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methyl eugenol

Chemical Structure

General Material Information

Preferred name methyl eugenol
Trivial Name Methyleugenol
Short Description 4-allyl veratrole
Formula C11 H14 O2
CAS Number 93-15-2
FEMA Number 2475
ECHA Number 202-223-0
FDA UNII 29T9VA6R7M
Nikkaji Number J4.669H
Beilstein Number 1910871
MDL MFCD00008652
COE Number 185
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1790 methyl eugenol
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 93-15-2 ; EUGENYL METHYL ETHER--NLFG
Synonyms
  • 4-allyl veratrole
  • 4-allyl-1,2-dimethoxybenzene
  • 4-allyl-1,2-dimethoxybenzol
  • 1-allyl-3,4-dimethoxybenzene
  • 4-allylveratrole
  • benzene, 1,2-dimethoxy-4-(2-propen-1-yl)-
  • 1,2-dimethoxy-4-(2-propen-1-yl)benzene
  • 1,2-dimethoxy-4-(2-propenylbenzene
  • 1,2-dimethoxy-4-(prop-2-en-1-yl)benzene
  • 1,2-dimethoxy-4-allyl benzene
  • 1,2-dimethoxy-4-prop-2-enylbenzene
  • 3,4-dimethoxyallyl benzene
  • 3-(3,4-dimethoxyphenyl)-1-propene
  • 1-(3,4-dimethoxyphenyl)-2-propene
  • eugenol methyl ether
  • 1,3,4-eugenol methyl ether
  • eugenyl methyl ether
  • 2-methoxy-4-propenylphenol methyl ether
  • o- methyl eugenol ether
  • ortho- methyl eugenol ether
  • methyl eugenol FCC
  • methyl eugenol natural
  • methyl eugenyl ether
  • methyleugenol
  • O- methyleugenol
  • o- methyleugenol ether
  • veratrole methyl ether
  • 1,2-dimethoxy-4-prop-2-enylbenzene
  • Benzene, 4-allyl-1,2-dimethoxy-
  • Benzene, 1,2-dimethoxy-4-(2-propenyl)-
  • Veratrole, 4-allyl-
  • 1,2-Dimethoxy-4-(2-propen-1-yl)benzene
  • Ent 21040
  • 4-Allylveratrole
  • 1,2-Dimethoxy-4-allylbenzene
  • 1,3,4-Eugenol methyl ether
  • Methyl eugenol ether
  • O-Methyleugenol
  • 3,4-Dimethoxyallylbenzene
  • 1-(3,4-Dimethoxyphenyl)-2-propene
  • Chavibetol methyl ether
  • 4-Allyl-1,2-dimethoxybenzene
  • 3-(3,4-Dimethoxyphenyl)propene
  • 1-Allyl-3,4-dimethoxybenzene
  • Methylchavibetol
  • NSC 209528
  • NSC 8900
  • 1,2-Dimethoxy-4-(2-propenyl)benzene
  • 3,4-Dimethoxy-1-(2-propenyl)benzene
  • 3-(3,4-Dimethoxyphenyl)-1-propene

