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2-pentanone

Chemical Structure

General Material Information

Preferred name 2-pentanone
Trivial Name 2-Pentanone
Short Description methyl propyl ketone
Formula C5 H10 O
CAS Number 107-87-9
FEMA Number 2842
Flavis Number 7.054
ECHA Number 203-528-1
FDA UNII I97392I10V
Nikkaji Number J5.065B
Beilstein Number 0506058
MDL MFCD00009400
COE Number 754
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 279 2-pentanone
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 107-87-9 ; 2-PENTANONE
Synonyms
  • ethyl acetone
  • ketone, methyl propyl
  • methyl N-propyl ketone
  • methyl propyl ketone
  • methyl propyl ketone natural
  • methyl propyl ketone, pure
  • methyl propyl ketone, regular grade
  • methyl-propyl-cetone
  • metylopropyloketon
  • MPK
  • pentan-2-one
  • 2-pentanone
  • 2-pentanone natural
  • propyl methyl ketone
  • Ethylacetone
  • 4-Methyl-2-butanone
  • NSC 5350

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Literature & References

pentan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:107-87-9
Pubchem (cid):7895
Pubchem (sid):134972736
Flavornet:107-87-9
Pherobase:View
Publications by Info
HEPTAN-2-ONE
Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.)
Publications by PubMed
Tetranychus urticae-triggered responses promote genotype-dependent conspecific repellence or attractiveness in citrus.
Enantioenrichment of a tungsten dearomatization agent utilizing chiral acids.
[Determination of methyl propyl ketone in air of workplace by capillary gas chromatography].
Hydrothermal conversion of bamboo: identification and distribution of the components in solid residue, water-soluble and acetone-soluble fractions.
The dynamics of the HS/SPME-GC/MS as a tool to assess the spoilage of minced beef stored under different packaging and temperature conditions.
Quantitative analysis of volatile organic compounds released and consumed by rat L6 skeletal muscle cells in vitro.
On the influence of column temperature on the isothermal retention indices of structurally different solutes on a poly(dimethylsiloxane) capillary column.
Multi-capillary column-ion mobility spectrometry of volatile metabolites emitted by Saccharomyces cerevisiae.
Binding of aroma compounds with myofibrillar proteins modified by a hydroxyl-radical-induced oxidative system.
Characterization of a new mobility separation tool: HRIMS as differential mobility analyzer.
2-Pentanone production from hexanoic acid by Penicillium roqueforti from blue cheese: is this the pathway used in humans?
Reaction rate constants of H-abstraction by OH from large ketones: measurements and site-specific rate rules.
Chemical characterization of Brickellia cavanillesii (Asteraceae) using gas chromatographic methods.
A powerful methodological approach combining headspace solid phase microextraction, mass spectrometry and multivariate analysis for profiling the volatile metabolomic pattern of beer starting raw materials.
Novel gas chromatographic detector utilizing the localized surface plasmon resonance of a gold nanoparticle monolayer inside a glass capillary.
Odorous gaseous emissions as influence by process condition for the forced aeration composting of pig slaughterhouse sludge.
Direct accurate analysis of cysteinylated and glutathionylated precursors of 4-mercapto-4-methyl-2-pentanone and 3-mercaptohexan-1-ol in must by ultrahigh performance liquid chromatography coupled to mass spectrometry.
Homogenization and lipase treatment of milk and resulting methyl ketone generation in blue cheese.
Assessment of the thermodynamic properties of poly(2,2,2-trifluoroethyl methacrylate) by inverse gas chromatography.
SoxR as a single-cell biosensor for NADPH-consuming enzymes in Escherichia coli.
Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats.
Influence of volatile thiols in the development of blackcurrant aroma in red wine.
Local conformation and intermolecular interaction of rigid ring polymers are not always the same as the linear analogue: cyclic amylose tris(phenylcarbamate) in Θ solvents.
Release and uptake of volatile organic compounds by human hepatocellular carcinoma cells (HepG2) in vitro.
Dissociation of proton bound ketone dimers in asymmetric electric fields with differential mobility spectrometry and in uniform electric fields with linear ion mobility spectrometry.
Characterization of olfactory sensilla of the olive fly: behavioral and electrophysiological responses to volatile organic compounds from the host plant and bacterial filtrate.
