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4-tert-butyl phenol

General Material Information

Preferred name	4-tert-butyl phenol
Trivial Name	4-tert-Butylphenol
Short Description	para-tert-butylphenol
Formula	C10 H14 O
CAS Number	98-54-4
FEMA Number	3918
Flavis Number	4.064
ECHA Number	202-679-0
FDA UNII	O81VMW36CV
Nikkaji Number	J3.579C
Beilstein Number	1817334
MDL	MFCD00002367
Bio Activity Summary	External link
NMR Predictor	External link
JECFA Food Flavoring	733 4-(1,1-dimethylethyl) phenol
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	98-54-4 ; 4-(1,1-DIMETHYLETHYL)PHENOL
Synonyms	butyl phen p-tert- butyl phenol para-tert- butyl phenol 1-tert- butyl-4-hydroxybenzene 4-(tert- butyl)phenol 4-tert- butylphenol p-tert- butylphenol para-tert- butylphenol 4-(1,1-dimethyl ethyl) phenol 4-(1,1-dimethyl)ethylphenol 4-(1,1-dimethylethyl) phenol 4-(1,1-dimethylethyl)phenol 1-hydroxy-4-tert-butyl benzene 1-hydroxy-4-tert-butylbenzene 4-(2-methyl-2-propanyl)phenol paraterciobutylphenol resin SC / 108575 phenol, 4-(1,1-dimethylethyl)- phenol, 4-t-butyl- terbutol 4-tert-butylphenol Phenol, p-tert-butyl- 4-(1,1-Dimethylethyl)phenol Butylphen p-tert-Butylphenol PTBP NSC 3697 B 110666

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Literature & References

	4-tert-butylphenol
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	98-54-4
Pubchem (cid):	7393
Pubchem (sid):	134971304