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Literature & References

1,2-dimethoxy-4-prop-2-enylbenzene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:93-15-2
Pubchem (cid):7127
Pubchem (sid):134972688
Flavornet:93-15-2
Pherobase:View
Publications by PubMed
Comparative chemical study and cytotoxic activity of Uvariodendron angustifolium essential oils from Benin.
Exocrine secretions of wheel bugs (Heteroptera: Reduviidae: Arilus spp.): clarification and chemistry.
Chemical composition and major odor-active compounds of essential oil from PINELLIA TUBER (dried rhizome of Pinellia ternata) as crude drug.
[Chemical studies on roots of Ficus hirta].
Simultaneous Determination of Volatile Constituents from Acorus tatarinowii Schott in Rat Plasma by Gas Chromatography-Mass Spectrometry with Selective Ion Monitoring and Application in Pharmacokinetic Study.
Chemical Composition, In Vitro Antimicrobial and Antioxidant Activities of the Essential Oils of Ocimum Gratissimum, O. Sanctum and their Major Constituents.
GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.
Performance of methyl eugenol + matrix + toxicant combinations under field conditions in Hawaii and California for trapping Bactrocera dorsalis (Diptera: Tephritidae).
Chemical composition and biological activities of the essential oils from three melaleuca species grown in Tunisia.
Efficient management of fruit pests by pheromone nanogels.
Chemical composition and larvicidal activity of essential oil from Ocimum basilicum (L.) against Culex tritaeniorhynchus, Aedes albopictus and Anopheles subpictus (Diptera: Culicidae).
Antinociceptive and wound healing activities of Croton adamantinus Müll. Arg. essential oil.
Field trials of solid triple lure (trimedlure, methyl eugenol, raspberry ketone, and DDVP) dispensers for detection and male annihilation of Ceratitis capitata, Bactrocera dorsalis, and Bactrocera cucurbitae (Diptera: Tephritidae) in Hawaii.
Methyl eugenol: its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination.
Trap capture of three economically important fruit fly species (Diptera: Tephritidae): evaluation of a solid formulation containing multiple male lures in a Hawaiian coffee field.
Myrtus communis L. infusions: the effect of infusion time on phytochemical composition, antioxidant, and antimicrobial activities.
Essential oil components from Asarum sieboldii Miquel are toxic to the house dust mite Dermatophagoides farinae.
Odorant receptor co-receptor Orco is upregulated by methyl eugenol in male Bactrocera dorsalis (Diptera: Tephritidae).
Fragrant volatile oil composition of Nutmeg Geranium (Pelargonium × fragrans Willd.) from India.
Field attraction of the vine weevil Otiorhynchus sulcatus to kairomones.
Prerelease exposure to methyl eugenol increases the mating competitiveness of sterile males of the oriental fruit fly (Diptera: Tephritidae) in a Hawaiian orchard.
Chemical and biological diversity in fourteen selections of four Ocimum species.
Chemical polymorphism of essential oils from populations of Laurus nobilis grown on Tunisia, Algeria and France.
Investigation on phenylpropanoids rich Melaleuca decora (Salisb.) Britt. essential oil.
A solid-phase microextraction GC/MS/MS method for rapid quantitative analysis of food and beverages for the presence of legally restricted biologically active flavorings.
Di- and tri-fluorinated analogs of methyl eugenol: attraction to and metabolism in the Oriental fruit fly, Bactrocera dorsalis (Hendel).
Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities.
Variation in essential oil composition within individual leaves of sweet basil (Ocimum basilicum L.) is more affected by leaf position than by leaf age.
The essential oil of Artemisia scoparia from tajikistan is dominated by phenyldiacetylenes.
Myrtus communis berry color morphs: a comparative analysis of essential oils, fatty acids, phenolic compounds, and antioxidant activities.
Capture probability of released males of two Bactrocera species (Diptera: Tephritidae) in detection traps in California.
Composition and antioxidant activity of essential oil of pimento (Pimenta dioica (L) Merr.) from Jamaica.
Induction of oxidative stress as a possible mechanism of the antifungal action of three phenylpropanoids.
Analysis of regulated suspected allergens in waters.
Chemical composition of the essential oil of Feronia elephantum Correa.
Accumulation of phenylpropanoid and sesquiterpenoid volatiles in male rectal pheromonal glands of the guava fruit fly, Bactrocera correcta.
Acaricidal effect and chemical composition of essential oils extracted from Cuminum cyminum, Pimenta dioica and Ocimum basilicum against the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
Recent advances in methyl eugenol and cue-lure technologies for fruit fly detection, monitoring, and control in Hawaii.
Evaluation of bioactivity of linalool-rich essential oils from Ocimum basilucum and Coriandrum sativum varieties.
Biotransformation of eugenol by suspension cultures of transgenic crown galls of Panax quinquefolium and suspension cultures of Nicotiana tabacum.