Development of a new in-vial standard gas system for calibrating solid-phase microextraction in high-throughput and on-site applications.
Mass and Ion Transport in Ketones and Ketone Electrolytes: Comparison with Acetate Systems.
Near real-time VOCs analysis using an aspiration ion mobility spectrometer.
An endophytic Nodulisporium sp. from Central America producing volatile organic compounds with both biological and fuel potential.
Identification of muscadine wine sulfur volatiles: pectinase versus skin-contact maceration.
Electrophysiological and behavioral responses of male fall webworm moths (Hyphantria cunea) to Herbivory-induced mulberry (Morus alba) leaf volatiles.
Cross-linked gold nanoparticles on polyethylene: resistive responses to tensile strain and vapors.
Picosecond rotational interconversion adjacent to a C═O bond studied by two-dimensional infrared spectroscopy.
Sensory and chemical characterisation of the aroma of Prieto Picudo rosé wines: The differential role of autochthonous yeast strains on aroma profiles.
Variability in the concentrations of volatile metabolites emitted by genotypically different strains of Pseudomonas aeruginosa.
Thermochemistry and bond dissociation energies of ketones.
Permeation profiles of potential urine-borne biomarkers of human presence over brick and concrete.
Identification of volatile lung cancer markers by gas chromatography-mass spectrometry: comparison with discrimination by canines.
High-temperature measurements of the reactions of OH with a series of ketones: acetone, 2-butanone, 3-pentanone, and 2-pentanone.
Urinary volatile compounds as biomarkers for lung cancer.
Temporal profiling of human urine VOCs and its potential role under the ruins of collapsed buildings.
Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice.
Okanin, a chalcone found in the genus Bidens, and 3-penten-2-one inhibit inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with lipopolysaccharide.
Color, lipid oxidation, sensory quality, and aroma compounds of beef steaks displayed under different levels of oxygen in a modified atmosphere package.
Formation of the aroma of a raw goat milk cheese during maturation analysed by SPME-GC-MS.
Bioactivity of short-chain aliphatic ketones against adults of the granary weevil, Sitophilus granarius (L.).
The application of statistical methods using VOCs to identify patients with lung cancer.
Investigation of lung cancer biomarkers by hyphenated separation techniques and chemometrics.
Volatile compounds responsible for aroma of Jutrzenka liquer wine.
Assessment of the aroma impact of major odor-active thiols in pan-roasted white sesame seeds by calculation of odor activity values.
Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein.
Effect of a hay-based diet or different upland grazing systems on milk volatile compounds.
The free energy landscape of small molecule unbinding.
SPME-GC-MS versus Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) analyses for the study of volatile compound generation and oxidation status during dry fermented sausage processing.
Optimization of ultrasound assisted-emulsification-dispersive liquid-liquid microextraction by experimental design methodologies for the determination of sulfur compounds in wines by gas chromatography-mass spectrometry.
Analysis, occurrence, and potential sensory significance of five polyfunctional mercaptans in white wines.
Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study.
Rapid analysis of acetone in human plasma by derivatization desorption electrospray ionization.
Spectrophotometric determination of traces of platinum with 5-chloro-2-hydroxythiobenzhydrazide after extraction into molten naphthalene.
TD-GC-MS analysis of volatile metabolites of human lung cancer and normal cells in vitro.
New factor characterizing the in-mouth release of odorants (volatile thiols): compositional changes in odorants exhaled from the human nose during drinking.
Thermodynamic properties of hyperbranched polymer, Boltorn U3000, using inverse gas chromatography.
Selective preconcentration of volatile mercaptans in small SPE cartridges: quantitative determination of trace odor-active polyfunctional mercaptans in wine.
Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831.
Pyrolytic product characteristics of biosludge from the wastewater treatment plant of a petrochemical industry.