Publications by PubMed
The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice.
Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol.
Absence of experimental evidence of a delta-shock in the system phenetole and 4-tert-butylphenol on Zorbax 300SB-C18.
Occurrence of 4-tert-butylphenol (4-t-BP) biodegradation in an aquatic sample caused by the presence of Spirodela polyrrhiza and isolation of a 4-t-BP-utilizing bacterium.
Toward a better understanding of Fe(III)-EDDS photochemistry: theoretical stability calculation and experimental investigation of 4-tert-butylphenol degradation.
A Biomimetic Mechanism for the Copper-Catalyzed Aerobic Oxygenation of 4-tert-Butylphenol.
New enzymatically polymerized copolymers from 4-tert-butylphenol and 4-ferrocenylphenol and their modification and inclusion complexes with β-cyclodextrin.
The 4-tert-butylphenol-utilizing bacterium Sphingobium fuliginis OMI can degrade bisphenols via phenolic ring hydroxylation and meta-cleavage pathway.
Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment.
Aromatic ring cleavage of 2-amino-4-tert-butylphenol by a nonheme iron(II) complex: functional model of 2-aminophenol dioxygenases.
Solid phase analytical derivatization of anthropogenic and natural phenolic estrogen mimics with pentafluoropyridine for gas chromatography-mass spectrometry.
Development of a fabric phase sorptive extraction with high-performance liquid chromatography and ultraviolet detection method for the analysis of alkyl phenols in environmental samples.
Fe(III)-EDDS complex in Fenton and photo-Fenton processes: from the radical formation to the degradation of a target compound.
Structure and vibrational spectrum of the hydrogen-bonded system between 4-tert-butylphenol and N-bases: Ab initio and DFT studies.
Prooxidant actions of bisphenol A (BPA) phenoxyl radicals: implications to BPA-related oxidative stress and toxicity.
3d early transition metal complexes supported by a new sterically demanding aryloxide ligand.
Effects of 4-tert-octylphenol, 4-tert-butylphenol, and diethylstilbestrol on prenatal testosterone surge in the rat.
[Kinetics of endocrine disrupting chemical 4-tert-butylphenol during chlorination in aqua].
In vitro effects of diethylstilbestrol, genistein, 4-tert-butylphenol, and 4-tert-octylphenol on steroidogenic activity of isolated immature rat ovarian follicles.
Copper-promoted overall transformation of 4-tert-butylphenol to its para-hydroxyquinonic derivative, 2-hydroxy-5-tert-butyl-1,4-benzoquinone. Biomimetic studies on the generation of topaquinone in copper amine oxidases.
Tyrosinase-mediated formation of a reactive quinone from the depigmenting agents, 4-tert-butylphenol and 4-tert-butylcatechol.
Kinetics study of the oxidation of 4-tert-butylphenol by tyrosinase.
Magnetically confined hydrophobic nanoparticles for the microextraction of endocrine-disrupting phenols from environmental waters.
A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo.
Contact allergy to 2-hydroxy-5-tert-butyl benzylalcohol and 2,6-bis(hydroxymethyl)-4-tert-butylphenol, components of a phenolic resin used in marking pens.
Determination of 4-tert.-butylphenol and 4-tert.-butylcatechol in cosmetic products by reversed-phase high-performance liquid chromatography.
A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols.
Patch test results in children and adolescents across Europe Analysis of the ESSCA Networkª 2002-2010.
Cu(II)-mediated phenol oxygenation: chemical evidence implicates a unique role of the enzyme active site in promoting the chemically difficult tyrosine monooxygenation in TPQ cofactor biogenesis of copper amine oxidases.
Certification of reference materials for the determination of alkylphenols.
Discrimination between alternative substrates and inhibitors of tyrosinase.
Chemical category approach of genotoxicity studies for branched alkylphenols.
Shaping of mesoporous AISBA-15 as cylindrical nano reactor for tertiary butylation of phenol.
Anionic bipyridyl ligands for applications in metallasupramolecular chemistry.
Is drinking water a major route of human exposure to alkylphenol and bisphenol contaminants in France?
Tyrosinase action on monophenols: evidence for direct enzymatic release of o-diphenol.
Allergic contact dermatitis from chromate and 4-tert-butylphenol-formaldehyde resin in a father and daughter.
An on-line push/pull perfusion-based hollow-fiber liquid-phase microextraction system for high-performance liquid chromatographic determination of alkylphenols in water samples.
Sustainable biodegradation of phenolic endocrine-disrupting chemicals by Phragmites australis-rhizosphere bacteria association.
Experimental evidence of a delta-shock in nonlinear chromatography.
Band splitting in overloaded isocratic elution chromatography I. The experimental evidence.
Apoptosis regulators and responses in human melanocytic and keratinocytic cells.
Determination of endocrine-disrupting phenols in water samples by a new manual shaking-enhanced, ultrasound-assisted emulsification microextraction method.
Dummy molecularly imprinted polymers as the coating of stir bar for sorptive extraction of bisphenol A in tap water.
Determination of phenols with ion chromatography-online electrochemical derivatization based on porous electrode-fluorescence detection.
Synthesis, structure and ethylene polymerisation behaviour of vanadium(IV and V) complexes bearing chelating aryloxides.
Biodegradation of bisphenol A and 4-alkylphenols by Novosphingobium sp. strain TYA-1 and its potential for treatment of polluted water.
Comparative study of IQ-ultra and Finn Chambers test methodologies in detecting 10 common standard allergens that cause allergic contact dermatitis.
Effect of 3-hydroxyanthranilic acid on mushroom tyrosinase activity.
Band splitting in overloaded isocratic elution chromatography III. Modeling of adsorbate-adsorbate interactions by a two-component extension of a BET kinetic isotherm model.
Band splitting in overloaded isocratic elution chromatography II. New competitive adsorption isotherms.
Low-dose exposure to alkylphenols adversely affects the sexual development of Atlantic cod (Gadus morhua): acceleration of the onset of puberty and delayed seasonal gonad development in mature female cod.
