated by GABAergic agents.
Partial G protein activation by fluorescent guanine nucleotide analogs. Evidence for a triphosphate-bound but inactive state.
Electrophysiological correlates of prior training: an in vitro study of an area of the avian brain which is essential for early learning.
The involvement of dopamine in the striatum in passive avoidance training in the chick.
Involvement of AMPA receptors in maintenance of memory for a passive avoidance task in day-old domestic chicks (Gallus domesticus).
Increases in NMDA receptor binding are specifically related to memory formation for a passive avoidance task in the chick: a quantitative autoradiographic study.
Volatile secretions of old world army antAenictus rotundatus and chemotaxonomic implications of army ant dufour gland chemistry.
Dendritic spine density in the lobus parolfactorius of the domestic chick is increased 24 h after one-trial passive avoidance training.
Corticosterone enhances long-term retention in one-day-old chicks trained in a weak passive avoidance learning paradigm.
Transient benzodiazepine-GABAA receptor increase after a passive avoidance learning in synaptosomal membranes from chick forebrain.
Tests and refinements of a general structure-activity model for avian repellents.
Na+,K(+)-ATPase activity in young chicks after taste stimulation.
Training-induced increases in neuronal activity recorded from the forebrain of the day-old chick are time dependent.
Nonlethal rodent repellents: Differences in chemical structure and efficacy from nonlethal bird repellent.
7-Chlorokynurenate, an antagonist of the glycine binding site on the NMDA receptor, inhibits memory formation in day-old chicks (Gallus domesticus).
Quantitative autoradiographic demonstration of changes in binding to delta opioid, but not mu or kappa receptors, in chick forebrain 30 minutes after passive avoidance training.
New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II.
Spatial re-arrangement of the vesicle apparatus in forebrain synapses of chicks 30 min after passive avoidance training.
Long-term increases in the numerical density of synapses in the chick lobus parolfactorius after passive avoidance training.
Avoidance of bird repellents by mice (Mus musculus).
Tryptophan analog resistance mutations in Chlamydomonas reinhardtii.
Fluorescent N-methylanthranilyl (Mantyl) tag for peptides: its application in subpicomole determination of kinins.
Role of electronic factors in binding and reduction of azo dyes by hepatic microsomes.
Quantitative Autoradiographic Demonstration of Changes in Binding to NMDA-sensitive [3H]Glutamate and [3H]MK801, but not [3H]AMPA Receptors in Chick Forebrain 30 min After Passive Avoidance Training.
Forebrain noradrenaline concentration following weakly reinforced training.
Possible noradrenergic involvement in training stimulus intensity.
Cerebral Glycoprotein Synthesis and Long-term Memory Formation in the Chick (Gallus domesticus) Following Passive Avoidance Training Depends on the Nature of the Aversive Stimulus.
Memory consolidation of weak training experiences by hormonal treatments.
New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note I.
Sex differences in response to the odor of alpha androstenone.
Chemistry of mandibular and Dufour's gland secretions of ants in genusMyrmecocystus.
Effect of retraining trials on memory consolidation in weakly reinforced learning.
Memory formation processes in weakly reinforced learning.
Alterations in synaptic structure in the paleostriatal complex of the domestic chick, Gallus domesticus, following passive avoidance training.
Cyclization under mild conditions of anthraniloyl- and N-methyl-anthraniloyl dipeptides.
Lasting changes in spontaneous multi-unit activity in the chick brain following passive avoidance training.
CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity.
Analysis of anthranilic acid by liquid chromatography.
Passive avoidance training increases fucose incorporation into glycoproteins in chick forebrain slices in vitro.
Prostaglandin anthrylmethyl ester: a membrane-permeant fluorescent analogue of prostaglandin with enhanced cell growth inhibitory activity.
Human (Homo sapiens) responses to the pig (Sus scrofa) sex pheromone 5 alpha-androst-16-en-3-one.
Sensitive fluorographic detection of 3H and 14C on chromatograms using methyl anthranilate as a scintillant.
Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. I. Chemistry.
Studies on bacterial chemotaxis. III. Effect of methyl esters on the chemotactic response of Escherichia coli.
Kidney and liver tumors in rats from 4,4'-methylene bis (2-carbomethoxyaniline).
The hydrolysis of flavouring esters by artificial gastrointestinal juices and rat tissue preparations.
A fluorescence detector for high-pressure liquid chromatography.
[Reaction of furfural with methyl anthranilate and methyl 2-aminonicotinate (author's transl)].
Media dependence of commitment in Bacillus subtilis.
Initiation of spore germination in Bacillus subtilis: relationship to inhibition of L-alanine metabolism.
Caste-specific compounds in male carpenter ants.
Acute and short-term toxicity of methyl-N-methyl anthranilate in rats.
Methyl anthranilate, an inhibitor for thegermination of spores of aerobic bacilli.
[Research on methyl anthranilate in Spanish honey from orange flower by thin-layer chromatography].
Assessment of the validity of maturity metrics for predicting the volatile composition of Concord grape juice.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C20634
HMDB (The Human Metabolome Database):HMDB29703
FooDB:FDB000897
Export Tariff Code:2922.49.3700
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: technical; fcc. •usepaopp pesticide code 128725; trade names: bird shield repellant concentrate (26.4%), rejex-it ag-145 (14.5%), rejex-it ag-36 (14.5%), rejex-it ma (98.5%), rejex-it tp-40 (40%).