Improved method to quantitatively determine powerful odorant volatile thiols in wine by headspace solid-phase microextraction after derivatization.
[Risk factor for lifestyle and way of living for symptoms of sick building syndrome: epidemiological survey in Japan].
Olfactory psychometric functions for homologous 2-ketones.
Solvent-dependent conformation of amylose tris(phenylcarbamate) as deduced from scattering and viscosity data.
The pollution characteristics of odor, volatile organochlorinated compounds and polycyclic aromatic hydrocarbons emitted from plastic waste recycling plants.
Identification of 5-hydroxy-3-mercapto-2-pentanone in the maillard reaction of thiamine, cysteine, and xylose.
Sequential injection wetting film extraction applied to the spectrophotometric determination of chromium(VI) and chromium(III) in water.
GC-MS analysis of breath odor compounds in liver patients.
Synthesis, reactivity, and characterization of sodium and rare-earth metal complexes bearing a dianionic N-aryloxo-functionalized beta-ketoiminate ligand.
A comparative study of the analysis of human urine headspace using gas chromatography-mass spectrometry.
Determination of volatile metabolites originating from mould growth on wall paper and synthetic media.
Chemical composition and inhibitory parameters of essential oil and extracts of Nandina domestica Thunb. to control food-borne pathogenic and spoilage bacteria.
Identification of volatile organic compounds secreted from cancer tissues and bacterial cultures.
Rate constants for the gas-phase reactions of OH radicals with dimethyl phosphonate over the temperature range of 278-351 K and for a series of other organophosphorus compounds at approximately 280 K.
The flavouring phytochemical 2-pentanone reduces prostaglandin production and COX-2 expression in colon cancer cells.
Metal-assisted in situ formation of a tridentate acetylacetone ligand for complexation of fac-Re(CO)3+ for radiopharmaceutical applications.
Improved solid-phase extraction procedure for the isolation and in-sorbent pentafluorobenzyl alkylation of polyfunctional mercaptans. Optimized procedure and analytical applications.
Acid-catalyzed isomerization and decomposition of ketone-2,4-dinitrophenylhydrazones.
Differentiation of closely related fungi by electronic nose analysis.
Kinetic analysis of volatile formation in milk subjected to pressure-assisted thermal treatments.
Rate constants for the reaction of cl with a series of C4 to C6 ketones using the relative rate method.
Ligand field photofragmentation spectroscopy of [Ag(L)N]2+ complexes in the gas phase: experiment and theory.
[Discharge ion mobility spectrometry of ketonic organic compounds].
Solvent as a competitive inhibitor for Candida antarctica lipase B.
Extractive liquid-liquid spectrophotometric procedure for the determination of thiocyanate ions employing the ion pair reagent amiloride monohydrochloride.
Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction.
Halitosis associated volatiles in breath of healthy subjects.
Relative gene expression quantification in a fungal gas-phase biofilter.
Quantitative determination of wine polyfunctional mercaptans at nanogram per liter level by gas chromatography-negative ion mass spectrometric analysis of their pentafluorobenzyl derivatives.
Pulsed laser photolysis vacuum UV laser-induced fluorescence kinetic study of the gas-phase reactions of Cl(2P3/2) atoms with C3-C6 ketones.
Effect of pH on the Maillard reaction of [13C5]xylose, cysteine, and thiamin.
Production of volatile compounds by Rhizopus oligosporus during soybean and barley tempeh fermentation.
Development of an impregnated reagent and automation of solid-phase analytical derivatization for carbonyls: proof of principle.
Storage stability of ketones on carbon adsorbents.
Occurrence of polyfunctional thiols in fresh lager beers.
Model studies on the efficacy of protein homogenates from raw pork muscle and dry-cured ham in binding selected flavor compounds.
Oviposition in Delia platura (Diptera, Anthomyiidae): the role of volatile and contact cues of bean.
Quantification of homogentisate-1,2-dioxygenase expression in a fungus degrading ethylbenzene.
Automated analysis of 2-methyl-3-furanthiol and 3-mercaptohexyl acetate at ng L(-1) level by headspace solid-phase microextracion with on-fibre derivatisation and gas chromatography-negative chemical ionization mass spectrometric determination.
Analysis of expired air of fasting male monks at Mount Athos.