Pre-release consumption of methyl eugenol increases the mating competitiveness of sterile males of the oriental fruit fly, Bactrocera dorsalis, in large field enclosures.
Variation of the chemical composition of essential oils in Tunisian populations of Thymus algeriensis Boiss. et Reut. (Lamiaceae) and implication for conservation.
Evaluation of methyl eugenol and cue-lure traps with solid lure and insecticide dispensers for fruit fly monitoring and male annihilation in the Hawaii Areawide Pest Management Program.
Antifungal activities of Ocimum sanctum essential oil and its lead molecules.
Determination of fragrance allergens in indoor air by active sampling followed by ultrasound-assisted solvent extraction and gas chromatography-mass spectrometry.
Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet.
Larvicidal and structure-activity studies of natural phenylpropanoids and their semisynthetic derivatives against the tobacco armyworm Spodoptera litura (Fab.) (Lepidoptera: Noctuidae).
Simultaneous quantitative determination of cinnamaldehyde and methyl eugenol from stem bark of Cinnamomum zeylanicum Blume using RP-HPLC.
Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors.
Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida.
Eugenol and methyl eugenol chemotypes of essential oil of species Ocimum gratissimum L. and Ocimum campechianum Mill. from Colombia.
Attraction of nontarget species to fruit fly (Diptera: tephritidae) male lures and decaying fruit flies in traps in hawaii.
Captures in methyl eugenol and cue-lure detection traps with and without insecticides and with a Farma Tech solid lure and insecticide dispenser.
Optimization of a phenylacetaldehyde-based attractant for common green lacewings (Chrysoperla carnea s.l.).
Essential oil composition and variability of Laurus nobilis L. growing in Tunisia, comparison and chemometric investigation of different plant organs.
Insecticidal activity of basil oil, trans-anethole, estragole, and linalool to adult fruit flies of Ceratitis capitata, Bactrocera dorsalis, and Bactrocera cucurbitae.
Biological activity evaluation of the oils from Laurus nobilis of Tunisia and Algeria extracted by supercritical carbon dioxide.
Essential oil composition of Laurus nobilis L. of different growth stages growing in Iran.
Ring-fluorinated analog of methyl eugenol: attractiveness to and metabolism in the oriental fruit fly, Bactrocera dorsalis (Hendel).
New attractants for males of the solanaceous fruit fly Bactrocera latifrons.
Evaluation of SPLAT with spinosad and methyl eugenol or cue-lure for "attract-and-kill" of oriental and melon fruit flies (Diptera: Tephritidae) in Hawaii.
Evaluation of in vitro antimicrobial activity of Thai basil oils and their micro-emulsion formulas against Propionibacterium acnes.
Effectiveness of attract-and-kill systems using methyl eugenol incorporated with neonicotinoid insecticides against the oriental fruit fly (Diptera: Tephritidae).
Screening of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils.
Evaluation of lure dispensers for fruit fly surveillance in New Zealand.
Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome.
Antimicrobial activity of essential oils of Ocimum gratissimum L. From different populations of Kenya.
Gas chromatography/mass spectrometry analysis of Laurus nobilis essential oil composition of northern Cyprus.
Mating activity of Bactrocera cacuminata (Hering) (Diptera: Tephritidae) on its larval host plant Solanum mauritianum Scopoli in southeast Queensland.
Yield and oil composition of 38 basil (Ocimum basilicum L.) accessions grown in Mississippi.
Nematicidal Activity of Plant Essential Oils and Components From Ajowan (Trachyspermum ammi), Allspice (Pimenta dioica) and Litsea (Litsea cubeba) Essential Oils Against Pine Wood Nematode (Bursaphelenchus Xylophilus).
Can ménage-a-trois be used for controlling insects?
Attraction of Bactrocera dorsalis (Diptera: Tephritidae) and nontarget insects to methyl eugenol bucket traps with different preservative fluids on Oahu Island, Hawaiian Islands.
Evaluation of mosquitocidal activity of essential oil and sesquiterpenes from leaves of Chloroxylon swietenia DC.
Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of Rhaponticum acaule DC growing wild in Tunisia.
Pharmacophagy of methyl eugenol by males enhances sexual selection of Bactrocera carambolae.
Use of biomonitoring data to evaluate methyl eugenol exposure.
The use of biomonitoring data in exposure and human health risk assessments.
Floral phenylpropanoid cocktail and architecture of Bulbophyllum vinaceum orchid in attracting fruit flies for pollination.
Female-biased attraction of Oriental fruit fly, bactrocera dorsalis (Hendel), to a blend of host fruit volatiles from Terminalia catappa L.
Comparative chemical composition and antioxidant activities of wild and cultivated Laurus nobilis L. leaves and Foeniculum vulgare subsp. piperitum (Ucria) coutinho seeds.
Estragole (4-allylanisole) is the primary compound in volatiles emitted from the male and female cones of Cycas revoluta.
