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3-acetyl pyridine

Chemical Structure

General Material Information

Preferred name 3-acetyl pyridine
Trivial Name 3-Acetylpyridine
Short Description 3-acetylpyridine
Formula C7 H7 N O
CAS Number 350-03-8
FEMA Number 3424
Flavis Number 14.039
ECHA Number 206-496-7
FDA UNII 00QT8FX306
Nikkaji Number J5.689H
Beilstein Number 0107751
MDL MFCD00006396
COE Number 2316
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1316 3-acetylpyridine
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 350-03-8 ; 3-ACETYLPYRIDINE
Synonyms
  • 3-acetopyridine
  • 3 acetyl pyridine
  • beta- acetyl pyridine
  • 3-acetylpyridine
  • 3-acetylpyridine FCC
  • ethanone, 1-(3-pyridinyl)-
  • ketone, methyl 3-pyridyl
  • methyl 3-pyridyl ketone
  • methyl beta-pyridyl ketone
  • methyl pyridyl ketone
  • 1-(3-pyridenyl)ethanone
  • 1-pyridin-3-yl-ethanone
  • 1-( pyridin-3-yl)ethan-1-one
  • 1-( pyridin-3-yl)ethanone
  • 1-pyridin-3-ylethanone
  • 1-(3-pyridinyl) ethanone
  • 1-(3-pyridinyl)ethanone
  • 3-pyridyl methyl ketone
  • 3-pyridylmethyl ketone
  • 1-pyridin-3-ylethanone
  • 1-(3-Pyridinyl)ethanone
  • β-Acetylpyridine
  • 3-Acetylpyridine
  • Methyl β-pyridyl ketone
  • 3-Acetopyridine
  • 3-Pyridyl methyl ketone
  • 3-Pyridinyl methyl ketone
  • NSC 761
  • 1-(Pyridin-3-yl)ethan-1-one
  • 1-(Pyridin-3-yl)ethanone
  • Methyl pyridin-3-yl ketone
  • 1-(3-Pyridyl)ethanone
  • 3-Pyridylethanone

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33131
FooDB:FDB011132
Export Tariff Code:2933.39.9100
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 121.13899230957
Specific gravity @ 25 °C
Pounds per Gallon 9.178 to 9.253
Refractive Index 1.53 to 1.54 @ 20 °C
Melting Point 13 to 14°C @ 760 mm Hg
Boiling Point 228 to 230°C @ 760 mm Hg
Vapor Pressure 0.111 mmHg @ 25 °C
Flash Point TCC Value 103.89 °C TCC
logP (o/w) 0.43
Solubility
acids Yes
alcohol Yes
ethyl ether Yes
water, 4.267e+004 mg/L @ 25 °C (est) Yes
water, 4.27E+04 mg/L @ 25 °C (exp) Yes

Organoleptic Properties

Odor Type: Nutty
sweet, nutty, dry, hawthorn, phenolic, woody, popcorn
Odor strength high , recommend smelling in a 1.00 % solution or less
Substantivity 45 hour(s) at 100.00 %
Luebke, William tgsc, (1998) At 1.00 % in dipropylene glycol. sweet nutty dry hawthorn phenolic woody popcorn
Flavor Type: Nutty
nutty, roasted, corn chip, nut skin, corn, popcorn
Luebke, William tgsc, (1998) Nutty roasted corn chip nut skin corn popcorn

Occurrences

Potential Uses

Applications
Odor purposes Bread baked bread, Filbert, Jasmin, Lily, Peanut, Popcorn, Tobacco, Tuberose
Flavoring purposes Beverage, Meat

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 25 - Toxic if swallowed.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 46 ul/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) MUSCULOSKELETAL: OTHER CHANGES
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 681, 1992.

intraperitoneal-mouse LD50 182 mg/kg
Journal of Pharmaceutical Sciences. Vol. 64, Pg. 528, 1975.

oral-quail LD50 422 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

oral-bird - wild LD50 178 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 3-acetyl pyridine usage levels up to:
0.1000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 23.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.80 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 8
Click here to view publication 8
average usual ppmaverage maximum ppm
baked goods: -3.00000
beverages(nonalcoholic): -2.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: -3.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -2.00000
fruit ices: -2.00000
gelatins / puddings: -2.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013)
View page or View pdf

Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):350-03-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9589
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2810
WGK Germany:1
1-pyridin-3-ylethanone
Chemidplus:0000350038
RTECS:OB5425000 for cas# 350-03-8