Effect of high-pressure treatment and a bacteriocin-producing lactic culture on the odor and aroma of hispánico cheese: correlation of volatile compounds and sensory analysis.
Production and characterization of a thermostable alcohol dehydrogenase that belongs to the aldo-keto reductase superfamily.
Screening for new hydroxynitrilases from plants.
Protonation thermochemistry of selected hydroxy- and methoxycarbonyl molecules.
[Determination of major flavor components in chinese spirits using a special domestic gas chromatograph with DNP packed column].
Degradation characteristics of methyl ethyl ketone by Pseudomonas sp. KT-3 in liquid culture and biofilter.
1,4-hydroxycarbonyl products of the OH radical initiated reactions of C5-C8 n-alkanes in the presence of NO.
Production of volatile compounds in cheese by Pseudomonas fragi strains of dairy origin.
Preliminary investigation of using volatile organic compounds from human expired air, blood and urine for locating entrapped people in earthquakes.
Influence of manufacturing conditions and crop season on the formation of 4-mercapto-4-methyl-2-pentanone in Japanese green tea (sen-cha).
Direct determination of several elements in MIBK extract by high-power nitrogen-oxygen mixed gas microwave-induced plasma optical emission spectrometry.
Synthesis and biological evaluation of 2-thiopyrimidine derivatives.
Unexpected formation of etheno-2'-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: evidence for a bis-hydroperoxide intermediate.
Tropospheric reaction of OH with selected linear ketones: kinetic studies between 228 and 405 K.
Interaction of soluble peptides and proteins from skeletal muscle with volatile compounds in model systems as affected by curing agents.
TBADH activity in water-miscible organic solvents: correlations between enzyme performance, enantioselectivity and protein structure through spectroscopic studies.
Test of the Binding Threshold Hypothesis for olfactory receptors: explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93.
Synthesis, crystal structure, and magnetic properties of oxime-bridged polynuclear Ni(II) and Cu(II) complexes.
Rapid identification of microbial VOCs from tobacco molds using closed-loop stripping and gas chromatography/time-of-flight mass spectrometry.
Multi-element analysis of saline matrices by inductively coupled plasma mass spectrometry following on-line preconcentration using a knotted reactor.
Controlled production of Camembert-type cheeses. Part II. Changes in the concentration of the more volatile compounds.
Field determination of trace iron in fresh water samples by visual and spectrophotometric methods.
Use of a chiral surfactant for enantioselective reduction of a ketone.
Safety assessment of MIBK (methyl isobutyl ketone).
Performance of a fungal biofilter treating gas-phase solvent mixtures during intermittent loading.
Photoelectron resonance capture ionization (PERCI): a novel technique for the soft-ionization of organic compounds.
Preliminary characterization of beta-decarboxylase activities in Staphylococcus carnosus 833, a strain used in sausage fermentation.
Interactions of soluble peptides and proteins from skeletal muscle on the release of volatile compounds.
Decomposition of 2-bromophenol in NaOH solution at high temperature.
Electrophysiological characterization of olfactory cell types in the antennae and palps of the housefly.
Combinatorial synthesis and sensorial properties of mercapto primary alcohols and analogues.
Impact odorants of different young white wines from the Canary Islands.
Formation of aroma compounds from ribose and cysteine during the Maillard reaction.
Enantiomerization study of some alpha-nitroketones by dynamic high-resolution gas chromatography.
Protective effect of a novel antioxidant non-steroidal anti-inflammatory agent (compound IA) on intestinal viability after acute mesenteric ischemia and reperfusion.
Unfunctionalized, alpha-epimerizable nonracemic ketones and aldehydes can be accessed by crystallization-induced dynamic resolution of imines.
Behavior of flavor compounds in model food systems: a thermodynamic study.
[Investigation on the changing regularity of the relationship between retention index and temperature of the GDX series stationary phases].
Comparative metabolism of methyl isobutyl carbinol and methyl isobutyl ketone in male rats.
Identification of potent odorants in different green tea varieties using flavor dilution technique.
Arylsulfotransferase from Clostridium innocuum-A new enzyme catalyst for sulfation of phenol-containing compounds.
