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    General Material Information
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dibenzyl ether

Chemical Structure

General Material Information

Preferred name dibenzyl ether
Trivial Name Dibenzyl ether
Short Description 1,1-(oxybis(methylene))bisbenzene
Formula C14 H14 O
CAS Number 103-50-4
FEMA Number 2371
Flavis Number 3.004
ECHA Number 203-118-2
FDA UNII 2O6CNO27RJ
Nikkaji Number J1.181I
Beilstein Number 1911156
MDL MFCD00004780
COE Number 11856
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1256 dibenzyl ether
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 103-50-4 ; DIBENZYL ETHER
Synonyms
  • benzene, 1,1'-(oxybis(methylene))bis-
  • benzene, 1,1'-[oxybis(methylene)]bis-
  • benzene, 1,1'-oxybis(methylene-
  • benzene,1'-[oxybis(methylene)]bis-
  • benzyl ether
  • benzyl oxide
  • di benzyl ether
  • dibenzyl ether FCC
  • dibenzyl oxide
  • dibenzylether
  • ether, dibenzyl
  • 1,1-oxybis methylene, bis benzene
  • 1,1'-oxybis( methylene) benzene
  • 1,1'-(oxybis( methylene)) bisbenzene
  • 1,1-(oxybis( methylene))bisbenzene
  • 1,1'-(oxybis( methylene))bisbenzene
  • 1,1'-[oxybis( methylene)]dibenzene
  • phenylmethoxymethylbenzene
  • plasticator BA
  • plastikator BA
  • Benzene, 1,1′-[oxybis(methylene)]bis-
  • 1,1′-[Oxybis(methylene)]bis[benzene]
  • BA (plasticizer)
  • BA
  • NSC 5931
  • [(Benzyloxy)methyl]benzene
  • (Oxybis(methylene))dibenzene

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

phenylmethoxymethylbenzene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:103-50-4
Pubchem (cid):7657
Pubchem (sid):134972229
Publications by PubMed
Safety evaluation of dibenzyl ether.
[Study on the chemical constituents of Gastrodia elata].
Phytotoxic aromatic constituents of Oxalis pes-caprae.
Microcapsules from starch granules.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB32078
FooDB:FDB008793
Export Tariff Code:2909.30.6000
VCF-Online:VCF Volatile Compounds in Food
Formulations/Preparations:
grade: technical

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 198.2647857666
Specific gravity @ 25 °C
Pounds per Gallon 8.646 to 8.687
Refractive Index 1.561 to 1.562 @ 20 °C
Melting Point 1.5 to 3.5°C @ 760 mm Hg
Boiling Point 295 to 298°C @ 760 mm Hg
Vapor Pressure 0.00103 mmHg @ 25 °C
Vapor Density 6.8
Flash Point TCC Value 135 °C TCC
logP (o/w) 3.31
Solubility
alcohol Yes
water, 40 mg/L @ 35 °C (exp) Yes
water No
Stability
cream Unspecified
lipstick Unspecified
non-discoloring in most media Unspecified
shampoo Unspecified
soap Unspecified

Organoleptic Properties

Odor Type: Earthy
sweet, fruity, cherry, earthy, mushroom, rose, plastic
Odor strength medium
Substantivity 400 hour(s) at 100.00 %
Luebke, William tgsc, (1987) At 100.00 %. sweet fruity cherry earthy mushroom rose plastic
Flavor Type: Fruity
fruity, cherry, fungal, plastic, mushroom
Luebke, William tgsc, (1987) Fruity cherry fungal plastic mushroom

Occurrences

Potential Uses

Applications
Odor purposes Almond, Balsam, Earth, Fungus, Geranium, Herbal, Lavender, Narcissus, Rose, Woody
Other purposes Plastic
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-mouse LD50 4300 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: FOOD INTAKE (ANIMAL)
Toksikologicheskii Vestnik. Vol. (1), Pg. 34, 1997.

oral-rat LD50 2500 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 703, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Dermal sensitization and systemic toxicity
View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.000040 %
Category 2: Products applied to the axillae
0.0028 %
Category 3: Products applied to the face/body using fingertips
0.00020 %
Category 4: Products related to fine fragrance
0.012 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.0023 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.00024 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.00032 %
Category 5D: Baby Creams, baby Oils and baby talc
0.000081 %
Category 6: Products with oral and lip exposure
0.0023 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
0.00093 %
Category 7B: Leave-on products applied to the hair with some hand contact
0.00093 %
Category 8: Products with significant anogenital exposure
0.000081 %
Category 9: Products with body and hand exposure, primarily rinse off
0.0037 %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
0.0037 %
Category 10B: Household aerosol/spray products
0.0037 %
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
0.000081 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
0.000081 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
0.24 %
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Maximised Survey-derived Daily Intakes (MSDI-EU): 0.49 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 241.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -25.00000
beverages(nonalcoholic): -8.30000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 85.00000160.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -5.60000
fruit ices: -5.60000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -23.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):103-50-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7657
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3082
WGK Germany:2
phenylmethoxymethylbenzene
Chemidplus:0000103504
EPA/NOAA CAMEO:hazardous materials
RTECS:DQ6125000 for cas# 103-50-4