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  1. 1.
    General Material Information
  2. 2.
    PhysChem Properties
  3. 3.
    Occurrences
  4. 4.
    Organoleptic Properties
  5. 5.
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  6. 6.
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    Literature & References

1-dodecanol

Chemical Structure

General Material Information

Preferred name 1-dodecanol
Trivial Name 1-Dodecanol
Short Description lauryl alcohol
Formula C12 H26 O
CAS Number 112-53-8
Deleted CAS Number 1173838-88-4
FEMA Number 2617
Flavis Number 2.008
ECHA Number 203-982-0
FDA UNII 178A96NLP2
Nikkaji Number J1.505I
Beilstein Number 1738860
MDL MFCD00004753
COE Number 56
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 109 lauryl alcohol
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 112-53-8 ; LAURYL ALCOHOL
Synonyms
  • alcohol C-12
  • alcohol C-12 (lauryl alcohol)
  • alcohol C-12 lauric
  • alcohol C-12 lauric FCC
  • alcohol C-12 natural
  • alcohol C12
  • dodecan-1-ol
  • N- dodecan-1-ol
  • 1-dodecanol
  • N- dodecanol
  • dodecyl alcohol
  • 1-dodecyl alcohol
  • N- dodecyl alcohol
  • 1-duodecyl alcohol
  • 1-hydroxydodecane
  • lauric alcohol
  • laurinic alcohol
  • lauryl alcohol
  • N- lauryl alcohol
  • undecyl carbinol
  • n-Dodecyl alcohol
  • Lauryl 24
  • Sipol L 12
  • Pisol
  • Siponol L 2
  • Siponol L 5
  • Siponol 25
  • n-Dodecan-1-ol
  • Alfol 12
  • S 1298
  • 1-Dodecyl alcohol
  • 1-Hydroxydodecane
  • Kalcohl 20
  • NAA 42
  • Conol 20P
  • Lorol C 12
  • Adol 10
  • Adol 11
  • Adol 12
  • Conol 20PP
  • Kalcohl 2098
  • Hainol 12SS
  • Nacol 12-96
  • Epal 12
  • Lorol C 12/98
  • NSC 3724
  • Conol 1275
  • K 20 (alcohol)
  • K 20
  • Kalcol 2098
  • C 1214N
  • Lipocol L
  • Nacol 12-99
  • Magnol 1216MB

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Literature & References

dodecan-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:112-53-8
Pubchem (cid):8193
Pubchem (sid):134973347
Flavornet:112-53-8
Pherobase:View
Publications by Info
Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.)

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C02277
HMDB (The Human Metabolome Database):HMDB11626
FooDB:FDB012483
Export Tariff Code:2905.17.0000
FDA Listing of Food Additive Status:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: technical, fcc •lorol 810: c6 alcohol, 0-5 wt%; c8 alcohol, 50-66 wt%; c10 alcohol, 30-40 wt%; c12 alcohol, 3-8 wt% from table

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 186.33842468262
Specific gravity @ 25 °C
Pounds per Gallon 6.898 to 6.981
Refractive Index 1.44 to 1.45 @ 20 °C
Melting Point 22 to 26°C @ 760 mm Hg
Boiling Point 260 to 262°C @ 760 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 0.00084 mmHg @ 25 °C
Vapor Density 7.4
Flash Point TCC Value 110 °C TCC
logP (o/w) 5.13
Shelf life 36 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
fixed oils Yes
propylene glycol Yes
water, 6.898 mg/L @ 25 °C (est) Yes
water, 4 mg/L @ 25 °C (exp) Yes
paraffin oil No
water No
glycerin No
Stability
non-discoloring in most media Unspecified
shampoo Unspecified

Organoleptic Properties

Odor Type: Waxy
earthy, soapy, waxy, fatty, honey, coconut
Odor strength medium
Substantivity 400 hour(s) at 100.00 %
Luebke, William tgsc, (1982) At 100.00 %. earthy soapy waxy fatty honey coconut
Flavor Type: Soapy
soapy, waxy, clean, aldehydic, earthy, cilantro, watery, fatty, greasy
Luebke, William tgsc, (1982) Soapy waxy clean aldehydic earthy cilantro watery fatty greasy

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 36/38 - Irritating to skin and eyes.
R 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 36 - Wear suitable protective clothing.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
GHS Label elements, including precautionary statements
Pictogramexclamation-mark.jpgenvironment.jpg
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
H400 - Very toxic to aquatic life
H410 - Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P391 - Collect spillage. Hazardous to the aquatic environment
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 > 12800 mg/kg
Medizin und Ernaehrung. Vol. 8, Pg. 244, 1967.

Dermal Toxicity:
skin-guinea pig LD50 > 10 ml/kg
Food and Cosmetics Toxicology. Vol. 11, Pg. 95, 1973.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 1-dodecanol usage levels up to:
4.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3. Update in publication number(s): 29
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: 9.0000014.00000
beverages(nonalcoholic): 2.000003.00000
beverages(alcoholic): 1.0000010.00000
breakfast cereal: --
cheese: --
chewing gum: 24.0000027.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 4.000007.00000
fruit ices: --
gelatins / puddings: 4.000007.00000
granulated sugar: --
gravies: --
hard candy: 6.000006.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 0.030000.03000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 5.000008.00000
soups: --
sugar substitutes: --
sweet sauces: 7.000007.00000

Safety references

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species
View page or View pdf

Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for Straight Chain Lepidopteran Pheromones (SCLPs) in light of confirmatory data
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):112-53-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8193
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3082
WGK Germany:2
dodecan-1-ol
Chemidplus:0000112538
EPA/NOAA CAMEO:hazardous materials
RTECS:JR5775000 for cas# 112-53-8