Background odour induces adaptation and sensitization of olfactory receptors in the antennae of houseflies.
Beneficial effect of a novel non-steroidal anti-inflammatory agent with basic character and antioxidant properties on experimental colitis in rats.
Decarboxylase activity involved in methyl ketone production by Staphylococcus carnosus 833, a strain used in sausage fermentation.
Characterization of the aroma of a meatlike process flavoring from soybean-based enzyme-hydrolyzed vegetable protein.
Chemosignalling of musth by individual wild African elephants (Loxodonta africana): implications for conservation and management.
Development of an enzymatic method to quantify methyl ketones from bacterial origin.
Biodegradation of volatile organic compounds by five fungal species.
Airborne carbonyls from motor vehicle emissions in two highway tunnels.
Characterization of the most odor-active compounds of Iberian ham headspace.
Products and mechanism of the reaction of OH radicals with 2,2,4-trimethylpentane in the presence of NO.
Structurally diagnostic ion-molecule reactions: acylium ions with alpha-, beta- and gamma-hydroxy ketones.
Aroma composition changes in early season grapefruit juice produced from thermal concentration.
Chemical composition and behavioral responses of the marine insect Halobates hawaiiensis (Heteroptera: Gerridae).
Biochemical characterization of ochratoxin A-producing strains of the genus Penicillium.
On-road emissions of carbonyls from light-duty and heavy-duty vehicles.
Generation of odorous acyloins by yeast pyruvate decarboxylases and their occurrence in sherry and soy sauce.
Regulated workplace ketones and their interference in the PFBHA method for aldehydes.
Solvent-stabilized alkylrhodium(III) hydride complexes: a special mode of reversible C-H bond elimination involving an agostic intermediate
Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink.
Production of flavour ketones in aqueous-organic two-phase systems by using free and microencapsulated fungal spores as biocatalysts.
Potent aroma compounds of two red wine vinegars.
Identification of potent odorants in Japanese green tea (Sen-cha).
Uptake of 10 polar organic solvents during short-term respiration.
Evidence for an inducible nucleotide-dependent acetone carboxylase in Rhodococcus rhodochrous B276.
Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?
The enantiomeric purity of alcohols formed by enzymatic reduction of ketones can be improved by optimisation of the temperature and by using a high co-substrate concentration.
Agonistic sensory effects of airborne chemicals in mixtures: odor, nasal pungency, and eye irritation.
Formation of Tetrahydrofuran Derivatives and Acetonylation of Alkenes Using Carbon Radicals Derived from Manganese(III) Oxidation of Diketene.
Volatile metabolites produced by two fungal species cultivated on building materials.
Analysis of polar organic compounds using charge exchange ionization and membrane introduction mass spectrometry.
Role of plant volatiles in the search for a host by parasitoidDiglyphus isaea (Hymenoptera: Eulophidae).
Flavor and texture characteristics of low fat ground beef patties formulated with whey protein concentrate.
Enhanced sensitivity to androstenone following regular exposure to pemenone.
Relative sensitivity of the ocular trigeminal, nasal trigeminal and olfactory systems to airborne chemicals.
Ketone EC50 values in the Microtox test.
The identification of potential aeroallergen/irritant(s) from oilseed rape (Brassica napus spp. oleifera): volatile organic compounds emitted during flowering progression.
Pharmacodynamic and metabolic interactions between ethanol and two industrial solvents (methyl n-butyl ketone and methyl isobutyl ketone) and their principal metabolites in mice.
Active-site peptides of acetylcholinesterase of Electrophorus electricus: labelling of His-440 by 1-bromo-[2-14C]pinacolone and Ser-200 by tritiated diisopropyl fluorophosphate.
Plant-natural enemy association in tritrophic system,Cotesia rubecula-Pieris rapae-brassicaceae (Cruciferae). III: Collection and identification of plant and frass volatiles.
A fiber optic sensor for water in organic solvents based on polymer swelling.
Purification, characterization, and cloning of alpha-hydroxynitrile lyase from cassava (Manihot esculenta Crantz).
Individual differences in the perceived intensity and quality of specific odors following self- and cross-adaptation.