Consumption and metabolism of 1,2-dimethoxy-4-(3-fluoro-2-propenyl)benzene, a fluorine analog of methyl eugenol, in the oriental fruit fly Bactrocera dorsalis (Hendel).
Transport of methyl eugenol-derived sex pheromonal components in the male fruit fly, Bactrocera dorsalis.
Bioactive fractions containing methyl eugenol-derived sex pheromonal components in haemolymph of the male fruit fly Bactrocera dorsalis (Diptera: Tephritidae).
Weathering trials of Amulet cue-lure and Amulet methyl eugenol "attract-and-kill" stations with male melon flies and oriental fruit flies (Diptera: Tephritidae) in Hawaii.
Composition and Antimicrobial Activity of Anemopsis californica leaf oil.
Rectal gland of Bactrocera papayae: ultrastructure, anatomy, and sequestration of autofluorescent compounds upon methyl eugenol consumption by the male fruit fly.
Evidence of natural hybridization between two sympatric sibling species of Bactrocera dorsalis complex based on pheromone analysis.
Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales.
Effects of methyl-eugenol administration on behavioral models related to depression and anxiety, in rats.
Male sex pheromonal components derived from methyl eugenol in the hemolymph of the fruit fly Bactrocera papayae.
Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in south India as influenced by method of harvest.
Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil.
Optimization of a chemical attractant for Epicometis (Tropinota) hirta Poda.
Field trials of spinosad as a replacement for naled, DDVP, and malathion in methyl eugenol and cue-lure bucket traps to attract and kill male oriental fruit flies and melon flies (Diptera: Tephritidae) in Hawaii.
Correlation of tumors with DNA adducts from methyl eugenol and tamoxifen in rats.
Chemical and biological evaluation of the essential oils of different Melaleuca species.
Methyl eugenol and cue-lure traps for suppression of male oriental fruit flies and melon flies (Diptera: Tephritidae) in Hawaii: effects of lure mixtures and weathering.
Field evaluation of herbivore-induced plant volatiles as attractants for beneficial insects: methyl salicylate and the green lacewing, Chrysopa nigricornis.
Changes in the chemical composition of basil caused by different drying procedures.
Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase.
Phylogenetic relationships among Bactrocera species (Diptera: Tephritidae) inferred from mitochondrial DNA sequences.
Anticonflict effects of rose oil and identification of its active constituents.
Floral synomone of a wild orchid, Bulbophyllum cheiri, lures Bactrocera fruit flies for pollination.
Thresholds of carcinogenicity of flavors.
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
Authenticity assessment of estragole and methyl eugenol by on-line gas chromatography-isotope ratio mass spectrometry.
Allomonal and hepatotoxic effects following methyl eugenol consumption in Bactrocera papayae male against Gekko monarchus.
Biosynthesis of estragole and methyl-eugenol in sweet basil (Ocimum basilicum L). Developmental and chemotypic association of allylphenol O-methyltransferase activities.
Infraspecific taxonomy and essential oil chemotypes in sweet basil, Ocimum basilicum.
Essential oils from fruits of three types of Thapsia villosa.
Saturated and monofluoro analogs of the oriental fruit fly attractant methyl eugenol show reduced genotoxic activities in yeast.
Synthesis of attractants for oriental fruit flyDacus dorsalis Hendel using a catalytic organocopper coupling reaction.
Sequestration of distasteful compounds by some pharmacophagous insects.
Mould growth on black table olives and prevention by sorbic acid, methyl-eugenol and spice essential oil.
Relationship of sexual maturation rate to response of oriental fruit fly strains (Diptera: Tephritidae) to methyl eugenol.
Antimicrobial activity of "Cörtük" (Echinophora sibthorpiana Guss.) spice, its essential oil and methyl-eugenol.
Semiochemical attractants ofDiabrotica undecimpunctata howardi barber, southern corn rootworm, andDiabrotica virgifera virgifera leconte, the western corn rootworm (Coleoptera: Chrysomelidae).
Genotoxicity of safrole-related chemicals in microbial test systems.
[The pharmacological studies on methyl-eugenol (author's transl)].
Molecular parameters and olfaction in the oriental fruit fly Dacus dorsalis.
Environmental fate of methyl eugenol.
Evolution of olfactory receptor in oriental fruit fly Dacus dorsalis.
Attraction of the oriental fruit fly, Dacus dorsalis, to methyl eugenol and related olfactory stimulants.
Glycerides of lard as an extender for cue-lure, medlure, and methyl eugenol in formulations for programs of male annihilation.
Publications by J-Stage
Chemical Composition and Major Odor-Active Compounds of Essential Oil from PINELLIA TUBER (Dried Rhizome of Pinellia ternata) as Crude Drug
Comparative Chemical Composition and Antioxidant Activities of Wild and Cultivated Laurus nobilis L. Leaves and Foeniculum vulgare subsp. piperitum (Ucria) Coutinho Seeds