Suppliers

Advanced Biotech Alfrebro
Ambles Nature et Chimie Anshul Specialty Molecules
Astral Extracts Augustus Oils
Aurochemicals Axxence Aromatic
Azelis UK Beijing Lys Chemicals
Bell Flavors & Fragrances Berjé
BOC Sciences Citrus and Allied Essences
Creatingperfume.com De Monchy Aromatics
Diffusions Aromatiques ECSA Chemicals
Elan Inc. EMD Millipore
Ernesto Ventós Excellentia International
ExtraSynthese Fleurchem
Foodchem International Foreverest Resources
Frutarom Givaudan
Glentham Life Sciences Global Essence
H. Interdonati, Inc. IFF
Indenta Group Indukern F&F
Jiangyin Healthway K.L. Koh Enterprise
Keva Kingchem Laboratories
Lluch Essence M&U International
Moellhausen Naturamole
Northwestern Extract OQEMA
PCW France Pell Wall Perfumes
Penta International PerfumersWorld
Pfaltz & Bauer Phoenix Aromas & Essential Oils
Prodasynth R C Treatt & Co Ltd
Reincke & Fichtner Sigma-Aldrich
SRS Aromatics SysKem Chemie
Taytonn ASCC TCI AMERICA
Tengzhou Xiang Yuan Aroma Chemicals The John D. Walsh Company
The Lermond Company The Perfumers Apprentice
United International Vigon International
WEN International Zanos
Advanced Biotech. Inc. Alfrebro LLC/ Archer Daniels Midland Company
Augustus Oils Ltd Axxence Aromatic GmbH
Azelis UK Ltd. Beijing Lys Chemicals Co, LTD.
Berje Inc. Fleurchem, Inc.
Foreverest Resources Ltd. Glentham Life Sciences Ltd
Global Essence Inc. FRUTAROM USA INC,
Indukern, S.A. F&F Ingredients Division Jiangyin Healthway International Trade Co., Ltd
Lluch Essence S.L. M&U International LLC
Moellhausen S.P.A. Penta International Corporation
PerfumersWorld Ltd. SRS Aromatics Ltd
Taytonn ASCC Pte Ltd The John D. Walsh Company, Inc
R C Treatt and Co Ltd Qingdao Free Trade Zone United International Co Ltd
Ernesto Ventós S.A. Zanos Ltd.

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 151.16513061523
Specific gravity @ 25 °C
Pounds per Gallon 9.661 to 9.727
Refractive Index 1.579 to 1.592 @ 20 °C
Melting Point 23 to 24.5°C @ 760 mm Hg
Boiling Point 238 to 241°C @ 760 mm Hg
Boiling Point 163 to 164°C @ 50 mm Hg
Vapor Pressure 0.016 mmHg @ 25 °C
Vapor Density 5.2
Flash Point TCC Value 104.44 °C TCC
logP (o/w) 1.88
Shelf life 12 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
dipropylene glycol Yes
fixed oils Yes
propylene glycol Yes
water, 2850 mg/L @ 25 °C (exp) Yes
paraffin oil No
glycerin No
Stability
alcoholic lotion Unspecified
antiperspirant Unspecified
deo stick Unspecified
detergent perborate Unspecified
fabric softener Unspecified
liquid detergent Unspecified
shampoo Unspecified
soap Unspecified

Organoleptic Properties

Odor Type: Fruity
fruity, grape, orangeflower, neroli, musty, floral, powdery
Odor strength medium
Substantivity 88 hour(s) at 100.00 %
Luebke, William tgsc, (1982) At 100.00 %. fruity grape orangeflower neroli
Mosciano, Gerard P&F 18, No. 2, 38, (1993) Fruity, concord grape, musty with a floral powdery nuance
Flavor Type: Fruity
sweet, fruity, grape, musty, berry
Mosciano, Gerard P&F 18, No. 2, 38, (1993) At 25.00 ppm. Sweet, fruity, concord grape, with a musty and berry nuance
Used in a wide variety of flavors including grape, plum, blueberry and cherry. Sweet fruity
General comment Sweet fruity concord grape musty berry

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Acute aquatic toxicity (Category 2), H401
Chronic aquatic toxicity (Category 2), H411
GHS Label elements, including precautionary statements
Pictogramexclamation-mark.jpg
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
H401 - Toxic to aquatic life
H411 - Toxic to aquatic life with long lasting effects
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P391 - Collect spillage. Hazardous to the aquatic environment
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
10 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 2910 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

oral-mouse LD50 3900 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

oral-guinea pig LD50 2780 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 935, 1974.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for methyl anthranilate usage levels up to:
10.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 686.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 3764.00 (μg/capita/day)
Threshold of Concern:1800 (μg/person/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3. Update in publication number(s): 18
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: 38.0000038.00000
beverages(nonalcoholic): 40.0000040.00000
beverages(alcoholic): 0.200002.00000
breakfast cereal: --
cheese: --
chewing gum: 200.000001583.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 40.0000040.00000
fruit ices: 40.0000040.00000
gelatins / puddings: 20.0000020.00000
granulated sugar: --
gravies: --
hard candy: 80.00000161.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: 6.000006.00000
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 80.0000080.00000
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 84, (FGE.84)[1] - Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):134-20-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8635
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
methyl 2-aminobenzoate
Chemidplus:0000134203
EPA/NOAA CAMEO:hazardous materials
RTECS:CB3325000 for cas# 134-20-3