Aminotransferase catalysis applied to the synthesis of a PAF antagonist.
Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice.
Sensory irritation and pulmonary irritation of n-methyl ketones: receptor activation mechanisms and relationships with threshold limit values.
Labeling of cysteine 231 in acetylcholinesterase from Torpedo nobiliana by the active-site directed reagent, 1-bromo-2-[14C] pinacolone. Effects of 2,2'-dipyridyl disulfide and other sulfhydryl reagents.
Simultaneous measurement of serum probucol and lipid-soluble antioxidants.
Substrate specificity and stereoselectivity of horse liver alcohol dehydrogenase. Kinetic evaluation of binding and activation parameters controlling the catalytic cycles of unbranched, acyclic secondary alcohols and ketones as substrates of the native and active-site-specific Co(II)-substituted enzyme.
Chemical characterization of fruit and fungal volatiles attractive to dried-fruit beetle,Carpophilus hemipterus (L.) (Coleoptera: Nitidulidae).
[Metabolism and toxicity of n-pentane and isopentane].
Anaerobic degradation of sorbic acid by sulfate-reducing and fermenting bacteria: pentanone-2 and isopentanone-2 as byproducts.
Atomic absorption spectrophotometric method for determination of polydimethylsiloxane residues in pineapple juice: collaborative study.
Exposure to methyl isobutyl ketone: toxicokinetics and occurrence of irritative and CNS symptoms in man.
Reactions of 1-bromo-2-[14C]pinacolone with acetylcholinesterase from Torpedo nobiliana. Effects of 5-trimethylammonio-2-pentanone and diisopropyl fluorophosphate.
Volatile methyl ketone seed-germination inhibitors fromAmaranthus palmeri S. Wats. Residues.
Screening method for determination of high levels of cadmium, lead, and copper in foods by polarized Zeeman atomic absorption spectrometry using discrete nebulization technique.
Observations concerning the nature of sites of anaesthetic action in Gammarus.
Odor similarity between stress-inducing odorants in wistar rats.
Determination of cadmium, copper, and lead in sodium chloride food salts by flame atomic absorption spectroscopy.
Cobalt content of foods and diets in a Spanish population (short communication).
Defensive secretions of New Zealand tenebrionids V. Presence of methyl ketones inUloma tenebrionoides (Coleoptera: Tenebrionidae).
Dose-response relationships in ketone-induced potentiation of chloroform hepato- and nephrotoxicity.
Nephrotoxic interactions between ketonic solvents and halogenated aliphatic chemicals.
Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats.
Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice.
Identification of new components from anal glands ofTapinoma simrothi pheonicium.
Relationship between the carbon skeleton length of ketonic solvents and potentiation of chloroform-induced hepatotoxicity in rats.
An improved method excluding hemoglobin interferences for lysosomal hydrolase assays using colorimetric synthetic substrates, 2-(N-hexadecanoylamino)-4-nitrophenol derivatives.
Interaction of L- and D-3-amino-1-chloro-2-pentanone with gamma-glutamylcysteine synthetase.
Microbial Oxidation of Gaseous Hydrocarbons: Production of Methylketones from Corresponding n-Alkanes by Methane-Utilizing Bacteria.
Microbial production of methyl ketones. Purification and properties of a secondary alcohol dehydrogenase from yeast.
Oxidation of secondary alcohols to methyl ketones by yeasts.
Aliphatic ketones are acetylcholinesterase inhibitors but not transition state analogs.
Behavior genetics of olfactory responses in Drosophila. II. An odorant-specific variant in a natural population of Drosophila melanogaster.
Mechanism of inactivation of ornithine decarboxylase by alpha-methylornithine.
Antimetabolites produced by microorganisms XVI. Synthesis of N5-hydroxy-2-methylarginine and N5-hydroxy-2-methylornithine.
Cholesterol autoxidation: identification of the volatile fragments.
Metal and metalloid indicator electrodes for the non-aqueous potentiometric titration of weak acids: comparative evaluation of group III, IV and V main-group elements.
A short stereoselective synthesis of cecropia juvenile hormone.
Caproic acid metabolism and the production of 2-pentanone and gluconic acid by Aspergillus niger.
Fatty acid toxicity and methyl ketone production in Aspergillus niger.
Sweat in schizophrenic patients: identification of the odorous substance.
Hygienic guide series. Methyl isobutyl ketone (4-methyl-2-pentanone, hexone, MIBK).