Preparation of metal wire supported solid-phase microextraction fiber coated with multi-walled carbon nanotubes.
Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress.
Removal of alkylphenols from polluted sites using surfactant-assisted soil washing and photocatalysis.
Enhanced removal of aqueous BPA model compounds using Metalloligs.
Synthesis and reactivity of fluorous and nonfluorous aryl and alkyl iodine(III) dichlorides: new chlorinating reagents that are easily recycled using biphasic protocols.
Kinetic cooperativity of tyrosinase. A general mechanism.
Determination of antioxidants in new and used lubricant oils by headspace-programmed temperature vaporization-gas chromatography-mass spectrometry.
Determination of endocrine-disrupting compounds in cereals by pressurized liquid extraction and liquid chromatography-mass spectrometry. Study of background contamination.
Effluents from oil production activities contain chemicals that interfere with normal function of intra- and extra-cellular estrogen binding proteins.
Indoor air pollution by alkylphenols in Tokyo.
Mechanistic implications of variable stoichiometries of oxygen consumption during tyrosinase catalyzed oxidation of monophenols and o-diphenols.
Brominated phenols: characterization of estrogen-like activity in the human breast cancer cell-line MCF-7.
A model molecule of the hydrogen-bonded chain in the active site of bacteriorhodopsin.
[Degradation of endocrine disrupting chemicals(EDCs)-BP by combination of UV/ micro-aeration process and impact factors].
Effects of alkylphenols on glycerophospholipids and cholesterol in liver and brain from female Atlantic cod (Gadus morhua).
Provoking factors, including chemicals, in Dutch patients with vitiligo.
A confirmatory method for the determination of phenolic endocrine disruptors in honey using restricted-access material-liquid chromatography-tandem mass spectrometry.
Synthesis, characterization, and stability of iron (III) complex ions possessing phenanthroline-based ligands.
Thermochemical and Theoretical Study of tert-Butyl and Di-tert-butylphenol Isomers.
Reactivity of a 10-I-3 hypervalent iodine trifluoromethylation reagent with phenols.
Synthesis and structures of niobium(V) complexes stabilized by linear-linked aryloxide trimers.
Determination of endocrine disruptors in honey by CZE-MS using restricted access materials for matrix cleanup.
Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.
Multiple headspace-solid-phase microextraction as a powerful tool for the quantitative determination of volatile radiolysis products in a multilayer food packaging material sterilized with γ-radiation.
Removal of BPA model compounds and related substances by means of column chromatography using Octolig®.
Determination of endocrine disrupting compounds using temperature-dependent inclusion chromatography: I. Optimization of separation protocol.
[Induction of occupational leucoderma and vitiligo. Can butylated hydroxytoluene induce vitiligo similarly to p-tert-butylphenol?].
Effect-directed investigation and interactive effect of organic toxicants in landfill leachates combining Microtox test with RP-HPLC fractionation and GC/MS analysis.
Uptake and tissue distribution of C4-C7 alkylphenols in Atlantic cod (Gadus morhua): relevance for biomonitoring of produced water discharges from oil production.
Column silylation method for determining endocrine disruptors from environmental water samples by solid phase micro-extraction.
Effects of alkylphenols on the reproductive system of Atlantic cod (Gadus morhua).
European Standard Series patch test results from a contact dermatitis clinic in Israel during the 7-year period from 1998 to 2004.
Stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography--mass spectrometry for measurement of phenolic xenoestrogens in human urine samples.
2:2 Fe(III):ligand and "adamantane core" 4:2 Fe(III):ligand (hydr)oxo complexes of an acyclic ditopic ligand.
Inhibition of peroxidase-catalyzed oxidation of 3,3 ,5,5 -tetramethylbenzidine by aminophenols.
[Estimation of daily intake of phenols in hospital meal samples].
Determination of weakly acidic endocrine-disrupting compounds by liquid chromatography-mass spectrometry with post-column base addition.
Photodegradation of bisphenol-A with TiO2 immobilized on the glass tubes including the UV light lamps.
Effects of alkylphenols on CYP1A and CYP3A expression in first spawning Atlantic cod (Gadus morhua).
Shoe contact dermatitis in Israel.
Separation and on-line concentration of bisphenol A and alkylphenols by micellar electrokinetic chromatography with cationic surfactant.
[Analysis of phenolic compounds in mineral water by high performance liquid chromatography (HPLC)].
Developmental aspects of human hepatic drug glucuronidation in young children and adults.
Floral Origin Markers of Chestnut and Lime Tree Honeys.
Determination of 4-nonylphenol, nonylphenol monoethoxylate, nonylphenol diethoxylate and other alkylphenols in fish and shellfish by high-performance liquid chromatography with fluorescence detection.
Oxidation by mushroom tyrosinase of monophenols generating slightly unstable o-quinones.
Issues arising when interpreting results from an in vitro assay for estrogenic activity.
Competitive binding of xenobiotic oestrogens to rat alpha-fetoprotein and to sex steroid binding proteins in human and rainbow trout (Oncorhynchus mykiss) plasma.
Occupational exposure to estrogenic chemicals and the occurrence of breast cancer: an exploratory analysis.
Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13.
Chromatographic analysis of water and wine samples for phenolic compounds released from food-contact epoxy resins.
The relationship between Van der Waals volume of 4-substituent of phenol and sulfation in the rat.
Three-dimensional mesoporous gallosilicate with Pm3n symmetry and its unusual catalytic performances.
Characterization of alkylphenol metabolites in fish bile by enzymatic treatment and HPLC-fluorescence analysis.
Uptake of some selected aquatic pollutants in semipermeable membrane devices (SPMDs) and the polar organic chemical integrative sampler (POCIS).
Chemistry of 4-alkylaryloxenium ion "precursors": sound and fury signifying something?
Reactivity study of a hydroperoxodicopper(II) complex: hydroxylation, dehydrogenation, and ligand cross-link reactions.
