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2-acetyl pyridine

Chemical Structure

General Material Information

Preferred name 2-acetyl pyridine
Trivial Name 2-Acetylpyridine
Short Description 2-acetylpyridine
Formula C7 H7 N O
CAS Number 1122-62-9
FEMA Number 3251
Flavis Number 14.038
ECHA Number 214-355-6
FDA UNII 629O10UI3L
Nikkaji Number J71.242F
Beilstein Number 0107759
MDL MFCD00006303
COE Number 2315
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1309 2-acetylpyridine
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 1122-62-9 ; 2-ACETYLPYRIDINE
Synonyms
  • 2-acetopyridine
  • acetyl-2 pyridine
  • 2-acetylpyridine
  • 2 acetylpyridine
  • ethanone, 1-(2-pyridinyl)-
  • ketone, methyl 2-pyridyl
  • methyl 2-pyridyl ketone
  • methyl-2-pyridyl ketone
  • methyl-2-pyridylketone
  • popcorn pyridine
  • 1-( pyridin-2-yl)ethanone
  • 1-pyridin-2-ylethanone
  • 1-(2-pyridinyl)ethanone
  • 2-pyridyl methyl ketone
  • 2-pyridylmethyl ketone
  • 1-pyridin-2-ylethanone
  • 1-(2-Pyridinyl)ethanone
  • 2-Acetylpyridine
  • 2-Pyridyl methyl ketone
  • Methyl 2-pyridinyl ketone
  • α-Acetylpyridine
  • NSC 15043
  • Pyridin-2-yl methyl ketone
  • 1-(2-Pyridyl)-1-ethanone
  • 1-(Pyridin-2-yl)ethan-1-one
  • 1-(2-Pyridyl)ethanone
  • 1-(Pyridin-2-yl)ethanone

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB35281
FooDB:FDB013943
Export Tariff Code:2933.39.9100
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 121.13899230957
Specific gravity @ 25 °C
Pounds per Gallon 8.962 to 9.02
Refractive Index 1.518 to 1.524 @ 20 °C
Boiling Point 189 to 193°C @ 760 mm Hg
Vapor Pressure 0.481 mmHg @ 25 °C
Flash Point TCC Value 73.33 °C TCC
logP (o/w) 0.85
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
dipropylene glycol Yes
ethyl ether Yes
water, 1.868e+004 mg/L @ 25 °C (est) Yes
water, 1.87E+04 mg/L @ 17C (exp) Yes

Organoleptic Properties

Odor Type: Popcorn
popcorn, corn chip, fatty, tobacco, corn, musty, nutty
Odor strength high , recommend smelling in a 1.00 % solution or less
Substantivity 9 hour(s) at 100.00 %
Luebke, William tgsc, (1996) At 1.00 % in propylene glycol. popcorn heavy corn chip fatty tobacco
Mosciano, Gerard P&F 17, No. 1, 41, (1992) Corn-like with a musty nutty nuance
Flavor Type: Corn
cornmeal, nutty, bready
Mosciano, Gerard P&F 17, No. 1, 41, (1992) At 10.00 ppm. Cornmeal with a nutty and bready nuance
This material has a cracker-popcorn-like aroma similar to 2-Acetylpyrazine, but not as clean or true. Used in roast nut, chocolate, coffee, bread, popcorn and possibly tobacco flavors. Normal use levels in finished consumer product: 0.05-5 ppm. Council of Europe limits: Foods (10 ppm). Harsh roasted
General comment Fat, hazel nut, almond

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2280 mg/kg
(Posternak et al., 1975)

oral-bird - wild LD50 1000 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

oral-rat LD50 2280 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 487, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-acetyl pyridine usage levels up to:
0.5000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 50.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 68.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
Click here to view publication 5
average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: -3.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -3.00000
hard candy: -3.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -3.00000
milk products: -3.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -3.00000
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013)
View page or View pdf

Safety and efficacy of pyridine and pyrrole derivatives belonging to chemical group 28 when used as flavourings for all animal species
View page or View pdf

Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1122-62-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :14286
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1-pyridin-2-ylethanone
Chemidplus:0001122629
RTECS:OB5310000 for cas# 1122-62-9