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C01949
HMDB (The Human Metabolome Database):HMDB34235
FooDB:FDB012547
Export Tariff Code:2914.19.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grade: technical •90.0% purity product available from eastman chemical products, inc.

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 86.133903503418
Specific gravity @ 25 °C
Pounds per Gallon 6.665 to 6.707
Refractive Index 1.387 to 1.392 @ 20 °C
Boiling Point 100 to 110°C @ 760 mm Hg
Acid Value 2 max KOH/g
Vapor Pressure 38.577 mmHg @ 25 °C
Vapor Density 3
Flash Point TCC Value 7.22 °C TCC
logP (o/w) 0.91
Solubility
alcohol Yes
water, 4.30E+04 mg/L @ 25 °C (exp) Yes
water No

Organoleptic Properties

Odor Type: Fruity
sweet, fruity, ethereal, winey, banana, woody, fermented
Odor strength high , recommend smelling in a 1.00 % solution or less
Substantivity < 10 hour(s) at 100.00 %
General comment At 1.00 % in dipropylene glycol. sweet fruity ethereal wine banana woody
Mosciano, Gerard P&F 20, No. 1, 31, (1995) Etherial, diffusive and sweet banana-like with fermented woody nuance
Flavor Type: Fruity
sweet, fruity, banana, fermented
Mosciano, Gerard P&F 20, No. 1, 31, (1995) At 25.00 ppm. Sweet, fruity and banana-like with a fermented nuance
Ethereal notes for wine, whiskey, and banana. Ethereal, witch hazel at lower level, wine, whiskey at higher level
2-PENTANONE has an interesting diffusive, sweet banana-like character with fermented woody nuances which work perfectly in dairy, fruit and alcoholic flavors. Sharp ethereal and slightly winey notes

Occurrences

Potential Uses

Applications
Odor purposes Apple, Banana, Butter, Coffee, Fruit, Grape, Pineapple, Strawberry
Flavoring purposes Carrot, Cheese blue cheese, Cheese cheddar cheese, Dairy
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 11 - Highly flammable.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 33 - Take precautionary measures against static discharge.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M] 3730 mg/kg
(Smyth et al., 1962)

oral-mouse LD50 [sex: M] 2205 mg/kg
(Tanii et al., 1986)

oral-mammal (species unspecified) LD50 3700 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.

intraperitoneal-mouse LD50 1600 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4735, 1982.

oral-mouse LD50 1600 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4735, 1982.

intraperitoneal-rat LD50 800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4735, 1982.

oral-rat LD50 1600 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4735, 1982.

Dermal Toxicity:
skin-rabbit LD50 6500 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 83, 1974.

Inhalation Toxicity:
inhalation-mammal (species unspecified) LC50 22000 mg/m3
HYSAAV. Vol. 51(5), Pg. 61

inhalation-guinea pig LCLo 13000 ppm/5H
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1036, 1991.

inhalation-human TCLo 1500 ppm
BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 83, 1974.

inhalation-mammal (species unspecified) LC50 22000 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.

inhalation-rat LCLo 2000 ppm/4H
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-pentanone usage levels up to:
0.5000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 120.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -32.00000
beverages(nonalcoholic): -13.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -34.00000
fruit ices: -34.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -32.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
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Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Safety and efficacy of saturated and unsaturated aliphatic secondary alcohols, ketones and esters with esters containing secondary alcohols belonging to chemical group 5 when used as flavourings for all animal species
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):107-87-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7895
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1249
WGK Germany:1
pentan-2-one
Chemidplus:0000107879
EPA/NOAA CAMEO:hazardous materials
RTECS:107-87-9