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10454
HMDB (The Human Metabolome Database):HMDB31864
FooDB:FDB008548
Export Tariff Code:2909.30.0000
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•small, absorbent fiber blocks containing combination of lure & naled... •grades: technical, fcc •vizubon-d (+naled)

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 178.23098754883
Specific gravity @ 25 °C
Pounds per Gallon 8.587 to 8.621
Specific gravity @ 20 °C
Pounds per Gallon 8.589 to 8.656
Refractive Index 1.532 to 1.536 @ 20 °C
Boiling Point 254 to 255°C @ 760 mm Hg
Vapor Pressure 0.027 mmHg @ 25 °C
Vapor Density 1
Flash Point TCC Value 110 °C TCC
logP (o/w) 2.973 est
Solubility
fixed oils Yes
paraffin oil Yes
water, 144.8 mg/L @ 25 °C (est) Yes
alcohol Yes
water, 500 mg/L @ 25 °C (exp) Yes
glycerin No
propylene glycol No
Stability
non-discoloring in most media Unspecified

Organoleptic Properties

Odor Type: Spicy
sweet, fresh, warm, spicy, clove, carnation, cinnamon, musty, vegetable, waxy, peppery, phenolic
Odor strength medium , recommend smelling in a 1.00 % solution or less
Substantivity 60 hour(s) at 100.00 %
Luebke, William tgsc, (1988) At 1.00 % in dipropylene glycol. sweet fresh warm spicy clove carnation cinnamon
Mosciano, Gerard P&F 21, No. 4, 51, (1996) Spicy, cinnamon, clove, musty, vegetative, waxy and peppery with phenolic nuances
Flavor Type: Spicy
spicy, cinnamon, clove, fresh, peppery, woody
Mosciano, Gerard P&F 21, No. 4, 51, (1996) At 5.00 ppm. Spice, cinnamon and clove, mouth tingle, fresh, peppery and woody
General comment Spicy, dry, clove, herbal

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 40 - Possible risks of irreversable effects.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
8 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 810 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 857, 1975.

intravenous-mouse LD50 112 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.

intraperitoneal-mouse LD50 540 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.

Dermal Toxicity:
skin-rabbit LD50 > 2025 mg/kg
Toxicology and Applied Pharmacology. Vol. 31, Pg. 421, 1975.

Inhalation Toxicity:
inhalation-rat LC50 > 4800 mg/m3
Toxicology and Applied Pharmacology. Vol. 31, Pg. 421, 1975.

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Dermal sensitization and systemic toxicity
IFRA fragrance material specification:

The Standard is based on long-term systemic effects and will therefore have a wider range of product type limitations as follows:

Fine fragrance: 0.02%

Eau de toilette: 0.008%

Fragrancing cream: 0.004%

Other leave on: 0.0004%

Rinse-off: 0.001%

Non skin (as defined in the introduction to the Standards): 0.02%*

Other non cosmetic products not covered above: 0.001%

*The limit of 0.02% applies to the concentration in the fragrance compound (see exposure calculation)

The limitations apply to Methyleugenol (ME) originating from all sources. Contributions from essential oils can be significant. Names of essential oils, which should also be considered in the application of the Standard, are given below. Maximum percentage of the reference material is included for use when no analytical data is available.

Fragrance material specification:

Contribution from other sources:

Contributions from essential oils (See also Annex 1)

Pimenta berry oil or leaf oil

Basil oil

Bay oil

Rose oil

Citronella oil

Estragon oil

Lovage leaf oil

Cascarilla oil

Hyssop oil

Savory winter oil

Nutmeg oil

Calamus oil

Clove oil

Cananga oil

Carrot oil

Mace oil

Cassia oil

This list is only indicative and should not be regarded as comprehensive. Maximum limits have been given. Variations to lower levels can result due to variations of species and time of harvest etc. It is recommended to base calculations on analytical data.

View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.00058 %
Category 2: Products applied to the axillae
0.0023 %
Category 3: Products applied to the face/body using fingertips
0.00029 %
Category 4: Products related to fine fragrance
0.016 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.0020 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.00058 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.00058 %
Category 5D: Baby Creams, baby Oils and baby talc
0.00019 %
Category 6: Products with oral and lip exposure
0.0014 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
0.00058 %
Category 7B: Leave-on products applied to the hair with some hand contact
0.00058 %
Category 8: Products with significant anogenital exposure
0.00019 %
Category 9: Products with body and hand exposure, primarily rinse off
0.00087 %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
0.00087 %
Category 10B: Household aerosol/spray products
0.0032 %
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
0.00019 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
0.00019 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
0.097 %
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -13.00000
beverages(nonalcoholic): -10.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -4.80000
fruit ices: -4.80000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -11.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: -52.00000
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):93-15-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7127
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
1,2-dimethoxy-4-prop-2-enylbenzene
Chemidplus:0000093152
EPA/NOAA CAMEO:hazardous materials
RTECS:CY2450000 for cas# 93-15-2