Activation of dual apoptotic pathways in human melanocytes and protection by survivin.
Water purification through bioconversion of phenol compounds by tyrosinase and chemical adsorption by chitosan beads.
Simultaneous determination of alkylphenols and bisphenol A in river water by stir bar sorptive extraction with in situ acetylation and thermal desorption-gas chromatography-mass spectrometry.
Effects of alkylphenols on redox status in first spawning Atlantic cod (Gadus morhua).
Simultaneous measurement of urinary bisphenol A and alkylphenols by automated solid-phase extractive derivatization gas chromatography/mass spectrometry.
Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust.
Separation and on-line concentration of bisphenol A and alkylphenols by micellar electrokinetic chromatography with anionic surfactant.
Comparison of the adsorption equilibrium of a few low-molecular mass compounds on a monolithic and a packed column in reversed-phase liquid chromatography.
Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications.
Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation.
Determination of dimethyl fumarate and other potential allergens in desiccant and antimould sachets.
Effects of environmental relevant doses of pollutants from offshore oil production on Atlantic cod (Gadus morhua).
Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant.
Patch-test reactions to plastic and glue allergens.
Increase in the levels of chaperone proteins by exposure to beta-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor alpha cDNA.
[Influence of p-tert-butylphenol on immunity of mice].
Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent.
An expedient one-pot synthesis of para-tert-butylcalix[8]- and [9]arene.
Binding of alkylphenols and alkylated non-phenolics to the rainbow trout (Oncorhynchus mykiss) plasma sex steroid-binding protein.
Allergic contact dermatitis due to orthopedic shoes and a prosthesis for an amputated foot.
Effect of the endcapping of reversed-phase high-performance liquid chromatography adsorbents on the adsorption isotherm.
[Improved method for determining bisphenol A in polycarbonate products without using dichloromethane].
Effects of bisphenol A and its derivatives on the response of GABA(A) receptors expressed in Xenopus oocytes.
Effects of commonly used mitogens on the cytotoxicity of 4-tertiary butylphenol to human melanocytes.
Contact allergy to the monomers of p-tert-butylphenol-formaldehyde resin in the guinea pig.
Active sensitization and occupational allergic contact dermatitis caused by para-tertiary-butylcatechol.
Hydrogen peroxide-dependent 4-t-butylphenol hydroxylation by tyrosinase--a new catalytic activity.
Is Bindi-induced depigmentation common in patients predisposed to vitiligo?
[Assessment of occupational exposure to p-tert-butylphenol in synthetic resin factories].
Contact depigmentation by adhesive material of bindi.
Contact depigmentation of the breast.
Contact depigmentation from free para-tertiary-butylphenol in bindi adhesive.
Urinary metabolite levels in workers handling p-tert-butylphenol as an index of personal exposure.
Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.
Occupational vitiligo due to unsuspected presence of phenolic antioxidant byproducts in commercial bulk rubber.
[Occupational asthma due to para-tert-butylphenol: case report].
Occupational leukoderma and contact dermatitis from paratertiary-butylphenol.
A study on the synthesis of calix[4 and 6]arenes using alternately arranged phloroglucinols and p-tert-butylphenols.
Shoe dermatitis from para-tertiary butylphenol formaldehyde.
Molecular and electronic structure of square-planar gold complexes containing two 1,2-Di(4-tert-butylphenyl)ethylene-1,2-dithiolato ligands: [Au(2L)2]1+/0/1-/2-. A combined experimental and computational study.
4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.
An attempt to improve diagnostics of contact allergy due to epoxy resin systems. First results of the multicentre study EPOX 2002.
Effect of deoxyarbutin on melanogenesis: in vivo comparison with other melanogenesis inhibitor.
Alkylphenol and bisphenol A levels in rubber products.
Molecular recognition by beta-cyclodextrin derivatives: FEP vs MM/PBSA study.
The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity.
Effects of 4-tertiary butylphenol on the tyrosinase activity in human melanocytes.
Demonstration of the contact sensitizer p-tert-butylcatechol in p-tert-butylphenol formaldehyde resin.
The acute toxicity of selected alkylphenols to young and adult Daphnia magna.
Is micropigmentation surgery an answer to stable bindi-induced depigmentation?
Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis. Application to cases from rubber footwear.
Allergic contact dermatitis from para-tertiary-butylphenol-formaldehyde resin (PTBP-F-R) in Northern Ireland.
Allergic contact dermatitis of the lip margins from para-tertiary-butylphenol in a lip liner.
Effects of p-tert-butylphenyl trans-4-guanidinomethylcyclohexane carboxylate hydrochloride (NCO-650) and its metabolite, p-tert-butylphenol(BP) on drug-metabolizing enzymes and fine structure in rat liver.
Acute toxicity and primary irritation of para-tertiary butylphenol.
[Skin and systemic disease caused by occupational contact with p-tert-butylphenol. Case reports].
[Analysis of para-tert-butylphenol, phenol and diphenylpropane].
[Shoe eczema caused by para-tertiary butylphenol. Making shoes with glue free of para-tertiary butylphenol].
[Dyschromia caused by para-tert-butylphenol].
Occupational vitiligo: clinical and epidemiological aspects.
[Vitiligo due to p-tert-butylphenol].
[Chemical vitiligo caused by para-tertiary butyl phenol (author's transl)].
[Vitiligo from p-tert. butylphenol; a contribution to the problem of the internal manifestations of this occupational disease].
Determination of phenolic xenoestrogens in water by liquid chromatography with coulometric-array detection.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
FDA Indirect Additives used in Food Contact Substances:	View
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C14200
HMDB (The Human Metabolome Database):	HMDB32063
FooDB:	FDB008772
Export Tariff Code:	2907.19.2000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Suppliers

