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methyl salicylate
General Material Information
| Preferred name | methyl salicylate |
| Trivial Name | Methyl salicylate |
| Short Description | benzoic acid, 2-hydroxy-, methyl ester |
| Formula | C8 H8 O3 |
| CAS Number | 119-36-8 |
| Deleted CAS Number | 648434-07-5 |
| FEMA Number | 2745 |
| Flavis Number | 9.749 |
| ECHA Number | 204-317-7 |
| FDA UNII | LAV5U5022Y |
| Nikkaji Number | J2.915G |
| Beilstein Number | 0971516 |
| MDL | MFCD00002214 |
| COE Number | 433 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 899 methyl salicylate |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 119-36-8 ; METHYL SALICYLATE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| methyl 2-hydroxybenzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 119-36-8 |
| Pubchem (cid): | 4133 |
| Pubchem (sid): | 134974376 |
| Flavornet: | 119-36-8 |
| Pherobase: | View |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C12305 |
| HMDB (The Human Metabolome Database): | HMDB34172 |
| FooDB: | FDB012459 |
| YMDB (Yeast Metabolome Database): | YMDB01370 |
| Export Tariff Code: | 2918.23.0000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •usp: liniment, compound: menthol 4.5 g, camphor oil rectified 25 ml, olive or peanut oil 30 ml, methyl salicylate to make 100 ml. ointment, compound: methyl salicylate 10 ml, menthol 10 g, white wax 5 g, hydrous wool fat to make 100 g. •usp: spirit, phenolated (podiatry): liquefied phenol 1 ml, methyl salicylate 3 ml, compound myrcia spirit 25 ml, alcohol rubbing compound to make 100 ml. •grades: technical; usp; fcc. | |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 152.14935302734 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 9.819 to 9.86 |
| Refractive Index | 1.535 to 1.538 @ 20 °C |
| Melting Point | -8 to -7°C @ 760 mm Hg |
| Boiling Point | 222 to 224°C @ 760 mm Hg |
| Boiling Point | 132 to 133°C @ 50 mm Hg |
| Acid Value | 1 max KOH/g |
| Vapor Pressure | 0.0343 mmHg @ 25 °C |
| Vapor Density | 5.26 |
| Flash Point TCC Value | 96 °C TCC |
| logP (o/w) | 2.55 |
| Shelf life | 24 months (or longer if stored properly.) |
| Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Solubility | |
| alcohol | Yes |
| dipropylene glycol | Yes |
| kerosene | Yes |
| paraffin oil | Yes |
| water, 700 mg/L @ 30 °C (exp) | Yes |
| water | No |
| Stability | |
| non-discoloring in most media | Unspecified |
Organoleptic Properties
| Odor Type: Minty | |
| wintergreen, minty, sweet, root beer, aromatic, phenolic, camphoreous | |
| Odor strength | medium , recommend smelling in a 10.00 % solution or less |
| Substantivity | 8 hour(s) at 100.00 % |
| Luebke, William tgsc, (1983) | At 10.00 % in dipropylene glycol. wintergreen mint |
| Mosciano, Gerard P&F 20, No. 6, 49, (1995) | Sweet, salicylate, root beer, wintergreen, aromatic, slightly phenolic and camphoreous |
| Flavor Type: Minty | |
| sweet, wintergreen, root beer, aromatic, balsamic | |
| Mosciano, Gerard P&F 20, No. 6, 49, (1995) | At 10.00 ppm. Sweet, salicylate and root beer with aromatic and balsamic nuances |
| General comment | Sweet, wintergreen |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Acacia, Alpine bouquet, Apple, Apricot, Blackberry, Blueberry, Boxwood berry, Bubble gum, Carnation, Cassia, Cassia blossom, Castoreum, Cherry, Chypre, Clove, Cornmint, Crabapple blossom, Cranberry, Currant, Currant bud absolute replacer, Date, Fern, Gardenia, Gooseberry, Grape, Hay new mown hay, Herbal, Huckleberry, Hyssop, Jasmin, Leather russian leather, Licorice, Magnolia, Meadowsweet, Mimosa, Mint, Mulberry, Oriental, Peach, Peppermint, Raspberry, Reseda, Root beer, Rue, Sassafras, Spearmint, Spice, Spicewood, Strawberry, Tea green tea, Tuberose, Valerian, Wallflower, Wintergreen, Wormwood oil replacer, Ylang ylang, Zibeline |
| Flavoring purposes | Beer birch beer, Cornmint, Currant bud absolute replacer, Grenadine, Hyssop, Rue, Sarsaparilla, Tomato, Valerian |
| Cosmetic purposes | Denaturants, Fragrance, Perfuming agents, Soothing agents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 3), H402 | |
| GHS Label elements, including precautionary statements | |
| Pictogram |  |
| Signal word | Warning |
| Hazard statement(s) | |
| H302 - Harmful if swallowed H402 - Harmful to aquatic life | |
| Precautionary statement(s) | |
| P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P273 - Avoid release to the environment. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P330 - Rinse mouth. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Human Experience: | |
| 8 % solution: no irritation or sensitization. | |
| Oral/Parenteral Toxicity: | |
| gavage-mouse LD50 [sex: M] 1390 mg/kg (Ohsumi et al., 1984) gavage-rat LD50 1250 mg/kg (Giroux et al., 1954b) oral-rat LD50 [sex: M,F] M:3049.00 F:2642 mg/kg (Givaudan Corporation, 1982) gavage-rat LD50 [sex: M,F] 887 mg/kg (Jenner et al., 1964) oral-rat LD50 1220 mg/kg (Nivikov et al., 1994) oral-mouse LD50 [sex: M] 1110 mg/kg (Davison et al., 1961) gavage-guinea pig LD50 [sex: M,F] 1060 mg/kg (Jenner et al., 1964) gavage-mouse LD50 [sex: M,F] 1440 mg/kg (NTP, 1984a) oral-woman LDLo 355 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: COMA American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. oral-rat LD50 887 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-rabbit LD50 1300 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. oral-mouse LD50 1110 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 207, 1961. unreported-man LDLo 522 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man LDLo 1329 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA BLOOD: HEMORRHAGE Clinical Toxicology. Vol. 6, Pg. 189, 1973. oral-man LDLo 101 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. oral-human LDLo 506 mg/kg "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 961, 1989. oral-guinea pig LD50 700 mg/kg "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1897, 1963. oral-dog LD50 2100 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. oral-child LDLo 700 mg/kg BEHAVIORAL: GENERAL ANESTHETIC PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953. oral-child LDLo 228 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: DYSPNEA American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945. | |
| Dermal Toxicity: | |
| subcutaneous-dog LDLo 2250 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. subcutaneous-guinea pig LDLo 1500 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 63, 1967. subcutaneous-rabbit LDLo 4250 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| cosmetic, flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| maximum skin levels for fine fragrances: | |||
| 0.2900 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey).(IFRA, 2002) | |||
| Recommendation for methyl salicylate usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| use level in formulae for use in cosmetics: | |||
| 0.1300 % | |||
| Dermal Systemic Exposure in Cosmetic Products: | |||
| 0.0034 mg/kg/day (IFRA, 2002) | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 410.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 44000.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 54.00000 | |
| beverages(nonalcoholic): | - | 59.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 8400.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 27.00000 | |
| fruit ices: | - | 27.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 840.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):119-36-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :4133 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 3082 |
| WGK Germany:1 |
| methyl 2-hydroxybenzoate |
| Chemidplus:0000119368 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:119-36-8 |