Parchem	Penta International
Sigma-Aldrich	TCI AMERICA
WholeChem	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	150.22077941895
Vapor Pressure	0.0381 mmHg @ 25 °C
Flash Point TCC Value	93.33 °C TCC
logP (o/w)	3.31
Solubility
alcohol	Yes
water, 580 mg/L @ 25 °C (exp)	Yes
water	No

Organoleptic Properties

Odor Type: Leathery
oakmoss, leathery
General comment	At 1.00 % in propylene glycol. oakmoss leather

Occurrences

Potential Uses

Applications	food contact resinous and polymeric coatings
Odor purposes	Animal , Leather
Cosmetic purposes	Not used anymore

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. S 57 - Use appropriate containment to avoid enviromental contamination. S 60 - This material and its container must be disposed of as hazardous waste. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3250 ul/kg American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. intraperitoneal-rat LD50 225 mg/kg National Technical Information Service. Vol. OTS0573039 intraperitoneal-mouse LD50 78 mg/kg Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975. oral-mammal (species unspecified) LD50 1500 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980. gavage-rat LD50 [sex: M,F] M: 5360 mg/kg (Klonne et al., 1988) gavage-rat LD50 [sex: M,F] F: 3620 mg/kg (Klonne et al., 1988) gavage-rat LD50 [sex: M] 3.25 ml/kg (Smyth et al., 1969a) oral-rat LD50 1400 mg/kg (Palanker & Denine, 1973) oral-guinea pig LD50 1400 mg/kg Value = LD100 (Dow Chemical Company, 1943) oral-guinea pig LD50 400 mg/kg Value = LD0 (Dow Chemical Company, 1943)
Dermal Toxicity:
skin-rabbit LD50 2520 ul/kg American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. skin-mammal (species unspecified) LD50 1580 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
Inhalation Toxicity:
inhalation-rat LCLo 5600 mg/m3/4H LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE Drug and Chemical Toxicology. Vol. 11, Pg. 43, 1988.

Safety in use information

Category:
food contact resinous and polymeric coatings
IFRA Critical Effect:
Dermal sensitization, dermal depigmentation
	View the IFRA Standard
Recommendation for 4-tert-butyl phenol usage levels up to:
	PROHIBITED: Should not be used as a fragrance ingredient.

Maximised Survey-derived Daily Intakes (MSDI-EU):		0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA):		0.01 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
Click here to view publication 19
		average usual ppm	average maximum ppm
baked goods:		0.10000	1.00000
beverages(nonalcoholic):		0.50000	0.50000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		0.01000	0.10000
granulated sugar:		-	-
gravies:		-	-
hard candy:		0.10000	2.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		1.00000	2.00000
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

EPI System: View

NIOSH International Chemical Safety Cards:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

Carcinogenic Potency Database:Search

EPA Substance Registry Services (TSCA):98-54-4

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :7393

National Institute of Allergy and Infectious Diseases:Data

WISER:UN 3077